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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： di Wu Yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

Optimal predictive sliding-mode guidance law for intercepting near-space hypersonic maneuvering target

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Chinese Journal of Aeronautics 2022年第4期35卷 320-331页

作者： Bolun ZHANG di ZHOU School of Astronautics Harbin Institute of TechnologyHarbin 150001China

The design of optimal guidance law for intercepting a near-space hypersonic maneuvering target with bounded inputs is considered. Firstly, a maneuvering model for near-space hypersonic aircraft is given. Then, the aircraft acceleration prediction can be obtained using this model with two neural networks. By using the target acceleration prediction, which is taken into account when calculating the Zero Effort Miss(ZEM), an optimal sliding-mode guidance law is proposed to fulfill the guidance task. An adaptive sliding-mode switch term is designed to deal with actuator saturation and prediction errors. Finally, numerical simulations show that the proposed guidance law can reduce the energy consumption and the terminal acceleration command of the interceptor effectively.

关键词： Adaptive sliding-mode control Near-space hypersonic aircraft Neural networks Optimal control Predictive guidance law

Strong convergence rate of principle of averaging for jump-diffusion processes

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Frontiers of Mathematics in China 2012年第2期7卷 305-320页

作者： di LIU Department of Mathematics Michigan State University East Lansing MI 48824 USA

We study jump-diffusion processes with two well-separated time scales. It is proved that the rate of strong convergence to the averaged effective dynamics is of order O（ε1/2）, where s 〈〈 1 is the parameter measuring the disparity of the time scales in the system. The convergence rate is shown to be optimal through examples. The result sheds light on the designing of efficient numerical methods for multiscale stochastic ,dynamics.

关键词： Stochastic differential equation time scale separation averaging ofperturbations

Strain amplitude-dependent internal friction of as-cast high damping magnesium alloy during cyclic vibration

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Rare Metals 2013年第1期32卷 25-28页

作者： di-Qing Wan Key Laboratory of Ministry of Education for Conveyance and Equipment East China Jiaotong University

An investigation on strain amplitude-dependent internal friction （IF） of an as-cast high damping Mg-7 wt% Ni alloy was carried out. In the range of our tested strain amplitudes, whether the strain amplitude is increasing or decreasing, the strain amplitude-dependent IF curve can be divided into two stages： one is the strain amplitude weakly dependent part and the other is the strain amplitude strongly dependent part. However, after several cyclic vibrations, the IF values measured during the strain amplitude increasing are smaller than those obtained during the strain amplitude decreasing. The phenomenon is also observed at 100 C. Partial dislocations generate a short-range slip under the cyclic stress to be responsible for it.

关键词： Magnesium alloys Strain amplitude Internal friction

Phase selection and performance of Mg–Cu–Y amorphous composite with different Mg/Cu ratios

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Rare Metals 2014年第1期33卷 91-94页

作者： di-Qing Wan School of Mechanical and Electronical Engineering East China Jiaotong University

In this article, Mg-Cu-Y alloys with two dif- ferent Mg/Cu ratios （in at%） were prepared using a water- cooled copper mold. Scanning electron microscopy and X-ray diffraction were applied to analyze the microstructure and phase composition. Moreover, corrosion resistance and wear resistance were studied systematically. The results show that both Mg65Cu25Ylo and Mg60Cu30Ylo alloys could form a composition of crystalline and amorphous phases. Although the microstructure of Mg65Cu25Ylo con- sists of an amorphous phase and ：t-Mg, Mg2Cu, and Cu2Y crystalline phases, the microstructure of Mg60Cu30Ylo alloy mainly consists of the amorphous phase and ：t-Mg, Mg2Cu. With reducing Mg/Cu ratio, the alloys have better corrosion resistance and wear resistance. The mechanism has also been discussed in detail.

关键词： Mg-Cu-Y alloy Amorphous composites Corrosion resistance Wear resistance

Stirred casting Al–Pb monotectic alloys with high damping capacity

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Rare Metals 2015年第8期34卷 560-563页

作者： di-Qing Wan Key Laboratory of Ministry of Education for Conveyance and Equipment East China Jiaotong University

In this study, the stirred casting with various processing parameters, such as stirring temperature and stirring speeds, was carried out on the Al–Pb monotectic alloys in order to make Pb particles distribute much more uniformly. More importantly, their damping capacities were systematically studied. The results show tha mechanical stirring can not only make Pb in the aluminum matrix uniformly distribute but also dynamically influence the damping capacity of this alloy system. The Al–Pb alloy was prepared under a slow speed at solid–liquid temperature region, wherein high volume fraction of Pb in alloy could be obtained. The high volume fraction of Pb gives high overall damping capacity. The dislocation damping and interface damping theories are mainly dominated to the alloys.

关键词： Al–Pb alloy Mechanical stirring Damping capacity

Synthesis, Anti-lung Cancer Activity and Docking Study of New Organic Compounds

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Chinese Journal of Structural Chemistry 2020年第6期39卷 1119-1125页

作者： LI di Inner Mongolia University for Nationalities Tongliao 028000China

Novel organic compounds(1~8) were designed, synthesized and characterized by IR, ~1H NMR, H RMS, and single-crystal X-ray crystallography. The anticancer activities of these compounds were investigated against four human lung cancer cells(H20, H2227, H69 and H524) by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT) assay. Furthermore, by taking compounds 1 and 5 as representatives, molecular docking studies supported the biological assay data, suggesting that compared with 1, compound 5 has stronger interaction with protein.

关键词： MTT assay anticancer activity molecular docking

Least-squares reverse-time migration for reflectivity imaging

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Science China Earth Sciences 2015年第11期58卷 1982-1992页

作者： YAO Gang WU di Department of Earth Science and Engineering Imperial College London The Unconventional Natural Gas Institute China University of Petroleum (Beijing)

A least-squares reverse-time migration scheme is presented for reflectivity imaging. Based on an accurate reflection modeling formula, this scheme produces amplitude-preserved stacked reflectivity images with zero phase. Spatial preconditioning, weighting and the Barzilai-Borwein method are applied to speed up the convergence of the least-squares inversion. In addition, this scheme compensates the effect of ghost waves to broaden the bandwidth of the reflectivity images. Furthermore, roughness penalty constraint is used to regularize the inversion, which in turn stabilizes inversion and removes high-wavenumber artifacts and mitigates spatial aliasing. The examples of synthetic and field datasets demonstrate the scheme can generate zerophase reflectivity images with broader bandwidth, higher resolution, fewer artifacts and more reliable amplitudes than conventional reverse-time migration.

关键词： adjoint migration least-squares reverse-time migration cross-correlation imaging condition deconvolution imagingcondition deghost

Effects of finishing rolling temperatures and reduction on the mechanical properties of hot rolled multiphase steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 797-804页

作者： LI Zhuang WU di Department of Materials Engineering Shenyang Institute of Aeronautical Engineering Shenyang 110034 China The State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 China

Effects of finishing rolling temperatures and reduction on the mechanical properties of hot rolled multiphase steel were investigated. Thermo-mechanical control processing (TMCP) was conducted by using a laboratory hot rolling mill, in which three different kinds of finishing rolling temperatures and reduction and various austempering times were applied. The results showed that polygonal ferrite, granular bainite and larger amount of stabilized retained austenite can be obtained by controlled rolling processes, and that the strain-induced transformation to martensite from the retained austenite can occur gradually when the steel is deformed during tensile test. Mechanical properties increase with decreasing finishing rolling temperature and increasing amount of deformation. The most TRIP (transformation induced plasticity) effect, and ultimate tensile strength (UTS), total elongation (TEL) and the product of ultimate tensile strength and total elongation (UTS×TEL) are obtained at 20 min.

关键词： Hot rolling conditions Retained austenite Hot rolled multiphase steels Mechanical properties