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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo di wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Synthesis, characterization, theoretical investigation, and properties of monoclinic-phase InWO4 hollow nanospheres

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Nano Research 2018年第9期11卷 4664-4672页

作者： Yuping wang di wang Ying Xie Guofeng wang Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education School of Chemistry and Materials ScienceHeilongjiang University Harbin 150080 China

As a newly discovered member of the ttmgstate famil3~ InWO4 hollow nanospheres with a monoclinic wolframite structure were synthesized successfully. The crystal phase of InWO4 was investigated via a combination of CASTEP geometric optimization and experimental simulation. InWO, has a space group of P2/c with two InWO, formula units per unit cell. The optimized cell dimensions are a = 5.16 A, b = 5.97 A, and c = 5.23 A, with a = 90°, β= 92.11°, 7 = 90°, giving a unit cell volume of 161.10 A^3, which is consistent with the experimental measurements. More importantly, InWO4 was a promising host material for different Ln^3＋（Ln = Eu and Yb/Er） ions. For InWO4：Yb^3＋/Er^3＋ excited at 980 nm, transitions from the ^4G11/2 （384 nm）, ^2H9/2 （411 nm）, and ^4F7/2 （487 nm） levels to the ground state （^4I15/2） of Er^3＋ were observed. In addition to the aforementioned properties, the InWO4 hollow nanospheres can be used to improve the performance of dye-sensitized solar cells, which is chiefly attributed to their light scattering.

关键词： InWO4 rare earth hollow nanospheres luminescence

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Rare metals preparation by electro-reduction of solid compounds in high-temperature molten salts

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Rare Metals 2016年第8期35卷 581-590页

作者： Wei Xiao di-Hua wang School of Resource and Environmental Sciences Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy Wuhan University

direct electro-reduction of solid compounds in molten salts is a simple and straightforward electrolytic metallurgical method, which outperforms traditional pyrometallurgical methods such as carbothermic and met- allothermic reductions in terms of economic viability, energy efficiency and carbon footprint. To better highlight the features of the direct electro-reduction of solid com- pounds in molten salts in extraction of rare metals, the scope of this paper is focused on the know-how of the cathodic process of the direct electro-reduction of solid compounds in molten salts in extraction of rare refractory metals including Ti, Zr, Hf, V, Nb, Ta, Mo and W, and rare disperse metals including Ga and Ge. In line with an introduction of the basic concept of the method, the char- acteristics of reaction paths in different systems are sum- marized and the corresponding strategy on tailoring energy efficiency and microstructure of electrolytic products are rationalized. The economic competence of the method might be enhanced by extending the method to controllable production of rare metals with high added values, well- defined microstructure and intriguing functionality.

关键词： Rare metals Molten salt electrolysis Solidcompounds Electrochemical metallurgy

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The progressive onset and evolution of Precambrian subduction and plate tectonics

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Science China Earth Sciences 2020年第12期63卷 2068-2086页

作者： Xiaolei wang Fulai Liu Junyong Li di wang State Key laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing210023China Institute of Geology Chinese Academy of Geological SciencesBeijing100037China

The regime of plate tectonics on early Earth is one of the fundamental problems in Earth *** era takes the majority(ca.88%)of Earth’s history and thus plays a key role in understanding the onset of plate tectonics and the mechanism,distribution and process of Precambrian subduction *** paper presents a review on the progresses of subduction and subduction zones in different stages of Precambrian era,and sorts out some key issues and fields that merits further *** suggest that there was progressive onset and evolution of subduction and plate tectonics from Archean to Proterozoic *** emphasize the importance of comprehensive studies on subduction mechanism,metamorphic type,plate tectonics regime,the compositional evolution of continental crust,and petrogenesis of diverse granitoids formed in the *** is proposed that innovative analytical techniques,big data,experimental petrology and numerical geodynamic modeling will facilitate future studies of Precambrian subduction zones.

关键词： Precambrian Subduction Plate tectonics Continent formation Progressive evolu

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Non-alkyl tin-oxo clusters as new-type patterning materials for nanolithography

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Science China Chemistry 2022年第1期65卷 114-119页

作者： di wang Xiaofeng Yi Lei Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

Nanolithography plays crucial roles in the miniaturization of dense integrated circuit,which extremely depends on innovative resist ***,metal-containing resists have been explored due to their higher short-wavelength photon absorption than traditional polymer ***,for the first time,the patterning performance of non-alkyl tin-oxo clusters has been ***,the influence of structural characteristics on resolution and sensitivity has been *** evaluate the surface ligand effect,three non-alkyl Sn_(10)-oxo clusters with the same core were functionalized with pyrazole,3-methylpyrazole and 4-methylpyrazole,***,another Sn_(14)-oxo cluster with similar core configuration was also prepared using 4-methylpyrazole ligand to study the influence of Sn ***-coating method was then applied to fabricate thin films of these non-alkyl tin-oxo clusters on Si substrate,which showed various thicknesses and *** interestingly,electron beam lithography(EBL)patterning studies indicated that for the same Sn_(10)core,the 4-methylpyrazoledecorated clusters showed the best *** for the different cluster cores with the same 4-methylpyrazole ligand,the patterns of Sn_(10)with the higher ligand:Sn ratio are also better than those of Sn_(14).Finally,distinguishable 50 nm resolution was achieved by 4-methylpyrazole-decorated Sn_(10)at expose energy of 100μC/cm2which can be significantly improved by increasing expose energy to 1,000μC/cm2as confirmed by atomic force microscopy(AFM)*** work not only opens the nanolithography applications of non-alkyl tin-oxo clusters,but also provides an effective structural methodology for improving their patterning performance in future.

关键词： non-alkyl tin-oxo clusters nanolithography ligands effect EBL patterning materials

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Homeostasis Research Model Based on Yin-Yang Theory:Five Examples

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Chinese Journal of Integrative Medicine 2021年第6期27卷 403-407页

作者： wang di QU Miao Department of Clinical Psychology Beijing Anding HospitalBeijing(100078)China Department of Neurology Xuanwu Hospital Capital Medical UniversityBeijing(100053)China

In recent years,the ancient yin-yang theory has been gradually adopted by modern researchers,especially European and American scholars,and it has also been applied to modern scientific research on sleep,viruses,metabolism,cancer,genes,autoimmune diseases,and so *** is very promising and fruitful results have been ***,the understanding of the connotations of yin-yang theory is not sufficient and thorough enough in these *** we understand and apply yin-yang theory more comprehensively,it may provide us with additional potential mechanisms and research directions worthy of *** the basis of promoting a comprehensive understanding of all three connotations of yin-yang theory,this review attempts to illustrate this theory,summarize its applications in modern scientific research,and reveal the potential research direction of modern medicine.

关键词： yin-yang theory homeostasis research sleep and cognitive infection and latency leptin and ghrelin cancer and autoimmunity gene expression and repression

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我国基层医生社区康复服务能力现状与对策研究

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中国全科医学 2025年第4期28卷 450-456页

作者：练璐王敌陈家应刘武江苏省人民医院南京医科大学第一附属医院江苏省妇幼保健院运营管理处江苏省南京市210029 江苏省人民医院南京医科大学第一附属医院江苏省妇幼保健院组织人事处江苏省南京市210029 南京医科大学康达学院人文与管理学部江苏省连云港市222000 江苏省人民医院南京医科大学第一附属医院江苏省妇幼保健院纪委办公室江苏省南京市210029

背景“康复回社区”是形成合理就医格局的重点要求,也是实现人人享有康复服务的重要策略,但目前我国基层医生的社区康复服务能力与居民日益增长的康复需求仍有差距。目的了解我国基层医生社区康复服务能力的现状、特点与不足,为制定能... 详细信息

背景“康复回社区”是形成合理就医格局的重点要求,也是实现人人享有康复服务的重要策略,但目前我国基层医生的社区康复服务能力与居民日益增长的康复需求仍有差距。目的了解我国基层医生社区康复服务能力的现状、特点与不足,为制定能力提升对策提供科学依据。方法2020年8月采用多阶段分层抽样与典型抽样相结合的方法对中国江苏省、安徽省、河南省、重庆市、甘肃省五地基层医疗卫生机构的医生开展问卷调查,从康复功能评定、康复医疗服务、中医药保健指导、中医理疗四个方面调查基层医生社区康复服务能力现状。结果共回收8374份问卷,接受调查的基层医生中,分别有4697名(56.1%)、6396名(76.4%)、5833名(69.7%)、4834名(57.7%)具备康复功能评定、康复医疗服务、中医药保健指导、中医理疗能力,且农村地区基层医生各项社区康复能力及综合能力具备率均高于城市地区(P<0.05)。不同年龄、学历、执业资格、岗位基层医生的康复医疗服务指导、中医药保健指导、中医理疗能力具备率比较,差异有统计学意义(P<0.05);组内两两比较结果显示,在年龄方面,30岁以下及60岁以上基层医生康复功能评定能力的具备率高于30~<45岁、45~<60岁(P<0.016),45~<60岁医生具备率高于30~<45岁(P<0.016),45岁以下的康复医疗服务指导能力具备率低于45岁以上的基层医生(P<0.016);30岁以下基层医生中医药保健指导、中医理疗能力具备率低于30~<45岁、45~<60岁和60岁以上(P<0.016),30~<45岁医生能力具备率低于45~<60岁和60岁以上(P<0.016),45~<60岁医生具备率低于60岁以上(P<0.016)。在学历方面,高中/中专及以下学历基层医生能力具备率高于大专学历和本科学历(P<0.016),大专学历医生能力具备率高于本科学历(P<0.016)。在执业资格方面,全科医师具备率高于乡村医师和执业(助理)医师(P<0.016),乡村医师具备率高于执业(助理)医师(P<0.016)。在工作岗位方面,中医岗位基层医生中医药保健指导、中医理疗能力具备率高于临床岗位和其他岗位(P<0.016),临床岗位具备率高于其他岗位(P<0.016)。基层医生康复医疗综合能力具备率高于中医康复综合能力(P<0.05)。结论基层医生社区康复服务能力总体不足,中医康复能力较为薄弱。应完善分级康复服务体系建设,促进基层医生康复经验的积累和能力的提升,加强基层医生中医康复与西医现代康复技术联合培养,完善基层康复人才队伍建设,使其能承担起社区康复的责任。

关键词：初级卫生保健基层医生社区康复分层分析城乡地区

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Improving interlaminar fracture toughness of flax fiber/epoxy composites with chopped flax yarn interleaving

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Science China(Technological Sciences) 2015年第10期58卷 1745-1752页

作者： LI Yan wang di MA Hao School of Aerospace Engineering and Applied Mechanics Tongji University Key Laboratory of Advanced Civil Engineering Materials Ministry of Education Tongji University

In this research, unidirectional flax fabrics reinforced epoxy laminates were intedeaved with randomly oriented chopped flax yarns at various yarn lengths and contents. Mode I interlaminar fracture toughness of the laminates was evaluated via Double Cantilever Beam （DCB） tests. The results showed that Mode I interlaminar fracture toughness increased with the introduction of the chopped yarns. With moderate yarn length and content, the best toughening effect （31% improvement in Mode I inter- laminar fracture toughness） was achieved. It was observed with the aid of Scanning Electronic Microscopy （SEM） that the in- troduction of the chopped yarns resulted in more tortuous in-plane crack propagation paths as well as the ＂trans-layer＂ phe- nomenon and fiber bridging effect of both the unidirectional yams and the chopped yams. These hindered the growth of the crack and led to more energy dissipation during delamination progress. Excessive yam length or content would induce unstable crack propagation and thus weakened the toughening improvement. No remarkable change was found in the tensile properties and the Charpy impact strength for the interleaved laminates, which indicated that this interleaving method was effective on interlaminar toughening without sacrificing the comprehensive mechanical properties of the laminates.

关键词： natural fiber reinforced composites interlaminar fracture toughness interlaminar toughening interleaving fiberbridging trans-layer effect

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Electrochemical preparation of the Fe-Ni36 Invar alloy from a mixed oxides precursor in molten carbonates

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International Journal of Minerals,Metallurgy and Materials 2020年第12期27卷 1695-1702页

作者： Yan-peng Dou di-yong Tang Hua-yi Yin di-hua wang School of Resource and Environmental Sciences Wuhan UniversityWuhan 430072China

The Fe-Ni36 alloy was prepared via the one-step electrolysis of a mixed oxides precursor in a molten Na2CO3-K2CO3 eutectic melt at 750℃,where porous Fe_(2)O_(3)-NiO pellets served as the cathode and the Ni10 Cu11 Fe alloy was an inert *** the electrolysis,Ni O was preferentially electro-reduced to Ni,then Fe_(2)O_(3)was reduced and simultaneously alloyed with nickel to form the Fe-Ni36 *** cell voltages were applied to optimize the electrolytic conditions,and a relatively low energy consumption of 2.48 k W·h·kg^(-1) for production of Fe Ni36 alloy was achieved under 1.9 V with a high current efficiency of 94.6%.The particle size of the alloy was found to be much smaller than that of the individual *** process provides a low-carbon technology for preparing the Fe-Ni36 alloy via molten carbonates electrolysis.

关键词： molten carbonates cyclic voltammetry electro-reduction inert anode Invar36 alloy

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An Al–Al interpenetrating-phase composite by 3D printing and hot extrusion

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International Journal of Minerals,Metallurgy and Materials 2023年第4期30卷 678-688页

作者： Yulin Lin di wang Chao Yang Weiwen Zhang Zhi wang School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510640China Guangdong Key Laboratory for Processing and Forming of Advanced Metallic Materials South China University of TechnologyGuangzhou 510640China

We report a process route to fabricate an Al–Al interpenetrating-phase composite by combining the Al–Mg–Mn–Sc–Zr lattice structure and Al_(84)Ni_(7)Gd_(6)Co_(3)nanostructured structure. The lattice structure was produced by the selective laser melting and subsequently filled with the Al_(84)Ni_(7)Gd_(6)Co_(3)amorphous powder, and finally the mixture was used for hot extrusion to produce bulk samples. The results show that the composites achieve a high densification and good interface bonding due to the element diffusion and plastic deformation during hot *** bulk samples show a heterogeneous structure with a combination of honeycomb lattice structure with an average grain size of less than1 μm and nanostructured area with a high volume fraction of nanometric intermetallics and nanograin α-Al. The heterogeneous structure leads to a bimodal mechanical zone with hard area and soft area giving rise to high strength and acceptable plasticity, where the compressive yield strength and the compressive plasticity can reach ~745 MPa and ~30%, respectively. The high strength can be explained by the rule of mixture,the grain boundary strengthening, and the back stress, while the acceptable plasticity is mainly owing to the confinement effect of the nanostructured area retarding the brittle fracture behavior.

关键词： Al-based composites heterogeneous structure additive manufacturing mechanical properties

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