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Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 236-244页

作者： Hital shah Tejal Gandhi Gujarat Technological University AhmedabadGujarat 382424India Department of Pharmacology Anand Pharmacy CollegeAnandGujarat 388001India

Objective:To investigate the cardioprotective potential of betulin in isoproterenol(ISO)-induced myocardial injury in ***:Wistar rats were divided into five groups(n=10):normal,ISO,nebivolol 5 mg/kg,and betulin(20&40 mg/kg).Nebivolol and betulin were administered orally for 29 ***(85 mg/kg)was administered subcutaneously on day 27 and day 28 to induce myocardial *** day 29,blood was collected for determination of cardiac markers,and hemodynamic parameters were *** levels of oxidative stress markers and the gene expressions of apoptotic markers and inflammatory mediators were ***,2,3,5-triphenyltetrazolium chloride staining and histopathological analysis were also ***:Betulin reduced the size of myocardial infarction,decreased elevated levels of cardiac enzymes,and maintained hemodynamic *** also inhibited ISO-induced upregulation of Bax,caspase-3,NF-κB,and IL-6,enhanced endogenous antioxidant enzymes,and reduced lipid ***,pretreatment with betulin alleviated myocardial ischemic damage,as reflected by reduced myonecrosis,edema,and inflammatory ***:Betulin exhibits strong cardioprotective activity against ISO-induced myocardial injury by anti-inflammatory,anti-apoptotic,and antioxidant activities.

关键词： NF-κB Isoproterenol Betulin Myocardial injury Oxidative stress Inflammation Apoptosis

Detection of internal crack growth in polyethylene pipe using guided wave ultrasonic testing

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 319-329页

作者： Jay Kumar shah Hao Wang Said El-Hawwat Centre of Advanced Infrastructure and Transportation RutgersThe State University of New JerseyNJ 08854USA Department of Civil and Environmental Engineering RutgersThe State University of New JerseyNJ 08854USA

Despite the success of guided wave ultrasonic inspection for internal defect detection in steel pipes,its application on polyethylene(PE)pipe remains relatively *** growth of internal cracks in PE pipe severely affects its pressure-holding capacity,hence the early detection of internal cracks is crucial for effective pipeline maintenance *** study extends the scope of guided wave-based ultrasonic testing to detect the growth of internal cracks in a natural gas distribution PE *** experiments and a finite element model were planned to study the wave-crack interaction at different stages of axially oriented internal crack growth with a piezoceramic transducer-based setup arranged in a pitch-catch *** dispersion analysis supplemented with preliminary experiments was performed to isolate the optimal inspection frequency,leading to the selection of the T(0,1)mode at 50-kHz for the investigation.A transmission index based on the energy of the T(0,1)mode was developed to trace the extent of simulated crack *** findings revealed an inverse linear correlation between the transmission index and the crack depth for crack growth beyond 20%crack depth.

关键词： polyethylene pipes internal cracks guided wave ultrasonic testing torsional modes finite element modeling

Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis

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Journal of Intensive Medicine 2024年第1期4卷 46-61页

作者： Nishel M shah Esmita Charani Damien Ming Fook-Choe Cheah Mark r Johnson Department of Metabolism Digestion and ReproductionImperial College LondonChelsea and Westminster HospitalLondonUK Health Protection research Unit in Healthcare Associated Infection and Antimicrobial resistance Imperial College LondonLondonUK Division of Infectious Diseases and HIV Medicine Department of MedicineGroote Schuur HospitalUniversity of Cape TownCape TownSouth Africa Department of Infectious Diseases Imperial College LondonChelsea and Westminster HospitalLondonUK Department of Paediatrics Faculty of MedicineUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia

Pregnant and postnatal women are a high-risk population particularly prone to rapid progression to sepsis with significant morbidity and mortality ***,severe maternal infections can have a serious detrimental impact on neonates with almost 1 million neonatal deaths annually attributed to maternal infection or *** this review we discuss the susceptibility of pregnant women and their specific physiological and immunological adaptations that contribute to their vulnerability to sepsis,the implications for the neonate,as well as the issues with antimicrobial stewardship and the challenges this poses when attempting to reach a balance between clinical care and urgent ***,we review advancements in the development of pregnancy-specific diagnostic and therapeutic approaches and how these can be used to optimize the care of pregnant women and neonates.

关键词： Sepsis Pregnancy Immunology Cardiovascular Personalised medicine Antibiotic stewardship

Twinning aspects and their efficient roles in wrought Mg alloys:A comprehensive review

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Journal of Magnesium and Alloys 2024年第6期12卷 2201-2230页

作者： S.S.A.shah Manping Liu Azim Khan Farooq Ahmad M.r.Abdullah Xingquan Zhang Shiwei Xu Zhen Peng School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Mechanical Engineering Anhui University of TechnologyMáanshan 243002China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Twinning is widely recognized as an effective and cost-efficient method for controlling the microstructure and properties of wrought magnesium(Mg)***,twins play a crucial role in initiating dynamic recrystallization(DrX),while twin regions experience rapid recrystallization during static recrystallization(SrX).The activation of twinning can lead to changes in lattice orientation,significantly impacting the final texture in Mg *** active roles of twinning are influenced by various factors during the activation process,and the mobility of twin boundaries(TB)can be amplified by stress effects,dislocation interactions,and thermal ***,annealing treatments that involve proper segregation or precipitation on TBs serve to stabilize them,restraining their *** such as segregation may also alter the twinning propensity in Magnesium-rare earth(Mg-rE)***{10-11}contraction twins(CT)and{10-11}-{10-12}double twins(DT)can promote dynamic recrystallization(DrX),they also pose a risk as potential sources of voids and ***,understanding the nucleation and growth mechanisms of twinning is crucial,and these aspects are briefly reviewed in this *** the factors mentioned above,this article summarizes the recent research progress in this field,shedding light on advancements in recent eras.©2024 Chongqing *** services provided by Elsevier *** behalf of KeAi Communications ***.

关键词： Mg alloys Twinning recrystallization Texture Mechanical properties

A novel fractional case study of nonlinear dynamics via analytical approach

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 276-290页

作者： Hassan Khan Adnan Khan rasool shah Dumitru Baleanu Department of Mathematics Abdul Wali khan UniversityMardan 23200Pakistan Department of Mathematics Faculty of Arts and SciencesCankaya UniversityAnkara 06530Turkey Institute of Space Sciences Magurele-BucharestRomania

The present work describes the fractional view analysis of Newell-Whitehead-Segal equations,using an innovative *** work is carried with the help of the Caputo operator of fractional *** analytical solutions of some numerical examples are presented to confirm the reliability of the proposed *** derived results are very consistent with the actual solutions to the problems.A graphical representation has been done for the solution of the problems at various fractional-order ***,the solution in series form has the desired rate of convergence and provides the closed-form *** is noted that the procedure can be modified in other directions for fractional order problems.

关键词： Homotopy Perturbation method Shehu transform Newell-Whitehead-Segel Equation Caputo operator

PETG:Applications in Modern Medicine

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Engineered regeneration 2024年第1期5卷 45-55页

作者： Catherine Yan Corinne Kleiner Aaron Tabigue Veer shah Gregory Sacks Darshi shah Vincent DeStefano renaissance School of Medicine at Stony Brook University Stony BrookNYUSA Department of Biology Niagara UniversityLewistonNYUSA Stony Brook University Stony BrookNYUSA Department of Mechanical and Industrial Engineering Northeastern UniversityBostonMAUSA

Polyethylene terephthalate glycol,PETG,is a miscible,transparent thermoplastic known to have strong tensile properties,high ductility,as well as resistance to heat and chemical *** may be manufactured in several ways,most notably 3D printing *** such,PETG has emerged as a viable biomaterial for a variety of medical applications such as tissue engineering,dentistry,optometry,vascular health,cardiology,orthopedics,neurology,gynecology,and *** also serves a valuable role in biomedical research and engineering by offering improvements in cell studies,drug carriers,and anti-bacterial *** medical research and innovation utilizing PETG will better characterize its value as an inexpensive and versatile biomaterial.

关键词： Polyethylene terephthalate glycol Tissue Engineering 3D Printing Clinical Applications Biomedical research

EPQ model with the effect of inflation and reliability for partial trade credit under fuzzy and cloudy fuzzy environment

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Journal of Management Analytics 2024年第1期11卷 110-134页

作者： Supriya Tiwari Kunal shah Kajal Bhimani Department of Science and Humanities Apollo Institute of Engineering&TechnologyGTUAhmedabadIndia Department of Mathematics SMMPISRKadi Sarva VishwavidyalayaGandhinagarIndia AVAerials 401 Swarnim Business Hub-1 New Chamunda SocietyGodrej Garden CityGotaAhmedabadIndia

The proposed study offers the first-of-its-kind economic production quantity model for deteriorating items having a demand rate to be price dependent under the effect of inflation and reliability with partial trade *** model is extended under an uncertain environment by assuming inventory parameters to be triangular fuzzy numbers and cloudy triangular fuzzy *** objective of the study is to maximize the profit of the inventory system and to identify the most suitable environment for the proposed *** are verified using the numerical ***,the comparative study is presented to justify the nature of fuzzy and cloudy fuzzy *** analysis under all environments is conducted to identify the most sensitive parameters of all.

关键词： EPQ partial trade credit inflation reliability triangular fuzzy number cloudy triangular fuzzy number

Bond-Slip Behavior of Steel Bar and recycled Steel Fibre-reinforced Concrete

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Journal of renewable Materials 2024年第1期12卷 167-186页

作者： Ismail shah Jing Li Nauman Khan Hamad r.Almujibah Muhammad Mudassar rehman Ali raza Yun Peng School of Architecture and Civil Engineering Yunnan Agricultural UniversityKunming650000China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu610041China Yunnan International Joint r&D Center of Smart Agriculture and Water Security Yunnan Agricultural UniversityKunming650201China School of Water Conservancy Yunnan Agricultural UniversityKunming650201China School of Civil Engineering Guizhou UniversityGuiyang550025China Department of Civil Engineering College of EngineeringTaif UniversityP.O.Box 11099Taif City21974Saudi Arabia School of Civil Engineering Zhengzhou UniversityZhengzhou450001China

recycled steel fiber reinforced concrete is an innovative construction material that offers exceptional mechanical properties and *** is considered a sustainable material due to its low carbon footprint and environmental friendly *** study examines the key influencing factors that affect the behavior of this material,such as the steel fiber volume ratio,recycled aggregate replacement rate,concrete strength grade,anchorage length,and stirrup *** study investigates the bond failure morphology,bond-slip,and bond strength constitutive relationship of steel fiber recycled *** results show that the addition of steel fibers at 0.5%,1.0%,and 1.5%volume ratios can improve the ultimate bond strength of pull-out specimens by 9.05%,6.94%,and 5.52%,*** replacement rate of recycled aggregate has minimal effect on the typical bond strength of pull-out ***,the ultimate bond strengths of pull-out specimens with concrete strength grades C45 and C60 have improved compared to those with C30 *** specimens with longer anchorage lengths exhibit lower ultimate bond strength,with a reduction of 33.19%and 46.37%for anchorage lengths of 5D and 7D,respectively,compared to those without *** restraint of 1φ8 and 2φ8 improves the ultimate bond strength by 5.29%and 6.90%,*** fibers have a significant effect on the behavior of concrete after it cracks,especially during the stable expansion stage,crack instability expansion stage,and failure stage.

关键词： recycled coarse aggregates(rCA) steel fiber bonding performance bond-slip environmental challenges

Navigating the future of malaria control:Insights from India's pioneering malaria slide bank

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 139-140页

作者： Sheikh Mohd Saleem shah Sumaya Jan Public Health Expert Health SectionInternational Non-Government OrganisationNew DelhiIndia Department of Anatomy Government.Medical CollegeSrinagarIndia

We applaud the authors for their illuminating perspective on India's malaria slide bank(MSB),featured in the recent publication in your esteemed journal[1].The article provides a comprehensive overview of the establishment,challenges,and future potential of MSBs,offering valuable insights into the complexities and opportunities inherent in this critical asset for India's malaria elimination program.

关键词： malaria journal offering