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Analysis of an Adulterated Herbal Medicinal Product Using Ultra-Performance Liquid Chromatography Coupled with QTOF Mass Spectrometry

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World Journal of Traditional Chinese Medicine 2016年第3期2卷 1-9页

作者： Kate Yu Mark Powell Margaret Maziarz dhavalkumar Narendrabhai patel Waters Corporation Quay Pharmaceuticals Deeside Industrial Park Mark Powell Scientific Waters Pacific Pte Ltd The CapricornSingapore Science Park Ⅱ

The reports of severe adverse effects and fatalities associated with herbal medicinal products adulterated with synthetic compounds have raised global *** objective of this study is to analyze one commercial herbal medicinal product suspected to be adulterated with synthetic drugs in order to identify potential adulterants,to verify if the product contained the herbs listed as ingredients in label claim and to determine quality consistency among different batches of the *** of suspected product obtained from seven different batches were performed using ultra performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) with multiple data processing tools and multivariate *** addition,23 individual powdered herbs(12 as per label claim and 11 suspected herbs),11 marker compounds of the labeled herbs and five suspected synthetic drugs as adulterants were also concurrently analyzed to have clear understanding of product *** on our analysis,the major ingredients of studied product were found to be 5 synthetic compounds:caffeine,chlorphenamine,piroxicam,betamethasone and *** of them have been found to exceed their recommended *** the herbal composition analysis,Gan Cao(Glycyrrhizae radix et rhizoma) was found to be the main ingredient,which is not among the claimed 12 herbs that were supposed to be in the *** herbs detected as minor ingredients were Mu Gua(Chaenomelis fructus),Dang Gui(Angelicae sinensis radix),and Huang Qi(Astragali radix),which are among the 12 herbs that were supposed to be in the *** on our results we demonstrated that UPLC-QTOF MS is an effective and versatile tool for the analysis of herbal medicinal *** is highly desirable to have a streamlined process with automatic workflow and fit-forpurpose database to increase efficiency and productivity of sample *** of this work also highlight the need for the be

关键词： Synthetic adulterants Adulteration UPLC-QTOF-MS Herbal products Data independent acquisition Multi-Variate Statistical Analysis

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Real World Evidence of Safety and Effectiveness of Combination of Vitamin E and <i>Fraxinus excelsior</i>in Treatment of Indian Patients with Nonalcoholic Fatty Liver Disease

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Open Journal of Gastroenterology 2020年第1期10卷 14-22页

作者： Virukalpatti Gopalratnam Mohan Prasad Prashant Rahate Husain Bohri Jyoti Ranjan Mahapatra Ashish Mungantiwar Priyanka Srivastava Nirali Bhatt dhavalkumar patel Soumen Roy Amit Qamra VGM Gastro Centre Singanallur Coimbatore Tamil Nadu India SevenStar Hospital Nagpur Maharashtra India Premium Digestive Diesase Liver and Endoscopy Clinic Nashik Maharashtra India Apollo Clinic Salt Lake City Kolkata West Bengal India R & D and Clinical Trials Department Macleods Pharmaceuticals Ltd. Mumbai Maharashtra India Medical Affairs Department Macleods Pharmaceuticals Ltd. Mumbai Maharashtra India

Introduction: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease ranging from liver steatosis to nonalcoholic steatohepatitis (NASH). Besides lifestyle modifications, Vitamin E (800 IU/day) is generally recommended for NASH. Vitamin E monotherapy is not sufficient for the multifaceted disease like NALFD. The combination of Vitamin E 400IU and Fraxinus excelsior 500 mg twice daily was found to be better than vitamin E 400 IU twice daily in improving the lipid profile and liver function parameters in patients with NAFLD. We conducted a study to assess safety and effectiveness of Vitamin E plus Fraxinus excelsior in Indian patients with NAFLD in real-world settings. Patients and Methods: This was a non-interventional study in NAFLD patients with varying grades of steatosis conducted by 234 physicians across India from January 2018 to August 2018. Patients received combination of Vitamin E (400 IU) and Fraxinus excelsior (500 mg) soft gelatin capsules twice daily after meals for 12 weeks. Effectiveness of the treatment was assessed at visit 2 (6 weeks) and visit 3 (12 weeks, end of study) from baseline. The parameters for assessment included severity of liver steatosis, liver function parameters and the global assessment of safety and effectiveness. Results: A total of 1114 patients were included in the study. At baseline, majority of the patients (71.18%) had Grade II liver steatosis followed by 21.01% and 7.81% patients who had Grade III and Grade I liver steatosis, respectively. After 12 weeks of treatment with vitamin E and Fraxinus excelsior combination, 21% patients had no steatosis, 58.79% patients were in Grade 1 steatosis, 19.57% in grade II steatosis and only 0.63% patients in Grade III steatosis. The mean percentage reduction in aspartate aminotransferase (AST) level at week 6 and week 12 from baseline was 24.92% and 43.79%, respectively. Similarly, the mean percentage reduction in alanine aminotransferase (ALT) level at week 6 and week 12 fr

关键词： NAFLD NASH Vitamin E Fraxinus excelsior Real Life India

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