检索结果-南通市图书馆

Study of locust bean gum reinforced cyst-chitosan and oxidized dextran based semi-IPN cryogel dressing for hemostatic application

引用

Bioactive Materials 2018年第3期3卷 370-384页

作者： Lalit Kumar Meena Pavani Raval dhaval kedaria Rajesh Vasita School of Life Sciences Central University of GujaratSector-30Gandhinagar 382030India Government Engineering College Sector-28Gandhinagar 382028India

Severe blood loss due to traumatic injuries remains one of the leading causes of death in emergency *** continues to be the candidate material for hemostatic applications due to its inherent hemostatic ***,available chitosan-based dressings have been reported to have an acidic odor at the wound site due to the incorporation of acid based solvents for their fabrication and deformation under compression owing to low mechanical strength limiting its *** the present study semi-IPN cryogel was fabricated via Schiff's base cross-linking between the polyaldehyde groups of oxidized dextran and thiolated chitosan in presence of locust bean gum(LBG)known for its *** at12C yielded macroporous semi-IPN cryogels with an average pore size of 124.57±20.31 mm and 85.46%*** hydrophobicity index of LBG reinforced semi-IPN cryogel was reduced 2.42 times whereas the swelling ratio was increased by 156.08%compare to control *** increased hydrophilicity and swelling ratio inflated the compressive modulus from 28.1 kPa to 33.85 for LBG reinforced semi-IPN *** structural stability and constant degradation medium pH were also recorded over a period of 12 *** cryogels demonstrated lower adsorption affinity towards *** cytotoxicity assays(direct,indirect)with 3T3-L1 fibroblast cells confirmed the cytocompatibility of the *** hemolysis assay showed<5%hemolysis confirming blood compatibility of the fabricated cryogel,while whole blood clotting and platelet adhesion assays confirmed the hemostatic potential of semi-IPN cryogel.

关键词： Chitosan Oxidized dextran Locust bean gum Cryogel Hemostasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomimetic polycaprolactone-chitosan nanofibrous substrate influenced cell cycle and ECM secretion affect cellular uptake of nanoclusters

引用

Bioactive Materials 2019年第1期4卷 79-86页

作者： Dhwani Jhala Hilal Rather dhaval kedaria Juhi Shah Sanjay Singh Rajesh Vasita Biomaterials and Biomimetics Laboratory School of Life SciencesCentral University of GujaratGandhinagar382030GujaratIndia Biological&Life Sciences School of Arts and SciencesAhmedabad UniversityCentral CampusNavrangpuraAhmedabad380009GujaratIndia

Biomimetic cell culture substrates are developed as an alternative to the conventional *** provide necessary biochemical and biophysical cues to the cells from their surrounding environment for their optimal growth,behaviour and *** in physiology of cells growing on biomimetic substrate can essentially affect results of in vitro biological experiments such as drug cytotoxicity,nanoparticle internalization or signalling *** majority of ECM proteins are fibrous in nature,nanofibrous scaffolds have more biomimicking ***,in this study,we developed ECM mimicking polycaprolactone-chitosan nanofiber substrate and evaluated its effect on cell morphology,proliferation,cell cycle and ECM ***,cellular uptake of BSA-AuNCs has been assessed on conventional and biomimetic substrate in order to demonstrate the effect of these events on cellular *** was observed that the cells that were grown for 15 days on the nanofibers,had majority of cells in the proliferative phase of cell cycle compared to ***,these cells showed extensive collagen and fibronectin *** to these conditions C3H10T1/2 cells displayed higher cell internalization of ***,this study indicates that the nano-topographical and biochemical environment could alter the cell proliferative behaviour and ECM production,which affects the cell internalization of ***,PCL-chitosan nanofibrous substrate could be a better alternative to TCPS for cell culture studies.

关键词： Polycaprolactone-chitosan nanofibers Biomimetic substrate Cell cycle ECM production BSA-AuNCs internalization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：