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Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

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Nano-Micro Letters 2024年第6期16卷 127-179页

作者： Amal George kurian Rajendra k.singh Varsha Sagar Jung‑Hwan Lee Hae‑Won kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&Bk21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

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Development of Optimized Phenomic Predictors for Efficient Plant Breeding Decisions Using Phenomic-Assisted Selection in Soybean

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Plant Phenomics 2019年第1期1卷 106-120页

作者： kyle Parmley koushik Nagasubramanian Soumik Sarkar Baskar Ganapathysubramanian Asheesh k.singh Department of Agronomy Iowa StateUniversityAmesIAUSA Department of Electrical Engineering Iowa State UniversityAmesIAUSA Department of Mechanical Engineering Iowa State UniversityAmesIAUSA

The rate of advancement made in phenomic-assisted breeding methodologies has lagged those of genomic-assisted techniques,which is now a critical component of mainstream cultivar development ***,advancements made in phenotyping technologies have empowered plant scientists with affordable high-dimensional datasets to optimize the operational efficiencies of breeding *** and seed yield data was collected across six environments for a panel of 292 soybean accessions with varying genetic *** forest,a machine learning(ML)algorithm,was used to map complex relationships between phenomic traits and seed yield and prediction performance assessed using two cross-validation(CV)scenarios consistent with breeding *** develop a prescriptive sensor package for future high-throughput phenotyping deployment to meet breeding objectives,feature importance in tandem with a genetic algorithm(GA)technique allowed selection of a subset of phenotypic traits,specifically optimal *** results illuminated the capability of fusingML and optimization techniques to identify a suite of in-season phenomic traits that will allow breeding programs to decrease the dependence on resource-intensive end-season phenotyping(e.g.,seed yield harvest).While we illustrate with soybean,this study establishes a template for deploying multitrait phenomic prediction that is easily amendable to any crop species and any breeding objective。

关键词： breeding soybean forest

Out-of-Distribution Detection Algorithms for Robust Insect Classification

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Plant Phenomics 2024年第2期6卷 433-444页

作者： Mojdeh Saadati Aditya Balu Shivani Chiranjeevi Talukder Zaki Jubery Asheesh k.singh Soumik Sarkar Arti singh Baskar Ganapathysubramanian Department of Computer Science Iowa State UniversityAmesIAUSA Department of Mechanical Engineering Iowa State UniversityAmesIAUSA Department of Agronomy Iowa State UniversityAmesIAUSA

Plants encounter a variety of beneficial and harmful insects during their growth *** identification(i.e.,detecting insects'presence)and classification(i.e.,determining the type or class)of these insect species is critical for implementing prompt and suitable mitigation *** timely actions carry substantial economic and environmental *** learning-based approaches have produced models with good insect classification *** aim to implement identification and classification models in agriculture,facing challenges when input images markedly deviate from the training distribution(e.g.,images like vehicles,humans,or a blurred image or insect class that is not yet trained on).

关键词： distribution robust detection algorithms classification insect

Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine

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Genes & Diseases 2021年第2期8卷 133-145页

作者： Manish Pratap singh Sandhya Rai Ashutosh Pandey Nand k.singh Sameer Srivastava Department of Biotechnology Motilal Nehru National Institute of TechnologyAllahabadUP211004India

Molecular subtypes-based therapies offer new potential framework for desired and precise outcome in clinical *** treatment strategies in colorectal cancer are largely‘one drug fit all’model for patients that display same pathological ***,CRC is a very heterogenous set ofmalignancy that does not support for above *** subtype displays different pathological and genetic *** on these features,therapeutic stratification for individual patients may be designed,which may ultimately lead to improved therapeutic *** this comprehensive review,we have attempted to briefly outline major CRC pathways.A detailed overview of molecular subtypes and their clinical significance has been *** and futuremethods,governing CRC subtyping in the era of personalized therapywith a special emphasis on CMS subtypes of CRC has been ***,discovery and validation of new CRC patient stratification methods,screening for novel therapeutic targets,and enhanced diagnosis of CRC may improve the treatment outcome.

关键词： Biomarkers CMS subtypes Immunotherapy Molecular screening Personalized medicine

Rapid accessibility evaluation for ballistic lunar capture via manifolds: A Gaussian process regression application

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Astrodynamics 2022年第4期6卷 375-397页

作者： Sandeep k.singh John L.Junkins Manoranjan Majji Ehsan Taheri Department of Aerospace Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Aerospace Engineering Auburn UniversityAuburnAL 36849USA

In this study,a supervised machine learning approach called Gaussian process regression(GPR)was applied to approximate optimal bi-impulse rendezvous maneuvers in the cis-lunar *** demonstrate the use of the GPR approximation of the optimal bi-impulse transfer to patch points associated with various invariant manifolds in the cis-lunar *** proposed method advances preliminary mission design operations by avoiding the computational costs associated with repeated solutions of the optimal bi-impulsive Lambert transfer because the learned map is computationally *** approach promises to be useful for aiding in preliminary mission *** use of invariant manifolds as part of the transfer trajectory design offers unique features for reducing propellant consumption while facilitating the solution of trajectory optimization *** ballistic capture coasts are also very attractive for mission guidance,navigation,and control robustness.A multi-input single-output GPR model is presented to represent the fuel costs(in terms of theΔV magnitude)associated with the class of orbital transfers of interest *** developed model is also proven to provide efficient *** multi-resolution use of local GPRs over smaller sub-domains and their use for constructing a global GPR model are also *** of the unique features of GPRs is that they provide an estimate of the quality of approximations in the form of covariance,which is proven to provide statistical consistency with the optimal trajectories generated through the approximation *** numerical results demonstrate our basis for optimism for the utility of the proposed method.

关键词： Gaussian process regression supervised learning invariant manifolds ballistic transfers Bayesian inference

Fermentation characteristics of resistant starch, arabinoxylan, andβ-glucan and their effects on the gut microbial ecology of pigs:A review

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Animal Nutrition 2019年第3期5卷 217-226页

作者： Utsav P.Tiwari Amit k.singh Rajesh Jha Department of Human Nutrition Food and Animal Sciences College of Tropical Agriculture and Human ResourcesUniversity of Hawaii at Manoa

Dietary fibers(DF)contain an abundant amount of energy,although the mammalian genome does not encode most of the enzymes required to degrade ***,a mutual dependence is developed between the host and symbiotic microbes,which has the potential to extract the energy present in these *** fibers escape digestion in the foregut and are fermented in the hindgut,producing shortchain fatty acids(SCFA)that after the microbial ecology in the gastrointestinal tract(GIT)of *** of the carbohydrates are fermented in the proximal part,allowing protein fermentation in the distal part,resulting in colonic *** structures of resistant starch(RS),arabinoxylan(AX),and β-glucan(βG)are complex;hence,makes their way into the hindgut where these are fermented and provide energy substrates for the colonic epithelial *** microbes have different preferences of binding to different *** RS,AX and βG act as a unique substrate for the microbes and modify the relative composition of the gut microbial *** granule dimension and surface area of each substrate are different,which influences the penetration capacity of *** and xylan are 2 different hemicelluloses,but arabinose is substituted on the xylan backbone and occurs in the form of *** of xylan produces butyrate primarily in the small intestine,whereas arabinose produces butyrate in the large *** of RS and forms of βG also exert beneficial effects by producing different metabolites and modulating the intestinal ***,it is important to have information of different types of RS,AX and(3 G and their roles in microbial modulation to get the optimum benefits of fiber fermentation in the *** review provides relevant information on the similarities and differences that exist in the way RS,AX,and βG are fermented,and their positive and negative effects on SCFA production and gut microbial ecology of *** insights will help nutr

关键词： Butyrate Fermentation Gut ecology Microbiota Short-chain fatty acids Swine

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Visceral leishmaniasis: An immunological viewpoint on asymptomatic infections and post kala azar dermal leishmaniasis

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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 98-108页

作者： Neeraj Tiwari Dhiraj kishore Surabhi Bajpai Rakesh k.singh Department of Biochemistry Institute of ScienceBanaras Hindu University Department of Medicine Institute of Medical SciencesBanaras Hindu University Department of Bioscience and Biotechnology Banasthali University

Elimination of visceral leishmaniasis is a priority programme in Indian *** World Health Organization has set a new target to eliminate kala-azar by the year 2020 as previous target elimination year(2015) has *** elimination programme has successfully curbed the rate of infection in endemic regions; however, there are still few challenges in its *** current drug control regime is extremely limited and comprises only two(amphotericin B and miltefosine) drugs, which are also susceptible for parasites ***, these drugs do not produce sterile cure, and cured patients may develop post kala-azar dermal leishmaniasis even after a decade of cure leaving behind a potent source of parasitic reservoirs for further disease transmission.A significant proportion of endemic population remain seropositive but aymptomatic for many years without any clinical symptom that serve as latent parasitic *** lack of tools to identify live parasites in asymptomatic infections and there association in disease transmission, parameters of sterile cure along with post kala-azar dermal leishmaniasis progression remain a major threat in its *** this review, we discuss the potential of host immune inhibitory mechanisms to identify immune correlates of protective immunity to understand the mystery of asymptomatic infections, sterile cure and post kala azar dermal leishmaniasis.

关键词： Visceral leishmaniasis Immune response Asymptomatic infection Sterile cure Post kala-azar dermal leishmaniasis

Does Glacial-Interglacial Transition Affect Sediment Accumulation in Monsoon-Dominated Regions?

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Acta Geologica Sinica(English Edition) 2017年第3期91卷 1079-1094页

作者： dharmendra Pratap singh Rajeev SARASWAT Dinesh k.NAIk Micropaleontology Laboratory Geological Oceanography DivisionNational Institute of Oceanography

The spatio-temporal changes in sedimentation rate along the continental margin of the monsoon-dominated eastern Arabian Sea during the last 24 kyr have been estimated from a compilation of 58 radiocarbon dated cores, in order to understand the effect of glacial-interglacial variation on sedimentation. The sedimentation rate has been computed for four-time slices, viz. the last glacial maximum, glacial-interglacial transition, early Holocene and late Holocene. We report that the average sedimentation rate in the slope to the abyssal region of the entire eastern Arabian Sea, although higher during the Holocene as compared with that during the last glacial maximum and glacial-interglacial transition, does not significantly vary during all four-time intervals. The sedimentation rate during any particular time interval, however, varies from core to core, thus indicating zonal changes. We report four zones of relatively high sedimentation rate, viz. the northeastern Arabian Sea, the region off the Gulf of khambhat, the region off Goa and Mangalore, and off the southern tip of India. We suggest that a complex interaction of land-ocean-atmospheric processes controlled sedimentation rate in the eastern Arabian Sea during the last 24 kyr in such a way that the average sedimentation rate does not vary significantly, even during highly contrasting climatic conditions.

关键词： Sedimentation rate monsoon glacial Holocene Arabian Sea

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Graphene derivatives as efficient hole transport materials for lead-free double perovskite（Cs2SnI6） solar cells: a numerical study

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Optoelectronics Letters 2025年第3期21卷 155-159页

作者： Sarita YADAV Saral k.GUPTA Chandra Mohan singh NEGI Department of Physical Science Banasthali Vidyapith

The double perovskite Cs2SnI6has notable optical and electrical characteristics, rendering it a highly prospective candidate for deployment as the absorber layer in perovskite solar cells （PSCs）. We simulated the performance of PSCs using lead-free Cs2SnI6double perovskite absorber layer and graphene derivatives, namely graphene oxide （GO） and reduced graphene oxide （rGO）, as hole transport layers （HTLs）. Our findings show that r GO offers an excellent hole extraction property with minimal interfacial recombination compared to GO.

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