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Diabetes mellitus is not associated with worse short term outcome in patients older than 65 years old post-liver transplantation

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World Journal of Hepatology 2023年第2期15卷 274-281页

作者： Saad Alghamdi Shaden Alamro dhari alobaid Elwy Soliman Ali Albenmousa Khalid Ibrahim Bzeizi Saleh Alabbad Saleh A Alqahtani Dieter Broering Waleed Al-Hamoudi Liver and Small Bowel Health Centre Department KFSHRCRiyadh 11211Saudi Arabia Department of Medicine KFSHRCRiyadh 11211Saudi Arabia Department of Internal Medicine Minia UniversityMinya 61519Egypt Division of Gastroenterology and Hepatology Johns Hopkins UniversityBaltimoreMD 21287United States Liver Disease Research Center Department of MedicineCollege of MedicineKing Saud UniversityRiyadh 11451Saudi Arabia

BACKGROUND Non-alcoholic fatty liver disease is a global health care challenge and a leading indication of liver transplantation(LT).Hence,more patients with diabetes mellitus(DM)are undergoing LT,especially,above the age of *** To evaluate the impact of DM on short-term outcomes post-LT in patients over the age of *** We collected data of patients who underwent LT from January 2001 until December 2019 using our electronic medical *** assessed the impact of DM on short-term outcomes,one-year,post-LT based on the following variables:Survival at one year;acute cellular rejection(ACR)rates;intensive care unit(ICU)and hospital length of stay;and *** Total of 148 patients who are 65 year or older underwent LT during the study *** mean age is 68.5±3.3 years and 67.6%were *** median Model for End-stage Liver Disease score at time of transplantation was 22(6-39),39%of patients had hepatocellular carcinoma and 77.7%underwent living donor *** one-year survival was similar between DM patients and others,91%.ACR occurred in 13.5%of patients(P=0.902).The median ICU stay is 4.5-day P=*** rates of ICU and 90-d readmission were similar(P=0.821)and(P=0.194),*** The short-term outcome of elderly diabetic patients undergoing LT is similar to *** presence of DM in elderly LT candidates should not discourage physicians from transplant consideration in this cohort of patients.

关键词： Acute cellular rejection Diabetes mellitus Elderly Graft survival Liver transplantation

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