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Integrating big data and blockchain to manage energy smart grids—TOTEM framework

Blockchain(Research and Applications) 2022年第3期3卷 36-45页

作者： dhanya therese jose Jørgen Holme Antorweep Chakravorty Chunming Rong Department of Computer Science Electrical Engineering University of Stavanger4036StavangerNorway

The demand for electricity is increasing exponentially day by day,especially with the arrival of electric *** the smart community neighborhood project,electricity should be produced at the household or community level and sold or bought according to the *** the actors can produce,sell,and buy according to the demands,thus the name *** solutions can contribute to this in several ways,such as machine learning for analyzing the household data for customer demand and peak hours for the usage of electricity,blockchain as a trustworthy platform for selling or buying,data hub,and ensuring data security and privacy of ***:Token for controlled computation is a framework that allows users to analyze the data without moving the data from the data owner's *** also ensures the data security and privacy of the ***,in this article,we will show the importance of the TOTEM architecture in the EnergiX project and how the extended version of TOTEM can be efficiently merged with the demands of the current and similar projects.

关键词： Blockchain Big data analytic Hyperledger fabric Hadoop Map Reduce Docker PIVT

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Comparative efficacy of sodium glucose cotransporter-2 inhibitors in the management of type 2 diabetes mellitus:A real-world experience

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World Journal of Diabetes 2024年第3期15卷 463-474页

作者： Lubna Islam dhanya jose Mohammed Alkhalifah Dania Blaibel Vishnu Chandrabalan joseph M Pappachan Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Department of Community Medicine Goa Medical CollegeGoa 403202India Department of Family Medicine King Faisal Specialist HospitalRiyadh 11564Saudi Arabia Department of Data Science Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityAll Saints BuildingManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT-2i)are a class of drugs with modest antidiabetic efficacy,weight loss effect,and cardiovascular benefits as proven by multiple randomised controlled trials(RCTs).However,real-world data on the comparative efficacy and safety of individual SGLT-2i medications is *** To study the comparative efficacy and safety of SGLT-2i using real-world clinical *** We evaluated the comparative efficacy data of 3 SGLT-2i drugs(dapagliflozin,canagliflozin,and empagliflozin)used for treating patients with type 2 diabetes *** on the reduction of glycated hemoglobin(HbA1c),body weight,blood pressure(BP),urine albumin creatinine ratio(ACR),and adverse effects were recorded *** Data from 467 patients with a median age of 64(14.8)years,294(62.96%)males and 375(80.5%)Caucasians were *** diabetes duration was 16.0(9.0)years,and the duration of SGLT-2i use was 3.6(2.1)***-2i molecules used were dapagliflozin 10 mg(n=227;48.6%),canagliflozin 300 mg(n=160;34.3%),and empagliflozin 25 mg(n=80;17.1).Baseline median(interquartile range)HbA1c in mmol/mol were:dapagliflozin-78.0(25.3),canagliflozin-80.0(25.5),and empagliflozin-75.0(23.5)*** respective median HbA1c reduction at 12 months and the latest review(just prior to the study)were:66.5(22.8)&69.0(24.0),67.0(16.3)&66.0(28.0),and 67.0(22.5)&66.5(25.8)respectively(P<0.001 for all comparisons from baseline).Significant improvements in body weight(in kilograms)from baseline to study end were noticed with dapagliflozin-101(29.5)to 92.2(25.6),and canagliflozin 100(28.3)to 95.3(27.5)*** reductions in median systolic and diastolic BP,from 144(21)mmHg to 139(23)mmHg;(P=0.015),and from 82(16)mmHg to 78(19)mmHg;(P<0.001)respectively were also observed.A significant reduction of microalbuminuria was observed with canagliflozin only[ACR 14.6(42.6)at baseline to 8.9(23.7)at the study end;P=0.043].Adverse effects

关键词： Sodium glucose cotransporter-2 inhibitors Empagliflozin Canagliflozin Dapagliflozin Type 2 diabetes mellitus Cardiovascular disease Albumin creatinine ratio Diabesity

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Single nucleotide polymorphism(SNP)in genes of lupus:A Philippine study(SIGLA-PH)

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Rheumatology & Autoimmunity 2022年第1期2卷 22-30页

作者： Michael L.Tee Cherica A.Tee jose B.Nevado Jr Angeline therese Santiago Aedrian A.Abrilla Carlo M.Lapid Francis A.Tablizo Joshua A.Dizon El K.B.Morado Eva Maria Cutiongco-Dela Paz College of Medicine University of the Philippines ManilaManilaPhillipines Institute of Human Genetics National Institutes of HealthUniversity of the Philippines ManilaManilaPhillipines College of Medicine and Philippine General Hospital University of the Philippines ManilaManilaPhillipines Core Facility for Bioinformatics Philippine Genome CenterUniversity of the PhilippinesManilaPhillipines National Institutes of Health University of the Philippines ManilaManilaPhillipines

Background:Systemic lupus erythematosus(SLE)is a complex prototypic autoimmune disease,with a prevalence of 20–150 per 100,000,most commonly affecting women at child-bearing ***-wide association studies and fine mapping of candidate regions have paved the way for greater understanding of SLE as a disease of genetic–environmental susceptibility and the functions of the genes ***:This study was conducted to determine the association of selected single nucleotide polymorphisms(SNPs)from established genomic databases based on theoretical risk and protective odds ratios>2.5 or<0.40)to susceptibility of developing SLE among ***:We analyzed data from 310 SLE patients and 318 *** identified eight significant SNPs namely rs9271100,rs9271366,rs9272105,rs9275328,rs2647087,rs12734338,rs17885098,and rs3883013 to be associated with an increased risk of developing SLE among ***:Eight SNPs were found to be associated with the development of SLE among *** to previous genetic studies in lupus patients,majority of the SNPs were found in the major histocompatibilty complex genes in the HLA *** study identified two unique SNPs that will be validated as potential diagnostic markers for *** findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos.

关键词： genetics lupus SLE SNP susceptibility

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An Assessment of Ingestion Dose due to the Intake of ^210Po and ^210Pb through Drinking Water of Eloor, Ernakulam District, Kerala, India

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Journal of Chemistry and Chemical Engineering 2011年第10期5卷 903-908页

作者： A. G. Umadev dhanya Balakrishnan jose P. Abraham M. Rajagopalan M. George P. Dharmalingam Sujatha Radhakrishnan M. Harikumar PG and Research Department of Chemistry Urummu Dhanalakshmi College Tiruchirapalli 620019 India Centre for Environmental ＆ Radiological Sciences Department of Physics The Cochin College Kochi-2 Kerala India Department of Chemistry and Research Centre Sacred Heart College Thevara. Kochi-13 Kerala India Environmental Assessment Division Bhabha Atomic Research Centre Health Physics Unit IREL Udyogmandal Kerala 683501lndia

The present study aims at measuring the activity concentrations of 210Po and 210Pb in the potable water of Eloor, a major industrial belt in the Ernakulam district of Kerala, India with an aim of evaluating resultant ingestion dose to critical population. The industrial units located in Eloor discharge their treated effluents into the river Periyar and the surrounding environs. The two major industries of interest with respect to NORMs are the fertilizer plant, processing rock phosphate and the monazite processing plant, which had been in operation for the last 50 years. For sampling, Eloor region was divided into four zones and a total of 55 water samples from different locations were collected and analysed as per standard analytical procedure manual of BARC. The 210Po concentration ranged between 0.3 to 4.7 mBq. L-1 and 210Pb ranged from 0.6 to 4.3 mBq. L-1. All values are well below the limit of 0.1 Bq. L-1 recommended by World Health Organization. Statistical analysis shows a good co-relation between 210Po and 210Pb in the water samples analyzed and the mean activity concentration is found to be relatively high in the western region of Eloor compared to other regions. The annual effective dose equivalent to man from 210Po and 210Pb through drinking water intake were estimated and found to be 1.13 μSv. y-1 and 0.99 μSv. y-1 respectively, which is well below the reference level of committed effective dose (100 μSv. y-1) recommended by WHO.

关键词：摄入剂量喀拉拉邦评估饮水印度年有效剂量世界卫生组织水样分析

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