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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa abd El-salam El-Sayed Mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

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Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： Manal abd El-salam Marwa Mohamed Anwar Rasha Mahmoud Gouda Naglaa Abou El Fattah Nadia Youssef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and Methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status

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A Suitable Active Control for Suppression the Vibrations of a Cantilever Beam

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Sound & Vibration 2022年第2期56卷 89-104页

作者： Y.A.Amer A.T.EL-Sayed M.N.abd EL-salam Mathematics Department Science FacultyZagazig UniversityZagazigEgypt Basic Sciences Department Modern Academy for Engineering and TechnologyCairoEgypt Basic Sciences Department Higher Technological Institute10th of Ramadan CityEgypt

In our consideration,a comparison between four different types of controllers for suppression the vibrations of the cantilever beam excited by an external force is carried *** four types are the linear velocity feedback control,the cubic velocity feedback control,the non-linear saturation controller(NSC)and the positive position feedback(PPF)*** suitable type is the PPF controller for suppression the vibrations of the cantilever *** approximate solution obtained up to the first approximation by using the multiple scale *** PPF controller effectiveness is studied on the *** used frequency-response equations to investigate the stability of a cantilever *** notified that,there is a good agreement between the analytical solution and the numerical solution.

关键词： Cantilever beam cubic velocity feedback control linear velocity feedback control non-linear saturation controller(NSC) positive position feedback(PPF)controller

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Effect of Al_(2)O_(3) Nanoparticles on the Compression Ignition Performances and Emitted Pollutants of a Diesel Engine

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Fluid Dynamics & Materials Processing 2023年第11期19卷 2847-2861页

作者： Noora S.Ekab Ahmed Q.salam Ali O.abd Miqdam T.Chaichan Electromechanical Engineering Department University of Technology-IraqBaghdad65035Iraq Environment Research Center University of Technology-IraqBaghdad65035Iraq Applied Science Department University of Technology-IraqBaghdad65035Iraq Energy and Renewable Energies Technology Center University of Technology-IraqBaghdad65035Iraq

To improve the performances of diesel engines and to reduce the pollutants they emit,aluminum oxide nanopar-ticles in varying quantities(50,100,150 ppm)have been added to conventional diesel *** results of such experimental tests have revealed that the addition of nano-Al_(2)O_(3) particles to the diesel fuel reduces its consump-tion by 0.488%,1.02%,and 1.377%,respectively and increases the brake thermal efficiency by 1.4%,2.6%,and 3.8%,*** concentrations of undesired gases decrease accordingly by 1.5%,1.7%,and 2.8%for HC and by 5.88%,11.7%,and 17.6%,respectively,for *** the same percentages of nanoparticles,NO_(x) increases by 2.65,4.36,and 5.37,while the TSP(Total Suspended Particulate)decreases by 22%,34.66%,and 49.7%,*** the same conditions,sulfur dioxide pollutants increase by 4.57%,8.8%and 12.89%,and H_(2)S levels by 4.7%,7.81%and 8.9%,respectively.

关键词： Nao-Al_(2)O_(3) suspension CO NO_(x)-PM trade-off SO_(2) H_(2)

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Anisotropy of Magnetic Susceptibility (AMS) of Bostonite Rocks, Um-Gir and El-Atshan-II Uranium Prospect Areas, Central Eastern Desert, Egypt

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Geomaterials 2022年第1期12卷 1-14页

作者： Hussein F. abd El-salam Nuclear Materials Authority El Maadi Cairo Egypt

Um-Gir and El-Atshan-II areas represent important structurally-controlled radioactive anomalies and have become promising areas for U exploration. The bostonite rocks represent the most promising rock unit in the two studied areas. They form the most promising rocks due to their high radioactivity and, hence uranium mineralization. Anisotropy of magnetic susceptibility (AMS) measurements was carried out for Um-Gir and El-Atshan-II bostonite rocks. The AMS results show that the mean magnitude of magnetic susceptibilities is low, of the order of 10-5 S.I. units. Consequently, the bostonite rocks of the two areas are considered as non-magnetic, reflecting the presence of hematite as the main ferromagnetic mineral. These results are in agreement with the measurements of initial remnant magnetization (NRM) and the results of isothermal remnant magnetization (IRM) for the two areas. Besides, the results of magnetic anisotropy degree (PJ), refer to and concluded that the magnetic fabric of bostonite of two the areas has secondary fabric. AMS results clearly show the differences between the bostonite dyke of Um-Gir and Bostonite sill of El Atshan-II. The lineation (P1) > foliation (P3), and the negative values of the ellipsoid shape (T) of Um-Gir bostonite reflect clearly magnetic lineation (prolate ellipsoid). However, in El Atshan-II, (P3 > P1), the values of T are positive, which indicate the predominance of magnetic foliation (oblate ellipsoid) over lineation. Furthermore, the foliation planes of the bostonite dyke of Um-Gir possess a shallow to moderate inclination and a nearly N-S direction, while, the foliation planes of the bostonite sill of El-Atshan-II show a shallow to moderate inclination and a NNE direction. Finally, the AMS method is a powerful tool for detecting the structures that affect

关键词： Central Eastern Desert Egypt Bostonite Rocks AMS NRM IRM

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Refractive errors and biometry of primary angle-closure disease in a mixed Malaysian population

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1246-1250页

作者： Jelinar Mohamed-Noor dhan.a. abd-salam Department of Ophthalmology Hospital Kuala Lumpur JalanPahang Kuala Lumpur 50586 Malaysia

AIM： To assess the refractive status, anterior chamber depth （ACD） and axial length （AL） of patients with primary angle-closure disease （PACD）. METHODS： Retrospective cohort. Data was collected from charts of all PACD patients treated from April 2013 to December 2015. Analysis was done on 137 patient charts with complete biometric data. Patient demographics, PACD type, refractive status （spherical equivalent）, ACD and AL were studied. RESULTS： The median age of 137 subjects [53 with primary angle-closure suspects （PACS）, 27 with primary angle- closure （PAC） and 57 with primary angle-closure glaucoma （PACG）] was 68y （range 21-88y）. The majority was Chinese （n=68; 49.6%） and most of them were women （n=75; 54.7%）. The distribution of myopia （n=51; 37.2%） and hyperopia （n=49; 35.8%） was similar. The ACD was shallower in myopes compared to hyperopes （P=-0.02） and emmetropia （P=-0.049） but the AL was not significantly different between groups. There were no patients blind from PACG. CONCLUSION： Both myopia and hyperopia can occur in PACD. Despite a shallower ACD in angle closure myopes, the AL was not different between groups.

关键词： primary angle-closure suspect primary angle- closure primary angle-closure glaucoma anterior chamber depth axial length

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Effect of Conductive Fillers on the Cyclic Stress-Strain and Nano-Scale Free Volume Properties of Silicone Rubber

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Chinese Journal of Polymer Science 2014年第5期32卷 558-567页

作者： M.H.abd-El salam S.El-Gamal M.Mohsen D.M.abd El-Maqsoud Physics Department Faculty of Education Ain Shams University Physics Department Faculty of Science Ain Shams University

The effect of carbon black （CB） and graphite （G） powders on the macroscopic and nano-scale free volume properties of silicone rubber based on poly（di-methylsiloxane）（PDMS） was studied through thermal and cyclic mechanical measurements, as well as with positron annihilation lifetime spectroscopy （PALS）. The melting temperature of the composites （Tm） and the endothermic enthalpy of melting （ΔHm） were estimated by differential scanning calorimetry （DSC）. Tm and the degree of crystallinity （χc） of PDMS composites were found to decrease with increasing the CB content. This can be explained due to the increase in physical cross-linking which results in a decrease in the crystallite thickness. Besides, χc was found to be dependent on the filler type. Cyclic stress-strain behavior of PDMS loaded with different contents of filler has been studied. Mullins ratio （RM） was found to be dependent on the filler type and content. It was found that, RM increases with increasing the filler content due to the increase in physical cross-linking which results in a decrease in the size of free volume, as observed through a decrease of the o-Ps lifetime τ3 measured by PALS. Moreover, the hysteresis in PDMS-CB composites was more pronounced than in PDMS-G composites. Furthermore, a correlation was established between the free volume Vf and the mechanical properties of PDMS composites containing different fillers. A negative correlation was observed between Vf and RM.

关键词： Positron annihilation Positronium Free volume Si-rubber Composite Cyclic mechanical properties.

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Spectral collocation method for solving continuous population models for single and interacting species by means of exponential Chebyshev approximation

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International Journal of Biomathematics 2018年第8期11卷 265-288页

作者： M. A. Ramadan M. A. abd El salam Mathematics Department Faculty of Science Menoufia University Shebin El-KomEgypt Mathematics Department Faculty of Science Al-Azhar University Nasr-City Cairo Egypt

In this paper, an efficient and accurate method is presented to solve continuous population models for single and interacting species using spectral collocation method with exponential Chebyshev (EC) functions. The first problem is a logistic growth model in a population, while the second problem is a prey-predator model: Lotka-Volterra system, the tbird is a simple 2-species Lotka-Volterra competition model, and the final one is a prey-predator model with limit cycle periodic behavior. The high accuracy of this method is verified through some numerical examples. The obtained numerical results are compared with other methods, showing that the proposed method gives higher accuracy.

关键词： Exponential Chebyshev functions continuous population models spectral collocation method

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Swarming Behavior of Harris Hawks Optimizer for Arabic Opinion Mining

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Computers, Materials & Continua 2021年第12期69卷 4129-4149页

作者： Diaa salam abd Elminaam Nabil Neggaz Ibrahim abdulatief Ahmed Ahmed El Sawy Abouelyazed Department of Information Systems Faculty of Computers and Artificial IntelligenceBenha University12311Egypt Department of Computer Science Faculty of Computer ScienceMisr International UniversityEgypt Universite des Sciences at de la Technologie d’Oran Mohamed Boudiaf USTO-MBBP 1505EL M’naouer31000 OranLaboratoire Signal Image Parole(SIMPA)Department d’informatiqueFaculte des Mathematiques et InformatiqueAlgerie Department of Computer Science Faculty of Computers and Artificial IntelligenceBenha University12311Egypt Department of Computer Science Obour High Institute for Computers and InformaticsEgypt

At present,the immense development of social networks allows generating a significant amount of textual data,which has facilitated researchers to explore the field of opinion *** addition,the processing of textual opinions based on the term frequency-inverse document frequency method gives rise to a dimensionality *** study aims to detect the nature of opinions in the Arabic language employing a swarm intelligence(SI)-based algorithm,Harris hawks algorithm,to select the most relevant *** experimental study has been tested on two datasets:Arabic Jordanian General Tweets and Opinion Corpus for *** terms of accuracy and number of features,the results are better than those of other SI based algorithms,such as grey wolf optimizer and grasshopper optimization algorithm,and other algorithms in the literature,such as differential evolution,genetic algorithm,particle swarm optimization,basic and enhanced whale optimizer algorithm,slap swarm algorithm,and ant–lion optimizer.

关键词： Arabic opinion mining Harris hawks optimizer feature selection AJGT and OCA datasets

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N-Methylimidazolium perchlorate as a new ionic liquid for the synthesis of bis(pyrazol-5-ol)s under solvent-free conditions

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Chinese Chemical Letters 2016年第1期27卷 104-108页

作者： Nader Ghaffari Khaligh Sharifah Bee abd Hamid salam J.J.Titinchi Nanotechnology & Catalysis Research Centre NANOCAT University Malaya Department of Chemistry University of the Western Cape

N-Methylimidazolium perchlorate（[MIm]ClO_4） was synthesized and some of its physico-chemical properties, such as density, surface tension were investigated. A thermo gravimetric analysis（TGA） and solvent performance were also studied. The results show that this ionic liquid is an excellent catalyst for the synthesis of 4,4＇-（arylmethylene）bis（1H-pyrazol-5-ol） derivatives under solvent-free *** method has the advantages of high yield, clean transformation, simple operation and short reaction time. The ionic liquid can be recycled without significant loss of activity.

关键词： Ionic liquid N-Methylimidazolium perchlorate Bis(pyrazol-5-ol)s Recycle

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