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Towards an actionable One Health approach

贫困所致传染病(英文) 2024年第2期13卷 77-82页

作者： Zhang Xiao-Xi Lederman Zohar Han Le-Fei Schurer Janna M. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan pfeiffer Dirk Ward Michael p. Sripa Banchob Gabri?l Sarah dhama kul.eep.acharya krishna p.asad Robertson Lucy J. Deem Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto Domenico Grace Delia Wang Yang Li peng Fu Chao poeta patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu Jiming Wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren Ming-Hui Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China Medical Ethics and Humanities Unit Hong Kong University Hong Kong People’s Republic of China Center for One Health University of Global Health Equity Butaro Rwanda College of Veterinary Medicine South China Agricultural University Guangzhou People’s Republic of China School of Ecology and Environment Hainan University Haikou Hainan People’s Republic of China Branch of animal and vector-borne diseases Division of Infectious Disease Control Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Centre for Applied One Health Research and policy Advice Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong SAR People’s Republic of China Department of pathobiology and population Sciences Royal Veterinary College London United Kingdom Sydney School of Veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémi

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Commission Research agenda

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Exploring phytochemicals of Withania somnifera from different vicinity for functional foods

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未来食品学报(英文) 2023年第3期3卷 278-287页

作者： pooja dhama Xianting Ding Alok Sharma Department of pharmacognosy ISF College of PharmacyPunjab 142001India School of Biomedical Engineering Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China

The well-known relation between food and bioactives explores the great prospective of innovative and novel food to maintain or improve health,increasing the demand investigating advance products with medicinal *** somnifera also known as‘Ashwagandha’in India,is one of the most utilized plants in different ancient medicine *** present work is an effort to develop a knowledge-based concept and a quality control approach for the development of functional *** study took into account the standardization criteria and examined how different geographies or different field sites(of India)would influence the phytoconstituents and their distribution in the different samples of *** level were strongly influenced by soil quality,cultivar,and growing *** increase in phenolic content,flavonoid content,antioxidants and the quality yield,were all correlated with increased phytoconstituent *** highest hydro-methanolic extract yield(by reflux(Soxhlet),sonication(20 min)and maceration(16 h)was from the sample collected from Rajasthan(18.61%,m/m)followed by West Bengal(11.21%)and Madhya pradesh(12.67%)*** methanolic extract of Rajasthan sample(produced by the reflux(Soxhlet)extraction method)had the highest concentrations of flavonoids(65.32 mg quercetin equivalent(QE)/g)and the total phenols(60.35 mg gallic acid equivalent(GAE)/g),while Madhya pradesh sample(distilled water reflux(Soxhlet))extract had the highest antioxidant content(74.13%).High performance thin layer chromatography(HpTLC)method was also utilized for identification of withanolides *** separations were carried out using V(ethyl acetate):V(toluene):V(acetic acid)=9.1:1:0.6 as the mobile *** gas chromatograph-mass spectrometer(GC-MS)study of hydro-methanolic Soxhlet extract of *** from 3 different regions of India was done and the total phytochemical substances identified were 132 in sample from Rajasthan,107

关键词： Withania somnifera Bioactives Gas chromatograph-mass spectrometer(GC-MS) Quality Functional foods

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Altered gut microbiota patterns in COVID-19:Markers for inflammation and disease severity

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World Journal of Gastroenterology 2022年第25期28卷 2802-2822页

作者： Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya kuldeep dhama Sang-Soo Lee School of Life Science and Biotechnology Adamas UniversityKolkata 700126India Institute for Skeletal Aging&Orthopaedic Surgery Hallym UniversityChuncheon-si 24252South Korea Department of Zoology Fakir Mohan UniversityBalasore 756020India Division of pathology Indian Council of Agricultural Research(ICAR)-Indian Veterinary Research Institute(IVRI)Bareilly 243122Uttar PradeshIndia Institute for Skeletal Aging&Orthopedic Surgery Hallym UniversityChuncheon-si 24252South Korea

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection leads to a severe respiratory illness and alters the gut microbiota,which dynamically interacts with the human immune *** alterations include decreased levels of beneficial bacteria and augmentation of opportunistic ***,we describe critical factors affecting the microbiota in coronavirus disease 2019(COVID-19)*** include,such as gut microbiota imbalance and gastrointestinal symptoms,the pattern of altered gut microbiota composition in COVID-19 patients,and crosstalk between the microbiome and the gut-lung axis/gut-brain-lung ***,we have illustrated the hypoxia state in COVID-19 associated gut microbiota *** role of ACE2 in the digestive system,and control of its expression using the gut microbiota is discussed,highlighting the interactions between the lungs,the gut,and the brain during COVID-19 ***,we address the gut microbiota in elderly or co-morbid patients as well as gut microbiota dysbiosis of in severe *** clinical trials to understand the role of probiotics in COVID-19 patients are listed in this *** inflammation is one of the major driving forces for COVID-19 symptoms and gut microbiome disruption and is associated with disease ***,understanding the role of the gut microbiota in immune modulation during SARS-CoV-2 infection may help improve therapeutic strategies for COVID-19 treatment.

关键词： COVID-19 Inflammation Gut microbiota Therapeutic

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A review on emerging smart technological innovations in healthcare sector for increasing patient's medication adherence

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Global Health Journal 2021年第4期5卷 183-189页

作者： pankaj pal Sharda Sambhakar Vivek Dave Shailendra Kumar paliwal Sarvesh paliwal Monika Sharma Aadesh Kumare Nidhi dhama Department of pharmacy Banasthali UniversityP.O.Banasthali VidyapithDistt.TonkRajasthan 304022India Department of pharmacy School of Health SciencesCentral University of South BiharSH-7Gaya-Panchanour RoadP.O.-FatehpurP.S.TekariGaya 824236India Department of pharmacy Lala Lajpat Rai Memorial Medical CollegeGarh RoadMeerut 250001India ABBOTT Healthcare private Limited Village Bhatauli KhurdSai RoadBaddiHimachal Pradesh 173205India Department of pharmaceutical Chemistry Kharvel Subharti college of PharmacySwami Vivekanand Subharti UniversitySubhartipuramNH-58Delhi-Haridwar Bypass RoadMeerut 250005India

In this paper,we reviewed the various advanced technologies and methods that could help patients for measuring ad herence of *** exist intelligent technologies that are available for measuring medication adherence,including medication event monitoring system(MEMS@),smart blister packs,radio frequency identifcation(RFID)embedded smart drawers,and wisely aware RFID dosage(WARD)system,Utilization of these advanced technologies and systems have aided in enhancing the adherence to a greater *** example,MEMS@refers to the electronic cap that counts the number of bottles opened,but it can be employed only with *** blisters are pharmaceutical packagings that possess the capability of monitoring when a pill or tablet is taken out of its *** those intelligent technologies can help in active monitoring of patients regarding adherence and capable of eradicating various medication errors due to which adherence is affected.

关键词： Radio frequency identification(RFID) mHealth Smart blister Smart drawer Wisely aware RFID dosage(WARD)system iCabiNET

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基于质量源于设计理念研究不同地区余甘子的关键性状

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数字中医药(英文) 2023年第3期6卷 272-284页

作者： Grishm Rohilla priya Masand pooja dhama Anurag Sunil Gupta Alok Sharma Department of pharmacognosy ISF College of PharmacyMogaPunjab 142001India Department of pharmaceutical Technology Meerut Institute of Engineering&TechnologyMeerutUttar Pradesh 250005India School of pharmacy Mangalayatan UniversityAligarhUttar Pradesh 202146India

目的探讨质量源于设计(QbD)工具在评估印度5个不同地区余甘子地理变异中的应用。方法在本实验中,采用简化四次模型的Box-Behnken设计,运行105次,结合使用Design Expert软件进行随机响应面映射。本研究使用了三种不同的浸提方法(索氏浸... 详细信息

目的探讨质量源于设计(QbD)工具在评估印度5个不同地区余甘子地理变异中的应用。方法在本实验中,采用简化四次模型的Box-Behnken设计,运行105次,结合使用Design Expert软件进行随机响应面映射。本研究使用了三种不同的浸提方法(索氏浸提、浸渍浸提和超声浸提)以及三种溶剂[蒸馏水、甲醇和水-甲醇混合物(50:50 v/v)]。采用气相色谱-质谱法(GC-MS)测定并分析余甘子的抗氧化活性、总黄酮含量(TFC)和总酚含量(TpC),以鉴定其主要成分。结果QbD叠加图显示余甘子的提取值不低于30%w/w,2,2-二苯基-1-三硝基苯肼(DppH)不低于60%mcg/mL(微克每毫升),TFC不低于75 mg QE/g(毫克槲皮素当量每克干原料),TpC不低于80 mg GAE/g(毫克没食子酸当量每克干原料)。此外,(GC-MS)数据证实了余甘子的生物活性存在变异。结论本研究模型能较好的描述浸提值、DppH、TFC和TpC的变化。QbD方法可能倾向于在浸提过程中优先考虑彻底性,最终提高浸提产品的质量。

关键词：余甘子质量源于设计气相色谱-质谱法浸提参数生物活性

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Monoclonal antibody and its use in the diagnosis of livestock diseases

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Advances in Bioscience and Biotechnology 2013年第4期4卷 50-62页

作者： Rajib Deb Sandip Chakraborty Belamaranahlly Veeregowda Amit Kumar Verma Ruchi Tiwari kuldeep dhama Animal Resource Development Department Pt. Nehru Complex Agartala India Department of Veterinary Epidemiology and preventive Medicine Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU) Mathura India Department of Veterinary Microbiology and Immunology Uttar pradesh pandit Deen Dayal Upadhayay pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU) Mathura India Division of pathology Indian Veterinary Research Institute Bareilly India Scientist Division of Animal Genetics & Breeding Project Directorate on Cattle (ICAR) Meerut India Veterinary College Bengaluru India

Since the discovery of hybridoma cells by Kohler and Milstein, the uses of monoclonal antibody (mAb), the protein produced by such cells are in vogue. Such antibodies with single isotype have higher specificity, and the serological tests employed in show higher reproducibility compared to those with use of polyclonal antisera. There are several procedures of mAb production which vary considerably but the principle remains the same which states that antigens introduced into animals generally result in the stimulation of lymphocytes, some of which produce antibody of only one type, although the isotype may change. The developments in the field of cell culture and transfection technology have lead to the production of improved qualities of mAbs. In general, monoclonal antibodies are important reagents used in biomedical research, such as, in the field of diagnostics and therapeutics as well as targeted drug delivery systems. They have got importance not only for infectious diseases caused by microbes and parasites, but also for cancer, metabolic and hormonal disorders, in the diagnosis of lymphoid and myeloid malignancies and tissue typing, enzyme linked immunosorbent assay (ELISA) (especially blocking ELISA), radio immunoassay (RIA), serotyping of pathogens and their immunological intervention with passive antibody, anti-idiotype inhibition or magic bullet therapy with cytotoxic agents coupled with antimouse specific antibody. The application of mAbs in diagnosis of various livestock diseases is an important area of concern as these diseases are a major and increasingly important factor reducing livestock productivity in various parts of the world. In this context, the application of mAbs for diagnosis of important bacterial diseases viz., Anthrax, Brucellosis, paratuberculosis, Leptospirosis, Listeriosis, Clostridial infections and Mycoplasmosis (CBpp), fungal diseases viz., Zygomycosis, Cryptococcosis, Histoplasmosis and paracoccidiodomycosis, viral diseases viz., F

关键词： Antibody Cell Engineering Diagnosis Livestock Microbes Monoclonal parasites

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Survival mechanisms of <i>Mycobacterium avium</i>subspecies <i>paratuberculosis</i>within host species and in the environment—A review

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Natural Science 2013年第6期5卷 710-723页

作者： Shoor Vir Singh Ajay Vir Singh Avnish Kumar pravin Kumar Singh Rajib Deb Amit Kumar Verma Amit Kumar Ruchi Tiwari Sandip Chakraborty kuldeep dhama Animal Genetics and Breeding Project Directorate on Cattle Indian Council of Agricultural Research Meerut India Animal Resource Development Department Pt. Nehru Complex Agartala India Department of Microbiology & Immunology Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU) Mathura India Department of Veterinary Epidemiology & preventive Medicine Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vi- gyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU) Mathura India Division of pathology Indian Veterinary Research Institute (IVRI) Bareilly India Microbiology Laboratory Animal Health Division Central Institute for Research on Goats (CIRG) Mathura India National JALMA Institute for Leprosy and Other Mycobacterial Diseases (NJIL and OMD) Agra India

Mycobacterium avium subsp. paratuberculosis causes chronic inflammation of the intestine known as Johne’s disease (JD) in domestic and wild ruminants including primates. MAp has also been associated with inflammatory bowel disease (IBD) so called Crohn’s disease (CD) of human beings, which is incurable even after surgery. By virtue of the pasteurization resistant power, high endemicity of the infection in animals continues to be the permanent source of infection to human population. High bio-burden of MAp in wide range of biotic (animal hosts including human beings) and abiotic environment in each and every country where it has been investigated, serves a reminder about the survival abilities of the MAp in diverse range of environmental conditions. Ability of the MAp to evade immune system of the host and the temporal events during infection of the macro-phages, is an area of major concern and research activities as the pattern of distribution are quiet different from those of other pathogenic intracellular organisms. Moreover, the organism can survive over a wide range of environmental conditions such as high and low environmental temperatures, pasteurization, low pH, and high salt concentration etc. This superior survival efficiency from environmental degradation and dormancy within host allows the pathogen to be available for causing disease and pathogenicity in animals and human beings, when conditions are favorable. perusal of literature reveal that, despite the availability of whole genome sequence of MAp, a very little is known about the replication, persistence and survival mechanisms of this pathogen. Therefore, this review tries to address the survival mechanisms of Mycobacterium avium subspecies paratuberculosis in the different host species and adverse environmental conditions in order to allow designing of more rational diagnostic and control procedures.

关键词： paratuberculosis Johne’s Disease Reservoir Disease Survival MAp Animal

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