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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： daniella da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

An Efficient Plant Regeneration System of Hydrangea bretschneideri Dipp via Stem Segments as Explants

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 595-604页

作者： Si ran Wang Jia Yan Bu er ha Yu’e Bai Institute of Forest Tree Genetic Breeding Forestry CollegeInner Mongolia Agricultural UniversityHohhot010000China

Hydrangea bretschneideri Dipp is a highly popular ornamental plant for garden *** engineering technology has been successfully used in many plant species,but it is limited in *** we established an efficient regeneration system by using stem segments as explants for the first *** our study,the plant growth regulators(PGRs)were evaluated at the different regeneration processes,including axillary shoots regeneration and root *** found that the optimal concentration for axillary buds’induction was 2.0 mgL^(-1)6-BA and 0.5 mgL^(-1)1 IAA,its highest induction rate was 70%.Moreover,the highest axillary shoots proliferation coefficient was 10.7 on the Murashige and Skoog(MS)medium with 2.0 mgL^(-1)6-benzyladenine(BA),0.2 mgL^(-1)indole-3-butyric acid(IBA),and 1.0 mgL^(-1)gibberellin A3(GA3).The highest frequency of root induction was 80.0±0.06%by culturing the elongated shoots in 1/2 MS medium containing 0.1 mgL^(-1)*** summary,our study will provide an effective technology for large-scale propagation and important pathway for promoting the popularization and application of Hydrangea bretschneideri Dipp.

关键词： Hydrangea bretschneideri Dipp stem segments regeneration

Estimation of hydraulic parameters from pumping tests in a multiaquifer system

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Underground Space 2020年第3期5卷 210-222页

作者： da ha Gang Zheng haizuo Zhou Chaofeng Zeng Huihui Zhang School of Civil Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Coast Civil Structure Safety of Ministry of Education Tianjin UniversityTianjin 300072China Hunan Provincial Key Laboratory of Geotechnical Engineering for Stability Control and Health Monitoring School of Civil EngineeringHunan University of Science and TechnologyXiangtanHunan 411201China School of Resources and Environmental Sciences Wuhan UniversityWuhan 430079China

The hydrogeologic conditions in Tianjin,China,are characterized by a system of multiple alternating aquifers and aquitards and a high groundwater ***,the groundwater system to a depth of 70 m includes one phreatic aquifer and three semiconfined aquifers(AqI–AqIII).The distribution of aquifers varies *** estimates of aquifer parameters from pumping tests are essential in geotechnical engineering *** this study,the applicability of different models for estimating hydraulic parameters in a multiaquifer system is *** avoid errors in the graphic-analytical process and to enhance the efficiency and accuracy,a hybrid algorithm,called GALMA(a genetic algorithm(GA)combined with the Levenberg–Marquardt(LM)algorithm),is used with the Neuman and Witherspoon model and ratio *** estimated values in the second and third semiconfined aquifers(AqII and AqIII)from various solutions are compared with the measured *** validations based on the prediction of the drawdown values are performed via a three dimensional numerical simulation.

关键词： Hydraulic parameter Leaky aquifer Pumping test Optimal approach

Development of a coupled supersonic inlet-fan Navier–Stokes simulation method

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Chinese Journal of Aeronautics 2018年第2期31卷 237-246页

作者： Qiushi LI Yongzhao LYU Tianyu PAN da LI ha'nan LU Yifang GONG National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeoing 100191 China School of Energy and Power Engineering Beihang University Beijing 100083 China Collaborative Innovation Center of Advanced Aero-Engine Beihang University Beijing 100083 China GL-Turbo Compressor Company Wuxi 214106 China

A coupled supersonic inlet-fan Navier–Stokes simulation method was developed by using COMSOL-CFD code. The flow turning, pressure rise and loss effects across blade rows of the fan and the inlet-fan interactions were taken into account as source terms of the governing equations without a blade geometry by a body force model. In this model, viscous effects in blade passages can also be calculated directly, which include the exchange of momentum between fluids and detailed viscous flow close to walls. NASA Rotor 37 compressor test rig was used to validate the ability of the body force model to estimate the real performance of blade rows. Calculated pressure ratio characteristics and the distribution of the total pressure, total temperature, and swirl angle in the span direction agreed well with experimental and numerical data. It is shown that the body force model is a promising approach for predicting the flow field of the turbomachinery. Then, coupled axisymmetric mixed compression supersonic inlet-fan simulations were conducted at Mach number 2.8 operating conditions. The analysis includes coupled steady-state performance, and effects of the fan on the inlet. The results indicate that the coupled simulation method is capable of simulating behavior of the supersonic inlet-fan system.

关键词： Body force model Coupled simulation Rapid numerical method Supersonic inlet-fan Viscous flow

An imaging spectrometer employing tunable hyperchromatic microlenses

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Light(Science & Applications) 2015年第1期4卷 33-41页

作者： Phuong-ha Cu-Nguyen Adrian Grewe Patrik Feßer Andreas Seifert Stefan Sinzinger hans Zappe Gisela and erwin Sick Chair of Micro-optics Department of Microsystems EngineeringUniversity of FreiburgFreiburg 79110Germany Fachgebiet Technische Optik Institut fur Mikro-und NanotechnologienTechnische Universitat IlmenauIlmenau 98684Germany

We present the design,fabrication and characterization of hydraulically-tunable hyperchromatic lenses for two-dimensional(2D)spectrally-resolved spectral *** hyperchromatic lenses,consisting of a positive diffractive lens and a tunable concave lens,are designed to have a large longitudinal chromatic dispersion and the images of different wavelengths from each other.2D objects of different wavelengths can consequently be imaged using the tunability of the lens *** hyperchromatic lens concepts are demonstrated and their spectral characteristics as well as their functionality in spectral imaging applications are shown.

关键词： hyperchromatic lens imaging spectrometer tunable filter tunable lens

THE STUDY ON NOVEL MICROELECTRODE ARRAY CHIPS FOR THE DETECTION OF HEAVY METALS IN WATer POLLUTION

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Journal of Innovative Optical Health Sciences 2012年第1期5卷 11-17页

作者： HUI-XIN ZhaO WEI CAI da ha haO WAN PING WANG Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027P.R.China

Qualitative and quantitative analysis of trace heavy metals in aqueous environment are rapidly assuming significance along with the rapid development of *** this paper,gold microelectrode array(MEA)plated with mercury film was used for simultaneous voltammetric detection of zinc,cadmium,lead and copper ions in *** electrochemical behavior and the actual surface area of the MEA were investigated by cyclic voltammetry in K_(3)[Fe(CN)_(6)].Electrochemical impedance spectrum(EIS)was utilized to examine the deposition of mercury on the electrode *** on anodic stripping voltammetry,mercury filmAu MEA was applied to the detection of heavy metals in artificial analyte,where good calibrate linearity was obtained for cadmium,lead and copper ions,but with zinc exhibiting poor linearity.

关键词： Microelectrode array(MEA)chip heavy metals detection water pollution

Expression rates of p16,p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity

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World Journal of Clinical Cases 2025年第9期13卷 13-23页

作者： ha-Jong Nam Heongrae Ryu da-Woon Lee Je Yeon Byeon Jun Hyuk Kim Ji Hye Lee Soomin Lim Hwan Jun Choi Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea Bachelor of Medicine and Bachelor of Surgery University College LondonMedical SchoolLondon WC1E 6DEUnited Kingdom

BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong ***-related tumors exhibit unique mechanisms that target p16 and p53 ***,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains *** retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin *** To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian *** All patients underwent wide excision and *** staining for HPV,p16,and p53 yielded positive and negative *** relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence *** Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.

关键词： Squamous cell carcinoma Oropharyngeal Non-oropharyngeal Human papillomavirus The p16 The p53

Non-expansive Mappings and Iterative Methods in Uniformly Convex Banach Spaces

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Acta Mathematica Sinica,English Series 2004年第5期20卷 829-836页

作者： ha|YunZHOU Dept.ofMath. ShijiazhuangMechanicalEngineeringCollegeShijiazhuang050003P.R.China

In this article,we will investigate the properties of iterative sequence for non-expansive mappings and present several strong and weak convergence results of successive approximations to fixed points of non-expansive mappings in uniformly convex Banach *** results presented in this article generalize and improve various ones concerned with constructive techniques for the fixed points of non-expansive mappings.

关键词： Non-expansive mapping Mann and lshikawa iteration schemes Convergence theorem Uniformly convex Banach space

Effects of Material and Dimension on TCF,Frequency,and Q of Radial Contour Mode AlN-on-Si MEMS Resonators

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Journal of Electronic Science and Technology 2021年第4期19卷 319-334页

作者： Thi Dep ha with the Faculty of Electronics Technology Industrial University of Ho Chi Minh CityHo Chi Minh City 70000

This paper investigates the effects of material and dimension parameters on the frequency splitting,frequency drift,and quality factor(Q)of aluminium nitride(AlN)-on-n-doped/pure silicon(Si)microelectromechanical systems(MEMS)disk resonators through analysis and *** parameters include the crystallographic orientation,dopant,substrate thickness,and *** resonators operate in the elliptical,higher order,and flexural *** simulation results show that i)the turnover points of the resonators exist at 55°C,-50°C,40°C,and-10°C for n-doped silicon with the doping concentration of 2×1019 cm-3 and the Si thickness of 3.5μm,and these points are shifted with the substrate thickness and mode variations;ii)compared with pure Si,the modal-frequency splitting for n-doped Si is higher and increases from 5%to 10%for all studied modes;iii)Q of the resonators depends on the temperature and ***,the turnover,modal-frequency splitting,and Q of the resonators depend on the thickness and material of the substrate and the *** work offers an analysis and design platform for high-performance MEMS gyroscopes as well as oscillators in terms of the temperature compensation by n-doped Si.

关键词： Anisotropic contour mode doping gyroscope microelectromechanical systems(MEMS)resonator piezoelectric temperature coefficient of frequency(TCF) temperature compensation thin-film piezoelectric-on-substrate(TPoS)