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Nanochaperones Based on Hydrophobic Interaction and Coordination Inhibit Protein Misfolding and Fibrillation

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Chinese Journal of Polymer Science 2024年第11期42卷 1710-1718,I0009页

作者： Hui Wang lin-lin Xu lin-Qi Shi Ru-Jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Amyloidosis is characterized by the deposition of fibrillar aggregates,with a specific peptide or protein as the primary component,in affected tissues or *** proliferation and deposition of amyloid fibrils can cause organismal dysfunction and lethal pathological outcomes associated with *** this study,a nanochaperone(nChap-NA)was developed to inhibit protein misfolding and fibrillation by simulating the function of natural molecular *** nanochaperone was prepared by self-assembly of two block copolymers PEG-b-PCL and PCL-b-P(NIPAM-co-AANTA),which had a phase-separated surface consisting of hydrophobic PNIPAM microdomains with coordinative NTA(Zn)moieties and hydrophilic PEG *** hydrophobic interaction of the PNIPAM microdomain and the coordination of NTA(Zn)synergistically work together to effectively trap the amyloid monomer and block its fibrillation *** and human islet amyloid polypeptide(hIAPP)were used as model proteins to investigate the nanochaperone's inhibition of amyloid misfolding and *** was proved that the nanochaperone could stabilize the natural conformation of the trapped insulin and hIAPP,and effectively inhibit their *** vivo study demonstrated that the nanochaperone could effectively preserve the bioactivity of insulin and reduce the cytotoxicity caused by hIAPP *** study may provide a promising strategy for the prophylactic treatment of amyloidosis.

关键词： Nanochaperone Amyloidosis Insulin hIAPP Inhibit fibrillation

A comparative electrochemical investigation of silicon nanowires formation via metal-catalyzed electroless etching

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Science China(Technological Sciences) 2015年第2期58卷 362-368页

作者： LIU lin Beijing Key Laboratory of Energy Conversion and Storage Materials Beijing Normal University Key Laboratory of Condition Monitoring and Control for Power Plant Equipment of Ministry of Education North China Electric Power University

In this study, the electrochemical behavior of monocrystalline bare Si and Ag-coated Si in hydrofluoric acid （HF） solutions with and without hydrogen peroxide （H202） was systematically tested with an electrochemical technique. By analyzing the po- larization curves, the corrosion processes were quantified and the etchants which govern the formation of silicon nanowires （SiNWs） were determined. It was discovered that both H202 and Ag enhanced the reduction reactions, irrespective of the con- ductivity type and doping concentration of Si. It is believed that the formation of SiNWs via Metal-Catalyzed Electroless Etching is a process controlled by cathodic reduction reactions.

关键词： silicon nanowires polarization curve electrochemistry

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Journal of Thermal Science 2009年第1期18卷 2-7页

作者： Sui lin Department of Mechanical and Industrial Engineering Concordia University Montreal Quebec Canada H3G 1M8

The particle paths of the Lagrangian flow field between two cylinders simulate well the spiral arms of Galaxy M51 image [1] and the interface curve of the Yin-Yang balance in the ancient Tai-Cbi diagram [2]. The particle paths of the Lagrangian flow field involve four parameters. The normalization of the system of equations significantly simplifies the formulation of the flow process and reduces the original four parameters to only one parameter. Furthermore it provides the similarity between the formulation of the spiral arms of Galaxy M51 and that of the interface curve of the Yin-Yang balance in the ancient Tai-Chi diagram.

关键词： Lagrangian flow field Particle path Simulation Galaxy M51 Ancient Tai-Chi diagram

ON NEARLY-CONTROLLABLE SUBSPACES OF A CLASS OF DISCRETE-TIME BIlinEAR SYSTEMS

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Journal of Systems Science & Complexity 2013年第4期26卷 512-526页

作者： TIE lin School of Automation Science and Electrical Engineering Beihang University

If a linear time-invariant system is uncontrollable,then the state space can be decomposed as a direct sum of a controllable subspace and an uncontrollable *** this paper,for a class of discrete-time bilinear systems which are uncontrollable but can be nearly controllable,by studying the nearly-controllable subspaces and defining the near-controllability index,the controllability properties of the systems are fully *** are provided to illustrate the conceptions and results of the paper.

关键词： Bilinear systems discrete-time systems near-controllability near-controllability index,nearly-controllable subspaces.

Multiple multicontrol unitary operations: Implementation and applications

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Science China(Physics,Mechanics & Astronomy) 2018年第4期61卷 44-53页

作者： Qing lin Fujian Key Laboratory of Light Propagation and Transformation College of Information Science and EngineeringHuaqiao University

The efficient implementation of computational tasks is critical to quantum computations. In quantum circuits, multicontrol unitary operations are important components. Here, we present an extremely efficient and direct approach to multiple multicontrol unitary operations without decomposition to CNOT and single-photon gates. With the proposed approach, the necessary twophoton operations could be reduced from O(n^3) with the traditional decomposition approach to O(n), which will greatly relax the requirements and make large-scale quantum computation feasible. Moreover, we propose the potential application to the(n-k)-uniform hypergraph state.

关键词： multicontrol unitary operation cross phase modulation c-path gate merging gate hypergraph state

Optical parity gate and a wide range of entangled states generation

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Science China(Physics,Mechanics & Astronomy) 2015年第4期58卷 30-39页

作者： lin Qing College of Information Science and Engineering Huaqiao University (Xiamen)

Generating entangled states efficiently is a hot topic in the area of quantum information *** the approach presented in this paper,a general parity gate could be realized and a wide range of entangled states,including GHZ state,W state,Dicke state,arbitrary graph state and locally maximally entanglable states,can be generated *** generation of GHZ state,W state,and Dicke state is probabilistic but heralded and the total success probability is *** addition,the arbitrary graph state and locally maximally entanglable states generation is deterministic,flexible,and highly ***,with the"simultaneous"generation pattern,the complexity of the graph state generation and locally maximally entanglable states generation could be reduced greatly,providing a more efficient and feasible way to generate the entangled states.

关键词： parity gate entangled states cross phase modulation c-path gate quantum information

外泌体miRNA治疗多发性骨髓瘤的作用与机制

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中国组织工程研究 2025年第31期29卷 6743-6752页

作者：赵艺涵孙旭杭赵琳蒋士卿河南中医药大学第一附属医院血液肿瘤科河南省郑州市450000 河南中医药大学第一临床医学院河南省郑州市450000 上海中医药大学附属曙光医院血液科上海市200000

背景:多发性骨髓瘤是最常见的血液恶性肿瘤之一,具有难治疗、易复发、易耐药的特点,至今仍无法治愈。外泌体的内源性转运系统通过影响细胞间功能成分的交换而发挥通讯作用,其中miRNA因尺寸微小更容易被包装在外泌体内,故影响细胞功能的... 详细信息

背景:多发性骨髓瘤是最常见的血液恶性肿瘤之一,具有难治疗、易复发、易耐药的特点,至今仍无法治愈。外泌体的内源性转运系统通过影响细胞间功能成分的交换而发挥通讯作用,其中miRNA因尺寸微小更容易被包装在外泌体内,故影响细胞功能的途径多、范围广。目的:归纳并总结多发性骨髓瘤中外泌体miRNA发挥作用的机制,提出潜在靶点。方法:以“multiple myeloma,bone marrow mesenchyml stem cell,fibroblasts,peripheral blood,complication,progression,drug resistance,exosomal miRNA”为英文关键检索词,检索PubMed数据库的相关文献。文献检索时限为数据库建库至2024年6月。通过阅读文题和摘要进行初筛,排除无关或内容重复或无参考意义的文献,最后纳入81篇文献进行综述。结果与结论:①多发性骨髓瘤细胞通过各种miRNA介导的外泌体调节成骨和破骨功能平衡参与多发性骨髓瘤骨病变、调控红细胞钙离子外排通道参与高钙血症的发生、促进肾上皮-间充质转化引发肾纤维化和肾功能不全、上调骨髓来源的单核抑制细胞促进免疫微环境的抑制;此外,多发性骨髓瘤细胞外泌体miRNA还参与了免疫治疗耐药的发生和发展以及血管生成、细胞增殖及细胞衰老等病理过程。②骨髓间充质干细胞和肿瘤相关成纤维细胞均可通过外泌体miRNA影响多发性骨髓瘤细胞的增殖、转移和凋亡,干预血管生成,调控化疗药物的耐药性。③外周血循环外泌体miRNA作为前沿的无创生物标志物,可发挥判断多发性骨髓瘤病程分期和进展,预测患者生存及预后,评估药物敏感性和耐药性等关键作用。④多发性骨髓瘤外泌体长链非编码RNA、环状RNA、miRNA及mRNA,靶基因多种研究因素可形成不同的组合,灵活地构建新型生物轴和生物分子网络,符合整体医学的发展理念。⑤外泌体miRNA作为预测生物标志物及新药研发的治疗靶点具有巨大的发展潜力,如何最大程度利用外泌体miRNA,如何加快相关科研结果的临床转化值得未来进一步研究。

关键词：多发性骨髓瘤进展耐药并发症骨髓间充质干细胞成纤维细胞外周血外泌体 miRNA

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植物源外泌体样纳米囊泡刺激成骨细胞、抑制破骨细胞并促进成骨

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中国组织工程研究 2025年第31期29卷 6765-6771页

作者：药文鑫王毅蔡林冯晓波武汉大学中南医院疼痛科湖北省武汉市430071 武汉大学中南医院脊柱与骨肿瘤科湖北省武汉市430071

背景:骨质疏松症易引发病理性骨折且严重影响患者的生活质量,植物源外泌体样纳米囊泡在调节骨质疏松症骨平衡方面发挥着重要作用。目的:综述不同植物源外泌体样纳米囊泡在骨质疏松症治疗中的研究现状与展望。方法:通过计算机在PubMed、W... 详细信息

背景:骨质疏松症易引发病理性骨折且严重影响患者的生活质量,植物源外泌体样纳米囊泡在调节骨质疏松症骨平衡方面发挥着重要作用。目的:综述不同植物源外泌体样纳米囊泡在骨质疏松症治疗中的研究现状与展望。方法:通过计算机在PubMed、Web of Science、中国知网中检索1995年1月至2024年3月发表的相关文献,以“osteoporosis,plant-derived exosome-like nanovesicles,exosomes,osteoblasts,osteoclasts”为英文检索词,以“骨质疏松症,植物源外泌体样纳米囊泡,外泌体,成骨细胞,破骨细胞”为中文检索词,最终纳入53篇文献进行分析。结果与结论:植物源外泌体样纳米囊泡具有生物相容性、低毒性和天然靶向性等优点,这些特性不仅确保了其在体内的稳定存在与有效作用,还避免了不必要的免疫反应,为长期治疗策略的设计奠定了基础。植物源外泌体样纳米囊泡可以通过刺激成骨细胞增殖、抑制破骨细胞分化以及促进成骨-抑制破骨双重作用抗骨质疏松症;此外,部分植物源外泌体样纳米囊泡因具有骨靶向性,未来或将成为新型示踪靶标和治疗方案广泛应用于骨质疏松症治疗过程中。

关键词：骨质疏松症植物源性外泌体样纳米囊泡外泌体成骨细胞破骨细胞工程化外泌体

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Seasonal abundance and distribution of pelagic tunicates (Chordata: Thaliacea) in the central South China Sea

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Acta Oceanologica Sinica 2006年第3期25卷 148-156页

作者： lin Mao lin Rongcheng Open Laboratory of Environment Science Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China Key Laboratory of Marine Biogenetic Resource Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China

A total of 168 macro-zooplankton samples from 42 stations in the central South China Sea （12° ～20° N, 111°～118°E, an area of about 64 × 10^4 km^2 ） were collected in September 1983 （autumn） , April 1984 （spring） , August 1984 （summer） and December 1984 （winter）. Twenty-three species and subspecies of tunicates were found, of which Thalia democratica complex （including T. d. orientalis and T. d. echinata） and Doliolum denticulatum were the dominant species, and accounted for 95.7% , 90. 0%, 91.8% and 90. 5% of the total tunicates found in autumn, winter, spring and summer, respectively. The highest abundance （with a mean of 2.37 ind./m^3 ） occurred in autumn. There are strong correlations between the abundances of the tunicates and those of phytoplankton and chlorophyll a concentration. However, tunicates also aggregate in areas with low primary production in the autumn survey, probably due to the water circulation pattern.

关键词： South China Sea tunicates abundance and distribution