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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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组合式自然曝气生物滤床脱氮效能与微生物特性分析

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广东化工 2025年第2期52卷 39-42页

作者：曾德阳於玲蔚李素芬广东佳园环保科技有限公司广东惠州516000 广东中大新华水环境工程研究院广东东莞523133

本研究从湖泊底泥中筛选功能微生物菌群,利用碳源补充及多孔滤料的微生物吸附固定技术,构建一种组合式自然曝气生物滤床系统。以城市污染水体为处理对象,研究其脱氮效果及其反应器内微生物群落结构的变化。结果表明,筛选富集的硝化菌群... 详细信息

本研究从湖泊底泥中筛选功能微生物菌群,利用碳源补充及多孔滤料的微生物吸附固定技术,构建一种组合式自然曝气生物滤床系统。以城市污染水体为处理对象,研究其脱氮效果及其反应器内微生物群落结构的变化。结果表明,筛选富集的硝化菌群和反硝化菌群对氨氮和硝酸盐氮的去除率分别达到93%和90%;该组合式自然曝气生物滤床系统运行初期对氨氮的去除率达到50%,系统中微生物菌群组成以不动杆菌属(Acinetobacter)、假单胞菌属(Pseudomonas)、食酸菌属(Acidovorax)、脱氯单胞菌属(Dechloromonas)、亚硝化单胞菌(Nitrosomonas)、博斯氏菌属(Bosea)、黄杆菌属(Flavobacterium)等为主,保证系统的高效脱氮效果。

关键词：组合式自然曝气生物滤床城市污染水体脱氮效能微生物菌群结构

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Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： Chen Chen Hongyu Xue Qilin Hu Mengfan Wang Pan Shang Ziyan Liu Tao Peng deyang Zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

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Comparative Mineralogical and Geochemical Compositions within the Fault Gouge in the Surface Exposures of the Mw7.9 Wenchuan Earthquake Fault and Their Implications for Mass Removal and Fluid-Rock Interactions

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Journal of Earth Science 2025年第1期36卷 266-274页

作者： Yangyang Wang Sijia Li Shiyuan Wang deyang Shi Weibing Shen National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Geological Exploration and Development Research Institute Chuanqing Drilling Engineering Co.Ltd.CNPCChengdu 610500China Sichuan Earthquake Agency Chengdu 610041China Institute of Geophysics China Earthquake AdministrationBeijing 100081China MLRKey Laboratory of Isotope Geology Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China

Geochemistry of the fault gouge record information on fault behaviors and environmental *** investigated variations in the mineralogical and geochemical compositions of the fault gouge sampled from the margin zone(MZ)to the slip central zone(CZ)of the fault gouge in the Beichuan-Yingxiu surface rupture zone of the Wenchuan *** show that the clay minerals contents increase from the MZ to CZ,and the quartz and plagioclase contents slight *** increasing enrichment in Al_(2)O_(3),Fe_(2)O_(3),and K_(2)O are observed toward the CZ;the decomposition of quartz and plagioclase,as well as the depletion of Si O_(2),Ca O,Na_2O,and P_(2)O_(5)suggest that the alkaline-earth elements are carried away by the *** can be explained that the stronger coseismic actions in the CZ allow more clay minerals to form,decompose quartz and plagioclase,and alter plagioclase to *** mass loss in the CZ is larger than that in MZ,which is maybe due to the more concentrated stress in the strongly deformed CZ,however other causes will not be excluded.

关键词： fault gouge mass transfer fluid-rock interactions geochemical transformation Wenchuan Earthquake

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Preparations of Mytilus edulis protein hydrolysate-iron complexes and their ameliorative effects on mice with iron deficiency anemia

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Food Science and Human Wellness 2025年

作者： Guang Li Xuening Yu Shuling Zhou Xiaoyang Liu Fawen Yin deyang Li Baocai Xu Dayong Zhou School of Food and Biological Engineering， Hefei University of Technology SKL of Marine Food Processing & Safety Control， National Engineering Research Center of Seafood， Collaborative Innovation Center of Seafood Deep Processing， Liaoning Province Key Laboratory for Marine Food Science and Technology， School of Food Science and Technology， Dalian Polytechnic University

Iron is a fundamental trace element essential for the immune system， and current research on iron supplements is increasingly focusing on food-derived peptides capable of binding iron ions. The objectives of this study were to characterize the iron-chelating peptide (MEPH) derived from Mytilus edulis and to investigate the effects of MEPH-Fe complexes on mice with iron deficiency-induced anemia (IDA). MEPH and iron(II) sulfate heptahydrate successfully formed MEPH-Fe complexes under conditions of 4.5 mg/mL concentration， 45 ℃ temperature， and 60 minutes of incubation， utilizing both carboxyl and amino binding sites. Compared to MEPH alone， the MEPH-Fe complexes exhibited fluorescence quenching， ultraviolet shifts， reduced X-ray diffraction peak intensities， stabilization during in vitro digestion， microstructural changes， increased particle size， and decreased absolute values of zeta potential. In the IDA mouse model， the MEPH-Fe complexes were able to restore body weight， hematological indices， organ coefficients， iron content in organs， and antioxidant capacity to normal levels. Additionally， they demonstrated beneficial effects on IDA-induced colonic inflammation by normalizing tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) levels. The results indicated that MEPH-Fe complexes had more positive effects on IDA mice compared to ferrous sulfate. In conclusion， this study provides valuable insights into the potential of MEPH-Fe complexes as iron supplements.

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二维功能填料尺寸对BN/EPDM柔性中子防护复合材料性能的影响

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核技术 2024年第9期47卷 102-111页

作者：宗波曾德洋王凯凯唐文偲付嘉佳常树全何佳霖陈芳雷李自平李达国家核安保技术中心北京102401 南京航空航天大学材料科学与技术学院南京211100

柔性中子防护复合材料对于异形构件和人员防护具有重要意义,其性能与功能填料的性质密切相关,但二维功能填料尺寸对材料性能的影响尚不明确。以性能良好的三元乙丙橡胶(Ethylene Propylene Diene Monomer,EPDM)作为柔性基体,以热中子吸... 详细信息

柔性中子防护复合材料对于异形构件和人员防护具有重要意义,其性能与功能填料的性质密切相关,但二维功能填料尺寸对材料性能的影响尚不明确。以性能良好的三元乙丙橡胶(Ethylene Propylene Diene Monomer,EPDM)作为柔性基体,以热中子吸收截面较高的层状氮化硼(Boron Nitride,BN)作为二维功能填料并作表面改性,通过开炼工艺将BN均匀分散于EPDM中,热压硫化后得到BN/EPDM柔性中子防护复合材料,对其微观结构进行表征分析。研究了BN尺寸对复合材料综合性能的影响,结果表明:减小BN尺寸有利于提升复合材料的拉伸强度和热中子屏蔽性能,当材料厚度为2 mm时,其拉伸强度最高可达8.13 MPa,热中子屏蔽率最高可提升约5%。该研究可为聚合物基柔性中子防护复合材料的设计与制备提供基础。

关键词：中子防护复合材料柔性二维功能填料氮化硼

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Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China

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General Psychiatry 2023年第6期36卷 541-546页

作者： Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song deyang zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan zeng Institute of Brain Science and Advanced Technology Wuhan University of Science and TechnologyWuhanHubeiChina Department of Neurology Geriatric Hospital Affiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Department of Neurology Tianyou Hospital Affiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Institute of Infection Immunology and Tumor MicroenvironmentHubei Province Key Laboratory of Occupational Hazard Identification and ControlMedical CollegeWuhan University of Science and TechnologyWuhanHubeiChina Department of Anesthesiology Zhongnan HospitalWuhan UniversityWuhanHubeiChina Department of Neurology Wuchang Hospital afiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Department of neurology Asian Heart HospitalWuhan University of Science and TechnologyWuhanHubeiChina School of Public Health Wuhan University of Science and TechnologyWuhanHubeiChina

To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were *** associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern.

关键词： acute impact consequences

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高产林可霉素链霉菌的筛选及发酵条件的优化

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中国酿造 2015年第11期34卷 99-102页

作者：邓加聪施潇蕊曾德样张文森徐慧诠唐慧华郑虹福建师范大学福清分校海洋与生化工程学院福建福清350300 福建师范大学福清分校朗姆多果酒研究所福建福清350300

采用平板划线,摇瓶复筛等方法从福清近海海域泥土中分离筛选到一株林可霉素产率较高的链霉菌株6204;采用单因素试验和正交设计试验,从葡萄糖添加量、磷酸二氢钾条件两及金属离子对菌株6204产林可霉素影响,并对其发酵条件进行优化。结果... 详细信息

采用平板划线,摇瓶复筛等方法从福清近海海域泥土中分离筛选到一株林可霉素产率较高的链霉菌株6204;采用单因素试验和正交设计试验,从葡萄糖添加量、磷酸二氢钾条件两及金属离子对菌株6204产林可霉素影响,并对其发酵条件进行优化。结果表明,最适的发酵条件为葡萄糖添加量10.0%,镁离子质量浓度0.10 g/L,磷酸二氢钾添加量0.020%,在此优化发酵条件下,菌株6204产林可霉素的含量可达3 907.738μg/m L,与优化前相比较,林可霉素的含量提高了1 823.082μg/m L。

关键词：链霉菌选育林可霉素发酵条件优化

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中年心血管危险因素增加阿尔茨海默病相关痴呆的流行病学和机制研究进展

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中华脑血管病杂志（电子版） 2024年第1期18卷 6-13页

作者：曾德阳董贺千禧陶凉肖红艳曾燕鄢华武汉科技大学亚洲心脏病医院心内科 430022 武汉科技大学医学部 430081

尽管越来越多的流行病学研究证明,中年心血管风险因素,如高血压、糖尿病、肥胖、缺乏运动和吸烟,通过脑动脉粥样硬化、脑灌注不足和神经退行性变等病理机制,增加阿尔茨海默病相关痴呆(ADRD)的发病率,但心血管危险因素和亚临床动脉粥样... 详细信息

尽管越来越多的流行病学研究证明,中年心血管风险因素,如高血压、糖尿病、肥胖、缺乏运动和吸烟,通过脑动脉粥样硬化、脑灌注不足和神经退行性变等病理机制,增加阿尔茨海默病相关痴呆(ADRD)的发病率,但心血管危险因素和亚临床动脉粥样硬化对ADRD临床前阶段的纵向影响尚未完全阐明。本篇综述系统阐述了心血管风险因素,亚临床或症状前动脉粥样硬化与ADRD之间的关系,提出识别心血管危险因素并确定预防和延迟ADRD发作的关键时间窗至关重要,开展大规模多中心的心血管危险因素预防试验将有助于确定血管因素是否对亚临床动脉粥样硬化有明显影响,并阐明中年心血管风险因素对大脑的影响。

关键词：危险因素心血管疾病动脉粥样硬化阿尔茨海默病痴呆

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VTL-1600ATC立式CNC车床自动化升级改造方案及效果分析

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中国高新科技 2025年第02期 89-91页

作者：何德阳沧州中车株机轨道装备服务有限公司

文章介绍了油机工业股份有限公司生产的VTL-1600ATC立式CNC车床的自动化升级改造方案。改造的目的是配合公司产能升级，提高机床的生产效率和加工精度。具体改造措施包括增加高精度自定心动力卡盘、液压回转缸、在机自动测量系统及刀具... 详细信息

文章介绍了油机工业股份有限公司生产的VTL-1600ATC立式CNC车床的自动化升级改造方案。改造的目的是配合公司产能升级，提高机床的生产效率和加工精度。具体改造措施包括增加高精度自定心动力卡盘、液压回转缸、在机自动测量系统及刀具自动测量系统等。改造后的机床能够实现工件自动上下料、自动装卡和自动测量，显著提升了生产效率和加工精度。为相关设备的改造提供参考和借鉴。

关键词：数控立式车床 VTL-1600ATC 自动化改造

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