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Science China Life Sciences 2024年

作者： dexin zhang Rui Zheng Zhoutong Chen Liren Wang Xi Chen Lei Yang Yanan Huo Shuming Yin Dan zhang Jiaxin Huang Xingang Cui Dali Li Hongquan Geng Department of Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Urology Children's Hospital of Fudan University Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University

Primary hyperoxaluria type 1(PH1) is a severe hereditary disease, leading to the accumulation of oxalate in multiple organs, particularly the kidney. Hydroxyacid oxidase 1(HAO1), a pivotal gene involved in oxalate production, is an approved target for the treatment of PH1. In this study, we demonstrated the discovery of several novel therapeutic sites of the Hao1 gene and the efficient editing of Hao1 c.290-2 A in vivo with lipid nanoparticles(LNP) delivered adenine base editing(ABE) mR NA. A single infusion of LNP-ABE resulted in a near-complete knockout of Hao1 in the liver, leading to the sustainable normalization of urinary oxalate(for at least 6 months) and complete rescue of the pathophysiology in PH1 rats. Additionally, a significant correlation between Hao1 editing efficiency and urinary oxalate levels was observed and over60% Hao1 editing efficiency was required to achieve the normalization of urinary oxalate in PH1 rats. These findings suggest that the LNPmediated base-editing of Hao1 c.290-2 A is an efficient and safe approach to PH1 therapy, highlighting its potential utility in clinical settings.

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Enhancement of Natural Convection for Cooling Active Antenna Unit Device in 5G Base Station

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Journal of Thermal Science 2022年第5期31卷 1551-1564页

作者： zhang dexin DING Bin ZHU Chuanyong GONG Liang College of New Energy China University of Petroleum(East China)Qingdao266580China

The Active Antenna Unit(AAU)on the outdoor tower is the key equipment to support the mobile communication of *** suppress the overheating of AAU in summer,effective cooling measures are *** the present study,a numerical model of an AAU device with two chips in the outdoor environment was established to explore the surface temperature distribution under a coupling heat transfer process with natural convection and solar radiation was ***,the effects of the fin number,the fin height and the heat flux were discussed on the cooling *** results proved that the fins with a number of 12 presented the best cooling performance in this *** contrast,increasing the height of fins was still an effective way to improve the cooling performance of fins in outdoor conditions and to resist the thermal shock of ***,punching through holes on the fins,adding graphite heat spreader and reducing surface emissivity are effective ways to improve the cooling *** the optimizations,the maximum temperature decreased by 3.5℃in *** other words,the contribution of these optimizations to the cooling performance was equivalent to an increase of fin height in 9 mm.

关键词： natural convection heat transfer enhancement structural optimization 5G base station

基于网络药理学探讨补阳还五汤治疗新型冠状病毒肺炎继发肺纤维化的潜在机制

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中国中医药现代远程教育 2024年第15期22卷 83-86页

作者：张德鑫张伟阎小燕山东中医药大学第一临床医学院山东济南250014 山东中医药大学附属医院呼吸与危重症医学科山东济南250014 山东中医药大学附属医院老年医学科山东济南250014

目的基于网络药理学探讨补阳还五汤治疗新型冠状病毒肺炎继发肺纤维化的作用机制。方法利用中药系统药理学分析平台(TCMSP)数据库、相关文献筛选出补阳还五汤的活性成分及相关靶点,在GeneCards和在线人类孟德尔遗传(OMIM)数据库中检索... 详细信息

目的基于网络药理学探讨补阳还五汤治疗新型冠状病毒肺炎继发肺纤维化的作用机制。方法利用中药系统药理学分析平台(TCMSP)数据库、相关文献筛选出补阳还五汤的活性成分及相关靶点,在GeneCards和在线人类孟德尔遗传(OMIM)数据库中检索新型冠状病毒肺炎与肺纤维化的疾病靶点,取三者的交集靶点。利用Cytoscape 3.7.2软件、String在线网站分别构建“药物-活性成分-疾病-靶点”网络和蛋白互作网络(PPI)。最后,利用R x644.1.2软件进行富集分析。结果筛选得到106个补阳还五汤的活性成分和70个药物-疾病共同靶点。富集分析结果涉及细胞因子及其受体配体活性等方面,其作用机制可能与白细胞介素-17(IL-17)、Toll样受体、肿瘤坏死因子(TNF)等信号通路有密切关系。结论补阳还五汤可通过多成分、多靶点、多信号通路发挥治疗新型冠状病毒肺炎继发肺纤维化的作用。

关键词：新型冠状病毒肺炎肺纤维化补阳还五汤网络药理学

4种方式治疗三叉神经第一支带状疱疹性神经痛的疗效比较

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遵义医科大学学报 2024年第7期47卷 719-724页

作者：张德新张桂友文松曹嵩遵义医科大学附属医院麻醉科贵州遵义563000 遵义医科大学附属医院疼痛科贵州遵义563000

目的对比研究临床常用的4种方式治疗三叉神经第一支带状疱疹性神经痛的疗效。方法分析遵义医科大学附属医院疼痛科2020年7月至2023年7月诊断为三叉神经第一支带状疱疹性神经痛的病人52例,根据治疗方案分为4组,SNB组(眶上神经阻滞)10例,S... 详细信息

目的对比研究临床常用的4种方式治疗三叉神经第一支带状疱疹性神经痛的疗效。方法分析遵义医科大学附属医院疼痛科2020年7月至2023年7月诊断为三叉神经第一支带状疱疹性神经痛的病人52例,根据治疗方案分为4组,SNB组(眶上神经阻滞)10例,S-PRF组(眶上神经脉冲射频)12例,TG-PRF组(三叉神经节脉冲射频)13例,PNS组(眶上神经电刺激)17例。对比4组术前、术后NRS评分及疼痛爆发次数、普瑞巴林和曲马多用量、PSQI评分。结果疼痛情况:与术前对比,4组患者术后1、4、12周的NRS评分及疼痛爆发次数较术前均降低(P<0.05)。组间对比,术后4周,SNB组NRS评分高于其他3组,PNS组评分最低(P<0.05);术后12周,PNS组NRS评分及疼痛爆发次数低于其他3组(P<0.05)。睡眠情况:与术前对比,4组患者术后1、4、12周的PSQI评分较术前均降低(P<0.05)。组间对比,术后12周,PNS组PSQI评分低于其他3组(P<0.05)。用药情况:与术前对比,只有PNS组术后12周的普瑞巴林用量较术前降低。组间对比,术后12周,PNS组普瑞巴林用量明显低于其他3组(P<0.05)。与术前对比,4组患者术后1、4、12周的曲马多用量较术前均降低(P<0.05)。组间对比,术后12周,PNS组曲马多用量明显低于其他3组。PNS组带状疱疹后遗神经痛(PHN)发生率低于其他3组(P<0.05)。结论4种治疗方式均能缓解疼痛、改善睡眠、减少止痛药用量及降低PHN发生率,但从远期效果上看,眶上神经电刺激的效果优于其它3种治疗方式。

关键词：带状疱疹性神经痛三叉神经周围神经电刺激脉冲射频

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智慧城轨网络安全综合防护体系研究

移动信息 2024年第7期46卷 212-215,221页

作者：安健张德馨苗勇中国软件评测中心北京100048

城市轨道交通是城市发展的关键基础设施。随着“互联网+城市轨道交通”项目的研究与发展,研究智慧城轨网络安全保障技术具备重要意义。文中分析了智慧城轨网络架构和潜在的安全威胁,基于“分区分域、标识解析、可信验证、纵深防御”的... 详细信息

城市轨道交通是城市发展的关键基础设施。随着“互联网+城市轨道交通”项目的研究与发展,研究智慧城轨网络安全保障技术具备重要意义。文中分析了智慧城轨网络架构和潜在的安全威胁,基于“分区分域、标识解析、可信验证、纵深防御”的安全防护思想,提出了智慧城轨网络安全综合防护体系,对列车网络、通信网络、智慧城轨控制网络进行分区、分域防护,建立基于资源标识解析和可信验证的纵深防御体系。

关键词：智慧城轨网络安全标识解析可信验证纵深防御

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铝镁混悬液(Ⅱ)在酸相关性疾病中的应用

智慧健康 2024年第8期10卷 80-83页

作者：张德新张延祯熊哲锟魏明通空军军医大学西京医院消化内科陕西西安710032 郑州大学第一附属医院消化科河南郑州450052 中山市中医院消化肝病科广东中山528401 广西医科大学第二附属医院消化内科广西南宁530005

目的探究铝镁混悬液(Ⅱ)在酸相关性疾病中的应用现状分析。方法选取2022年4月—2023年4月本院收治的酸相关性疾病患者202例临床资料开展回顾性分析。分析患者基本人口学特征、生命体征、既往史、主要临床症状及诊断、疗效结果分析、治... 详细信息

目的探究铝镁混悬液(Ⅱ)在酸相关性疾病中的应用现状分析。方法选取2022年4月—2023年4月本院收治的酸相关性疾病患者202例临床资料开展回顾性分析。分析患者基本人口学特征、生命体征、既往史、主要临床症状及诊断、疗效结果分析、治疗期间不良反应发生情况,为优化诊疗方案寻求循证医学支持。结果抗酸药记录表1填写者202例,其中铝镁混悬液(Ⅱ)为抗酸药物使用最常见药物。使用铝镁混悬液(Ⅱ)治疗的130例患者中男性76例,女性54例;年龄阶段以23~55岁居多;收缩压平均值106~120mmHg居多;舒张压平均值66~80mmHg居多;体重平均值51~70kg居多;心率平均值76~90次/分居多;既往疾病史中发生率最高的为高血压;个人史中发生率最高为饮酒史;既往治疗用药最常见为奥美拉唑。常出现的几种症状发生率依次为反酸、烧心、腹痛、嗳气、黑便;而临床诊断统计中显示主要为慢性胃炎。铝镁混悬液(Ⅱ)治疗130例患者的总体疗效有效率为95.89%。药物不良反应者1例,具体为大便黏稠和胃肠道不适。结论铝镁混悬液(Ⅱ)在酸相关性疾病中临床应用较为普遍,使用群体较为广泛,临床治疗疗效较好,且安全性较好。

关键词：酸相关性疾病症状治疗铝镁混悬液(Ⅱ) 应用现状

Thermal Modeling and Analysis of Metal Foam Heat Sink with Thermal Equilibrium and Non-Equilibrium Models

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Computer Modeling in Engineering & Sciences 2020年第5期123卷 895-912页

作者： Yongtong Li Liang Gong Hui Lu dexin zhang Bin Ding College of New Energy China University of Petroleum(East China)Qingdao266580China

In the present study,the thermal performance of metal foam heat sink was numerically investigated by adopting the local thermal non-equilibrium(LTNE)model and local thermal equilibrium(LTE)*** field distributions and temperature difference field distributions of solid and fluid phases were *** thermal performance comparisons based on the LTE and LTNE models were evaluated by considering the effects of the relevant metal foam morphological and channel geometrical *** indicate that a distinct temperature difference exists between the solid and fluid phases when the LTNE effect is *** average Nusselt numbers predicted by both the LTE and LTNE models are approaching with the increase of porosity,pore density,Reynolds number,large thermal conductivity ratio,and large aspect *** is attributed to the significant reduction of the interstitial convective thermal resistance between the solid and fluid phases,as a result,the LTE model can replace the LTNE model for thermal modeling in these *** addition,the overall thermal performance assessment of metal foam heat sink is compared with the non-porous heat sink,and it shows that the thermal performance factor of metal foam heat sink is approximately two times of the non-porous heat sink.

关键词： Metal foam LTE and LTNE heat transfer numerical simulation

Hot deformation behavior and strain compensation constitutive model of equiaxed fine grain diffusion-welded micro-duplex TC4 titanium alloy

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Chinese Journal of Aeronautics 2023年第4期36卷 510-522页

作者： Can LI Imran SARDAR MUHAMMAD Lihui LANG Yingjian GUO Xiaoxing LI Sergei ALEXANDROVA dexin zhang School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China

In this work,two-stage diffusion bonding of micro-duplex TC4 titanium alloy was car-ried out to study the flow behavior and constitutive models of the bonding joint and the base metal after the same thermal cycling during the hot forming *** and mechanical properties test were used to verify the good quality of the equiaxed fine grain diffusion-welded TC4 ***-static tensile experiment was carried out at temperatures ranging from 750–900℃and strain rates of 0.0001–0.1 s^(-1).The joint showed the weak dynamic recovery at strain rates of 0.01–0.1 s^(-1)and temperatures of 750–850℃.At strain rates of 0.0001–0.001 s^(-1)and tempera-tures of 850–900℃,the flow stress of joint presented steady-state *** defor-mation conditions lead to the remarkable difference of dynamic softening performance between the joint and heat-treated base metal,but the flow stress in elastic and strain hardening stages exhibited similar *** strain compensated Arrhenius-type constitutive models of TC4 joint and heat-treated base metal were developed *** fifth-order polynomial functions between the material property correlation coefficients and strain were *** models have shown good correlation,with correlation coefficient values of 0.984 and *** percentage average absolute relative error for the models were found to be 10%and 9.46%,respectively.

关键词： Constitutive models Deformation Diffusion bonding Micro-duplex Titanium alloys

TEACHING CHINESE AS A FOREIGN LANGUAGE IN CHINA

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世界汉语教学 1991年第4期5卷 250-255页

作者： Office of the State Leading Group for TCFL zhang dexin

In China the teaching of Chinese as a foreign language (TCFL) goes back to ancient times. It is recorded in the historical literature that China accepted foreign students as early as in the East Han Dynasty (25-220 A.D.). In each of the subsequent dynasties, there were many foreigners who came to learn both written and spoken Chinese. TCFL hadn’t been developed into a specialized undertaking prior to the founding of New China in 1949, however. To put it more precisely, it wasn’t until the early 1950s. As

关键词：汉语教学世界责任编辑飞云

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基于改进支持向量机的电磁信号参数优选方法

电子信息对抗技术 2024年第3期39卷 56-61页

作者：苗锡奎张德欣袁翔宇杨林卓中国人民解放军63891部队河南洛阳471000

在电子对抗中构建动态博弈的电磁环境,需要根据电子对抗装备行为,以及对抗策略和历史试验数据,动态改变电磁环境构建装备的电磁行为。电磁环境构建装备的电磁行为通常是由若干组电磁信号参数来控制,选择一组最优的电磁信号参数控制其电... 详细信息

在电子对抗中构建动态博弈的电磁环境,需要根据电子对抗装备行为,以及对抗策略和历史试验数据,动态改变电磁环境构建装备的电磁行为。电磁环境构建装备的电磁行为通常是由若干组电磁信号参数来控制,选择一组最优的电磁信号参数控制其电磁行为,对于构建电磁环境至关重要。为此,提出了一种基于改进支持向量机的电磁信号参数优选方法,能够根据对抗博弈策略和历史试验数据,选择最优的电磁信号参数。首先,对反映电磁环境构建装备工作状态的电磁信号参数进行建模。其次,根据历史数据和博弈对抗策略,构建电磁信号参数数据集。然后,设计基于改进支持向量机的电磁信号参数优选模型,利用构建的数据集对模型进行训练。最后,对模型进行实验验证。实验结果表明,所提出方法的电磁信号参数优选精度优于现有典型方法。

关键词：电子对抗电磁环境构建电磁信号参数选择支持向量机