检索结果-南通市图书馆

Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第7期11卷 1835-1852页

作者： Chenchen Han Yifan Li Yuwen Zhang Yang Wang Dongqian Cui Tingting Luo Yu Zhang Qian Liu Hao Li Chun Wang dexiang xu Yang Ma Wei Wei Institute of Clinical Pharmacology Anhui Medical UniversityKey Laboratory of Anti-Inflammatory and Immune Medicine(Anhui Medical University)Ministry of EducationAnhui Collaborative Innovation Center of Antiinflammatory and Immune MedicineHefei 230032China Public Health and Preventive Medicine Postdoctoral Research Station of Anhui Medical University Hefei 230032China

Rheumatoid arthritis(RA)is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes(FLS).The up-regulated cellular membrane expression of G protein coupled receptor kinase 2(GRK2)of FLS plays a critical role in RA progression,the increase of GRK2 translocation activity promotes dysfunctional prostaglandin E4 receptor(EP4)signaling and FLS abnormal ***,although our group found that paeoniflorin-6’-O-benzene sulfonate(CP-25),a novel compound,could reverse FLS dysfunction via GRK2,little is known as to how GRK2 translocation activity is *** findings revealed that GRK2 expression up-regulated and EP4 expression down-regulated in synovial tissues of RA patients and collagen-induced arthritis(CIA)rats,and prostaglandin E2(PGE2)level increased in ***-25 could down-regulate GRK2 expression,up-regulate EP4 expression,and improve synovitis of CIA ***-25 and GRK2 inhibitors(paroxetine or GSK180736 A)inhibited the abnormal proliferation of FLS in RA patients and CIA rats by down-regulating GRK2 translocation to EP4 *** results of microscale thermophoresis(MST),cellular thermal shift assay,and inhibition of kinase activity assay indicated that CP-25 could directly target GRK2,increase the protein stability of GRK2 in cells,and inhibit GRK2 kinase *** docking of CP-25 and GRK2 suggested that the kinase domain of GRK2 might be an important active pocket for CP-25.G201,K220,K230,A321,and D335 in kinase domain of GRK2 might form hydrogen bonds with ***-directed mutagenesis and co-immunoprecipitation assay further revealed that CP-25 down-regulated the interaction of GRK2 and EP4 via controlling the key amino acid residue of Ala321 of *** data demonstrate that FLS proliferation is regulated by GRK2 translocation to *** inhibition of GRK2 kinase domain by CP-25 improves FLS function and represents an innovative drug for the treatment of RA by targeting G

关键词： CP-25 Rheumatoid arthritis Fibroblast-like synoviocyte MH7A G protein coupled receptor kinase 2 Prostaglandin E4 receptor

Vitamin D deficiency promotes prostatic hyperplasia in middle-age mice through exacerbating local inflammation

在线全文

学校读者我要写书评

暂无评论

Vitamin D deficiency promotes prostatic hyperplasia in middl...

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： Zhihui Zhang Biao Luo Shen xu dexiang xu Department of Toxicology Anhui Medical University

Objectives This study investigated the effects of vitamin D persistent deficiency from early life on prostatic hyperplasia in middle-aged ICR *** Pregnant mice were divided randomly into two *** the control group,dams were fed with standard diets(with 1000 IU vitamin D/kg) throughout pregnancy and *** weaning,male pups were fed with standard diets for 37 *** the VDD group,dams were fed with VDD diets(with 0 IU vitamin D/kg)throughout pregnancy and *** weaning,male pups were divided randomly into two *** the VDD group,male pups were fed with VDD diets for 37 *** the VDS group,male pups were fed with VDD diets for 17 weeks and then replaced with standard diets for 20 *** weeks after birth,mice were *** Prostate weight was elevated and prostatic hyperplasia was observed in VDD-fed *** number of prostatic Ki67-positive epithelial cells was increased in VDD-fed *** analysis found that vitamin D deficiency promoted inflammatory infiltration and stromal fibrosis in prostate of middle-aged ***,vitamin D deficiency activated NF-kB and up-regulated I1-6 mRNA in prostate of middle-aged *** addition,vitamin D deficiency activated prostatic STAT3,a proliferation pathway in middle-aged *** interest,VDD-induced prostatic inflammation and hyperplasia were partially reversed when VDD diets was replaced with standard *** These results provide evidence that vitamin D persistent deficiency from early life promotes prostatic hyperplasia in middle-aged mice through exacerbating local inflammation.

关键词： Vitamin D deficiency Prostatic hyperplasia Inflammation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

支井河特大桥钢管拱预拼与吊装的测量控制

铁道建筑 2009年第6期49卷 28-30页

作者：徐德祥中铁十三局集团第一工程有限公司辽宁大连116033

宜昌至恩施高速公路支井河特大桥为上承式钢管混凝土拱桥,主跨430 m。为确保钢管拱安装的线形和各部位尺寸,测量监控至关重要。对施工中预拼测量、吊装测量及变形监测做了介绍。

关键词：钢管拱预拼安装测量控制

超大直径变截面空心桩的荷载传递特征与理论模型

在线全文

学校读者我要写书评

暂无评论

岩石力学与工程学报 2018年第10期37卷 2370-2383页

作者：黄明江松许德祥邓涛上官兴方焘福州大学土木工程学院福建福州350116 赣州市城乡规划设计研究院江西赣州341000 华东交通大学土木建筑学院江西南昌330013

一种适用于串珠状溶洞地层的超大直径变截面空心桩的荷载传递机制较为复杂。基于超大直径变截面空心桩的荷载传递特征,重点研究变截面处变阶阻对侧阻的增强效应,同时基于扰动状态理论,提出适用于超大直径变截面空心桩的荷载传递函数模... 详细信息

一种适用于串珠状溶洞地层的超大直径变截面空心桩的荷载传递机制较为复杂。基于超大直径变截面空心桩的荷载传递特征,重点研究变截面处变阶阻对侧阻的增强效应,同时基于扰动状态理论,提出适用于超大直径变截面空心桩的荷载传递函数模型。首先,利用半无限空间体明德林解推导变截面处变阶阻对侧阻力增大系数α的表达式,并结合工程算例,通过对比提出的理论解析方法、软件数值解以及2种既有解析算法的结果,论证该算法的可靠性。而后,选取双曲线模型与抛物线模型分别描述桩侧与桩端接触相对完整状态,选取莫尔–库仑模型描述完全调整状态,系统构建桩–土界面荷载传递函数模型,通过编程计算分析模型参数对模型曲线的影响规律,同时结合工程实例进行计算模型的有效性检验。结果表明,超大直径变截面空心桩变截面处的变阶阻对侧阻具有显著的增强效应,基于扰动状态理论的荷载传递函数模型可较好描述桩–土相互作用的的非线性力学特征,采用上述方法计算变截面处的侧阻的增强效应具有较好的适用性,为超大直径变截面空心桩的应用推广提供了可靠的理论依据。

关键词：桩基础超大直径变截面桩扰动状态理论荷载传递非线性

在线全文

学校读者我要写书评

暂无评论

变电站开关检修更换技术方案及注意事项

农村电气化 2022年第3期 87-89页

作者：徐德翔广东先达电业有限公司广东梅州514011

从110 kV梅南站2#主变现状出发,分析开关检修更换中的注意事项,并在该基础上形成科学、规范的变中开关检修更换施工方案。同时,针对110 kV梅南站2#主变变中开关检修更换风险要素,开展全周期安全管控,为变电站施工管控提供相应参考。

关键词： 110 kV变电站检修更换安全管控

Maternal serum lead concentration is associated with risk of small-for-gestational-age infants

在线全文

学校读者我要写书评

暂无评论

Maternal serum lead concentration is associated with risk of...

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： Hua Wang Jun Li JiaHu Hao YuanHua Chen Lu Liu Zhen Yu Lin Fu FangBiao Tao dexiang xu Laboratory of Environmental Toxicology Anhui Medical University

Objectives A recent study found that gestational serum Pb concentration is associated with an increased risk of preterm *** purpose of this study was to analyze whether gestational Pb exposure elevates risk of small-for-gestational-age(SGA) births in a Chinese *** In the present study,total 3125 mother-infant pairs were recruited from the China-Anhui Birth Cohort Study(C-ABCS).Pb concentration in maternal serum was detected by *** subjects were classified into three groups according to the tertile division of serum Pb concentration:L-Pb(low-Pb,<1.18 μg/dl),M-Pb(medium-Pb,1.18-1.70 μg/dl),and H-Pb(high-Pb,≥1.71 μg/dl).Results There was no difference on birth length,head circumference and chest circumference among different *** rate of SGA was 6.2%in subjects with L-Pb,8.7%in subjects with M-Pb,and 10.1%in subjects with H-Pb,*** adjusted OR of SGA was 1.45(95%CI:1.04,2.02;P = 0.03) in subjects with M-Pb and 1.69(95%CI:1.22,2.34;P = 0.002) in subjects with ***,the rate of SGA infants was elevated only in subjects with H-Pb in the first trimester(adjusted OR:2.13;95%CI:1.24,3.38;P = 0.007).Conclusions Collectively,high serum Pb level in the first trimester is associated with an elevated risk of SGA infants.

关键词： Lead Serum Small-for-gestational-age Infants Birth cohort study

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

44Si2CrV钢弹簧弹性减退机理的研究

特殊钢 2007年第2期28卷 4-6页

作者：刘德富徐德祥东北特殊钢集团有限责任公司大连116031

研究了影响44Si2CrV钢弹簧在低于屈服强度的应力下长时间加载引起自由高度变化的因素。结果表明,44Si2CrV钢弹簧在900 MPa的应力下压缩72 h,自由高度的缩短由两部分组成:表面脱碳层的塑性变形,造成对内部材料的牵制而使部分弹性变形不... 详细信息

研究了影响44Si2CrV钢弹簧在低于屈服强度的应力下长时间加载引起自由高度变化的因素。结果表明,44Si2CrV钢弹簧在900 MPa的应力下压缩72 h,自由高度的缩短由两部分组成:表面脱碳层的塑性变形,造成对内部材料的牵制而使部分弹性变形不能恢复,由此所造成的弹簧自由高度缩短占总变形量的84％;钢的室温蠕变,占自由高度缩短的16％。

关键词： 44Si2CrV弹簧钢脱碳弹性减退室温蠕变

The association between maternal serum lead level during pregnancy and preterm birth in a Chinese population

在线全文

学校读者我要写书评

暂无评论

The association between maternal serum lead level during pre...

观察伏诺拉生治疗难治性胃食管反流患者的临床疗效及对睡眠质量的影响

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： Jun Li Hua Wang JiaHu Hao YuanHua Chen Lu Liu Zhen Yu Lin Fu FangBiao Tao dexiang xu Laboratory of Environmental Toxicology Anhui Medical University

Objectives Lead(Pb) is a well-known developmental *** aim of the present study was to analyze the association between maternal serum Pb level and risk of preterm birth in a population-based birth cohort *** The present study analyzed a sub-study of the China-Anhui Birth Cohort that recruited 3125 eligible mother-and-singleton-offspring *** serum Pb level was measured by graphite furnace atomic absorption *** subjects were classified into three groups by tertile division according to serum Pb level:Low-Pb(L-Pb,<1.18 μg/dl),Medium-Pb(M-Pb,1.18-1.70 μg/dl),and High-Pb(H-Pb,≥1.71 ug/dl).Results The rate of preterm birth was 2.8%among subjects with L-Pb,6.1%among subjects with M-Pb,and 8.1%among subjects with H-Pb,*** controlling confounding factors,the adjusted OR for preterm birth was 2.33(95%CI:1.49,3.65) among subjects with M-Pb and 3.09(95%CI:2.01,4.76) among subjects with *** interest,maternal Pb exposure in early gestational stage than in middle gestational stage was more susceptible to preterm ***,maternal serum Pb level was only associated with increased risk of late preterm *** The present study provides evidence that maternal serum Pb level during pregnancy is positively associated with risk of preterm birth in a Chinese population.

关键词： Lead Serum Preterm birth Birth cohort study

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

世界睡眠医学杂志 2024年第3期11卷 527-529页

作者：徐德祥福建省莆田学院附属医院莆田351100

目的:观察伏诺拉生治疗难治性胃食管反流(rGERD)患者的临床疗效及对睡眠质量的影响。方法:选取2021年9月至2022年9月福建省莆田学院附属医院消化内科收治的rGERD患者114例作为研究对象,按照随机数字表法分为对照组和观察组,每组57例。... 详细信息

目的:观察伏诺拉生治疗难治性胃食管反流(rGERD)患者的临床疗效及对睡眠质量的影响。方法:选取2021年9月至2022年9月福建省莆田学院附属医院消化内科收治的rGERD患者114例作为研究对象,按照随机数字表法分为对照组和观察组,每组57例。对照组给予兰索拉唑片治疗,观察组在兰索拉唑片治疗的基础上加用伏诺拉生治疗。采用匹兹堡睡眠质量指数(PSQI)比较2组患者干预前后睡眠质量的变化,并比较2组患者的治疗效果及不良反应发生情况。结果:治疗后,观察组治疗总有效率显著高于对照组,观察组PSQI评分、不良反应发生率均显著低于对照组,差异均有统计学意义(均P<0.05)。结论:伏诺拉生治疗GERD的疗效确切,能有效改善患者的睡眠质量,防止不良反应的发生,值得临床推广应用。

关键词：伏诺拉生难治性胃食管反流睡眠质量疗效