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Chinese Journal of che.ical Engineering 2008年第4期16卷 590-598页

作者：张伟勇黄德先王毓栋王京春 School of Information science and Technology Beijing University of Chemical Technology Beijing 100029 China Department of Automation Tsinghua University Beijing 100084 China Tsinghna National Laboratory for Information Science and Technology Beijing 100084 China

An adaptive state feedback predictive control （SFPC） sche.e and an expert control sche.e are presented and applied to the temperature control of a 1200 kt·a^-1 delayed coking furnace, which is the key equipment for the delayed coking process. Adaptive SFPC is used to improve the performance of temperature control in normal operation. A simplified nonlinear model on the basis of first principles of the furnace is developed to obtain a state space model by linearization. Taking advantage of the nonlinear model, an online model adapting method is presented to accommodate the dynamic change of process characteristics because of tube coking and load changes. To compensate the large inverse response of outlet temperature resulting from the sudden increase of injected steam of a particular velocity to tubes, a monitoring method and an expert control sche.e based on heat balance calculation are proposed. Industrial implementation shows the effectiveness and feasibility of the proposed control strategy.

关键词： delayed coking furnace adaptive control state feedback predictive control expert control

Antibody gene therapy: an attractive approach for the treatment of cancers and other chronic diseases

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Cell Research 2007年第4期17卷 303-306页

作者： dexian Zheng ~1National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Monoclonal antibodies(mAb)have been successfullyapplied to the treatment of chronic diseases,such as cancer,inflammation and immune *** the technicaladvances in antibody engineering,development of smallrecombinant antibody fragments as high affinity therapeu-tics with reduced immunogenicity has become under thespotlight.A popular format of the engineered recombinantantibody fragments is the single-chain fixed-variable(scFv)molecules,in which the VH and VL regions of the parentalantibody are jointed together by a polypeptide *** fragment retains the target specificity and antigen-binding affinity of the intact antibody,and can be geneti-cally designed and produced in large quantity by ectopicallyexpressing both VH and VL regions from a single cDNAin *** to its smaller size,the scFv molecule showsimproved pharmacokinetics in tumor penetration and isbetter tolerated by the host immune *** thesepotential advantages of using scFv molecules for immu-notherapy,especially for chronic diseases such as cancers,the treatment efficacy,however,is often compromised bythe rapid blood clearance and insufficient concentration ofthe infused scFv fragments at the target *** achievehigh local concentrations in the target tissues,large amountof the recombinant scFv proteins(hundreds milligrams or

关键词： gene an attractive approach for the treatment of cancers and other chronic diseases Antibody gene therapy

有棱丝瓜种质资源在华南地区夏植的适应性评价

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种子 2024年第3期43卷 73-81页

作者：郭元元康德贤陈琴李洋梁劲文俊丽卢发仕黎冬梅张力宋焕忠农芳玲陈振东广西农业科学院南宁530007 玉林市农业科学院广西玉林537000 贺州市农业科学院广西贺州542813 广西蔬菜育种与产业科技创新合作基地南宁530007

为鉴定评价有棱丝瓜种质资源夏植的适应性,选育适宜在华南地区夏植的有棱丝瓜品种提供种质基础,本试验以广西玉林市夏植的44份有棱丝瓜种质资源为研究对象,分析各种质夏植中主要农艺性状,并对种质资源的11个主要农艺性状进行主成分分析... 详细信息

为鉴定评价有棱丝瓜种质资源夏植的适应性,选育适宜在华南地区夏植的有棱丝瓜品种提供种质基础,本试验以广西玉林市夏植的44份有棱丝瓜种质资源为研究对象,分析各种质夏植中主要农艺性状,并对种质资源的11个主要农艺性状进行主成分分析、相关性分析、聚类分析等综合评价。结果表明,44个有棱丝瓜种质资源在夏植过程中主要农艺性状的表现差异较大。变异系数以单次采收产量折合产量变异较丰富,多样性指数以第一成瓜节位为最高。相关性分析发现,重要性状单次采收折合产量与全生育期长短和单瓜重呈极显著正相关,而与播种至始收天数和瓜花斑大小呈极显著负相关,与第一成瓜节位呈显著负相关。主成分分析将原有11个农艺性状指标转化为4个综合因素指标,累积贡献率达71.987%。通过聚类分析,将供试材料分为四大类群,其中第Ⅰ类群包括31份种质,属中低产类型;第Ⅱ类群包含1份种质,属晚熟高产类型;第Ⅲ类群包含1份种质,属长生育期高感霜霉病低产类型;第Ⅳ类群包括11份种质,属早熟高产类型。通过农艺性状综合对比分析,筛选出越夏产量表现较佳的5份种质:LCH8、LCH2、LCH4、LCH14、LCH25,适宜作为华南地区夏植品种选育的种质资源。

关键词：有棱丝瓜种质资源夏植聚类分析适应性评价

基于差分进化算法和HYSYS机理模型的催化重整过程优化

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化工学报 2008年第7期59卷 1755-1760页

作者：王钧炎黄德先清华大学自动化系北京100084

选取催化重整18集总31反应集总动力学模型,以流程模拟软件HYSYS为工具,建立了催化重整机理模型。以最大化芳烃产率为优化目标,以4个反应器入口温度为决策变量,建立了过程优化模型。利用差分进化算法求解该优化问题,并利用可行性规则处... 详细信息

选取催化重整18集总31反应集总动力学模型,以流程模拟软件HYSYS为工具,建立了催化重整机理模型。以最大化芳烃产率为优化目标,以4个反应器入口温度为决策变量,建立了过程优化模型。利用差分进化算法求解该优化问题,并利用可行性规则处理约束。仿真结果表明,芳烃产率有较大提高,证实了差分进化算法的有效性。

关键词：催化重整动力学模型约束优化差分进化算法可行性规则

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基于混合差分进化算法的软测量时延参数估计

化工学报 2008年第8期59卷 2058-2064页

作者：王钧炎黄德先清华大学自动化系北京100084

时延参数估计是系统控制与信号处理的关键问题。通过构造一个适当的适应度函数,将软测量系统的时延参数估计问题转化为一个多维非线性优化问题,然后利用混合差分进化算法的全局搜索能力求解该优化问题。对两个典型问题进行了仿真实验,... 详细信息

时延参数估计是系统控制与信号处理的关键问题。通过构造一个适当的适应度函数,将软测量系统的时延参数估计问题转化为一个多维非线性优化问题,然后利用混合差分进化算法的全局搜索能力求解该优化问题。对两个典型问题进行了仿真实验,仿真结果表明了混合算法的有效性和鲁棒性。以石油炼制工业中典型装置常压塔为例,对其一线航空煤油的闪点软测量进行了应用验证,结果表明,时延参数估计的引入大大提高了软测量模型的精度,证实了混合差分进化算法的有效性。

关键词：混合差分进化软测量模型时延估计偏最小二乘

Method to Detect Granary Storage Weight Based on the Janssen Model

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Grain & Oil Science and Technology 2018年第1期1卷 20-27页

作者： ZHANG dexian ZHANG Miao ZHANG Qinghui ZHANG Yuan LYU Lei College of Information Science and Engineering Henan University of Technology Grain Information Processing and Control Key Laboratory of Ministry of Education

This study proposes a new model of granary storage weight detection based on the Janssen model to satisfy the strategic requirements of granary storage quantity detection in China. The model theoretically elucidates the relationship between granary storage weight and bottom/side pressure. A new layout of pressure sensors along the inner and outer rings is also proposed to obtain the pressure value. The experimental results indicate that the detection error of the proposed model is significantly lower than 1% with respect to the low-cost detection system, and this effectively satisfies the actual requirement for real-time monitoring of granary storage quantity.

关键词： Granary storage quantity detection Janssen model Pressure sensor Detection model Detection accuracy

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像元尺寸对空间光学探测系统性能的影响

中国空间科学技术 2011年第3期31卷 51-55页

作者：曾德贤杜小平装备指挥技术学院北京101416

针对空间光学探测系统的组成和特点,采用调制传递函数(MTF)作为系统性能指标,通过建立光学系统、探测器系统、离焦和像移调制传递函数模型,仿真分析了像元尺寸对系统成像性能的影响。结果表明,随着像元尺寸减小,探测器系统MTF值增大,光... 详细信息

针对空间光学探测系统的组成和特点,采用调制传递函数(MTF)作为系统性能指标,通过建立光学系统、探测器系统、离焦和像移调制传递函数模型,仿真分析了像元尺寸对系统成像性能的影响。结果表明,随着像元尺寸减小,探测器系统MTF值增大,光学系统、离焦、像移等的MTF值都变小,从而为像元尺寸的确定提供了参考依据。

关键词：像元尺寸图像传感器调制传递函数空间光学探测性能指标航天遥感

Statistical Analysis of the Hole Primary Halo in Dachang Sn-Zn Polymetallic Mining Area of Guangxi

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Engineering Sciences 2008年第1期6卷 66-69页

作者： Yang Xiaokun Qin dexian Wu Wei Feng Meili The Geological Institute of Mineral Deposit Kunming University of Science and Technology Kunming 650093 China Bank of China Yunnan Branch Kunming 650093 China

The complexity and diversity of Ore forming is the commonness, of which the difficulty is the evolutional characteristics of geoche.ical elements. The metallogetie process can be speculated and get useful and microcosmic message for next exploration. In this paper, the research of cluster analysis and factor analysis of the hole primary halo in Dachang Sn-Zn polymetallic mining area in Guangxi reveal that metallogenic process is very complex and superposed by mineralization . It is considered that the enrichment of Zn, Sn superposed anaphase. By sulphide polymetallic, Au is very independency and that Sb, Pb, Ag and Cu are proximal indicator elements for exploring Zn, Sn in the mine.

关键词： Dachang Guangxi mine geoche.ical elements factor analysis

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滇西马厂箐金矿金的赋存状态及工艺特性研究

金属矿山 2006年第3期35卷 49-51页

作者：普传杰秦德先昆明理工大学

应用矿相显微镜、电子探针、X射线衍射仪和化学物相分析等测试手段,研究了马厂箐金矿中金及有害元素砷的赋存状态。金呈次显微粒和显微粒自然金,多以包裹体形式散布于毒砂和黄铁矿为主的载金矿物中,毒砂和黄铁矿主要以自形、半自形晶状... 详细信息

应用矿相显微镜、电子探针、X射线衍射仪和化学物相分析等测试手段,研究了马厂箐金矿中金及有害元素砷的赋存状态。金呈次显微粒和显微粒自然金,多以包裹体形式散布于毒砂和黄铁矿为主的载金矿物中,毒砂和黄铁矿主要以自形、半自形晶状态产出,少部份呈极细粒状(<10μm)包裹于脉石矿物中;矿石中有害元素砷主要以毒砂和含砷黄铁矿的矿物形式存在。还对矿石工艺特性进行了研究,为选冶工艺提供了必要依据。

关键词：金矿工艺矿物学毒砂黄铁矿矿相显微镜电子探针 X射线衍射仪