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Efficacy of standard therapy with synbiotic or without synbiotic to reduce Gardnerella vaginalis,Atopobium vaginae and Megaesphaera phylotypeⅠin pregnant women with bacterial vaginosis

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Asian pacific Journal of Reproduction 2020年第3期9卷 111-117页

作者： deviana soraya riu Efendi Lukas Firdaus Kasim Rizalinda Sjahril Department of Obstetrics and Gynecology Faculty of MedicineHasanuddin UniversityIndonesia Epidemiology Biostatistics&Occupational Health Medical FacultyHasanuddin UniversityIndonesia Department of Microbiology Medical FacultyHasanuddin UniversityIndonesia

Objective: To evaluate whether addition of symbiotic to clindamycin could reduce Gardnerella vaginalis,Atopobium vaginae,and Megasphaera phylotypeⅠin pregnant women with bacterial ***: This randomized controlled trial(RSUP *** Sudirohusodo Makassar clinical trial registry UH17010021)included 61 *** intervention group was given clindamycin and synbiotic while the control group was given clindamycin and placebo(without synbiotic).Wilcoxon test and hypothesis test of two independent samples were used to compare the treatment ***: This study showed a significant difference in Nugent score before and after treatment in each *** there was no difference in Nugent score between the intervention group and the control group after treatment or in Nugent scores reduction in both *** most common type of bacteria found was Megasphaera phylotypeⅠ.There were no significant differences in the three types(Gardnerella vaginalis,Atopobium vaginae,and Megasphaera phylotypeⅠ)of bacteria after treatment between both ***,there was no difference in therapeutic effect between the intervention group and the control ***: Clindamycin along with synbiotics is no more effective for treated bacterial vaginosis than clindamycin without *** is the most commonly found bacteria,which cannot be eradicated with clindamycin.

关键词： Bacterial vaginosis Synbiotic Nugent score Amsel criteria

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