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Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics

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Genes & Diseases 2023年第4期10卷 1367-1401页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra devendra kumar pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu José M.Pérez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affiliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples Federico IINaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarh AjmerRajasthan 305817India CSIR-Indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(IIIT-D)Okhla Industrial EstatePhase IIINew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologíaIPNA-CSICSan Cristóbal de La Laguna 38206TenerifeSpain

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every *** the new understanding of the molecular mechanism(s)of disease progression,our knowledge about the disease is snowballing,leading to the evolution of many new therapeutic regimes and their successive *** the past few decades,various combinations of therapies have been pro-posed and are presently employed in the treatment of diverse *** drug therapy,immunotherapy,and personalized medicines are now largely being employed,which were not common a few years *** field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies,extending patients’disease-free survival *** growing evidence shows that a systematic and targeted approach could be the future of cancer medicine,chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological ***-apeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific *** present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals;it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.

关键词： Antimicrobial peptides Cancer therapies Clinical trials Combination therapy Immunotherapy Patient survival Personalized medicine Targeted drug delivery

Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra devendra kumar pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

The Impingement Heat Transfer Data of Inclined Jet in Cooling Applications: A Review

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Journal of Thermal Science 2020年第1期29卷 1-12页

作者： PAWAR Shashikant PATEL devendra kumar SMEC Vellore Institute of Technology

On the impingement heat transfer data,the experimental studies of air and liquid jets impingement to the flat surfaces were collected and critically *** oblique impingements of both single circular and planar slot jets were considered in *** review focused on the surface where the jet impingement cooling technique was *** nozzle exit Reynolds numbers based on the hydraulic diameter varied in the range of 1,500–52,*** oblique angles relative to the plane surface and the dimensionless jet-to-plate spacing vary in the range of 15°–90°and 2–12 *** review suggested that the magnitude of maximum heat transfer shifted more for air jets compared with the liquid *** drop in the inclination angle and the jet-to-plate separation led to the increase in the asymmetry of heat transfer *** displacement of maximum Nusselt number(heat transfer)locations was found to be sensitive to the inclination angle and the smaller jet-to-plate ***,the Nusselt number correlations proposed by various researchers were discussed and compared with the results of the cited references.

关键词： heat and fluid flow jet impingement Nusselt number oblique angle

Power Generalized Weibull Distribution Based on Record Values and Associated Inferences with Bladder Cancer Data Example

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Communications in Mathematics and Statistics 2024年第2期12卷 213-238页

作者： devendra kumar Manoj kumar Jagdish Saran Department of statistics Central University of HaryanaJant-PaliMahendergarhIndia Department of Statistics University of DelhiDelhiIndia

The power generalized Weibull distribution has been proposed recently by[24]as an alternative to the gamma,Weibull and the exponentiated Weibull *** power generalized Weibull family is suitable for modeling data that indicate nonmonotone hazard rates and can be used in survival analysis and reliability *** andﬂexibility of the family are illustrated by reanalyzing Efron’s data pertaining to a head-and-neck cancer clinical *** data involve censoring and indicate unimodal hazard *** this distribution,some recurrence relations are established for the single and product moments of upper record ***,using these relations,we have obtained means,variances and covariances of upper record values from samples of sizes up to 10 for various values of the parameters and present them inﬁ*** data set is analyzed to illustrate theﬂexibility and importance of the model.

关键词： Record values Moments Characterization Power generalized Weibull distribution

Probing the degradation of pharmaceuticals in urine using MFC and studying their removal efficiency by UPLC-MS/MS

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Journal of Pharmaceutical Analysis 2021年第3期11卷 320-329页

作者： Priya Sharma devendra kumar Srikanth Mutnuri Applied Environmental Biotechnology Laboratory Birla Institute of Technology&Science(BITS)Pilani403726ZuarinagarIndia Central Sophisticated Instrumentation Facility Birla Institute of Technology&Science(BITS)Pilani403726ZuarinagarIndia Department of Pharmaceutical Sciences College of PharmacyUniversity of Nebraska Medical CenterOmahaNE68198-602USA

Nutrient recovery from source-separated human urine has attracted interest as it is rich in nitrogen and phosphorus that can be utilized as ***,urine also contains pharmaceuticals,steroid hormones,*** their removal is crucial as they have detrimental effects on the environment and human *** current study focuses on investigating the degradation of pharmaceuticals using a double-chamber microbial fuel cell(MFC).Urine was spiked with four pharmaceuticals(trimethoprim,lamivudine,levofloxacin,and estrone)at a concentration of 2 mg/*** MFC was operated for 7 months in batch mode with this spiked urine as *** degradation efficiency of the MFC was studied,for which a selective liquid chromatography-tandem mass-spectrometric method was developed for the quantitation of compounds used in the spiking experiments and was validated with a lower limit of quantification of 0.39 ng/*** maximum removal rate achieved was 96%±2%.The degradation mechanism involved processes like sorption and anoxic *** voltage curve obtained showed that the presence of pharmaceuticals had an initial negative impact on power generation along with increased organic content;however,after the reactor acclimatization,increased power output was achieved with maximum organics removal at 30 h of retention *** work opens a new perspective for the anoxic biodegradation of pharmaceuticals and can be useful in future bioremediation studies.

关键词： Pharmaceuticals Urine MFC Biodegradation Liquid chromatography mass spectroscopy

VARIABLE MESH FINITE DIFFERENCE METHOD FOR SELF-ADJOINT SINGULARLY PERTURBED TWO-POINT BOUNDARY VALUE PROBLEMS

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Journal of Computational Mathematics 2010年第5期28卷 711-724页

作者： Mohan K.Kadalbajoo devendra kumar Department of Mathematics & Statistics

A numerical method based on finite difference method with variable mesh is given for self-adjoint singularly perturbed two-point boundary value problems. To obtain parameter- uniform convergence, a variable mesh is constructed, which is dense in the boundary layer region and coarse in the outer region. The uniform convergence analysis of the method is discussed. The original problem is reduced to its normal form and the reduced problem is solved by finite difference method taking variable mesh. To support the efficiency of the method, several numerical examples have been considered.

关键词： Singularly perturbed boundary value problems Finite difference method,Boundary layer Parameter uniform-convergence Variable mesh.

Approximate analytical solution of fractional order biochemical reaction model and its stability analysis

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International Journal of Biomathematics 2019年第5期12卷 241-261页

作者： Ved Prakash Dubey Rajnesh kumar devendra kumar Faculty of Mathematical and Statistical Sciences Shri Ramswaroop Memorial University Lucknow-Deva Road Uttar Pradesh-225003India Department of Mathematics University of Rajasthan Jaipur-302004RajasthanIndia

Approximate analytical solution of the system of coupled nonlinear Ordinary Differential Equations (ODEs) of a biochemical reaction model is much relevant due to its practical significance to *** this paper,an effective and powerful mathematical technique,*** homotopy analysis transform method (FHATM),is employed to get the numerical solutions of biochemical reaction model with time fractional *** adopted scheme is the beautiful copulation of homotopy analysis technique and Laplace transform *** paper shows that the adopted scheme is quite easy as well as computationally attractive in the context of a solution *** Caputo-type fractional derivatives are considered in the present *** results of the probability density functions of the time fractional biochemical reaction model are computed for miscellaneous fractional Brownian motions as well as for classical motion and are presented *** time fractional biochemical reaction model with respect to stability analysis for various values of fractional order q is also *** the context of stability discussion,we have used the fractional Routh-Hurwitz stability criterion to establish the local stability of the biochemical reaction model of fractional order.

关键词： Biochemical reaction model FHATM Laplace transform homotopy stability analysis fractional order

Numerical solution of time-fractional three-species food chain model arising in the realm of mathematical ecology

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International Journal of Biomathematics 2020年第2期13卷 53-74页

作者： Ved Prakash Dubey Rajnesh kumar devendra kumar Faculty of Mathematical and Statistical Sciences Shri RamswaroopMemorial University Lucknow-Deva Road Barabanki 225003Uttar PradeshIndia Department of Mathematics University of Rajasthan Jaipur 302004RajasthanIndia

T'his research paper implements the fractional homotopy analysis transform technique to compute the approximate analytical solution of the nonlinear three-species food chain model with time-fractional *** offered technique is a fantastic blend of homotopy analysis method(HAM)and Laplace transform(LT)operator and has been used fruitfully in the numerical computation of various fractional differential equations(FDEs).This paper involves the fractional derivatives of Caputo *** numerical solutions of this selected fractional-order food chain model are evaluated by making use of the associated initial *** is revealed by the adopting procedure that the more desirable estimation of the solution can be easily acquired through the calculation of some number of iteration terms only-a fact which authenticates the easiness and soundness of the suggested hybrid *** variations of fractional order of time derivative on the solutions for different specific cases have been depicted through graphical *** outcomes demonstrated through the graphs expound that the adopted scheme is very fantastic and accurate.

关键词： Three-species food chain model homotopy analysis transform method Laplace transform fractional order FDEs

An efficient computational technique for time-fractional modified Degasperis-Procesi equation arising in propagation of nonlinear dispersive waves

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Journal of Ocean Engineering and Science 2021年第1期6卷 30-39页

作者： Ved Prakash Dubey Rajnesh kumar Jagdev Singh devendra kumar Faculty of Mathematical and Statistical Sciences Shri Ramswaroop Memorial UniversityLucknow-Deva RoadUttar Pradesh-225003India Department of Applied Science and Humanities Government Engineering CollegeNawadaDepartment of Science and TechnologyBihar-805122India Department of Mathematics JECRC UniversityJaipur-303905RajasthanIndia Department of Mathematics University of RajasthanJaipur-302004RajasthanIndia

In this paper,an efficient hybrid numerical scheme which is based on a joint venture of the q-homotopy analysis method and Sumudu transform is applied to investigate the time-fractional modified Degasperis-Procesi(DP)*** present study considers the Caputo fractional *** fractional order modified DP model is very important and plays a great role in study of ocean engineering and *** proposed scheme provides a beautiful opportunity for proper selection of the auxiliary parameter h and the asymptotic parameterρ(≥1)to handle mainly the differential equations of nonlinear *** offered scheme produces the solution in the shape of a convergent series in a large admissible domain which is helpful to regulate the region of convergence of a series *** proposed work computes the approximate analytical solution of the fractional modified DP equation systematically and also presents graphically the variation of the obtained solution for diverse values of the fractional parameterβ.

关键词： Fractional Degasperis-Procesi equation Nonlinear dispersive waves Analytical solution q-homotopy analysis method Sumudu transform