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Cardiometabolic risk factors in young Indian men and their association with parameters of insulin resistance and beta-cell function

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World Journal of Cardiology 2022年第8期14卷 462-472页

作者： Yashdeep Gupta Alpesh Goyal Mani Kalaivani Nikhil tandon Department of Endocrinology and Metabolism All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Biostatistics All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is an unmet need to evaluate the burden of cardiometabolic risk factors in young South Asian adults,who are not preselected for *** To evaluate young North Indian men(aged 20-50 years)for burden of cardiometabolic risk factors,in relation to parameters of homeostatic model assessment for insulin resistance(HOMA-IR)and beta-cell function(oral disposition index[oDI]).METHODS Study participants were invited in a fasting ***,anthropometric,and medical data were collected,and 75 g oral glucose tolerance test was performed with serum insulin and plasma glucose estimation at 0,30,and 120 *** were divided into quartiles for HOMA-IR and oDI(category 1:Best HOMA-IR/oDI quartile;category 3:Worst HOMA-IR/oDI quartile)and composite HOMA-IR/oDI phenotypes(phenotype 1:Best quartile for both HOMA-IR and oDI;phenotype 4:Worst quartile for both HOMA-IR and oDI)were *** We evaluated a total of 635 men at a mean(±SD)age of 33.9±5.1 years and body mass index of 26.0±3.9 kg/m^(2).Diabetes and prediabetes were present in 34(5.4%)and 297(46.8%)participants,***/obesity,metabolic syndrome,and hypertension were present in 388(61.1%),258(40.6%),and 123(19.4%)participants,*** prevalence of dysglycaemia,metabolic syndrome,and hypertension was significantly higher in participants belonging to the worst HOMA-IR and oDI quartiles,either alone(category 3 vs 1)or in combination(phenotype 4 vs 1).The adjusted odds ratios for dysglycaemia(6.5 to 7.0-fold),hypertension(2.9 to 3.6-fold),and metabolic syndrome(4.0 to 12.2-fold)were significantly higher in individuals in the worst quartile of HOMA-IR and oDI(category 3),compared to those in the best quartile(category 1).The adjusted odds ratios further increased to 21.1,5.6,and 13.7,respectively,in individuals with the worst,compared to the best composite HOMA-IR/oDI phenotypes(phenotype 4 vs 1).CONCLUSION The burden of cardiometabolic risk factors is hi

关键词： Cardiometabolic Insulin resistance Asian Disposition index Men Young

Formation of E-cyanomethamine in a nitrile rich environment

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Research in Astronomy and Astrophysics 2017年第1期17卷 1-10页

作者： Shivani Alka Misra Poonam tandon Department of Mathematics & Astronomy University of Lucknow Lucknow India Department of Physics University of Lucknow Lucknow 226007 India

Recently a new molecule, cyanomethamine, has been detected towards Sagittarius B2（N）（Sgr B2（N））. Studying the formation mechanisms of complex interstellar molecules is difficult. Hence, a theoretical quantum chemical approach for analyzing the reaction mechanism describing the forma- tion of interstellar cyanomethamine through detected interstellar molecules and radicals （NCCN＋H） is discussed in the present work. Calculations are performed by using quantum chemical techniques, such as Density Functional Theory （DFT） and Mφ11er-Plesset perturbation （MP2） theory with a 6-311G（d,p） basis set, both in the gas phase and in icy grains. The proposed reaction path （NCCN＋H＋H） has exother- micity with no barrier which indicates the possibility of cyanomethamine formation in the interstellar medium.

关键词： interstellar medium: abundances general - general: extraterrestrial intelligence - mete-orites - individual: Sgr B2(N) region

Real-world five-year outcomes of FlexyRap®cobalt-chromium rapamycin-eluting stents with biodegradable polymer in patients with de-novo coronary artery disease

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World Journal of Cardiology 2023年第3期15卷 84-94页

作者： Nitish Garg Raman Chawla Vivek tandon Deepak Garg Nilesh Parshottam Preeti Vani Malte Neuss Department of Interventional Cardiology Cardinova HospitalJalandhar 144001India Department of Interventional Cardiology CareMax HospitalJalandhar 144001India Department of Interventional Cardiology EMC HospitalAmritsar 143001India Department of Interventional Cardiology Moga Medicity HospitalMoga 142001India Department of Interventional Cardiology Sunshine Global HospitalSurat 394370India Medical Division Sahajanand Laser Technology Ltd.GandhinagarGujarat382028India

BACKGROUND The use of biodegradable polymer drug-eluting stents(BP-DES)has been proven to minimize restenosis and stent *** current post-marketing monitoring was observed at the 5-year clinical outcomes of individuals who had been treated with FlexyRap®DES in the real *** To assess the safety and effectiveness of FlexyRap®DES at the 5-year follow-up in real-world *** Findings from a retrospective,multi-center,observational,post-market clinical follow-up study of patients treated with FlexyRap®DES for de novo coronary artery disease(CAD)were *** the 12-mo follow-up,the primary endpoint was target lesion failure,which was defined as the composite of cardiovascular death, target vessel myocardial infarction(TV-MI), and clinically driven target lesion *** The data of 500 patients received with FlexyRap®DES was obtained at the completion of the surveillance timeline of *** the implantation of FlexyRap®DES,the device success rate was 100%.Adverse events that led to major bleeding,permanent disability,or death were not experienced in the *** major adverse cardiac event rate at 12-mo,3-year,and 5-year follow-up was 1(0.2%),0(0%),and 1(0.2%)respectively with 0(0%)cardiovascular death,2(0.4%)TV-MI,and 0(0%)TLR ***,late stent thrombosis was found in 2(0.4%)patients at the follow-up of 12-mo,very late stent thrombosis was observed in 2 patients(0.4%)at 3-year *** FlexyRap®DES was proved to be safe and efficacious in real-world patients with de novo CAD,indicating a lowered rate of cardiac events and stent thrombosis at 5-year follow-up.

关键词： Coronary artery disease Drug-eluting stents Percutaneous coronary intervention Rapamycin Sirolimus

Modeling the effects of environmental pollution intensified by urbanization on human population

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第3期7卷 74-86页

作者： Abhinav tandon Kumari Jyotsna Department of Mathematics Birla Institute of Technology(BIT)Mesra Ranchi-835215JharkhandIndia

A mathematical model is presented here to investigate the effects of environmental pollution,intensified by urbanization,on the density of human ***,urbanization is assumed to grow with constant rate and also,induced through growing population and the corresponding population *** model analysis,qualitatively and numerically,show that though the growth of population or population pressure is responsible for the growing urbanization,but for very large increase of urbanization,the population may not survive in the long run due to environmental pollution driven by urbanization.

关键词： Pollution population urbanization population pressure stability numerical analysis

A NUMERICAL APPROACH STUDYING THE EFFECTS OF PRECIPITATION SCAVENGING ON STEADY-STATE DISPERSION OF AIR POLLUTANTS

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第1期3卷 51-67页

作者： MANJU AGARWAL ABHINAV tandon Department of Mathematics and Astronomy University of Lucknow LucknowUttar PradeshIndia Department of Mathematics Shri Ramswaroop Memorial Group of Professional Colleges Tiwariganj Faizabad RoadLucknowUttar PradeshIndia

The present paper demonstrates the applicability of finite element method of weighted residuals to study the effects of precipitation scavenging through raindrops on the steady-state dispersion of air pollutants in the atmosphere under realistic variable wind and diffusivity ***,the washout of pollutants by rain droplets is considered and the whole analysis for the pollutant concentration is carried out in two phases *** phase and droplet *** model solutions are obtained by using local basis and asymmetric quadratic weighting functions which can provide a promising alternative to the standard Galerkin formulation for problems with advective and diffusive *** results of the model reveal that the precipitation scavenging by rain is quite effective in cleaning the polluted *** the need of pollutant concentration in rain drops regarding acid precipitation(or acid rain),the concentration of the absorbed pollutant in the droplet phase are also ***,the present study provides an understanding on the concentration distribution of pollutant in gaseous and droplet phases,under the effects of variable wind and diffusivity profiles.

关键词： Precipitation scavenging pollutant gaseous phase droplet phase finite element asymmetric weighting functions

Modeling the impact of migrated population on human-to-human transmission of Ebola virus disease

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第1期9卷 185-206页

作者： Abhinav tandon Sankha Banerjee Department of Mathematics Birla Institute of Technology(BIT)Mesra Ranchi 835215JharkhandIndia

A nonlinear SEIR mathematical model is developed to investigate the impact of migrated population,infected with Ebola virus,on human-to-human transmission of Ebola Virus Disease(EVD)in a disease-free *** view of the dynamics of Ebola virus disease,here,the infected class is supposed to be divided into subclasses,*** and secondary *** proposed model is analyzed qualitatively using the stability theory of differential equations and quantitatively using numerical *** obtained results,qualitatively and quantitatively,suggest that migration and contact rates play an important role in controlling the spreading of *** values for migration and contact rates are evaluated and it is revealed that if these rates go beyond their critical values,it leads to delay in the stabilization of the *** is also found that primary reproductive number increases with increase in migration *** this,the approximate time required to attain stability of the disease model system is also *** model analysis recommends quarantining the noninfected from the secondary infected in order to control the spreading out of disease.

关键词： Mathematical model primary infected secondary infected migration Ebola virus qualitative analysis quantitative analysis

Theoretical approach to study the formation of C2H4O2 isomers in interstellar medium through reaction between interstellar formaldehyde molecules

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Research in Astronomy and Astrophysics 2020年第1期20卷 124-136页

作者： Aftab Ahmad Shivani Alka Misra Poonam tandon Department of Mathematics&Astronomy University of LucknowLucknowIndia Department of Physics University of LucknowLucknowIndia

The three isomers of C2H4O2,viz.,glycolaldehyde(HCOCH2 OH),acetic acid(CH3 COOH)and methyl formate(HCOOCH3),have been detected in copious amounts in the interstellar medium(ISM).The possibility for formation of these molecules through interstellar formaldehyde(HCHO)has been explored by using the quantum chemical approach described by density functional theory(DFT)and second order Moller-Plesset perturbation(MP2)theory with a 6–311 G(d,p)basis set in the gas phase as well as in icy *** associated molecule-molecule interactions have been discussed to study the formation of isomers of C2H4O2 in *** reactions of two formaldehyde molecules exhibit a considerable potential barrier but due to quantum tunneling,these reactions could be possible in *** chemical pathway is exothermic,which gives rise to a high probability for the formation of all three isomers,***,methyl formate and acetic acid,in interstellar *** rotational vibration,centrifugal distortion constants and coupling constants are also calculated and results suggest that the vibrations are harmonic in nature.

关键词： ISM:molecules astrochemistry astrobiology abundances

Formation of cyanoallene(buta-2, 3-dienenitrile) in the interstellar medium: a quantum chemical and spectroscopic study

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Research in Astronomy and Astrophysics 2014年第3期14卷 275-284页

作者： Amresh Singh Shivani Alka Misra Poonam tandon Department of Mathematics & Astronomy University of Lucknow Department of Physics University of Lucknow

The interstellar medium, filling the vast space between stars, is a rich reser-voir of molecular material ranging from simple diatomic molecules to more com-plex, astrobiologically important molecules such as vinylcyanide, methylcyanodiac-cetylene, cyanoaUene, etc. Interstellar molecular cyanoallene is one of the most stableisomers of methylcynoacetylene. An attempt has been made to explore the possibilityof forming cyanoallene in interstellar space by radical-radical and radical-moleculeinteraction schemes in the gaseous phase. The formation of cyanoallene starting fromsome simple, neutral interstellar molecules and radicals has been studied using densityfunctional theory. The reaction energies and structures of the reactants and productsshow that the formation of cyanoallene is possible in the gaseous phase. Both of theconsidered reaction paths are totally exothermic and barrierless, thus giving rise to ahigh probability of occurrence. Rate constants for each step in the formation processof cyanoallene in both the reaction paths are estimated. A full vibrational analysishas been attempted for cyanoallene in the harmonic and anharmonic *** spectroscopic parameters such as rotational constants, rotation-vibrationcoupling constants and centrifugal distortion constants have been calculated.

关键词： astrochemistry techniques: spectroscopic ISM: abundances ISM: molecules

Quantum chemical analysis for the formation of glycine in the interstellar medium

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Research in Astronomy and Astrophysics 2013年第8期13卷 912-920页

作者： Amresh Singh Shivani Alka Misra Poonam tandon Department of Mathematics & Astronomy University of Lucknow Department of Physics University of Lucknow

Glycine （C2H5NO2） was the first amino acid to be detected in space by the stardust space probe in Comet Wild2, and is used by living organisms to make proteins. We discuss three different reaction paths for the formation of glycine in interstellar space from some simpler molecules detected in the interstellar medium. The possibility of the formation of glycine in interstellar space is considered by radicalradical and radical-molecule interaction schemes using quantum chemical calculations with density functional theory at the B3LYP/6-31G （d,p） level. In the chemical pathways we discuss, a few reactions are found to be totally exothermic and barrierless while others are endothermic with a very small reaction barrier, thus giving rise to a high probability of forming glycine in interstellar space.

关键词： astrobiology - astrochemistry - ISM: abundances - ISM: molecules