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Synthesis and Antimicrobial Activity of 2-Methyl-5-nitroaniline Derivatives： A Structure-Activity Relationship Study

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Chinese Journal of Chemistry 2011年第1期29卷 102-108页

作者： Lingappa, Mallesha Kikkeri, N. Mohana devaraju, rakshith Sreedharamurthy, Satish Department of Studies in Chemistry University of Mysore Manasagangotri Mysore 570006 India Department of Studies in Microbiology University of Mysore Manasagangotri Mysore 570006 India

A series of 2-methyl-5-nitroaniline derivatives, 5a--Sk and 6a--6f, were synthesized in order to determine their in vitro antimicrobial activity. The chemical structures of the synthesized compounds were confirmed by elemental analyses, UV-visible, FT-IR, 1H NMR and 13C NMR spectral studies. The structure-activity relationships of the synthesized compounds were also discussed. Among the synthesized compounds, 5f, 5d, 6b and 6e showed good antimicrobial activity compared to standard drugs.

关键词： 2-methyl-5-nitroaniline aldehydes ketones antimicrobials

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Antimicrobial properties of endophytic actinomycetes isolated from Combretum latifolium Blume, a medicinal shrub from Western Ghats of India

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Frontiers in Biology 2015年第6期10卷 528-536页

作者： H. C. Yashavantha Rao devaraju rakshith Sreedharamurthy Satist~ Microbial Drugs Laboratory Department of Studies in Microbiology Manasagangotri University of Mysore Mysore-570006 Karnataka India Department of Plant Pathology University of Georgia Athens 30602 USA

Endophytic actinomycetes were isolated from Combretum latifolium Blume （Combretaceae）, Western Ghats of Southern India and identified by its characteristic culture morphology and molecular analysis of 16S rRNA gene sequences. In this survey of endophytic actinomycetes, a total of 117 isolates representing 9 different genera of endophytie actinomycetes were obtained using four different isolation media and several of them seemed to be novel taxa. Streptomyces genera （35%） was the most frequently isolated strains, followed by Nocordiopsis （17%） and Micromonospora （13%）. ISP-4 medium recovered more isolates （47%） when compared to rest of the media used. Preliminary antibacterial activity of the isolates was carried out by confrontation test. Ethyl acetate fraction of selected isolates in disc diffusion assay exhibited broad spectrum antimicrobial activity against test human pathogens. All Streptomyces spp. strains displayed significant antimicrobial activity against test pathogens. Strain CLA-66 and CLA-68 which are Nocordipsis spp. inhibited both bacterial and fungal pathogens where as other isolates inhibited atleast three test human pathogens in disc diffusion assay. Antimicrobial screening of endophytic actinomycetes from this host may represent a unique potential niche for antimierobial compounds of industrial and pharmaceutical applications. This work is the first comprehensive report on incidence of potential endophytic actinomycetes inhabiting C. latifolium Blnme.

关键词： endophytic actinomycetes Combretum latifolium Blume Streptomyces antimicrobial activity

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