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Protein extract of kenaf seed exhibits anticoagulant,antiplatelet and antioxidant activities

Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 47-58页

作者： Sujatha M.Hanumegowda Chandramma Srinivasa Ashwini Shivaiah Manjula M.Venkatappa Ramesha Hanumanthappa Rajesh Rangappa Ramesh K.Laxmaiah Sathisha J.Gonchigar devaraja sannaningaiah Department of Biochemistry Jnansahydri Kuvempu UniversityShankarghatta-577451ShivamoggaKarnatakaIndia Department of Studies and Research in Biochemistry and Centre for Bioscience and Innovation Tumkur UniversityTumkurKarnatakaIndia Liveon Biolabs Private Limited Tumkur-572106India Department of Food Science and Nutrition Maharani's Science College for WomenMysoreIndia

Objective:To explore the anticoagulant,antiplatelet and antioxidant activities of protein extract of kenaf seed(PEKS).Methods:Sodium dodecyl sulphate polyacrylamide gel electrophoresis and reverse-phase high-performance liquid chromatography techniques were employed for protein *** activity of PEKS was assessed using 1,1-diphenyl-2-picrylhydrazyl(DPPH)*** protective effect of PEKS on sodium nitrite(NaNO2)induced oxidative stress was evaluated using the in vitro red blood cell model,while the effect of PEKS on diclofenacinduced oxidative stress was examined in vivo in ***-rich plasma and platelet-poor plasma were used for anticoagulant and antiplatelet activities of ***:PEKS revealed similar protein bands on SDS-PAGE under reduced and non-reduced *** acidic proteins were present in native *** showed antioxidant properties by scavenging DPPH with an IC50 of 24.58μ*** exhibited a protective effect on NaNO2 induced oxidative stress in red blood cells by restoring the activity of stress *** addition,PEKS alleviated diclofenac-induced tissue damage of the liver,kidney,and small *** showed an anticoagulant effect in both in vivo and in vitro experiments by enhancing normal clotting *** did not affect prothrombin time but increase activated partial thromboplastin ***,PEKS inhibited adenosine diphosphate and epinephrine-induced platelet ***:PEKS protects tissues from oxidative stress and exhibits antithrombotic activity.

关键词： Protein Extract Kenaf seed Oxidative stress Antioxidant Anticoagulant Antiplatelet

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Prompt neutron emission in ^(250)No spontaneous fission associated with ground and isomeric state decays

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Chinese Physics C 2024年第6期48卷 112-117页

作者： R.S.Mukhin A.V.Isaev A.V.Andreev M.L.Chelnokov V.I.Chepigin H.M.devaraja I.N.Izosimov A.A.Kuznetsova O.N.Malyshev A.G.Popeko Yu.A.Popov A.Rahmatinejad B.Sailaubekov T.M.Shneidman E.A.Sokol A.I.Svirikhin M.S.Tezekbayeva M.A.Bychkov A.V.Yeremin O.Dorvaux B.Gall K.Kessaci K.Hauschild A.Lopez-Martens Joint Institute for Nuclear Research Dubna141980Russia Dubna State University Dubna141982Russia Institute of Nuclear Physics Almaty050032Kazakhstan L.N.Gumilyov Eurasian National University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde Strasbourg CNRSStrasbourg67000France IJCLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

The complete-fusion reaction^(204)Pb(^(48)Ca,2n)^(250)No was used to study two activities of^(250)No with distinct half-lives.A total of 1357 events were observed in the SFiNx neutron detection *** average number of neutrons emitted per spontaneous fission of^(250)No was determined to be(4.1±0.1).The unusually symmetrical shape of the prompt neutron multiplicity distribution was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distributions associated with the ground state and K-isomer state decays.

关键词： spontaneous fission prompt neutrons actinide

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Myringitis:An update

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Journal of Otology 2019年第1期14卷 26-29页

作者： K.devaraja Department of Otorhinolaryngology-Head and Neck Surgery Kasturba Medical College Manipal Academy of Higher Education

Myringitis can be acute or chronic. Though they commonly present with ear discharge with or without pain, the etiology and the management principles differ. Granular myringitis generally is an external ear pathology extending to tympanic membrane and present as painless otorrhea, whereas the bullous myringitis is commonly associated with acute inflammation of middle ear cleft and present with severe ear pain. This literature review discusses the clinical as well as the therapeutic aspects of these inflammatory conditions.

关键词： Myringitis Bullous myringitis Granular myringitis Hemorrhagic myringitis

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Malignant otitis externa with subsequent internal jugular vein thrombosis and hypoglossal palsy:a report and review of literature

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Journal of Otology 2020年第3期15卷 112-116页

作者： K devaraja Dipak Ranjan Nayak Department of Otorhinolaryngology and Head and Neck Surgery Kasturba Medical CollegeManipal Academy of Higher EducationUdupiKarnataka576104India

Inflammation of a part or whole of the temporal bone and surrounding soft tissue is termed as malignant otitis externa,which typically spreads to skull base to involve cranial nerves *** can it also effect one or more of cranial nerves IX,X,XI,and *** present a case of malignant otitis externa which presented with symptomatic palsy of IX and XII nerves sparing the VII cranial *** patient though later on had internal jugular vein thrombosis,which we presume is due to the involvement of the parapharyngeal space that prompted us to reconsider the diagnosis,and later on,to aggravate the *** proper blood sugar control and appropriate long term antibiotics,not only that the patient is disease free at one year follow up,but the cranial nerve deficits also *** from sharing the clinical and management details of this patient,we have reviewed the relevant literature in the discussion,which has shed some light onto some of the interesting facts about this condition and its prognosis.

关键词： Skull base osteomyelitis Malignant otitis externa Hypoglossal palsy Diabetes mellitus Internal jugular vein

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Observational insights into the accelerating universe through reconstruction of the deceleration parameter

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中国物理C:英文版 2023年第8期47卷 184-194页

作者： devaraja Mallesha Naik N.S.Kavya V.Venkatesha Department of P.G.Studies and Research in Mathematics Kuvempu UniversityShankaraghattaShivamogga 577451KarnatakaINDIA

Recent developments in the exploration of the universe suggest that it is in an accelerated phase of ***,our study aims to probe the current scenario of the universe with the aid of the reconstruction *** primary factor that describes cosmic evolution is the deceleration ***,we provide a physically plausible,newly defined model-independent parametric form of the deceleration ***,we constrain the free parameters through statistical MCMC analysis for different datasets,including the most recent Pantheon+.With the statistically obtained results,we analyze the dynamics of the model through the phase trans-ition,EoS parameter,and energy ***,we make use of the tool Om diagnostic to test our model.

关键词： deceleration parameter parametric reconstruction observational constraints accelerating universe Om diagnostics

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Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

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Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 237-251页

作者： Yangzom D.Bhutia Jiro Ogura Paul J.Grippo Carolina Torres Toshihiro Sato Mitchell Wachtel Sabarish Ramachandran Ellappan Babu Sathish Sivaprakasam devaraja Rajasekaran Bradley Schniers Nhu On Logan Smoot Muthusamy Thangaraju Jaya P.Gnana-Prakasam Vadivel Ganapathy Department of Cell Biology and Biochemistry Texas Tech University Health Sciences CenterLubbockTX 79430USA Department of Pharmaceutical Sciences Tohoku University Hospital1-1 Seiryo-machiAoba-kuSendaiMiyagi 980-8574Japan Department of Medicine University of Illinois at ChicagoChicagoIL 60607USA Department of Surgical Pathology Texas Tech University Health Sciences CenterLubbockTX 79430USA Department of Biological Sciences Texas Tech UniversityLubbockTX 79410USA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTX 79410USA Department of Biochemistry and Molecular Biology Augusta UniversityAugustaGA 30912USA Department of Ophthalmology St.Louis UniversitySt.LouisMO 63104USA

Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed cell culture studies to interrogate the connection between excess iron and cancer, and combined in vitro and in vivo studies to explore the connection further. Ferric ammonium citrate was used as an exogenous iron source. Chronic exposure to excess iron induced epithelial-mesenchymal transition(EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes(p21, cyclin D1, Bax, SLC7A11). To further extrapolate our cell culture data, we generated EL-KrasG12D( EL-Kras) mouse(pancreatic neoplastic mouse model) expressing Hfe+/+ and Hfe-/- genetic background. p53 target gene expression decreased in EL-Kras/Hfe-/- mouse pancreas compared to EL-Kras/Hfe+/+ mouse pancreas. Interestingly, the incidence of acinar-to-ductal metaplasia and cystic pancreatic neoplasms(CPN) decreased in EL-Kras/Hfe-/- mice, but the CPNs that did develop were larger in these mice than in EL-Kras/Hfe+/+ mice. In conclusion, these in vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells.

关键词： SLC7A11 p53 Iron Heme Epithelial-mesenchymal transition

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