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Preliminary exploration of animal models of congenital choledochal cysts

World Journal of Gastroenterology 2024年第10期30卷 1420-1430页

作者： Shu-Hao Zhang Yue-Bin Zhang Duo-Te Cai Tao Pan Ken Chen Yi Jin Wen-Juan Luo Zong-Wei huang Qing-Jiang Chen Zhi-gang Gao Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Various animal models have been used to explore the pathogenesis of choledochal cysts(CCs),but with little convincing *** surgical techniques can achieve satisfactory outcomes for treatment of ***,recent studies have focused more on clinical issues rather than basic ***,we need appropriate animal models to further basic *** To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of *** Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group,sham surgical group,or control group.A rat model of CC was established by partial ligation of the bile *** reliability of the model was confirmed by measurements of serum biochemical indices,morpho-logy of common bile ducts of the rats as well as molecular biology experiments in rat and human *** Dilation classified as mild(diameter,≥1 mm to<3 mm),moderate(≥3 mm to<10 mm),and severe(≥10 mm)was observed in 17,17,and 2 rats in the surgical group,respectively,while no dilation was observed in the control and sham surgical *** levels of alanine aminotransferase,aspartate aminotrans-ferase,total bilirubin,direct bilirubin,and total bile acids were significantly elevated in the surgical group as compared to the control group 7 d after surgery,while direct bilirubin,total bilirubin,and gamma-glutamyltransferase were further increased 14 d after *** of the biochemical indices gradually decreased to normal ranges 28 d after *** protein expression trend of signal transducer and activator of transcription 3 in rat model was consistent with the human CC *** The model of partial ligation of the bile duct of juvenile rats could morphologically simulate the cystic or fusiform CC,which may contribute to investigating the pathogenesis of CC.

关键词： Choledochal cyst Animal model Partial ligation Cystic and fusiform dilation Juvenile rats

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全球地表气温对CO_(2)浓度变化的非对称响应:能量平衡模式研究

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地球科学进展 2024年第6期39卷 632-646页

作者：屈侠黄刚中国科学院大气物理研究所季风系统研究中心北京100029 中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室北京100029

气候系统属性可影响二氧化碳(CO_(2))浓度变化背景下全球地表气温演变的非对称性,但目前仍不清楚哪些属性的贡献相对关键。因第六次国际耦合模式比较计划(CMIP6)试验样本不足,基于45个CMIP6模式数据,逐一构建了快速、再现能力理想的两... 详细信息

气候系统属性可影响二氧化碳(CO_(2))浓度变化背景下全球地表气温演变的非对称性,但目前仍不清楚哪些属性的贡献相对关键。因第六次国际耦合模式比较计划(CMIP6)试验样本不足,基于45个CMIP6模式数据,逐一构建了快速、再现能力理想的两层能量模型,共开展了391组试验。该模型试验结果显示,在对称的CO_(2)浓度上升和下降演变下,平衡气候响应、深海热容量和海表—深海热传输系数对全球地表气温演变的非对称性起主要贡献,它们主要通过改变CO_(2)浓度下降期全球地表气温达峰后的降温速度来实现。因此,加深对气候系统平衡气候响应、深海热容量和海表—深海热传输系数的理解,有助于更科学地实现巴黎协定目标。

关键词：全球地表气温非对称响应 CO_(2)浓度变化

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Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan gang Wang Fang Yu Jun Luo Meng‑Xin Lu Zhong‑Hua Yang Tao Liu Xing huang Hang Zheng Xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

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Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma

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World Journal of Clinical Oncology 2024年第1期15卷 62-88页

作者： Jie-Zhuang huang Jian-Di Li gang Chen Rong-Quan He Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Transcatheter arterial embolisation(TACE)is the primary treatment for intermediate-stage hepatocellular carcinoma(HCC)patients while some HCC cases have shown resistance to *** To investigate the key genes and potential mechanisms correlated with TACE refractoriness in *** The microarray datasets of TACE-treated HCC tissues,HCC and non-HCC tissues were collected by searching multiple public *** respective differentially expressed genes(DEGs)were attained via limma R *** gene co-expression network analysis was employed for identifying the significant modules related to TACE *** refractoriness-related genes were obtained by intersecting up-regulated TACE-associated and HCC-associated DEGs together with the genes in significant modules related to TACE *** key genes expression in the above two pairs of samples was compared respectively via Wilcoxon tests and standard mean differences *** prognostic value of the key genes was evaluated by Kaplan-Meier *** analysis was utilised to investigate the independent prognostic factor in key ***-cell RNA(scRNA)sequencing analysis was conducted to explore the cell types in *** refractoriness-related genes activity was calculated via AUCell *** CellChat R package was used for the investigation of the cell–cell communication between the identified cell *** HCC tissues of TACE non-responders(n=66)and TACE responders(n=81),HCC(n=3941)and non-HCC(n=3443)tissues were *** five key genes,DLG associated protein 5(DLGAP5),Kinesin family member 20A(KIF20A),Assembly factor for spindle microtubules(ASPM),Kinesin family member 11(KIF11)and TPX2 microtubule nucleation factor(TPX2)in TACE refractoriness-related genes,were *** five key genes were all up-regulated in the TACE non-responders group and the HCC *** expression of the five key genes predicted poor prognosis in *** the key genes,TP

关键词： Hepatocellular carcinoma Transcatheter arterial embolisation refractoriness Weighted gene co-expression network analysis Single-cell RNA sequencing AUCell CellChat

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Study on the Mechanism of Glutamine Promoting the Synthesis of Colonic Mucin and Maintaining the Stability of Intestinal Microbiota in Septic Mice

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Food Science and Human Wellness 2024年

作者： Yanyan Pan gang Yang Dan Wu Yan Wei Shijun Fan Lin Xia Qian Chen Qianying huang Yongling Lu Xi Peng Clinical Medical Research Center Southwest Hospital Third Military Medical University (Army Medical University) Burn Department Ningbo No.2 Hospital nstitute of Burn Research State Key Laboratory of Trauma and Chemical Poisoning Southwest Hospital Third Military Medical University (Army Medical University)

Colonic mucus and gut microbiota closely linked through mutual regulatory effect. While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are unclear. Cecal ligation and puncture-induced sepsis in mice was utilized to observe changes in colonic mucus， gut microbiota， and their interaction with glutamine intervention. Our findings indicated that glutamine mitigated sepsis-induced intestinal damage and restores colonic mucus barrier function by augmenting mucin synthesis. Further analysis revealed that goblet cells were under oxidative stress after sepsis， resulting in anterior gradient-2 (AGR2)， the key mucin-modifying enzyme， being dissynthesized， and inhibiting mucin2 (MUC2) maturation. glutamine could ameliorates this situation by promoting the key enzyme glucose-6-phosphate dehydrogenase (G6PD) glycosylation in the pentose phosphate pathway， increasing the reduced nicotinamide adenine dinucleotide phosphate (NADPH) synthesis， reducing endoplasmic reticulum stress， and accelerating AGR2 synthesis and MUC2 maturation. Additionally， glutamine aided in maintaining gut microbiota stability during sepsis， up-regulating mucin-associated bacteria such as Akkermansia and Alistipes. These bacteria， intimately linked to mucin synthesis and degradation， may impact intestinal mucus stability. In conclusion， glutamine can maintain goblet cell redox balance， promotes AGR2 synthesis and MUC2 maturation， shields the mucus barrier， and potentially maintains gut microbiota stability by regulating the interaction between bacteria and mucus， thus alleviating sepsis-induced intestinal damage.

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公共性重塑:乡村文化振兴的善治逻辑

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河南师范大学学报（哲学社会科学版） 2024年第1期51卷 38-44页

作者：王刚黄鹏东北林业大学马克思主义学院黑龙江哈尔滨150040

乡村文化振兴是实现国家善治的重要议题。村落文化作为乡村共同体的呈现样态,存在乡村文化的多元化来源和展演形态。文化公共性与乡村建设休戚相关,村庄政治精英不但引领了文化资源的运作方向,而且重新整合了村民的“文化习惯”,为村庄... 详细信息

乡村文化振兴是实现国家善治的重要议题。村落文化作为乡村共同体的呈现样态,存在乡村文化的多元化来源和展演形态。文化公共性与乡村建设休戚相关,村庄政治精英不但引领了文化资源的运作方向,而且重新整合了村民的“文化习惯”,为村庄的可持续发展提供了有力保障。具体而言,要通过政策宣传激发村庄文化的活力,围绕党群关系发挥村规民约的影响力,进而践行文化制度的本土化适应力。同时,乡村文化公共性的流失贯穿于公共议题的失语和公共空间的日渐式微。因此,要不断涵养乡村公共精神,加强村民公共意识的培育,促进村民之间的交流与合作,发挥乡村精英的引领作用,完善乡村公共空间的设施建设;不断拓展文化赓续的公共空间,重构乡村社会资本和关系,通过重构社区空间,促进村民之间的交流与合作;明确公共规则的内容和制定程序,加强公共规则的宣传和教育,健全监督机制的信息反馈渠道。

关键词：乡村文化文化振兴公共性善治

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Microvascular structural changes in esophageal squamous cell carcinoma pathology according to intrapapillary capillary loop types under magnifying endoscopy

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3471-3480页

作者： Wei-Yang Shu Yan-Yan Shi Jiu-Tian huang Ling-Mei Meng He-Jun Zhang Rong-Li Cui Yuan Li Shi-gang Ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 10019China Department of Gastroenterology Pathology Laboratory Peking University Third HospitalBeijing 100191China Department of Gastroenterology Peking University International HospitalBeijing 102206China

BACKGROUND The intrapapillary capillary loop(IPCL)characteristics,visualized using magnifying endoscopy,are commonly assessed for preoperative evaluation of the infiltration depth of esophageal squamous cell carcinoma(ESCC).Japan Esophageal Society(JES)classification is the most widely used *** structural changes are evaluated by magnifying endoscopy for the presence or absence of each morphological factor:tortuosity,dilatation,irregular caliber,and different ***,the pathological characteristics of IPCLs have not been thoroughly investigated,especially the microvascular structures corresponding to the deepest parts of the lesions'*** To investigate differences in pathological microvascular structures of ESCC,which correspond to the deepest parts of the lesions'*** Patients with ESCC and precancerous lesions diagnosed at Peking University Third Hospital were enrolled between January 2019 and April *** first underwent magnified endoscopic examination,followed by endoscopic submucosal dissection or surgical *** images were scanned using a threedimensional slice scanner,and the pathological structural differences in different types,according to the JES classification,were analyzed using nonparametric tests and *** The 35 lesions were divided into four groups according to the JES classification:A,B1,B2,and *** analyses revealed significant differences(aP0.05).However,significant differences in the short calibers,long calibers,and area of IPCL were observed between types B1 and B3(aP0.05).CONCLUSION Pathological structures of IPCLs in the deepest infiltrating regions differ among va

关键词： Esophageal squamous cell carcinoma Intrapapillary capillary loop The Japan Esophageal Society classification Magnifying endoscopy Pathological characteristics

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Exploration of pathogenic microorganism within the small intestine of necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 165-172页

作者： Yan Wang Kun Jiang Qiao Xia Xia Kang Shan Wang Ji-Hong Yu Wen-Feng Ni Xiao-Qin Qi Ying-Na Zhang Jin-Bao Han gang Liu Lei Hou Zhi-Chun Feng Liu-Ming huang Clinical Biobank Center Medical Innovation Research Division of ChinesePLA General HospitalBeijingChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Senior Department of Pediatrics The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Neurology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Emergency Center National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background Necrotizing enterocolitis(NEC)is the most common severe gastrointestinal emergency in *** designed this study to identify the pathogenic microorganisms of NEC in the microbiota of the small intestine of *** Using the 16S ribosomal DNA(rDNA)sequencing method,we compared and analyzed the structure and diversity of microbiotas in the intestinal feces of different groups of neonates:patients undergoing jejunostomy to treat NEC(NP group),neonates undergoing jejunostomy to treat other conditions(NN group),and neonates with NEC undergoing conservative treatment(NC group).We took intestinal feces and saliva samples from patients at different time *** The beta diversities of the NP,NN,and NC groups were all *** comparing the beta diversities between different time points in the NP group,we found similar beta diversities at time points El to E3 but significant differences between the E2-E3 and E4 time points:the abundances of Klebsiella and Enterococcus(Proteobacteria)were higher at the E1-E3 time points;the abundance of Escherichia-Shigella(Proteobacteria)increased at the E2 time point,and the abundance of Klebsiella decreased significantly,whereas that of Streptococcus increased significantly at the E4 time *** Our results suggest that the pathological changes of intestinal necrosis in the small intestine of infants with NEC are not directly caused by excessive proliferation of pathogenic bacteria in the small *** sources of microbiota in the small intestine of neonates,especially in premature infants,may be affected by multiple factors.

关键词： Microbiota Necrotizing enterocolitis-Small intestine 16S rDNA

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Identification of earthquake induced structural damage based on synchroextracting transform

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 475-487页

作者： Roshan Kumar Gaurav Kumar Wei Zhao Arvind R Yadav gang Yu Jayendra Kumar Evans Amponsah Department of Electronic and Information Technology Miami College of Henan UniversityHenan 475004China Alliance University Alliance College of Engineering and DesignBanglore 562106India Department of Electronics and Comm Parul UniversityVadodra 391760India School of Electrical Engineering University of JinanJinan 250022China Department of Electronics and Comm NIT JamshedpurJamshedpur 831014India Department of Civil engineering Kwame Nkrumah University of Science and TechnologyKumasi 10959Ghana

Several popular time-frequency techniques,including the Wigner-Ville distribution,smoothed pseudo-Wigner-Ville distribution,wavelet transform,synchrosqueezing transform,Hilbert-huang transform,and Gabor-Wigner transform,are investigated to determine how well they can identify damage to *** this work,a synchroextracting transform(SET)based on the short-time Fourier transform is proposed for estimating post-earthquake structural *** performance of SET for artificially generated signals and actual earthquake signals is examined with existing *** other tested techniques,SET improves frequency resolution to a great extent by lowering the influence of smearing along the time-frequency ***,interpretation and readability with the proposed method are improved,and small changes in the time-varying frequency characteristics of the damaged buildings are easily detected through the SET method.

关键词： cross-term damage detection earthquake signal synchroextracting transform time-frequency

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Time Modulated Array Antennas: A Review

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Electromagnetic Science 2024年第1期2卷 1-19页

作者： Wen Wu Qiaoyu Chen Jin-Dong Zhang Tongde huang Da-gang Fang Laboratory of Near-Range RF Sensing ICs&Microsystems(NJUST) Ministry of EducationSchool of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China

Time-modulated array(TMA)antennas,introduce the dimension of time into antenna design to control the radiation patterns and frequency spectral characteristics,thus improve the reconfigurability of array antennas and provide multiple *** have great application potential in military and civilian fields,such as precision guidance and mobile communication,and are currently a hot spot of academic *** article provides a review on the fundamentals and applications of ***,the basic theory and mathematical formulations of TMAs are ***,the most important applications of TMAs,namely time-modulated phased arrays(TMPA),are discussed from the perspectives of harmonic suppression and harmonic utiliza-tion,which are used for single-beam and multibeam ***,we survey the combination of TMA with various types of novel antenna arrays,such as single-channel digital beamforming(DBF)arrays,frequency diverse arrays(FDAs),and retrodirective arrays,to create new hardware implementation methods and enhance their ***,recent advances in dedicated integrated chips for TMA,which have played a significant role in driving the progress of TMAs from academic research to practical applications,are ***,the challenges and prospects for TMAs are discussed,including new research directions and emerging applica-tion scenarios.

关键词： Time modulated array Phased array Single RF channel digital beam forming Frequency diversity array Retrodi-rective arrays Chips.

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