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室内设计与装修 2019年第6期 110-115页

作者：〔保加利亚〕Branimira ivanova desislava ivanova 叮当(编译) 不详

'印象派花园'所想要呈现空间就如同它的名字一样,设计师希望能够将使用者带入当下的艺术世界。这个住宅项目的设计灵感来源于19世纪一些伟大的印象派画家,而它的名字则直接源自画家克劳德·莫奈的花园。花园本身就是一个拥有各种形状和... 详细信息

'印象派花园'所想要呈现空间就如同它的名字一样,设计师希望能够将使用者带入当下的艺术世界。这个住宅项目的设计灵感来源于19世纪一些伟大的印象派画家,而它的名字则直接源自画家克劳德·莫奈的花园。花园本身就是一个拥有各种形状和颜色的私密场所,住宅同样也是一个非常私人的空间,人们可以在这里放松、冥想,是一个可以卸下防备、不被束缚、释放自我的安全港湾。

关键词：印象派设计灵感

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形式和颜色之间的舞蹈与蒙德里安共进早餐

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室内设计与装修 2019年第6期 105-109页

作者：〔保加利亚〕Branimira ivanova desislava ivanova 悠悠(编译) 不详

'与蒙德里安共进早餐'是一个实验性项目,空间的形式、使用的线条和颜色都旨在能够对使用者产生愉悦身心的积极影响。整个项目的设计灵感来源于荷兰画家蒙德里安的作品,他采用水平和垂直两种线条,以此构成各种不同的正方形和长方形,简单... 详细信息

'与蒙德里安共进早餐'是一个实验性项目,空间的形式、使用的线条和颜色都旨在能够对使用者产生愉悦身心的积极影响。整个项目的设计灵感来源于荷兰画家蒙德里安的作品,他采用水平和垂直两种线条,以此构成各种不同的正方形和长方形,简单而又复杂的图形以红、黄、蓝三原色或黑、白、灰来表示色彩的纯净。在他的笔下色彩充满了活力,运用黄金分割和等比数列将画面或图形按照一定的比例进行分割、排列,创造富有节奏与韵律的秩序与美感,蒙德里安用画作展示了他如何将世界、自然和人类视为一体,他的画作呈现出一种不同元素在统一整体内的完美和谐。

关键词：蒙德里安设计灵感

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Role of GM3 ganglioside in the pathology of some progressive human diseases and prognostic importance of serum anti-GM3 antibodies

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BIOCELL 2021年第6期45卷 1485-1494页

作者： VERA KOLYOVSKA SONYA ivanova desislava DRENSKA DIMITAR MASLAROV RENETA TOSHKOVA Institute of Experimental Morphology Pathology and Anthropology with MuseumBulgarian Academy of SciencesSofia1113Bulgaria University Hospital for Neurology and Psychiatry“St.Naum” Sofia1797Bulgaria University First MHAT-Sofia “St.John Krastitel”Neurology ClinicSofia1142Bulgaria Medical University of Sofia Medical College“Y.Filaretova”Sofia1606Bulgaria

Glycosphingolipids(gangliosides)have been characterized as important biological molecules with a key role as regulators in many physiological processes on cellular,tissue,organ,and organism *** deviations in their normal amounts,production,and metabolism are very often related to the development of many multi-factor socially important ***3 ganglioside,as a small molecule,plays important roles in the cascade regulatory pathways in the pathology of many disorders like neurodegenerative diseases,autoimmune diseases,inflammation,diabetes,malignant transformation,and *** GM3 and its derivatives are membrane-bound glycosphingolipids composed of an oligosaccharide head structure containing one sialic acid *** molecules transduce signals involved in cell surface events,including the phosphorylation of transmembrane *** ganglioside is the most widely distributed among tissues,and it serves as a precursor for most of the more complex ganglioside ***3 inhibits the function of fibroblast growth factor receptor,and cell growth is regulated by GM3-enriched ***3 is thought to inhibit immunologic functions,such as the proliferation and production of cytokines by T *** the other hand,the anti-ganglioside antibodies(AGAs)are important in many acquired demyelinating immunemediated neuropathies,like Multiple sclerosis(MS),Guillain–Barrésyndrome(GBS)and its variation,Miller–Fisher syndrome(MFS)and could be suggested as important diagnostic and prognostic markers about the describe diseases and their *** show that the complexes of anti-ganglioside antibodies to GM3(detected by ELISA)may be useful diagnostic and prognostic tool markers for autoimmune diseases,neurodegenerative disorders,malignancy,diabetes,and *** pilot studies suggest increased serum IgG anti-GM3 antibodies titers in patients with secondary progressive MS(SPMS),throat cancer,elder people with diabetes(89–96 years),old Lewis rat

关键词： Biomarkers Serum GM3 Serum anti-GM3 antibodies ELISA

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Treg/Th17 cell balance and phytohaemagglutinin activation of T lymphocytes in peripheral blood of systemic sclerosis patients

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World Journal of Experimental Medicine 2017年第3期7卷 84-96页

作者： Ekaterina Krasimirova Tsvetelina Velikova Ekaterina ivanova-Todorova Kalina Tumangelova-Yuzeir desislava Kalinova Vladimira Boyadzhieva Nikolay Stoilov Tsvetelina Yoneva Rasho Rashkov Dobroslav Kyurkchiev Laboratory of Clinical Immunology University Hospital "St. Ivan Rilski"Department of Clinical Laboratory and Clinical ImmunologyMedical University of Sofia Clinic of Rheumatology University Hospital "St. Ivan Rilski"Department of Internal MedicineMedical University of Sofia

AIM To investigate T-cell activation, the percentage of peripheral T regulatory cells(Tregs), Th17 cells and the circulating cytokine profile in systemic sclerosis(SSc).METHODS We enrolled a total of 24 SSc patients and 16 healthy controls in the study and divided the patients as having diffuse cutaneous SSc(dc SSc, n = 13) or limited cutaneous SSc(lc SSc, n = 11). We performed a further subdivision of the patients regarding the stage of the disease-early, intermediate or late. Peripheral venous blood samples were collected from all subjects. We performed flow cytometric analysis of the activationcapacity of T-lymphocytes upon stimulation with PHA-M and of the percentage of peripheral Tregs and Th17 cells in both patients and healthy controls. We used ELISA to quantitate serum levels of human interleukin(IL)-6, IL-10, tissue growth factor-β1(TGF-β1), and IL-17 *** We identified a decreased percentage of CD3+CD69+ cells in PHA-stimulated samples from SSc patients in comparison with healthy controls(13.35% ± 2.90% vs 37.03% ± 2.33%, P < 0.001). However, we did not establish a correlation between the down-regulated CD3+CD69+ cells and the clinical subset, nor regarding the stage of the disease. The activated CD4+CD25+ peripheral lymphocytes were represented in decreased percentage in patients when compared to controls(6.30% ± 0.68% vs 9.36% ± 1.08%, P = 0.016). Regarding the forms of the disease, dc SSc patients demonstrated lower frequency of CD4+CD25+ T cells against healthy subjects(5.95% ± 0.89% vs 9.36% ± 1.08%, P = 0.025). With regard to Th17 cells, our patients demonstrated increased percentage in comparison with controls(18.13% ± 1.55% vs 13.73% ± 1.21%, P = 0.031). We detected up-regulated Th17 cells within the lc SSc subset against controls(20.46% ± 2.41% vs 13.73% ± 1.21%, P = 0.025), nevertheless no difference was found between dc SSc and lc SSc patients. Flow cytometric analysis revealed an increased percentage of CD4+CD25-Foxp3+ in dc SSc patients c

关键词： Systemic sclerosis T-cell activation Th17 Tregs CD4+CD25-Foxp3+cells Interleukin-17 Tissue growth factor-β Interleukin-10 Interleukin-6

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Indoor Radon Concentrations of School Buildings in Varna District, Bulgaria

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Journal of Environmental Science and Engineering(B) 2022年第2期11卷 43-48页

作者： desislava Djunakova Bistra Kunovska Jana Djounova Kremena ivanova Zdenka Stojanovska National Centre of Radiobiology and Radiation Protection Sofia 1606Bulgaria Faculty of Medical Sciences Goce Delcev UniversityStip 2000Republic of North Macedonia

Radon is a radioactive gas that is naturally produced by the breakdown of uranium in soil,rock and *** International Commission on Radiological Protection(ICRP)and World Health Organization(WHO)requirements include controlling indoor radon exposure and settings of a reference level for the annual average activity concentration of up to 300 Bq/m3 for dwellings and public *** measurements in school buildings have long been carried out in many *** measurements in schools in Bulgaria have started and are *** study concerns the measurements of radon concentration(CRn)in all state school buildings in one of the Black Sea regions,Varna district,and the analysis of indoor *** survey of 1,185 premises of 107 schools was conducted from December 2019/January 2020 to March/May 2020 using a passive *** AM(Arithmetic Mean)of CRn in the premises of the studied schools on the territory of Varna district is 130 Bq/m^(3),and the geometric mean is 97 Bq/m^(3).The number of premises exceeding the national reference level of 300 Bq/m^(3) is 72 located in 38 schools(about 36% of schools).A statistically significant difference(KW(Kruskal-Wallis),p<0.0001)was found between the radon data,grouped by ***,the radon data were classified into two groups based on municipality location:on the Black Sea coast and *** located near the sea have a higher value of *** order to more accurately assess the exposure of pupils and teachers,the results are divided into four groups,depending on the type of use of the premises and the floor on which they are *** highest CRn value was found in the study rooms used for specialized education such as physics,chemistry,music etc.(AM=155 Bq/m3),which can be explained by their smaller size and less frequent use.A statistically significant difference(KW,p<0.0001)was found,which means that the radon exposure in the examined rooms depends on the type of use.T

关键词： Radon schools measurement classrooms Bulgaria

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