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Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus

World Journal of Clinical Cases 2024年第3期12卷 525-537页

作者： Dharmsheel Shrivastav desh deepak singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002India

BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose *** high sugar levels lead to advanced glycation end products(AGEs),which affects several metabolic pathways by its receptor of advanced glycation end products(RAGE)and causes diabetic *** are small RNA molecules which regulate genes linked to diabetes and affect AGEs pathogenesis,and target tissues,influencing health and disease *** To explore miRNA roles in T2DM's metabolic pathways for potential therapeutic and diagnostic advancements in diabetes *** We systematically searched the electronic database PubMed using *** included free,full-length research articles that evaluate the role of miRNAs in T2DM and its complications,focusing on genetic and molecular disease *** assessing the full-length papers of the shortlisted articles,we included 12 research *** Several types of miRNAs are linked in metabolic pathways which are affected by AGE/RAGE axis in T2DM and its ***-96-5p,miR-7-5p,miR-132,has_circ_0071106,miR-143,miR-21,miR-145-5p,and more are associated with various aspects of T2DM,including disease risk,diagnostic markers,complications,and gene *** Targeting the AGE/RAGE axis,with a focus on miRNA regulation,holds promise for managing T2DM and its *** have therapeutic potential as they can influence the metabolic pathways affected by AGEs and RAGE,potentially reducing inflammation,oxidative stress,and vascular ***,miRNAs may serve as early diagnostic biomarkers for *** research in this area may lead to innovative therapeutic strategies for diabetes and its associated complications.

关键词： Type 2 diabetes mellitus MicroRNAs Advanced glycation end products Receptor for advanced glycation end products

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Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease

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World Journal of Diabetes 2024年第7期15卷 1603-1614页

作者： Dharmsheel Shrivastav Satyam Kumar Kumbhakar Shivangi Srivastava desh deepak singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002RajasthanIndia Department of Biotechnology Govt Veer Surendra Say P.G.CollegeGariaband 493889ChhattisgarhIndia Department of Life Science Chhatrapati Shahu ji Maharaj UniversityKanpur 208024Uttar PradeshIndia

BACKGROUND Type 2 diabetes(T2D)is a metabolic disease of impaired glucose utilization and a major cause of cardiovascular disease(CVD).The pathogenesis of both diseases shares common risk factors and mechanisms,and both are significant contributors to global morbidity and *** of natural products for T2D mellitus(T2DM)and CVD can be seen as a potential preventive and effective therapeutic *** To critically evaluate the therapeutic potential of natural products in T2D and coronary artery disease(CAD).METHODS By using specific keywords,we strategically searched the PubMed *** controlled trials(RCTs)were searched as the primary focus that examined the effect of natural products on glycemic control,oxidative stress,and antioxidant *** focused on outcomes such as low blood glucose levels,adjustment on markers of oxidative stress and *** screening fulllength papers,we included 9 RCTs in our review that met our inclusion *** In the literature search on the database,we found that various natural products like plant secondary metabolites play a diverse role in the management of *** ginseng,sesame oil and cocoa flavanols proved effective in lowering blood glucose levels and controlling blood pressure,which are key factors in managing T2DM and *** diabetic patients Melissa officinalis effectively reduce inflammation and shows diabetes *** fish oil and flaxseed oil reduced insulin levels and inflammatory markers,suggesting benefits for both *** lipid profile and endothelial function were enhanced by Nigella sativa oil and Terminalia chebula,which is significant for the management of cardiovascular risk factors in *** Bilberry extract also showed promise for improving glycemic control in patients with *** The high level of antioxidant,anti-inflammatory,and anti-angiogenic properties found in natural products makes them promising therapeutic opt

关键词： Type 2 diabetes mellitus Cardiovascular disease Natural products Antioxidants Oxidative stress Therapeutic impact Global burden

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Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients

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World Journal of Diabetes 2023年第12期14卷 1754-1765页

作者： Dharmsheel Shrivastav desh deepak singh Rashid Mir Pratishtha Mehra Vimal Mehta Pradeep Kumar Dabla Amity Institute of Biotechnology Amity UniversityJaipur 303002RajasthanIndia Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India Department of Medical Lab Technology Faculty of Applied Medical SciencesUniversity of TabukTabuk 71491India Department of Cardiology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India

BACKGROUND Coronary artery disease(CAD)is a major cause of death worldwide,and India contributes to about one-fifth of total CAD *** development of CAD has been linked to the accumulation of Nε-carboxymethyl-lysine(CML)in heart muscle,which correlates with *** To assess the impact of CML and inflammatory markers on the biochemical and cardiovascular characteristics of CAD patients with and without *** We enrolled 200 consecutive CAD patients who were undergoing coronary angiography and categorized them into two groups based on their serum glycosylated hemoglobin(HbA1c)levels(group I:HbA1c≥6.5;group II:HbA1c<6.5).We analyzed the levels of lipoproteins,plasma HbA1c levels,CML,interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α),and nitric *** Group I (81 males and 19 females) patients had a mean age of 54.2 ± 10.2 years, with a mean diabetes duration of4.9 ± 2.2 years. Group II (89 males and 11 females) patients had a mean age of 53.2 ± 10.3 years. Group I had moresevere CAD, with a higher percentage of patients with single vessel disease and greater stenosis severity in the leftanterior descending coronary artery compared to group II. Group I also exhibited a larger left atrium *** I patients exhibited significantly higher levels of CML, TNF-α, and IL-6 and lower levels of nitric oxide ascompared with group II patients. Additionally, CML showed a significant positive correlation with IL-6 (r = 0.596,P = 0.001) and TNF-α (r = 0.337, P = 0.001) and a negative correlation with nitric oxide (r=-4.16, P = 0.001). Oddsratio analysis revealed that patients with CML in the third quartile (264.43-364.31 ng/mL) were significantlyassociated with diabetic CAD at unadjusted and adjusted levels with covariates.

关键词： Coronary artery disease Diabetes Nε-carboxymethyl-lysine Inflammatory markers Interleukin-6 Tumor necrosis factor alpha Nitric oxide

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Co-positivity of anti-dengue virus and anti-Japanese encephalitis virus IgM in endemic area:co-infection or cross reactivity?

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 124-129页

作者： Kaleshwar Prasad singh Gitika Mishra Parul Jain Nidhi Pandey Rachna Nagar Shikha Gupta Shantanu Prakash Om Prakash Danish Nasar Khan Sakshi Shrivastav desh deepak singh Amita Jain Department of Microbiology K.G.Medical University

Objective:To report high co-positivity of anti-dengue virus(DV)and anti-Japanese encephalitis virus(JEV)IgM in an area endemic for both the viruses and to discuss the possibilities of ***:Serum samples from the patients who presented with fever,suspected central nervous system infection and thrombocytopenia,were tested for anti-DV IgM and antiJEV IgM *** reverse transcriptase polymerase chain reaction was done for detection of DV RNA and JEV ***:Of 1 410 patient sera tested for anti-DV and antiJEV antibodies,129(9.14%)were co-positive for *** co-positivity was observed only in those months when anli-JEV IgM positivily was *** of both anli-DV IgM and anti-JEV IgM were high in most of the co-positive *** these 129 co-positive cases,76 were lesled by conventional reverse Iranscriplase polymerase chain reaction for both flaviviruses,of which eight cases were co-positive for DV and ***:Co-infection with more than one fluvivirus species can occur in hyperendemic areas.

关键词： Co-infection Co-circulation Dengue virus IgM Japanese encephalitis virus Reverse transcriptase polymerase chain reaction

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Snow and regolith albedo variations using CRISM data at McMurdo crater,Mars

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Earth and Planetary Physics 2024年第2期8卷 338-355页

作者： Sehajpal singh deepak singh Centre of Studies in Resources Engineering Indian Institute of Technology BombayMumbaiIndia

The cryosphere component provides the most reliable and insightful indications of any planet’s climate *** data from the Compact Reconnaissance Imaging Spectrometer for Mars(CRISM),we develop a novel approach to determining the broadband Visible and Near Infrared(VNIR)albedo of the Martian *** study focuses on albedo changes in the McMurdo crater,part of Mars’s south polar layer *** compare seasonal and interannual variations of the McMurdo surface albedo before,during,and after the Global Dust Storm(GDS)of Martian Year(MY)*** the seasons progressed from spring to summer,the mean albedo in MY 32 and 34 plunged by over 40%,by about 35%in MY 33,and by slightly more than 30%in MY *** interannually,however,mean albedo values within both seasons(spring and summer)exhibited no significant differences in those same ***,interannual albedo difference maps reveal albedo variation of more than±0.3 in certain regions of the *** only snow-covered pixels,interannual albedo differences suggest that Mars dust had a pervasive impact on Mars’s *** in maximum and minimum albedo values as high as 0.5 were observed,depending upon differences in the dust levels in Martian snow/*** maximum and the minimum snow albedo values were lowest in MY 34,indicating the effect of the intense dust storm event that *** average snow albedo decreased from 0.45 in MY 32 to 0.40 in MY 33 and to 0.33 in MY 34,and then rose back to 0.40 in MY *** trajectory suggests a temporary deposition of dust,partially reversed after the GDS by self-cleaning mechanisms(local aeolian process and CO_(2)sublimation/deposition cycle).

关键词： Mars Martian ice albedo dust storm Mars surface Martian climate

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The Challenges of Diagnosis and Control of Enterotoxaemia Caused by <i>Clostridium perfringens</i>in Small Ruminants

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Advances in Microbiology 2020年第5期10卷 238-273页

作者： Rajveer singh Pawaiya Kumaresan Gururaj Neeraj Kumar Gangwar desh deepak singh Rahul Kumar Ashok Kumar Division of Animal Health ICAR-Central Institute for Research on Goats Mathura India Department of Veterinary Pathology College of Veterinary Science & Animal Husbandry DUVASU Mathura India Department of Veterinary Pathology College of Veterinary Science & Animal Husbandry NDAUT Kumarganj Faizabad India

Enterotoxaemia is one of the important pathologies caused by Clostridium perfringens, which produces intestinal and systemic disease in goats, sheep and other animals. These Gram-positive anaerobic bacteria are normally resident in the intestinal tract of ruminants but during favourable conditions, proliferate uncontrollably and release toxins which produce disease in the host. Different strains of C. perfringens are responsible for several clinical syndromes, including lamb dysentery, pulpy kidney disease and struck. However, the pathology and pathogenesis of caprine enterotoxaemia is not well understood, with limited studies available in goats. Caprine enterotoxaemia can be controlled with the better understanding of its risk factors and pathogenesis. The diagnosis of enterotoxaemia in animals is complex and often requires group of tests than one single test for better specificity and sensitivity. Tentative diagnosis of enterotoxaemia in sheep and goats is based on the history, clinical signs and gross lesions during post-mortem examination of animals;however, confirmatory diagnosis of enterotoxaemia requires different laboratory diagnostic tools. Toxin detection of C. perfringens in case of enterotoxaemia is furthermost accepted benchmark in establishing a definitive diagnosis of enterotoxaemia in intestinal contents. Measuring urine glucose or observing Gram-stained smears of intestinal mucosa can be used as supplementary tests. However, it is also imperative that enterotoxaemia cannot be ruled out in the event of negativity of aforementioned diagnostic tests. Hence, definitive diagnosis of enterotoxaemia in goats can be achieved with the use of molecular techniques (PCR, ELISA and immune-fluorescence) coupled with toxin detection in intestine or biological assays including mouse inoculation test (MIT). In case of goats, vaccine efficacy is poor which may be due to need of high to moderate level of serum antibodies to protect against both systemic and enteric ef

关键词： Clostridium perfringens Control Diagnosis Enterotoxaemia Goat Prevention Sheep Small Ruminants

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Analysis of the urethral stricture score and patient-related factors as predictors of outcomes following oral mucosal graft urethroplasty

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Asian Journal of Urology 2024年第3期11卷 473-479页

作者： Nikita Shrivastava Rahul Jena deepak Prakash Bhirud Mahendra singh Gautam Ram Choudhary Arjun singh Sandhu Department of Urology All India Institute of Medical SciencesJodhpurRajasthanIndia

Objective:The complexity of urethral strictures can predict outcomes following *** previously described urethral stricture score(U score)considered only stricture-related factors to grade the complexity of urethral strictures and to predict recurrence post urethroplasty,but not considered patient-related factors for the *** aimed to study the correlation of both of these factors to the outcomes of oral mucosal graft ***:We retrospectively reviewed data of 101 patients who underwent oral mucosal graft urethroplasty in our institute with a minimum follow-up of 6 *** patient characteristics and stricture-related parameters were *** U score was calculated for all patients which consisted of the length,location,number,and etiology of *** and multivariate Cox proportional hazard regression models were used to determine significant risk factors of ***:The mean follow-up of patients was 15 *** was seen in 28 patients and the mean time for detection of recurrence was 8 months of *** Charlson Comorbidity Index,history of previous intervention,length of strictures,location of strictures,number of strictures,history of smoking,and etiology were independent predictors of recurrence following *** on these parameters,we formulated the modified U score(MU score).The scores ranged from 0 to 6 and a score of>2 was found to be predictive of *** comparing receiver operating characteristic curves for both scores by the DeLong test,the MU score had larger area under the curve than the U ***:The MU scoring system is the first of its kind attempt taking into consideration both patient-and stricture-related factors to predict recurrence following oral mucosal graft urethroplasty.

关键词： Urethral stricture Urethral stricture score Recurrence Urethroplasty

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Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

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Oncology Research 2024年第5期32卷 877-897页

作者： KARAN WADHWA PAYAL CHAUHAN SHOBHIT KUMAR RAKESH PAHWA RAVINDER VERMA RAJAT GOYAL GOVIND singh ARCHANA SHARMA NEHA RAO deepak KAUSHIK Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical Sciences and Research University(DIPSAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

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Readmission rate and early complications in patients undergoing total knee arthroplasty:A retrospective study

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World Journal of Orthopedics 2024年第8期15卷 713-721页

作者： Tushar Jethi deepak Jain Rajnish Garg Harpal singh Selhi Department of Orthopedics Fortis Hospital LudhianaLudhiana 141123PunjabIndia Department of Orthopedics Dayanand Medical College&HospitalLudhiana 141001PunjabIndia Department of Orthopedic Surgery Dayanand Medical College&HospitalLudhiana 141001PunjabIndia

BACKGROUND Total knee arthroplasty(TKA)can improve pain,quality of life,and functional *** uncommon,postoperative complications are extremely consequential and thus must be carefully tracked and communicated to patients to assist their decision-making before *** of the risk factors for complications and readmissions after TKA,taking into account common causes,temporal trends,and risk variables that can be changed or left unmodified,will benefit this *** To assess readmission rates,early complications and their causes after TKA at 30 days and 90 days *** This was a prospective and retrospective study of 633 patients who underwent TKA at our hospital between January 1,2017,and February 28,*** the 633 patients,28 were not contactable,leaving 609 who met the inclusion *** inpatient and outpatient hospital records were retrieved,and observations were noted in the data collection *** Following TKA,the 30-day and 90-day readmission rates were determined to be 1.1%(n=7)and 1.8%(n=11),*** unplanned visit rate at 30 days following TKA was 2.6%(n=16)and at 90 days was 4.6%(n=28).At 90 days,the unplanned readmission rate was 1.4%(n=9).Reasons for readmissions included medical(27.2%,n=3)and surgical(72.7%,n=8).Unplanned readmissions and visits within 90 days of follow-up did not substantially differ by age group(P=0.922),body mass index(BMI)(P=0.633),unilateral vs bilateral TKA(P=0.696),or patient comorbidity status(30-day P=0.171 and 90-day P=0.813).Reoperation rates after TKA were 0.66%(n=4)at 30 days and 1.15%(n=8)at 90 *** average length of stay was 6.53 *** In this study,there was a low readmission rate following *** was no significant correlation between readmission rate and patient factors such as age,BMI,and co-morbidity status.

关键词： Total knee arthroplasty Length of stay Readmission Rates Causes Risk factors Prospective Retrospective Follow-up Reoperation

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Anesthetic consideration in Meigs syndrome with large pleural effusion and lung collapse

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Journal of Acute Disease 2024年第1期13卷 43-44,I0006,I0007页

作者： Shalendra singh deepak Mishra Deepu K Peter Munish Sood Department of Anaesthesiology and Critical Care Command Hospital(NC)UdhampurIndia Department of Anaesthesiology and Critical Care Command Hospital(SC)PuneIndia Department of Pulmonary Medicine Command Hospital(NC)UdhampurIndia Department of Orthopaedics INHSMumbaiIndia

Meigs syndrome(MS)is characterized by a benign ovarian tumor(fibroma),hydrothorax on the right side,and ascites;which can be resolved permanently after *** literature reveals that most MS surgeries were performed under general anesthesia(GA)[1].However,GA poses major risks to the *** the high risk of gastric content regurgitation,poor general condition or dyselectrolytemia may lead to delayed arousal,and associated multi-organ *** mechanical ventilation is also difficult due to ascites and hydrothorax(reduced cardiac output,impaired ventilation-perfusion in lungs causing hypoxia and hypercapnia)[1,2].In this letter,we report a case of MS tumor resection under the subarachnoid block(SAB)to mitigate these issues and also review the complications associated with both techniques.

关键词： anesthesia impaired ascites

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