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Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters

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World Journal of Gastroenterology 2007年第3期13卷 426-431页

作者： derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer Department of Pathology of Affiliated Hospital Faculty of Medicine Cukurova University Adana 01330 Turkey Department of Pathology of Affiliated Hospital Baskent University Adana Resarch and Practice Center Adana 01330 Turkey Department of Biostatistics of Affiliated Hospital Faculty of Medicine Cukurova University Adana 01330 Turkey Department of Surgery of Affiliated Hospital Faculty of Medicine Cukurova University Adana 01330 Turkey

AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time.

关键词： Gastrointestinal stromal tumor Cyclooxygenase-2 Proliferating cell nuclear antigen Ki-67 p53 Immunohistochemistw

Exploring multidimensional aspects of walkability:An innovative analysis approach in Besiktas,Istanbul

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Frontiers of Architectural Research 2023年第6期12卷 1097-1126页

作者： Ozge Ceylin Yıldırım AslıSungur derya Gülec Ozer Department of Architecture Yildiz Technical UniversityIstanbul 34349Turkey Department of Architecture Istanbul Technical UniversityIstanbul 34367Turkey

This study develops a holistic approach that underlines the effect of spatial,behavioral,and perceptional dimensions on walkability at the neighborhood *** study recognizes quantitatively measured tangible factors and qualitatively assessed intangible values to evaluate the level of walkability in Besiktas,Istanbul(Turkey).The research explores the independent and combined effects of physical characteristics,individual perceptions,and walking behavior on *** Information Systems urban analyses,space syntax analysis,and observation to establish an analytical framework for spatial and behavioral dimensions of walkability in Besiktas central district are used as a ***,perceptional data is gathered through an experimental approach,which involves participants walking along pre-determined routes using cartography techniques and employing“shared walks”as a mobile *** results of study confirmed previous findings from studies that the physical,social,and typological attributes of the built environment have a significant correlation between walking behavior and the physical and social aspects of the built *** study provides a comprehensive walkability assessment framework,encompassing quantitative and qualitative *** incorporating spatial,behavioral,and perceptual dimensions,this approach provides an efficient and integrated analytical methodology for evaluating walkability,distinguishing itself with its originality in the field of walkability research.

关键词： Walkability Mixed methods Space syntax Mobile methodologies Critical cartography

Adsorptive stripping voltammetric methods for determination of aripiprazole

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Journal of Pharmaceutical Analysis 2012年第3期2卷 193-199页

作者： derya Asangil brahim Hüdai Tasdemir Esma KIlI Ankara University Faculty of ScienceDepartment of Chemistry06100 AnkaraTurkey Amasya University Faculty of Arts and ScienceDepartment of Chemistry05100 AmasyaTurkey

Anodic behavior of aripiprazole(ARP) was studied using electrochemical *** transfer,diffusion and surface coverage coefcients of adsorbed molecules and the number of electrons transferred in electrode mechanisms were calculated for quasi-reversible and adsorp-tion-controlled electrochemical oxidation of ARP at 1.15 V versus Ag/AgCl at pH 4.0 in Britton-Robinson buffer(BR) on glassy carbon *** methods for direct determination of ARP in pharmaceutical dosage forms and biological samples were *** range is found as from 11.4 μM(5.11 mg/L) to 157 μM(70.41 mg/L) without stripping mode and it is found as from 0.221 μM(0.10 mg/L) to 13.6 μM(6.10 mg/L) with stripping *** of detection(LOD) was found to be 0.11 μM(0.05 mg/L) in stripping *** were successfully applied to assay the drug in tablets,human serum and human urine with good recoveries between 95.0% and 104.6% with relative standard deviation less than 10%.

关键词： Adsorptive stripping voltammetry Aripiprazole Electrochemical behavior Human serum and urine Pharmaceuticals

Total estimated effective doses from radiologic imaging modalities of children with cancer:a single center experience

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World Journal of Pediatrics 2017年第3期13卷 242-247页

作者： derya Ozyorük Suna Emir HacιAhmet Demir Gülsah Bayram Kabacam Bahattin Tunc Division of Pediatric Oncology Ankara Children's Hematology and Oncology Education and Research HospitalAnkaraTurkey Division of Radiology Ankara Children's Hematology and Oncology Education and Research HospitalAnkaraTurkey

Background:Recently,awareness of the cumulative radiation exposure for pediatric oncology patients has been increasing,together with increased survival rates and longer life *** aim of our study was to quantify the amount of ionising radiation from imaging modalities of pediatric oncology ***:Eighty-eight patients who were diagnosed with childhood cancer and followed up for 5 years between 2004-2014 in our center were included in the ***' medical files were reviewed retrospectively for imaging history in the first 5 years after *** estimated effective doses from radiologic imaging modalities were ***,the basic demographic data,histologic type,stage,and outcomes of disease were collected for all ***:The individual total estimated effective doses ranged from 8.73 to 167 mSv,with a median of 62.92 *** tomography was the greatest contributor of total effective *** doses ranged 21.45-113.20 mSv (median:62.92 mSv) in Hodgkin lymphoma,12.53-167.10 mSv (median:52 mSv) in non-Hodgkin lymphoma,4.13-172.98 mSv (median:52 mSv) in neuroblastoma,31-149.89 mSv (median:63.10 mSv) in Wilms' tumor,11.50-73.72 mSv (median:36.90 mSv) in germ cell tumor,26.46-125.86 mSv (median:80.90 mSv) in other solid tumor and 0.02-13.31 mSv (5.25 mSv) in brain tumor ***-two children (25%) died with progressive disease during the 5-year follow-up ***:Similar to previous studies,the total estimated effective doses in children with cancer have been found various according to diagnosis,stage and clinical *** clarify the harmfull effects of radiation burden,prospective studies should be conducted in children with cancer.

关键词： children effective dose ionizing radiation

Estimating Construction Material Indices with ARIMA and Optimized NARNETs

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Computers, Materials & Continua 2023年第1期74卷 113-129页

作者： Ümit Isıkdag Aycan Hepsag Sureyya Imre Bıyıklı deryaÖz Gebrail Bekdas Zong Woo Geem Department of Informatics Mimar Sinan Fine Arts UniversityIstanbulTurkey Econometrics Department Istanbul UniversityIstanbulTurkey MIS Department Istanbul Gelisim UniversityIstanbulTurkey Computing HND Prog. Nisantasi UniversityIstanbulTurkey Department of Civil Engineering Istanbul University-CerrahpasaIstanbulTurkey College of IT Convergence Gachon UniversitySeongnam13120Korea

Construction Industry operates relying on various key economic *** of these indicators is material *** the other hand,cost is a key concern in all operations of the construction *** the uncertain conditions,reliable cost forecasts become an important source of *** cost is one of the key components of the overall cost of *** addition,cost overrun is a common problem in the construction industry,where nine out of ten construction projects face cost *** order to carry out a successful cost management strategy and prevent cost overruns,it is very important to find reliable methods for the estimation of construction material *** prices have a time dependent *** order to increase the foreseeability of the costs of construction materials,this study focuses on estimation of construction material indices through time series *** different types of analysis are implemented for estimation of the future values of construction material *** first method implemented was Autoregressive Integrated Moving Average(ARIMA),which is known to be successful in estimation of time series having a linear *** second method implementedwas Non-LinearAutoregressive Neural Network(NARNET)which is known to be successful in modeling and estimating of series with non-linear *** results have shown that depending on the nature of the series,both these methods can successfully and accurately estimate the future values of the *** addition,we found out that Optimal NARNET architectures which provide better accuracy in estimation of the series can be identified/discovered as result of grid search on NARNET hyperparameters.

关键词： Construction material indices ARIMA non-linear autoregressive neural network NARNETs

Compulsory Migration From Syria to Gaziantep and Reviews About Residences

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Sociology Study 2018年第2期8卷 49-67页

作者： derya Bakbak University of Hasan Kalyoncu Turkey

As the staying duration of the refugees who come from Syria to Gaziantep prolonged,the need for residence together with the need for shelter came *** city,which received internal migration previously and which already had an intense squatting problem,increased its housing demand further with the fast migration of Syrian refugees to the city and unfortunately had to open up even the unhealthy,unused structures to be *** study aims to identify the lifestyle,family structure,economic condition,type of housing,and places that refugees use both in Syria and in Gaziantep in order to solve the housing problem more optimally,to compare and evaluate the condition and use of the cultural and social areas available around residences,and to shed light on the housing projects which will be built *** a result,the size of the residences which Syrians use *** new structures which will be preferred also by Syrians will be built,the green areas and social facilities of these structures should be *** apartment type structures are preferred more,more number of rooms and the separate design of the bathroom and WC should also be organized.

关键词： Syrian refugees comparing housing residence problems

Etiology of granulomatous inflammation:A retrospective study of 174 children in a tertiary care center

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 511-517页

作者： Ummühan Cay derya Alabaz ÖzlemÖzgür Gündeşlioğlu Aysun Hatice Uguz Hande Yanar Department of Pediatric Infectious Diseases Faculty of MedicineÇukurova UniversityAdanaTurkey Department of Pathology Faculty of MedicineÇukurova UniversityAdanaTurkey

Objective:To investigate granulomatous inflammation etiology based on clinical history and ancillary ***:Children aged<18 years with biopsy proven granulomatous lesions in any tissue specimens between January 2014 and January 2022 were included in the *** diagnosis was based on the results of immunohistochemical staining,molecular tests,culture,serology,radiological and other auxiliary laboratory *** were categorized into infectious and noninfectious ***:In total,174 patients with granulomatosis inflammation confirmed by histopathology were *** 59.2%patients were males,and the median age was 4.48(IQR 2.36-6.39)years(range:16 months-18 years).The tissues/organs that were most commonly biopsied were lymph node,bone,skin,and lung(51.1%,17.8%,9.2%,and 5.7%,respectively).Infectious and non-infectious causes were identified in 73.0%and 12.6%patients,respectively,in terms of granulomatosis inflammation etiology;however,no cause was identified in 14.4%*** most common infectious cause was tuberculosis(in 51.7%patients),followed by toxoplasmosis,aspergillosis,mucormycosis,leishmaniasis,and cat-scratch disease(in 8.6%,5.7%,1.7%,1.7%,and 1.1%patients,respectively).The common non-infectious cause was chronic granulomatous *** evaluation revealed granulomatosis inflammation in 33.3%patients,necrotizing granulomatosis inflammation in 30.5%patients,and caseating granulomatosis inflammation in 12.1%*** the pathology results of patients with and without tuberculosis were compared,the incidence of caseating granulomatosis inflammation(P=0.003)and necrotizing granulomatosis inflammation(P=0.005)was higher in patients with ***:Chronic granulomatous disease is the most common non-infectious cause in ***,primary or secondary immune deficiencies may cause granulomatosis inflammation,especially in pediatric patients.

关键词： Granulomatous Children Tuberculosis Chronic granulomatous disease

Pulmonary involvement in inflammatory bowel disease

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World Journal of Gastroenterology 2010年第39期16卷 4952-4957页

作者： Aydin Yilmaz Nilgün Yilmaz Demirci derya Hosgün Enver ner Yurdanur Erdogan Atila Gkek Atalay aglar Atatürk Chest Disease and Chest Surgery Training and Research Hospital Pulmonary Medicine Department of Pulmonary Medicine Agri Public Hospital Numune Education and Research Hospital Gastroenterology Atatürk Chest Disease and Chest Surgery Training and Research Hospital Pamukkale University Faculty of Economic and Administrative Sciences

AIM:To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease(IBD).METHODS:Thirty ulcerative colitis(UC)and nine Crohn's disease patients,and 20 control subjects were enrolled in this prospective *** clinical information was *** and activity of the bowel disease were established *** patient underwent pulmonary function tests and high-resolution computed tomography(HRCT).Blood samples for measurement of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),angiotensin converting enzyme and total IgE were delivered by the ***:Ten(25.6%)patients had respiratory symptoms.A pulmonary function abnormality was present in 22 of 39 *** all patients,the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s(FEV1),FEV1/forced vital capacity(FVC),forced expiratory flow(FEF)25%-75%,transfer coefficient for carbon monoxide(DLCO),DLCO/alveolar *** respiratory symptoms score was associated with high endoscopic activity index in UC *** and clinical activities in UC patients were correlated with FEV1,FEV1/FVC,and FEF 25%-75%.Smoking status,duration of disease and medication were not correlated with pulmonary physiological test results,HRCT abnormalities,clinical/endoscopic disease activity,CRP,ESR or total IgE level or body mass ***:It is important that respiratory manifestations are recognized and treated early in ***,they can lead to destructive and irreversible changes in the airway wall.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease High-resolution computed tomography Pulmonary function tests Lung diseases

A fully inkjet-printed disposable glucose sensor on paper

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npj Flexible Electronics 2018年第1期2卷 263-270页

作者： Eloïse Bihar Shofarul Wustoni Anna Maria Pappa Khaled N.Salama derya Baran Sahika Inal Division of Biological and Environmental Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955Saudi Arabia Division of Physical Science and Engineering KAUST Solar CenterKAUSTThuwal 23955Saudi Arabia Department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK Division of Computer Electrical and Mathematical Sciences and EngineeringAdvanced Membranes and Porous Materials CenterKAUSTThuwal 23955Saudi Arabia

Inexpensive and easy-to-use diagnostic tools for fast health screening are imperative,especially in the developing world,where portability and affordability are a *** monitoring of metabolite levels can provide useful information regarding key metabolic activities of the body and detect the concomitant irregularities such as in the case of diabetes,a worldwide chronic ***,the majority of daily glucose monitoring tools rely on piercing the skin to draw *** pain and discomfort associated with finger pricking have created a global need to develop non-invasive,portable glucose *** this work,we develop a disposable analytical device which can measure physiologically relevant glucose concentrations in human saliva based on enzymatic electrochemical *** use inkjet-printing technology for the rapid and low-cost deposition of all the components of this glucose sensor,from the electronics to the biorecognition elements,on commercially available paper *** only electronic component of the sensor is the conducting polymer poly(3,4 ethylenedioxythiophene)doped with polystyrene sulfonate(PEDOT:PSS),while the biorecognition element comprises of the enzyme glucose oxidase coupled with an electron *** demonstrate that one month after its fabrication and storage in air-free environment,the sensor maintains its function with only minor performance *** fully printed,all-polymer biosensor with its ease of fabrication,accuracy,sensitivity and compatibility with easy-to-obtain biofluids such as saliva aids in the development of next generation low-cost,noninvasive,eco-friendly,and disposable diagnostic tools.

关键词： maintain sensor printing