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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao yao feng lai yangfan Liang Chuanchuan Liu yujia Lu Sijia Tian yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory.for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory.for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dy.function,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by.facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dy.function exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis flos and Rosae Rugosae flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-lai Zhan Guang-Lu Chang yan Gao Xia Li Wen-yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory.for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis flos(yueji)and Rosae Rugosae flos(Meigui).Methods:In this study,40 batches of samples including Meigui and yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期 350-359页

作者： Can Zhu yiyang Wang Lei Meng Beibei Qiu Jing Li Shucheng Qin Ke Hu Xin Jiang Wenbin lai Minchao Liu Zhe Liu Chenxing Lu Jinyuan Zhang yongfang Li Beijing National Laboratory.for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on fAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

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Nano-phase transformation of composite precipitates in multicomponent Al-Mg-Si(-Sc)alloys

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Journal of Materials Science & Technology 2022年第15期110卷 216-226页

作者： S.B.Wang C.f.Pan B.Wei X.Zheng y.X.lai J.H.Chen Key Laboratory of LCR Materials and Devices of yunnan Province National Center for International Research on Photoelectric and Energy MaterialsSchool of Materials and EnergyYunnan UniversityKunming 650091China Collaborative Innovation Center of Renewable Energy Materials and Department of Physics Guangxi UniversityNanning 530004China Center for High-Resolution Electron Microscopy College of Materials Science and EngineeringHunan UniversityChangsha 410082China

Sc-addition can significantly enhance the performance of the micro-alloyed Al-Mg-Si-Sc ***,the mechanisms by which the Sc element modifies the microstructure of the alloys are still unknown in many ***,using atomic-scale transmission electron microscopy and atomic-resolution spectroscopy,we have revealed the microstructural differences between two age-hardened Al-0.5Mg-0.4Si(wt.%)alloys with and without *** first significant effect of Sc-addition on the precipitation microstructure of the Al-Mg-Si-Sc alloy is that Sc-atoms may distribute at theβ"-precipitate/Al-matrix interface and therefore accelerate aging kinetics at the initial stage of *** second significant effect of Sc-addition is that in the transition from theβ"-hardened peak-age stage to theβ′-hardened late stage,Sc-atoms can greatly improve the stability of transitionalβ"/B'/β′composite precipitates by entering the B'-substructures and/or locating at the precipitate/Al *** such Sc-atoms effectively suppressβ"toβ'transformation and cross-sectional coarsening of bothβ"and composite precipitates,leading to much finer precipitate needles with smaller diameter but much larger length,as compared with those precipitate needles formed in the alloy without ***,the alloy with Sc-addition exhibits a much better thermal stability than that without Sc.

关键词： Al alloy Strengthening mechanism Phase transition Transmission electron microscopy

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Is PAWP the ＂real＂ sperm factor？

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Asian Journal of Andrology 2015年第3期17卷 444-446页

作者： Michail Nomikos Karl Swann f Anthony lai Institute of Molecular and Experimental Medicine School of Medicine Cardiff University Cardiff UK

Mammalian embryo development is initiated by intracellular Ca2＋ oscillations that result in oocyte activation following gamete membrane fusion. It is widely believed that oocyte Ca2＋ oscillations are triggered by a sperm-specific protein, phospholipase C-zeta （PLCζ） that activates InsP3 production leading to repetitive Ca2. release from intracellular stores. However, a recent report in the fASEB Journal by Aarabi et al. challenges this view by proposing postacrosomal WW domain-binding protein （PAWP） as another sperm-derived protein that can also initiate Ca2＋ oscillations and zygotic development at fertilization. Here we discuss these new findings and examine the evidence suggesting PAWP as the ＂real＂ sperm factor.

关键词： @@

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组织工程技术修复颞下颌关节:问题与挑战

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中国组织工程研究 2025年第22期29卷 4804-4812页

作者：赖鹏宇梁冉沈山暨南大学口腔医学院广东省广州市510632

背景:颞下颌关节疾病的传统疗法受限于疾病严重程度和个体差异。相比之下,组织工程作为一种新兴治疗方法,可以根据患者具体情况定制个性化治疗方案,减少手术过程中的不确定性,提高治疗效果。目的:综述组织工程修复颞下颌关节的最新研究... 详细信息

背景:颞下颌关节疾病的传统疗法受限于疾病严重程度和个体差异。相比之下,组织工程作为一种新兴治疗方法,可以根据患者具体情况定制个性化治疗方案,减少手术过程中的不确定性,提高治疗效果。目的:综述组织工程修复颞下颌关节的最新研究成果和进展。方法:以“颞下颌关节,组织工程,种子细胞,支架,生长因子,动物模型”为中文检索词,以“temporomandibular joint,tissue engineering,seed cell,scaffold,growth factor,animal model”为英文检索词,分别在PubMed数据库和中国知网进行文献检索,检索时限为各数据库建库时间至2024年3月。通过分析和阅读文献进行筛选,按照排除筛选标准纳入文献,最终纳入57篇文献进行综述。结果与结论:(1)随着生物学、材料学与工程学等技术的发展,颞下颌关节组织工程己取得较大进展,例如种子细胞的筛选、新型支架的开发、生长因子作用机制的探索、多种动物模型的构建等,目前大多数研究尚处于体外实验阶段,动物实验等体内研究尚未大规模开展,组织工程修复颞下颌关节的临床应用还需更多证据支持。(2)尽管颞下颌关节组织工程研究仍存在许多问题和挑战等待解决,依然展现出广阔的临床应用前景,有望在将来成为颞下颌关节疾病出色高效的治疗方式。

关键词：组织工程颞下颌关节软骨缺损种子细胞支架水凝胶脱细胞外基质生长因子外泌体动物模型

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Development of Soda Residue Concrete Expansion Agent

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Journal of Wuhan University of Technology(Materials Science) 2003年第3期18卷 79-82页

作者：王宝民 M f Mohd Zain f C lai Department of Civil Engineering Dalian University of Technology faculty of Engineering U.K.M (Malaysia)

A new type of concrete expansion agent has been successfully developed for the first time in the world by utilizing an industrial waste residue soda residue and an industrial *** 3%-6% of the agent into Portland cement enables a shrinkage compensating concrete to be *** and concrete containing this expansion agent have better shrinkage compensating and mechanical *** raw materials component,production process,technical properties,micro analysis of mortar made with this expansion agent,mechanism of expansion and research results are described in this *** experimental results show that the new type of concrete expansion agent accords with the standard and its main mineral component is xCaO ySO 3 zAl 2O 3.

关键词： industrial waste soda residue concrete expansion agent expansive concrete shrinkage compensating concrete

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INfLUENCE Of THE NONMAGNETIC METAL SPACER ON THE MAGNETIC PROPERTIES AND MICROSTRUCTURE Of THE MULTILAyER fILMS

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Acta Metallurgica Sinica(English Letters) 2006年第4期19卷 235-243页

作者： M.H. Li G.H. yu f.W. Zhu H.W. Jiang W.y. lai College of Mechanical Engineering South China University of Technology Guangzhou 510640 China Department of Materials Physics University of Science and Technology Beijing Beijing 100083 China Department of Physics Capital Normal University Beijing 100037 China Institute of Physics Chinese Academy of Sciences Beijing 100080 China

Ta / Nife/Bi （ Ag, Cu ）/feMn/Ta and Ta / Nife1/feMn / Bi （ Ag, Cu ）/Nifen/Ta films were prepared by magnetic sputtering. The texture and the dependences of the exchange-coupling field on the thickness of Bi, Ag, and Cu in Ta/Nife/Bi（Ag, Cu） /feMn/Ta and Ta/Nife/feMn/Bi（Ag, Cu）/Nife/Ta films were studied. XPS results indicate that the Bi atoms migrated into the feMn layer during the deposition process and a feMnBi alloy was probably.formed or the Bi atoms existed as an impurity in the feMn layer in Ta/Nife/Bi（Ag, Cu ）/feMn/Ta. Otherwise, in Ta/Nife/feMn/Bi （Ag, Cu）/Nife/Ta films, Bi, Ag, and Cu atoms do not remain entirely at the interface of the feMn/ NifeⅡfilm, but at least partly segregate to the surface of the Nife film.

关键词： Nife/feMn nonmagnetic spacer exchange coupling XPS (X-ray photoelectron spectroscopy)

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EffECT Of Cu-Ni CONTENT ON THE CORROSION RESISTANCE Of(Cu-Ni)/(10NiO-90Nife_2O_4)CERMET INERT ANODE fOR ALUMINUM ELECTROLySIS

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Acta Metallurgica Sinica(English Letters) 2008年第1期21卷 72-78页

作者： Z.L. Tian y.Q. lai J. Li y.X. Liu School of Metallurgical Science and Engineering Central South University Changsha 410083 China

（Cu-Ni）/（10NiO-90Nife204） cermet inert anodes containing metal Cu-Ni0, 5, 10, 15 and 20 wt pct were prepared and their corrosion resistance to Na3Alf6-Al2O3 melts was investigated. The results indicate that the content of metal Cu-Ni has little effect on the steady-state concentration of Ni in the electrolyte and the values could not be used to effectively differentiate their corrosion resistance. The steady-state concentration of fe decreases from 304×10^-6 to 168×10^-6 and that of Cu increases from 21×10^-6 to 71×10^-6 with the content of metal Cu-Ni increasing from 0 to 20 wt pct. Post-examination shows that metallic phase Cu-Ni is corroded preferentially during electrolysis and many pores are left at the anode surface. Considering the corrosion resistance and electrical conductivity, the cermet containing metal Cu-Ni 5 wt pct should be selected and studied further.

关键词： Aluminum electrolysis Inert anode Nife2O4 based cermet Corrosion resistance

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COUPLED SIMULATION Of 3D ELECTRO-MAGNETO-fLOW fIELD IN HALL-HEROULT CELLS USING fINITE ELEMENT METHOD

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Acta Metallurgica Sinica(English Letters) 2006年第2期19卷 105-116页

作者： J. Li W. Liu y.Q. lai Q.y. Li y.X. Liu School of Metallurgy Science and Engineering Central South University Changsha 410083 China Chemistry Department Guangxi Normal University Guilin 531400 China

Two full 3D steady mathematical models are developed by.finite element method （fEM） to calcalate coupled physics fields. the electro-magnetic model is built and solved first and so is the fluid motion model with the acquired electromagnetic force as source body.forces in Navier-Stokes equations. Effects caused by the ferromagnetic shell, busbar system around, and open boundary problem as well as inside induced current were considered in terms of the magnetic field. furthermore, a new modeling method is found to set up solid models and then mesh them entirely with so-called structuralized grids, namely hex-mesh. Examples of 75kA prebaked cell with two kinds of busbar arrangements are presented. Results agree with those disclosed in the literature and confirm that the coupled simulation is valid. It is also concluded that the usage of these models facilitates the consistent analysis of the electric field to magnetic field and then flow motion to the greater extent, local distributions of current density and magnetic flux density are very much dependent on the cell structure, the steel shell is a shield to reduce the magnetic field and flow pattern is two dimensional in the main body of the metal pad.

关键词： coupled simulation electromagnetic field flow field aluminum reduction cell finite element analysis

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