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Effect of routine iron supplementation on copper level and oxidative stress status in pregnant women

Asian pacific Journal of Reproduction 2020年第2期9卷 64-69页

作者： derouiche samir Doudi Dalal Atia Noura Department of Cellular and Molecular Biology Faculty of the Sciences of Nature and LifeEl Oued UniversityEl Oued 39000El OuedAlgeria Laboratory of Biodiversity and Application of Biotechnology in the Agricultural Field Faculty of the Sciences of Nature and LifeUniversity of El OuedEl-Oued 39000Algeria

Objective:To determine the effects of routine iron supplementation on oxidative stress markers in pregnant ***:This study enrolled 122 pregnant women aged between 20-38 years throughout three stages of pregnancy:beginning with pregnancy,until the twentieth week and up to the thirtieth *** were divided into two groups:61 pregnant women not supplemented with iron(the control group),and 61 pregnant women supplemented with iron(the iron group).Blood samples were collected and protein,iron,uric acid,total bilirubin level and oxidative stress status were estimated using molecular spectrophotometric *** levels were estimated by using atomic absorption spectroscopy ***:Iron,protein and copper concentrations were significantly increased(P<0.05)at 20 and 30 weeks of pregnancy and hemoglobin level was significantly increased(P<0.05)at the beginning of pregnancy and until 20 weeks in the iron group compared to the control *** addition,levels of serum uric acid,serum total bilirubin and malondialdehyde in serum and erythrocytes were significantly increased at 20 and 30 weeks of pregnancy whereas the reduced glutathione level was significantly decreased in serum(30 weeks of pregnancy)and erythrocytes(20 and 30 weeks of pregnancy)in the iron group as compared to the control *** oxygen radical absorbance capacity was not significantly *** was a significant positive correlation between serum iron level and serum copper,malondialdehyde level in serum and erythrocytes in pregnant women supplemented with ***:Iron supplement at 20 and 30 weeks of pregnancy plays a role in the development of oxidative stress which is the origin of several maternal-fetal complications.

关键词： Pregnancy Iron Copper Oxidative stress Women

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Protective effects of Aristolochia longa and Aquilaria malaccensis against lead induced acute liver injury in rats

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Journal of Acute Disease 2017年第5期6卷 193-197页

作者： derouiche samir Zeghib Khaoula Gharbi Safa Khelef Yahia Feriani Anouar Department of Cellular and Molecular Biology Faculty of natural science and lifeUniversity of Echahid Hamma Lakhdar-ElouedEl-oued39000El-ouedAlgeria Laboratory of Animal Ecophysiology Faculty of Science of Sfax3018SfaxTunisia

Objective: To investigate the protective effects of Aristolochia longa (A. longa) and Aquilaria malaccensis (A. malaccensis) on acute hepatotoxicity induced by lead in female albino rats. Methods: Twenty five (25) apparently healthy female Wistar rats were randomly divided into five groups of five rats in each: control, Pb, Pb + A. longa (Ar), Pb+ A. malaccensis (Aq), and Pb+ A. longa (Ar) + A. malaccensis (Aq) lead (100 mg/kg b.w.) as Pb (C2H3O2)2 added in their drinking water for 75 days. A. longa (rhizome powder at a dose of 10 g/kg of diet ) and A. malaccensis (heartwood powder at a dose 10 g/kg of diet) were added to the feed during the last 15 days of lead exposed in the animals. Results: Obtained results revealed that lead treatment caused a significant increase in serum GOT, GPT and ALP activities and in liver of MDA level and CAT activity. In contrast, it led to an decrease in the liver GOT, GPT and GST activities and in GSH level in rats. Also, the results clearly showed that lead causes alterations of hepatic tissue in comparison with controls. Our results showed that treatment with A. malaccensis and A. longa a partial correction of the previous parameters. The histological observations confirmed the hepatoprotection results by the biochemical parameters. Conclusions: Results demonstrated beneficial effects of A. longa and A. malaccensis treatment in Pb-induced oxidative stress and tissue damage in liver.

关键词： Aristolochia longa Aquilaria malaccensis Acute hepatotoxicity Acetate lead Stress oxidative

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Triazinone herbicide metribuzin induced acute liver injury: A study of animal model

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Journal of Acute Disease 2018年第4期7卷 152-157页

作者： derouiche samir Rezzag mohcen Om Selma Serouti Asma Department of Cellular and Molecular Biology Faculty of Natural Sciences and LifeEl Oued UniversityEl-Oued 39000El-OuedAlgeria

Objective: To evaluate the acute toxicity effect of metribuzin at low dose on liver of mother rabbits and its ***: Pregnant female rabbitsOryctolagus cuniculus were divided into three groups (n=5). The first group of non-treated pregnancy rabbits served as control;the second group of pregnancy rabbits were treated with 1/100 LD50 of metribuzin and the third group of pregnancy rabbits were treated with 1/50 LD50 of metribuzin. Metribuzin was added in their drinking water for 60 d before and during pregnancy. Levels of liver malondialdehyde, liver glutathione S transferase, serum glutamic oxaloacetic transaminase and serum glutamic-pyruvic transaminase were determined. Liver reduced glutathione level was also determined by a colorimetric method. And hepatic homogenate was analyzed by HPLC analysis to determine the existence of traces of ***: Results revealed a significant increase in level of liver malondialdehyde, glutathione S transferase, serum glutamic oxalacetic transaminase and serum glutamic-pyruvic transaminase activities in mother and fetuses rabbits of both metribuzin treatment groups as compared to the control group. However the level of reduced glutathione was decreased in mother and fetuses rabbits of both groups treated with metribuzin compared to control group. Also, the results obtained by HPLC technique showed the presence of trace metribuzin in liver cells of mothers and fetuses rabbits of the both metribuzin treated ***: In conclusion, this study shows that exposure to metribuzin at low concentrations causes a acute toxicity in liver of mother rabbits and its fetus, also the trace of the metribuzin detected in the liver is the origin of possible malformation of the fetuses or abortion of the rabbits.

关键词： Metribuzin Liver Fetus Acute toxicity Rabbits

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