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Adeno-associated virus as a delivery vector for gene therapy of human diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1808-1840页

作者： Jiang-Hui Wang Dominic J.Gessler Wei Zhan Thomas l.Gallagher Guangping Gao Horae Gene Therapy Center University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Microbiology and Physiological Systems University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVIC3002Australia Department of Neurological Surgery University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Neurosurgery University of MinnesotaMinneapolisMN55455USA Department of Medicine University of Massachusetts Chan Medical SchoolWorcesterMA01605USA li Weibo Institute for Rare Diseases Research University of Massachusetts Chan Medical SchoolWorcesterMA01605USA

Adeno-associated virus(AAV)has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different *** AAV(rAAV)has been engineered for enhanced specificity and developed as a tool for treating various ***,as rAAV is being more widely used as a therapy,the increased demand has created challenges for the existing manufacturing *** rAAV-based gene therapy products have received regulatory approval,but there continue to be concerns about safely using high-dose viral therapies in humans,including immune responses and adverse effects such as genotoxicity,hepatotoxicity,thrombotic microangiopathy,and *** this review,we explore AAV biology with an emphasis on current vector engineering strategies and manufacturing *** discuss how rAAVs are being employed in ongoing clinical trials for ocular,neurological,metabolic,hematological,neuromuscular,and cardiovascular diseases as well as *** outline immune responses triggered by rAAV,address associated side effects,and discuss strategies to mitigate these *** hope that discussing recent advancements and current challenges in the field will be a helpful guide for researchers and clinicians navigating the ever-evolving landscape of rAAV-based gene therapy.

关键词： diseases specificity approval

WC对316 l钢表面的镍基激光熔覆涂层的性能影响研究

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激光技术 2024年第5期48卷 677-683页

作者：吴敬权李德荣安芬菊黄江王有明吴香林广东海洋大学机械工程学院湛江524088 广东省海洋设备及制造工程技术研究中心湛江524088 广东海洋大学电子与信息工程学院湛江524088

为了提升316l不锈钢的耐腐蚀性能,延长其在海洋环境中的使用寿命,讨论了激光熔覆技术在316l基材表面熔覆了纯Ni60涂层和WC+Ni60复合涂层的方法和效果。WC+Ni60复合涂层结合了WC颗粒的硬度和Ni60基体的韧性,具有更优异的综合性能,适用于... 详细信息

为了提升316l不锈钢的耐腐蚀性能,延长其在海洋环境中的使用寿命,讨论了激光熔覆技术在316l基材表面熔覆了纯Ni60涂层和WC+Ni60复合涂层的方法和效果。WC+Ni60复合涂层结合了WC颗粒的硬度和Ni60基体的韧性,具有更优异的综合性能,适用于对基材表面进行更高强度的保护。分别利用硬度仪、X射线衍射仪和电化学工作站对涂层检索和测试。结果表明,WC+Ni60复合涂层的平均截面硬度为719 HV,但各区域波动较大,同时熔覆层表面相较纯Ni60涂层更耐腐蚀,自腐蚀电位提高了0.12 V,自腐蚀电流密度降低了2.49×10^(-6)A/cm^(2)。本研究为后期制备耐海水腐蚀复合涂层提供了参考。

关键词：激光技术激光熔覆微观组织硬度耐腐蚀性

β-环糊精/茶多酚包合物制备及其对涤纶织物的抗菌消臭性能

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东华大学学报（自然科学版） 2024年第3期50卷 61-68页

作者：朱梦程高思梦袁如超孙德荣王学利东华大学纺织学院上海201620 东华大学纺织科技创新中心上海201620 江苏斯尔克集团股份有限公司江苏徐州221437

以具有空腔结构的β-环糊精(β-CD)为主体、天然抗菌剂茶多酚(TP)为客体,通过共沉淀法制备β-CD/TP包合物。利用红外光谱、广角X射线衍射仪、扫描电镜及差示扫描量热仪等对包合物的化学结构、相态结构、形态结构和热性能进行系统研究。... 详细信息

以具有空腔结构的β-环糊精(β-CD)为主体、天然抗菌剂茶多酚(TP)为客体,通过共沉淀法制备β-CD/TP包合物。利用红外光谱、广角X射线衍射仪、扫描电镜及差示扫描量热仪等对包合物的化学结构、相态结构、形态结构和热性能进行系统研究。通过单因素法研究包合比例、包合时间和溶液静置时间对TP包合率、产率及负载率的影响,结果表明:当β-CD与TP的包合比例为1∶1、包合时间为15 h、溶液静置时间为24 h时,包覆效果最优,包合物的产率为76.2%、包合率为29.2%、负载率为7.7%。通过化学接枝法制得具有良好抗菌消臭性能的β-CD/TP包合物/涤纶织物,当β-CD/TP包合物占织物质量的5%时,该织物对金黄色葡萄球菌和大肠埃希菌的抑菌率分别达94.5%和92.6%,对氨气的消除率均可达99.9%。

关键词： β-环糊精茶多酚包合物涤纶织物抗菌除臭性能

Protection of steel hooks embedded in glass-fiber-reinforced concrete against macrocell corrosion

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Petrol.um Research 2024年第2期9卷 317-326页

作者： Husnu Gerengi Muhammed Maraşlı Marziya Rizvi Beni Kohen Ismail Taşkıran Corrosion Research laboratory Department of Mechanical EngineeringDuzce University81620DuzceTurkey Department of Engineering and Applied Sciences University of BergamoBGItaly Fibrobeton Company R&D Center DuzceTurkey Department of Chemistry Babasaheb Bhimrao Ambedkar UniversityLucknow226003U.PIndia

This study evaluated the corrosion behavior of steel hooks embedded in GFRC,which were protected by a zinc-rich(96%Zn)galvanizing *** coating provided the hooks with active cathodic protection and a passive physical *** corrosion may form when the anode is smaller than the total steel ***,the steel hooks at the embedment juncture were additionally sealed against water ingress and air exchange using a construction *** study was conducted in three phases in a salt-spray ***,the electrogalvanized steel hooks embedded in GFRC were allowed to freely corrode for 7 *** the second phase,the electrogalvanized steel hooks were painted with the zinc-rich coating and observed over 7 *** the third phase,the steel hooks were protected by the zinc-rich coating together with a primer and construction sealant,and observed over 7 *** evaluate the electrogalvanized hooks and the corrosion products formed,the thickness of the material was *** on the metal surface was inferred by studying the surface morphology of the hooks at various points of contact and after different periods of time.

关键词： Steel rebars Concrete corrosion GFRC Galvanization Sealant

Radiation Spectral Analysis of 3D Dust Molecular Clusters(PAHs)and Peptoids under Ionization and Electric Field in ISM

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Research in Astronomy and Astrophysics 2024年第1期24卷 70-77页

作者： Ruiqing Wu Chunhua Zhu Guoliang lü Xiaojiao Zhang Xizhen lu Jinlong Yu Wujin Chen Mengqiu long School of Physics and Electronics Central South UniversityChangsha 410083China School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China School of Microelectronics and Physics Hunan University of Technology and BusinessChangsha 410205China College of Mechanical and Electronic Engineering Tarim UniversityAlar 843300China School of Medicine Xinjiang Medical UniversityUrumqi 830011China

Polycyclic aromatic hydrocarbons(PAHs),PANHs,and peptoids dust spectral cal.ulations from the interstellar medium(ISM)are important for dust observations and *** goal is to cal.ulate the radiation spectrum of spherical PAHs dust clusters in a vacuum containing ionized and applied in the presence of an electric *** propose a new simple computational model to cal.ulate the size of three-dimensional spherical dust clusters formed by different initial dust *** the Vienna Ab-initio Simulation Package code,the density functional theory with the generalized approximation was used to cal.ulate the electron density gradient and obtain the radiation spectrum of *** the radius of spherical dust clusters is~[0.009-0.042]μm,the dust radiation spectrum agrees well with the Z=0.02 mMMP stellar spectra,and the PAHs radiation spectrum of NGC 4676 at wavelengths of(0-5]μm and(5-10]μm,*** the ionized state,the N-PAH,C_(10)H_(9)N,2(C_(4)H_(4))^(1+),and peptoids 4(CHON),(C_(8)H_(10)N_(2)O_(5))^(1+)dust clusters at 3.3μm,while the 2(C_(22)H_(21)N_(3)O_(2))^(1+),4(CHON)dust clusters at 5.2μm have obvious *** is a characteristic of part of PAHs and peptoids clusters radiation at the nearinfrared wavelength of 2μ***,especially after applying an electric field to the dust,the emission spectrum of the dust increases significantly in the radiation wavelength range[3-10]μ***,the dust clusters of PAHs,PANHs,and peptoids of the radius size~[0.009-0.042]μm are likely to exist in the ISM.

关键词： ISM:structure ISM:molecules radiation mechanisms:general (ISM:)dust extinction

Pumping-induced Well Hydraulics and Groundwater Budget in a leaky Aquifer System with Vertical Heterogeneity in Aquitard Hydraulic Properties

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 477-490页

作者： ZHuANG Chao lÜChenyang YAN long lI Yabing ZHOu Zhifang WANG Jinguo DOu Zhi Walter A.IllMAN School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTU.K. Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027China Department of Earth and Environmental Sciences University of WaterlooOntario N2L 3G1Canada

In groundwater hydrology,aquitard heterogeneity is often less considered compared to aquifers,despite its significant impact on groundwater hydraulics and groundwater resources evaluation.A semi-analytical solution is derived for pumping-induced well hydraulics and groundwater budget with consideration of vertical heterogeneity in aquitard hydraulic conductivity(K)and specific storage(S_(s)).The proposed new solution is innovative in its partitioning of the aquitard into multiple homogeneous sub-layers to enable consideration of various forms of vertically heterogeneous K or S_(s).Two scenarios of analytical investigations are explored:one is the presence of aquitard interlayers with distinct K or S_(s) values,a common field-scale occurrence;another is an exponentially depth-decaying aquitard S_(s),a regional-scale phenomenon supported by statistical *** investigations reveal that a low-K interlayer can significantly increase aquifer drawdown and enhance aquifer/aquitard depletion;a high-S_(s) interlayer can noticeably reduce aquifer drawdown and increase aquitard *** of low-K or high-S_(s) interlayers also significantly impact well hydraulics and groundwater *** the context of an exponentially depth-decaying aquitard S_(s),a larger decay exponent can enhance aquifer *** using current models with a vertically homogeneous aquitard,half the sum of the geometric and harmonic means of exponentially depth-decaying aquitard S_(s) should be used to cal.ulate aquitard depletion and unconfined aquifer leakage.

关键词： hydrogeology aquitard vertical heterogeneity semi-analytical solution well hydraulics groundwater budget

Wear of semi-solid rheocast SiC_p/Al metal matrix composites

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中国有色金属学会会刊：英文版 2010年第S3期20卷 852-856页

作者： u.A.CuRlE l.IVANCHEV Materials Science and Manufacturing Council for Scientific and Industrial Research(South Africa)

Rheocasting of plates in Al alloy 359 reinforced with SiC at 11%,27% and 50%(volume fractions) exhibits the capability of the council for scientific and industrial research-rheocasting system(CSIR-RCS) in rheo-processing and high pressure die casting of SiC metal matrix *** metal matrix consisting of nearly spherical proeutectic α(Al) globules was *** of fibrous eutectic silicon took place upon heat treatment of the as-cast metal matrix composites(MMCs).Hardness increases as the volume fractions of SiC *** rates of the MMCs in the F and T6 heat treatment conditions were assessed with a metallographic preparation *** is found that the 11% SiC MMC wear rate is higher on SiC abrasives compared with the 50% SiC MMC wear rate due to wear of the aluminum *** trend is reversed on diamond abrasives due to pull-out of the irregular shaped composite *** 50% SiC MMC suffers from composite particle fracture porosity after high pressure die casting(HPDC).

关键词： CSIR-RCS HPDC SiC F condition T6 condition wear rate hardness porosity

On the detection of closed orbits in time-dependent systems by using double-pulse lasers

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Communications in Theoretical Physics 2020年第9期72卷 111-117页

作者： S u Khan M l Du Institute of Theoretical Physics Chinese Academy of Sciences.Beijing 100190China university of Chinese Academy of Sciences Beijing100049China

In the photodetachment of atoms or negative ions by a double-pulse laser, the first pulse of the double-pulse laser generates waves and the delayed second pulse may detect them. The phenomenon of the excitation and detection of waves by a double-pulse laser can be used to identify the closed orbits in the system. We demonstrate this phenomenon with a negative hydrogen ion(H^-) by analyzing the total population excited by a double-pulse laser in a timedependent field for different physical parameters. By analyzing the total excited population using a double-pulse laser, we can uncover all the closed orbits existing in the system. We demonstrate that this can be realized by scanning the first pulse position and the time delay between the two pulses.

关键词： double-pulse laser detection of closed orbits photodetachment spectra time-dependent systems

Surface Water Quality Profiling using Physicochemical Parameters in Open Defecation Free and Non-Open Defecation Free local Government Areas in Benue State, Nigeria

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Open Journal of Modern Hydrology 2024年第3期14卷 174-191页

作者： Moses T. Asoo Celestine u. Aguoru Innocent O. Ogbonna Hyacinth O.A. Oluma Benue State Ministry of Health Makurdi Nigeria Department of Plant Science and Biotechnology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria Department of Microbiology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria

Physicochemical parameters of surface water sources in the study of local government areas (lGAs) were assessed using standard procedures. The mean physicochemical parameters for pH (5.49), NO2 (0.23 mg/l), SO4 (0.77 mg/l), Na (28.72 mg/l), Ca (28.94 mg/l), Mg (17.50 mg/l), Cl (11.65 mg/l), TSS (6.27 mg/l), TDS (104.23 mg/l), BOD (2.83 mg/l) and F (0.87 mg/l) were below WHO standards irrespective of their defecation status. The values for electrical conductivity (EC) (2770.50 µs/cm, turbidity (481.24 NTu), dissolved oxygen (DO) (5.32 mg/l), chemical oxygen demand (COD) (445.50 mg/l), K (125.06 mg/l), PO4 (0.78 mg/l) and Fe (0.57 mg/l) were above the WHO limits for safe water. Higher EC and COD values obtained in the study is evidence of pol.ution of the water sources by organic matter.

关键词： Open Defecation Surface Water Water Quality Standard Physicochemical Parameters