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Measurement of Metabolic and Inflammatory serum Markers and Immune Marker Gene Expression during superovulation in Beef Cattle

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Open journal of Animal sciences 2021年第2期11卷 175-196页

作者： Alexandria P. snider derek j. McLean Alfred R. Menino 112 Withycombe Hall Department of Animal and Rangeland Sciences Oregon State University Corvallis USA UsDA ARS U.S. Meat Animal Research Center Livestock Biosystems Unit Clay Center NE USA Eunice Kennedy shriver National Institute of Child Health and Human Development Bethesda MD USA

Health status of donor cows during superovulation is important to ensure optimal embryo quality at time of collection. Because nutritional and metabolic status impact embryo quality some form of nutritional supplementation is often provided before and during superovulation. OmniGen-AF® (OG) feeding has been shown to assist in the maintenance of animal health through regulation of metabolic status and balance and supporting aspects of immune function. We observed feeding donor cows OG decreased percent degenerate embryos recovered following superovulation increased serum progesterone concentration and improved in vitro embryo development. Evaluation of OG feeding on markers of metabolic function and inflammatory and immune function in beef cattle embryo donors are reported here. similarly, cow metabolic and inflammatory response with repeated superovulation protocols is not known. Biomarkers to monitor and evaluate cow health during superovulation may provide management options to improve embryo recovery and quality. Twenty-four Angus cross-bred cattle were randomly assigned to four treatment groups, fed 0 or 56 g/hd/day for 49 days and superovulated with 200 or 400 mg Folltropin V (FsH). Blood was collected weekly for analyses. The protocol was repeated on all cows 90span> - 120 d later with cows reassigned to their original groups. No differences (P > 0.10) were observed due to OG feeding or FSH dose on metabolic and inflammatory markers. Replicate exerted a significant effect where serum concentration of albumin, IL1β, IL6, PGEsub>2sub> and leptin were lower (P<

关键词： Bovine Metabolism Estrous Cycle Follicle stimulating Hormone Inflammation

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Bioelectronic protein nanowire sensors for ammonia detection

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Nano Research 2020年第5期13卷 1479-1484页

作者： Alexander F.smith Xiaomeng Liu Trevor L.Woodard Tianda Fu Todd Emrick juan M.jiménez derek R.Lovley jun Yao Department of Biomedical Engineering University of MassachusettsAmherstMA 01003USA Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Microbiology University of MassachusettsAmherstMA 01003USA Department of Polymer science and Engineering University of MassachusettsAmherstMA 01003USA Department of Mechanical and Industrial Engineering University of MassachusettsAmherstMA 01003USA Institute for Applied Life sciences(IALs) University of MassachusettsAmherstMA 01003USA

Electronic sensors based on biomaterials can lead to novel green technologies that are low cost,renewable,and *** we demonstrate bioelectronic ammonia sensors made from protein nanowires harvested from the microorganism Geobacter *** nanowire sensor responds to a broad range of ammonia concentrations(10 to 10^6 ppb),which covers the range relevant for industrial,environmental,and biomedical *** sensor also demonstrates high selectivity to ammonia compared to moisture and other common gases found in human *** results provide a proof-of-concept demonstration for developing protein nanowire based gas sensors for applications in industry,agriculture,environmental monitoring,and healthcare.

关键词： nanowire protein nanowire biomaterial bioelectronics biosensor ammonia sensor

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中西医结合防治术后胃肠功能紊乱临床实践指南(2023版)

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中国循证医学杂志 2024年第6期24卷 637-651页

作者：薛建军徐紫清侯怀晶王强魏莉莉张杰赵晓红陈丽萍丁凡帆马丽赵永强王迎斌马大青王天俊刘仁玉 Tong j Gan Nicky robinson Yurasek Frank 苏帆迟永良杨佃会刘淑娟崔苏扬魏友松陈志强秦有曹立幸陈贵平舒宽勇肖仲清张晖余剑波胡志前程化坤马武华刘国凯王秀丽曹兴华高巨孔高茵陶清王保华王均炉李洪吕翠霞张志明李天佐杨克虎兰州大学基础医学院循证医学中心兰州730000 甘肃省中医院兰州730050 甘肃省中西医结合麻醉临床医学研究中心兰州730050 西安交通大学第一附属医院西安710061 甘肃中医药大学经贸与管理学院兰州730000 兰州大学第二医院兰州730030 英国帝国理工学院英国伦敦SW72AZ 浙江大学医学院附属儿童医院杭州310005 英国伦敦中医针灸学院英国伦敦IG26QS 美国宾夕法尼亚大学美国宾夕法尼亚州19104 美国石溪大学美国纽约NY11794 英国伦敦南岸大学英国伦敦SE13NQ 美国芝加哥库克郡医院美国芝加哥60675 山东中医药大学附属医院济南250014 江苏省中医院南京210029 广东省中医院广州510030 浙江省中医院杭州310006 江西省妇幼保健院南昌330006 天津市南开医院天津300100 第二军医大学附属长征医院上海200003 黑龙江省医院哈尔滨150036 广州中医药大学第一附属医院广州510405 北京中医药大学东直门医院北京100700 河北医科大学第三医院石家庄050051 新疆医科大学附属中医医院乌鲁木齐830000 江苏省苏北人民医院江苏扬州225001 湖南省人民医院长沙410005 安徽中医药大学第一附属医院合肥230031 长春中医药大学附属医院长春130021 温州医科大学附属第一医院浙江温州325000 陆军军医大学第二附属医院重庆400037 山东中医药大学基础学院济南250013 首都医科大学附属北京世纪坛医院北京100038 世界卫生组织指南实施与知识转化合作中心兰州730000 甘肃省医学指南行业技术中心兰州730000 中国GRADE中心兰州大学兰州730000

术后胃肠功能紊乱是麻醉手术后的常见并发症。中西医结合技术在防治此类疾病上疗效确切,但目前缺少标准化和规范化的相关临床实践指南。为此,中国中西医结合学会围手术期专业委员会和中国中西结合学会麻醉专业委员会,联合甘肃省中西医... 详细信息

术后胃肠功能紊乱是麻醉手术后的常见并发症。中西医结合技术在防治此类疾病上疗效确切,但目前缺少标准化和规范化的相关临床实践指南。为此,中国中西医结合学会围手术期专业委员会和中国中西结合学会麻醉专业委员会,联合甘肃省中西医结合麻醉临床医学研究中心/甘肃省中医院麻醉疼痛医学中心及WHO指南实施与知识转化合作中心/GRADE中国中心/甘肃省医学指南行业技术中心/兰州大学循证医学中心,遵循循证指南制订的原则、方法和步骤,组建多学科专家团队,通过文献调研和专家共识确定临床问题(7个背景问题和12个临床问题)。基于系统评价/Meta分析结果,综合证据质量,权衡干预措施的利弊,考虑患者偏好和价值观,通过德尔菲法专家共识会议形成20条推荐意见。涉及对疾病的定义、病因病机、辨证分型和诊断,以及围手术期防治措施。

关键词：中西医结合术后胃肠功能紊乱指南

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Imaging atomic-scale chemistry from fused multi-modal electron microscopy

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npj Computational Materials 2022年第1期8卷 164-171页

作者： jonathan schwartz Zichao Wendy Di Yi jiang Alyssa j.Fielitz Don-Hyung Ha sanjaya D.Perera Ismail El Baggari Richard D.robinson jeffrey A.Fessler Colin Ophus steve Rozeveld Robert Hovden Department of Materials science and Engineering University of MichiganAnn ArborMIUSA Mathematics and Computer science Division Argonne National LaboratoryLemontILUSA Advanced Photon source Facility Argonne National LaboratoryLemontILUSA Dow Chemical Co. MidlandMIUSA Department of Material science and Engineering Cornell UniversityIthacaNew YorkUSA school of Integrative Engineering Chung-Ang UniversitySeoulRepublic of Korea Department of Physics Cornell UniversityIthacaNYUSA The Rowland Institute at Harvard CambridgeMAUSA Department of Electrical Engineering and Computer science University of MichiganAnn ArborMIUSA National Center for Electron Microscopy Lawrence Berkeley National LaboratoryMolecular FoundryBerkeleyCAUSA Applied Physics Program University of MIchiganAnn ArborMIUnited States

Efforts to map atomic-scale chemistry at low doses with minimal noise using electron microscopes are fundamentally limited by inelastic ***,fused multi-modal electron microscopy offers high signal-to-noise ratio(sNR)recovery of material chemistry at nano-and atomic-resolution by coupling correlated information encoded within both elastic scattering(high-angle annular dark-field(HAADF))and inelastic spectroscopic signals(electron energy loss(EELs)or energy-dispersive x-ray(EDX)).By linking these simultaneously acquired signals,or modalities,the chemical distribution within nanomaterials can be imaged at significantly lower doses with existing detector *** many cases,the dose requirements can be reduced by over one order of *** high sNR recovery of chemistry is tested against simulated and experimental atomic resolution data of heterogeneous nanomaterials.

关键词： materials chemistry fused

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Menaquinone (Vitamin K2) Enhancement of <i>staphylococcus aureus</i>Biofilm Formation

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journal of Biosciences and Medicines 2014年第1期2卷 26-32页

作者： derek T. Kirby joyce M. savage Balbina j. Plotkin Department of Microbiology and Immunology Midwestern University Downers Grove USA

During infection, staphylococcus aureus is exposed to exogenous menaquinone which is essential for the human blood clotting cascade. The effect of exogenous menaquinone on s. aureus phenotypic expression is not known. To test whether menaquinone affects expression of virulence-associated phenotypes, methicillin-sensitive (MssA) and -resistant (MRsA) s. aureus strains (n = 8) were grown in the presence of menaquinone (0.001 - 12 μg/ml). Capsule production, biofilm formation (plastic and fibronectin-coated microtiter plates) and carotenoid levels were determined spectrophotometrically after growth in Mueller Hinton broth (MH;24-hr, 37°C). All experiments were, at minimum, done in triplicate and repeated twice. Menaquinone at physiologic levels (0.01 μg/ml MH) significantly increased (p 0.05) biofilm formation on plastic in a manner that was bacterial population size dependent. In addition, menaquinone (0.05 - 4 μg/ml) significantly increased (p 0.05) biofilm formation on fibronectin-coated surfaces for four MssA strains and one MRsA strain by two to six-fold as compared to medium controls. However, menaquinone had no effect on capsule production or cell-associated carotenoid levels. Menaquinone’s effect on biofilm formation on fibronectin-coated surfaces appears to be regulated by sarA. These findings are the first to demonstrate that a vitamin at concentrations reported in humans affects s. aureus virulence-associated phenotypes.

关键词： Quorum s. aureus Menaquinone Fibronectin Biofilm Capsule Plastic Adherence Carotenoid

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Evolving paradigms in biological carbon cycling in the ocean

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National science Review 2018年第4期5卷 481-499页

作者： Chuanlun Zhang Hongyue Dang Farooq Azam Ronald Benner Louis Legendre Uta Passow Luca Polimene Carol robinson Curtis A.suttle Nianzhi jiao Department of Ocean science and Engineering Southern University of Science and Technology state Key Laboratory of Marine Environmental science Institute of Marine Microbes and Ecospheres College of Ocean and Earth Sciences Xiamen University scripps Institution of Oceanography University of California San Diego Department of Biological sciences and school of the Earth Ocean and EnvironmentUniversity of South Carolina sorbonne Université Laboratoired' Océanographie de Villefranche LOV 6. Marine Science Institute University of California Santa Barbara 7. Plymouth Marine Laboratory 8. School of Environmental SciencesUniversity of East Anglia 9. Departments of Earth Ocean and Atmospheric SciencesBotany and Microbiology and Immunology and the Institute for the Oceans and Fisheries University of British Columbia

Carbon is a keystone element in global biogeochemical *** plays a fundamental role in biotic andabiotic processes in the ocean,which intertwine to mediate the chemistry and redox status of carbon in the ocean and the *** interactions between abiotic and biogenic carbon(***2,Ca CO3,organic matter)in the ocean are complex,and there is a half-century-old enigma about the existence of a huge reservoir of recalcitrant dissolved organic carbon(RDOC)that equates to the magnitude of the pool of atmospheric *** concepts of the biological carbon pump(BCP)and the microbial loop(ML)shaped our understanding of the marine carbon *** more recent concept of the microbial carbon pump(MCP),which is closely connected to those of the BCP and the ML,explicitly considers thesignificance of the ocean’s RDOC reservoir and provides a mechanistic framework for the exploration of its formation and *** of the MCP has benefited from advanced‘omics’and novel research in biological oceanography and microbial *** need to predict the ocean’sresponse to climate change makes an integrative understanding of the BCP,ML and MCP a high *** this review,we summarize and discuss progress since the proposal of the MCP in 2010 and formulate research questions for the future.

关键词： biological carbon pump microbial loop microbial carbon pump ocean carbon cycle global climate change

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Cross-neutralization and cross-protection among sARs-CoV-2 viruses bearing different variant spikes

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signal Transduction and Targeted Therapy 2022年第9期7卷 3202-3205页

作者： Yang Liu jianying Liu jing Zou Birte Kalveram Rafael R.G.Machado Ping Ren sina Tureli derek j.s.ith scott C.Weaver Xuping Xie Pei-Yong shi Department of Biochemistry and Molecular Biology University of Texas Medical BranchGalvestonTXUSA Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenChina Department of Microbiology and Immunology University of Texas Medical BranchGalvestonTXUSA Department of Pathology University of Texas Medical BranchGalvestonTXUSA Center for Pathogen Evolution Department of ZoologyUniversity of CambridgeCambridgeUK sealy Institute for Drug Discovery University of Texas Medical BranchGalvestonTXUSA sealy Center for structural Biology&Molecular Biophysics University of Texas Medical BranchGalvestonTXUSA

Dear Editor The rapid evolution of sARs-CoV-2 mandates a better under-standing of cross-neutralization and cross-protection among *** information is essential to guide vaccine strategy and public *** examine the cross-protection among different variant spikes,we initially prepared four chimeric sARs-CoV-2 viruses(Fig.1a),each bearing the spike gene from Alpha,Beta,Gamma,or Epsilon in the backbone of UsA-WA1/2020[isolated in january 2020 and defned as wild-type(WT)].

关键词： vaccine cross backbone

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Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

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journal of Molecular Cell Biology 2021年第4期13卷 282-294页

作者： Maarten C.Hardenberg Tessa sinnige sam Casford samuel T.Dada Chetan Poudel Elizabeth A.robinson Monika Fuxreiter Clemens F.Kaminksi Gabriele s.Kaminski schierle Ellen A.A.Nollen Christopher M.Dobson Michele Vendruscolo Centre for Misfolding Diseases Department of ChemistryUniversity of CambridgeCambridge CB21EWUK Department of Chemical Engineering and Biotechnology University of CambridgeCambridge CB3 OASUK MTA-DE Laboratory of Protein Dynamics Department of Biochemistry and Molecular BiologyUniversity of DebrecenHungary European Research Institute for the Biology of Aging University Medical Center GroningenUniversity of GroningenGroningen 9713 AVThe Netherlands Present address Bijvoet Centre for Biomolecular Research Department of ChemistryUtrecht UniversityUtrecht 3584 CHThe Netherlands

Misfoldedα-synudein is a major component of Lewy bodies,which are a hallmark of Parkinson's disease(PD).A large body of evidence shows thatα-synuclein can aggregate into amyloid fibrils,but the relationship between a-synuclein self-assembly and Lewy body formation remains ***,we show,both in vitro and in a Caenorhabditis elegans model of PD,thatα-synuclein undergoes liquid-liquid phase separation by forming a liquid droplet state,which converts into an amyloid-rich hydrogel with Lewy-body-like *** maturation process towards the amyloid state is delayed in the presence of model synaptic vesicles in *** together,these results suggest that the formation of Lewy bodies may be linked to the arrested maturation ofα-synuclein condensates in the presence of lipids and other cellular components.

关键词： α-synuclein,liquid-liquid phase separation,Parkinson's disease

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A database of experimentally measured lithium solid electrolyte conductivities evaluated with machine learning

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npj Computational Materials 2023年第1期9卷 2265-2278页

作者： Cameron j.Hargreaves Michael W.Gaultois Luke M.Daniels Emma j.Watts Vitaliy A.Kurlin Michael Moran Yun Dang Rhun Morris Alexandra Morscher Kate Thompson Matthew A.Wright Beluvalli-Eshwarappa Prasad Frédéric Blanc Chris M.Collins Catriona A.Crawford Benjamin B.Duff jae Evans jacinthe Gamon Guopeng Han Bernhard T.Leube Hongjun Niu Arnaud j.Perez Aris robinson Oliver Rogan Paul M.sharp Elvis shoko Manel sonni William j.Thomas Andrij Vasylenko Lu Wang Matthew j.Rosseinsky Matthew s.Dyer Department of Chemistry University of LiverpoolLiverpool L697ZDUK Leverhulme Research Centre for Functional Materials Design Materials Innovation FactoryUniversity of LiverpoolLiverpool L73NYUK Department of Computer science University of LiverpoolLiverpool L693BXUK stephenson Institute for Renewable Energy University of LiverpoolLiverpool L697ZFUK

The application of machine learning models to predict material properties is determined by the availability of high-quality *** present an expert-curated dataset of lithium ion conductors and associated lithium ion conductivities measured by *** *** dataset has 820 entries collected from 214 sources;entries contain a chemical composition,an expert-assigned structural label,and ionic conductivity at a specific temperature(from 5 to 873°C).There are 403 unique chemical compositions with an associated ionic conductivity near room temperature(15–35°C).The materials contained in this dataset are placed in the context of compounds reported in the Inorganic Crystal structure Database with unsupervised machine learning and the Element Movers *** dataset is used to train a CrabNet-based classifier to estimate whether a chemical composition has high or low ionic *** classifier is a practical tool to aid experimentalists in prioritizing candidates for further investigation as lithium ion conductors.

关键词： spectroscopy lithium classifier

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中国和美国原始土壤中非高温发现和鉴定

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生物多样性 2006年第3期14卷 181-187页

作者：樊昊心 derek j. Fairley Christopher Rensing Ian L. Pepper 王革娇华中农业大学农业微生物学国家重点实验室 Queen’s University Environmental science & Technology Research Centre (QUEsTOR) The Queen’s University of Belfast Belfast BT9 5AG UK Department of soil Water and Environmental Science The University of Arizona Tucson AZ 85721 USA

近年来在非极端环境中已经发现有古菌(Archaea)的存在, 但在中国原始土壤中还未见报道。本研究的目的是调查古菌是否存在于两个分别取自中国新疆和广西的土壤及两个美国亚利桑那州南部地区的土壤中。我们分别构建了这四个原始土壤的古菌... 详细信息

近年来在非极端环境中已经发现有古菌(Archaea)的存在, 但在中国原始土壤中还未见报道。本研究的目的是调查古菌是否存在于两个分别取自中国新疆和广西的土壤及两个美国亚利桑那州南部地区的土壤中。我们分别构建了这四个原始土壤的古菌16s rDNA文库并对28个克隆的16s rDNA进行了鉴定。所有这些16s rDNA的序列都归类于古菌的泉古菌门(Crenarchaeota)。进化树分析表明, 这些泉古菌的16s rDNA属于非高温陆地环境中的泉古菌种群, 明显区别于海洋和淡水地带的泉古菌种群。这个泉古菌种群又有两个分支, 这两个分支在16s rDNA序列上和G+C含量上有明显的区别。本研究在两个中国和两个美国原始土壤中鉴定了非高温泉古菌的存在, 由此证明泉古菌的存在范围不只局限于高温等极端环境。另外, 美国原始土壤中的泉古菌只属于一个进化分支, 这说明非高温泉古菌种群的类型和土壤的地理位置及土壤特性有关。

关键词： 16srDNA 古菌非高温泉古菌免培养法原始土壤

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