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Core needle biopsy and embolization of fat-poor renal tumors in children with tuberous sclerosis complex

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World journal of Pediatrics 2023年第6期19卷 614-618页

作者： derek j.Roebuck Samantha Chippington Bligh D.Berry Craig Gibson Department of Medical Imaging Perth Children's Hospital15 Hospital AvenueNedlands 6009Australia Division of Paediatrics Medical SchoolUniversity ofWestern AustraliaCrawley 6009Australia Department of Radiology Great Ormond Street Hospital for ChildrenLondon WCIN 3JHUK PathWest Laboratory Medicine WA Murdoch 6150Australia

Tuberous sclerosis complex(TSC)is an autosomal dominant disease caused by inactivating germline mutations in TSC1 or *** genes code for hamartin and tuberin,proteins that normally form a complex that down-regulates the mechanistic(or mammalian)target of rapamycin(mTOR)pathway,which is crucial to cell growth,proliferation and survival.

关键词： needle sclerosis biopsy

Sexual signal conspicuity is correlated with tail autotomy in an anoline lizard

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Current Zoology 2022年第1期68卷 129-132页

作者： Kelly LinWUTHRICH derek STOCK janelle B.TALAVERA Breanna j.PUTMAN Lindsey SWIERK Department of Biological Sciences Binghamton UniversityState University of New YorkBinghamtonNY 13902USA Department of Biology California State UniversityNorthridgeCA 91330-8303USA Department of Biology California State UniversitySan BernardinoCA 92407USA Department of Ecology and Evolutionary Biology University of California621 Young Drive SouthLos AngelesCA 90095-1606USA Department of Herpetology and Urban Nature Research Center Natural History Museum of Los Angeles CountyLos AngelesCA 90007USA School of Forestry and Environmental Studies Yale UniversityNew HavenCT 06511USA Amazon Conservatory for Tropical Studies IquitosLoreto 16001Peru The Morpho Institute Kansas CityMO 64113USA

Sexual selection favors conspicuous signals that animals can use to communicate with conspecifics and/or to attract ***,natural and sexual selection are often in opposition,as conspicuous sexual signals can also be detected by eavesdropping predators,forcing these signals to also evolve in light of natural selection(Andersson 1994).

关键词： signal evolve selection

Improving modeling of low-altitude particulate matter emission and dispersion:A cotton gin case study

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journal of Environmental Sciences 2023年第11期133卷 8-22页

作者： Zijiang Yang Michael N.Evans Michael D.Buser Cathleen j.Hapeman Alba Torrents derek P.Whitelock Department of Civil and Environmental Engineering University of Maryland College Park1173 Glenn L.Martin HallCollege ParkMaryland 20742United States Department of Geology University of Maryland College Park1212B Chemistry BuildingCollege ParkMaryland 20742United States Earth System Science Interdisciplinary Center 1120 Geology BuildingUniversity of MarylandCollege ParkMaryland 20742United States United States Department of Agriculture Agricultural Research ServiceOffice of National Programs5601 Sunnyside Ave(GWCC 4–2282)BeltsvilleMaryland 20705United States United States Department of Agriculture Agricultural Research ServiceHenry A.Wallace Beltsville Agricultural Research Center10300 Baltimore AvenueBeltsvilleMaryland 20705United States United States Department of Agriculture Agricultural Research ServiceSouthwestern Cotton Ginning Research LaboratoryPO Box 578Mesilla ParkNew Mexico 88047United States

Monitoring and modeling of airborne particulate matter(PM)from low-altitude sources is becoming an important regulatory target as the adverse health consequences of PM become better ***,application of models not specifically designed for simulation of PM from low-altitude emissions may bias *** address this problem,we describe the modification and validation of an air dispersion model for the simulation of lowaltitude PM dispersion from a typical cotton ginning *** found that the regulatory recommended model(AERMOD)overestimated pollutant concentrations by factors of 64.7,6.97 and 7.44 on average for PM 2.5,PM 10,and TSP,*** concentrations were negatively correlated with height(pjustment and application of pre-existing models for risk assessment and development of remediation *** same approach may also be applied to improve simulations of other air pollutants and environmental conditions of concern.

关键词： Air quality Particulate matter Air dispersion modelling Cotton gin

Sol-gel derived nanocrystalline and mesoporous barium strontium titanate prepared at room temperature

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Particuology 2011年第3期9卷 235-242页

作者： Mohammad Reza Mohammadi derek j.Fray Department of Materials Science & Engineering Sharif University of Technology Department of Materials Science & Metallurgy University of Cambridge

Perovskite-type barium strontium titanate （BST） thin films and powders with nanocrystalline and mesoporous structure were prepared by a straightforward particulate sol-gel route at room temperature. The prepared sol had a narrow particle size distribution of about 20 nm. X-ray diffraction （XRD） revealed that phase composition and preferable orientation growth of BST depended upon the annealing temperature. Transmission electron microscope （TEM） images showed that the crystallite size of the powders decreased with increasing annealing temperature from 8 nm at 25 ℃ down to 5 nm at 800 ℃. Field emission scanning electron microscope （FE-SEM） analysis and atomic force microscope （AFM） images revealed that BST thin films had mesoporous and nanocrystafiine structure with average grain size of 3Onm at 600 ℃. Based on Brunauer-Emmett-Teller （BET） analysis, the synthesized BST showed mesoporous structure containing nnres with needle, and nlate shanes and BET surface area in the range of 49-32 m^2/g at 500-800℃

关键词： Barium strontium titanate Room temperature Sol-gel chemistry Nanostructure

Analysis of the damage mechanism of strainbursts by a global-local modeling approach

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journal of Rock Mechanics and Geotechnical Engineering 2022年第6期14卷 1671-1696页

作者： jun Wang derek B.Apel Artur Dyczko Andrzej Walentek Stanislaw Prusek Huawei Xu Chong Wei School of Mining and Petroleum Engineering University of AlbertaEdmontonAlbertaT6G 2R3Canada jastrze˛bska Spółka We˛glowa S.A.Group Aleja Jana Pawła II 4Jastrze˛bie-Zdrój44-330Poland Central Mining Institute Plac GwarkówKatowice140-166Poland

Strainburst is the most common type of *** research of strainburst damage mechanisms is helpful to improve and optimize the rock support design in the burst-prone *** this study,an improved global-local modeling approach was first adopted to study strainburst damage *** extracted stresses induced by multiple excavations from a three-dimensional(3D)global model established by fast Lagrangian analysis of continua in 3 dimensions(FLAC3D)are used as boundary conditions for a two-dimensional(2D)local model of a deep roadway built by universal distinct element code(UDEC)to simulate realistic stress loading paths and conduct a detailed analysis of rockburst damage from both micro and macro *** results suggest that the deformation and damage level of the roadway gradually increase with the growth of surrounding rock stress caused by the superposition of mining-or excavation-induced stresses of the panel and nearby *** significant increase of surrounding rock stresses will result in more accumulated strain energy in two sidewalls,providing a necessary condition for the strainburst occurrence in the dynamic *** strainburst damage mechanism for the study site combines three types of damage:rock ejection,rock bulking,and *** the strainburst,initiation,propagation,and development of tensile cracks play a crucial role in controlling macroscopic failure of surrounding rock masses,although the shear crack always accounts for the main proportion of damage *** deformation and damage level of the roadway during a strainburst positively correlate with the increasing peak particle velocities(PPVs).The yielding steel arch might not dissipate kinetic energy and mitigate strainburst damage effectively due to the limited energy absorption *** principles to control and mitigate strainburst damage are proposed in this *** study presents a systematic framework to investigate strainburst damage mechanisms

关键词： Strainburst Numerical modeling Damage mechanism Finite difference method(FDM) Discrete element method(DEM) Underground mining

Template-based growth of titanium dioxide nanorods by a particulate sol-electrophoretic deposition process

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Particuology 2011年第2期9卷 161-169页

作者： Mohammad Reza Mohammadi Farideh Ordikhani derek j.Fray Farzad Khomamizadeh Department of Materials Science & Engineering Sharif University of Technology Department of Materials Science & Metallurgy University of Cambridge

TiO2 nanorods have been successfully grown into a track-etched polycarbonate （PC） membrane by a particulate sol-electrophoretic deposition from an aqueous medium. The prepared sols had a narrow particle size distribution around 17 nm and excellent stability against aging, with zeta potentials in the range of 47-50 mV at pH 2. It was found that TiO2 nanorods were grown from dilute aqueous sol with a low, 0.1-M concentration. Fourier transform infrared spectroscopy （FT-IR） analysis confirmed that a full conversion of titanium isopropoxide was obtained by hydrolysis, resulting in the formation of TiO2 particles. X-ray diffraction （XRD） results revealed that TiO2 nanorods dried at 100℃ were a mixture of anatase and brookite phases, whereas they were a mixture of anatase and futile structures at 500℃. Moreover, the rutile content of the TiO2 nanorods was higher than that of TiO2 powders. Transmission electron microscope （TEM） images confirmed that TiO2 nanorods had a smooth morphology and longi- tudinal uniformity in diameter. Field emission scanning electron microscope （FE-SEM） images showed that TiO2 nanorods grown by sol-electrophoresis from the dilute aqueous sol had a dense structure with a uniform diameter of 200 rim, containing small particles with an average size of 15 nm. Simultaneous differential thermal （SDT） analysis verified that individual TiO2 nanorods, grown into a PC template, were obtained after annealing at 500℃. Based on kinetic studies, it was found that uniform TiO2 nanorods with high-quality morphology were obtained under optimum conditions at an applied potential of 0.3 V/cm and a deposition time of 60 min.

关键词： Nanorod Crystal morphology Electrophoretic deposition Sol-electrophoresisTitanium dioxide

Transient Expression of Virally Delivered Meganuclease In Planta Generates Inherited Genomic Deletions

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Molecular Plant 2015年第8期8卷 1292-1294页

作者： Arik Honig Ira Marton Michal Rosenthal j. jeff smith Michael G. Nicholson derek jantz Amir Zuker Alexander Vainstein Danziger Innovations Ltd. Mishmar Hashiva Village Beit Dagan 50297 Israel Precision Biosciences 302 East Pettigrew Street Dibrell Building Suite A-100 Durham NC 27701 USA Institute of Plant Sciences and Genetics in Agriculture Robert H. Smith Faculty of Agriculture Food and Environment Hebrew University of Jerusalem Rehovot 76100 Israel

Dear Editor The use of sequence-specific nucleases for plant genomic DNA mutagenesis is an exciting and rapidly developing tech- nology （Voytas and Merchant, 2013; Baltes and Voytas, 2014）. To date, most mutated plants have been recovered from transgenic plants stably expressing nucleases. However, transient nuclease delivery by plant DNA- and RNA-based viral vectors followed by regeneration of plantlets from modi- fied tissues has emerged as an alternative, efficient strategy in some plant species （Marton et al., 2010; Baltes et al., 2014）. Delivery of nucleases by plant RNA viruses is particularly attractive because they typically do not integrate into the plant genome, and therefore the mutated plants are not classified as transgenic （Marton et al., 2013; Voytas and Gao, 2014）.

关键词： CELLS

Bank erosion in an Andean páramo river system: Implications for hydro-development and carbon dynamics in the neotropical Andes

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journal of Mountain Science 2019年第2期16卷 243-255页

作者： derek j.MARTIN Christopher ELY Beverley C.WEMPLE Department of Geography and Planning Appalachian State University Department of Geography University of Vermont

The páramo of the Northern Andes provide critically important ecosystem services to the Northern Andean region in the form of water provisioning and carbon sequestration, both of which are a result of the páramo?s organic-rich soils. Little is known, however, about the hydro-geomorphic characteristics of the rivers that drain these ecosystems. With impending plans for widespread hydro-development and increasing implementation of carbon-sequestering compensation for ecosystem services programs in the region it is imperative that we develop a thorough understanding of the hydrogeomorphic role that rivers play in this unique ecosystem. The objective of this study was to quantify bank erosion along an Amazonian headwater stream draining a small, relatively undisturbed páramo catchment to gain a better understanding of the natural erosion regime and the resulting sediment contributions from this unique ecosystem. This study implemented a combination of field, laboratory, and Geographic Information Systems techniques to quantify bank erosion rates and determine a bank erosion sediment yield from the Ningar River, a small páramo catchment(22.7 km^2) located in the eastern Andean cordillera of Ecuador. Results show that bank erosion rates range from 3.0 to ≥ 390.0 mm/yr, are highly episodic, and yield at least 487 tons of sediment annually to the Ningar River. These results imply that 1) páramo ecosystems substantially contribute to the sediment load of the Amazon River basin; 2) bank erosion is a potentially significant flux component of basin-scale carbon cycles in páramo ecosystems; and 3) hydrologic alteration campaigns(dam building) will likely critically alter these contributions and concomitantly disconnect a critical source of sediment and nutrients to downstream ecosystems.

关键词： Bank erosion Páramo Fluvial geomorphology Andes

Generalized Baumslag-Solitar Graphs with Soluble Fundamental Groups

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Algebra Colloquium 2014年第1期21卷 53-58页

作者： Alberto L. Delgado derek j.S. Robinson Mathew Timm vDepartment of Mathematics illinois State University Normal IL 61790 USA Department of Mathematics University of Illinois at Urbana-Champaign Urbana IL 61801 USA Department of Mathematics Bradley University Peoria IL 61625 USA

It is shown that the generalized Baumslag-Solitar graphs which have soluble fundamental groups can be constructed from four simple types of graph by a process of decoration. The method of proof is elementary and emplo... 详细信息

关键词： generalized Baumslag-Solitar graph soluble fundamental group