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Modelling and Characterization of Basalt/Vinyl Ester/siC Micro-and Nano-hybrid Biocomposites Properties Using Novel ANN–GA Approach

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journal of Bionic Engineering 2024年第2期21卷 938-952页

作者： Yesudhasan Thooyavan Lakshmi Annamali Kumaraswamidhas robinson Dhas Edwin Raj j.s.ph selvi Binoj Bright Brailson Mansingh Antony sagai Francis Britto Alamry Ali Department of Mechanical Engineering Indian Institute of Technology Dhanbad(ISM)DhanbadJharkhand826004India Gati shakti Vishwavidyalaya(GsV-A Central University Funded By GoI in the Ministry of Railways) LalbaugVadodaraGujarat390004India Institute of Mechanical Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiTamilnadu602105India Metal joining Research Centre Department of Mechanical EngineeringSri Ramakrishna Engineering CollegeCoimbatoreTamilnadu641022India Department of Mechanical Engineering Rohini College of Engineering and TechnologyPalkulamTamil Nadu629401India Department of Mechanical Engineering College of Engineering in Al-KharjPrince Sattam Bin Abdulaziz University11942Al-KharjSaudi Arabia

Basalt fiber reinforcement in polymer matrix composites is becoming more and more popular because of its environmental friendliness and mechanical qualities that are comparable to those of synthetic *** fiber strengthened vinyl ester matrix polymeric composite with filler addition of nano-and micro-sized silicon carbide(siC)element spanning from 2 weight percent to 10 weight percent was studied for its mechanical and wear *** application of Artificial Neural Network(ANN)to correlate the filler addition composition for optimum mechanical properties is required due to the non-linear mechanical and tribological features of *** stuffing blend and composition of the composite are optimized using the hybrid model and Genetic Algorithm(GA)to maximize the mechanical and wear-resistant *** predicted and tested ANN–GA optimal values obtained for the composite combination had a tensile,flexural,impact resilience,hardness and wear properties of 202.93 MPa,501.67 MPa,3.460 j.s.43 HV and 0.196 g,respectively,for its optimum combination of filler and *** can be noted that the nano-sized siC filler particle enhances most of the properties of the composite which diversifies its *** predicted mechanical and wear values of the developed ANN–GA model were in closer agreement with the experimental values which validate the model.

关键词： Hybrid polymer composite Prediction Process modelling Artificial neural networks Genetic algorithm

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： j.s.n Philip Appleton Lisa j Woodhouse Craig s Anderson sandeep Ankolekar Lesley Cala Mark Dixon Timothy j England Kailash Krishnan Grant Mair Keith W Muir john Potter Christopher I Price Marc Randall Thompson G robinson Christine Roffe Else C sandset jeffrey L saver Angela shone Aloysius Niroshan siriwardena joanna M Wardlaw Nikola sprigg Philip M Bath stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance service NHs Trust NottinghamUK stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK stroke Research in stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRs)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRs,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(sD),median[IQR],adj.s.ed common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRs>2107(18%),Glasgow Coma scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** Is ALREADY KNOWN ON THIs TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

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The Innovation 2024年第2期5卷 107-114页

作者： johan Gustafsson Fariba Roshanzamir Anders Hagnestål sagar M.Patel Oseeyi I.Daudu Donald F.Becker jonathan L.robinson jens Nielsen Department of Life sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

Combatting anthrax outbreaks across Nigeria's national land borders: need to optimize surveillance with epidemiological surveys

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Infectious Diseases of Poverty 2024年第1期13卷 100-100页

作者： Hammed O.Mogaji Babatunde Adewale stella I.smith Ehimario U.Igumbor Chidumebi j.Idemili Andrew W.Taylor-robinson Yale school of Public Health Yale University New Haven USA Parasitology and Epidemiology Unit Federal University Oye-Ekiti Oye-Ekiti Nigeria Department of Public Health and Epidemiology Nigerian Institute of Medical Research Lagos Nigeria Department of Molecular Biology and Biotechnology Nigerian Institute of Medical Research Lagos Nigeria Centre for Infectious Disease Research Nigerian Institute of Medical Research Lagos Nigeria Department of Public Health Walter Sisulu University Mthatha South Africa Institute of Health Policy Management and Evaluation University of Toronto Toronto Canada College of Health sciences Vin University Hanoi Vietnam Center for Global Health Perelman School of Medicine University of Pennsylvania Philadelphia USA

Background Anthrax is a non-contagious zoonotic disease caused by the Gram-positive,spore-forming bac-terium Bacillus *** is common in livestock and wild animals such as cattle,goats,sheep,camels,and *** humans,anthrax may occur after contact with contaminated carcasses or animal products like milk and *** best method to prevent anthrax in people is to ensure livestock are vaccinated,which significantly limits the risk of zoonotic spread to ***,the rate of vaccination of domesticated animals kept by nomadic pastoralists in West Africa is *** groups regularly cross over national boundaries with their grazing *** is a country that historically has done comparatively well to contain this public health ***,in 2023 several outbreaks of human disease appear linked to the consumption of anthrax-contaminated animal products brought into Nigeria by pastoralists from neighboring *** manifestations include skin sores or ulcers,nausea,vomiting,and *** article aims to raise awareness of recent outbreaks of anthrax in West Africa and to callfor a renewed focus on measures to combat this neglected public health concern to the *** body The imperative to pinpoint pivotal issues relating to the ongoing emergence of anthrax cases in Nigeria cannot be *** delving into the prevalence of anthrax in both livestock and human populations residing along Nigeria's borders,unraveling the genetic diversity and potential sources of *** strains,and identify-ing the primary animal host(s)responsible for transmission,we stand to enhance our understanding of this critical ***,investigating the multifaceted factors contributing to anthrax transmission,assessing community knowledge and practices,mapping common migratory routes of pastoralists,and formulating targeted interven-tion strategies tailored to the challenges of border communities,are each crucial steps towards eff

关键词： border Combat doubt

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深海环境海洋生态系统监测与修复新技术

Engineering 2024年第3期34卷 195-211页

作者： jacopo Aguzzi Laurenz Thomsen sascha Flögel Nathan j.robinson Giacomo Picardi Damianos Chatzievangelou Nixon Bahamon sergio stefanni jordi Grinyó Emanuela Fanelli Cinzia Corinaldesi joaquin Del Rio Fernandez Marcello Calisti Furu Mienis Elias Chatzidouros Corrado Costa simona Violino Michael Tangherlini Roberto Danovaro Instituto de Ciencias del Mar(ICM-CsIC) Barcelona 08003Spain stazione Zoologica Anton Dohrn Naples 80121Italy University of Gothenburg Göteborg 40530Sweden GEOMAR Helmholtz Centre for Ocean Research Kiel 24148Germany Fundación Oceanogràfic de la Comunitat Valenciana Valencia 46013Spain Royal Netherlands Institute for sea Research(NIOZ) Den Burg Texel 1790 ABNetherlands Polytechnic University of Marche(UNIVPM) Ancona 60131Italy sARTI-MAR of the Universitat Politecnica de Catalunya(UPC) Vilanova i la Geltrú08800Spain Lincoln Institute for Agri-food Technology University of LincolnLincoln LN22LGUK Engitec systems International Limited Limassol 3083Cyprus Consiglio per la Ricerca in Agricoltura e L’analisi Dell’economia Agraria(CREA) Centro di Ricerca Ingegneria e Trasformazioni AgroalimentariMonterotondo 00015Italy

The United Nations(UN)’s call for a decade of“ecosystem restoration”was prompted by the need to address the extensive impact of anthropogenic activities on natural *** ecosystem restoration is increasingly necessary due to increasing habitat degredation in deep waters(>200 m depth).At these depths,which are far beyond those accessible by divers,only established and emerging robotic platforms such as remotely operated vehicles(ROVs),autonomous underwater vehicles(AUVs),landers,and crawlers can operate through manipulators and multiparametric sensor arrays(e.g.,optoacoustic imaging,omics,and environmental probes).The use of advanced technologies for deep-sea ecosystem restoration can provide:①high-resolution three-dimensional(3D)imaging and acoustic mapping of substrates and key taxa,②physical manipulation of substrates and key taxa,③real-time supervision of remote operations and long-term ecological monitoring,and④the potential to work ***,we describe how robotic platforms with in situ manipulation capabilities and payloads of innovative sensors could autonomously conduct active restoration and monitoring across large spatial *** expect that these devices will be particularly useful in deep-sea habitats,such as①reef-building cold-water corals,②soft-bottom bamboo corals,and③soft-bottom fishery resources that have already been damaged by offshore industries(i.e.,fishing and oil/gas).

关键词： Ecosystem restoration Robotic manipulation Acoustic tracking Fishery resources Artificial reefs

Core needle biopsy and embolization of fat-poor renal tumors in children with tuberous sclerosis complex

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World journal of Pediatrics 2023年第6期19卷 614-618页

作者： derek j.Roebuck samantha Chippington Bligh D.Berry Craig Gibson Department of Medical Imaging Perth Children's Hospital15 Hospital AvenueNedlands 6009Australia Division of Paediatrics Medical SchoolUniversity ofWestern AustraliaCrawley 6009Australia Department of Radiology Great Ormond Street Hospital for ChildrenLondon WCIN 3JHUK PathWest Laboratory Medicine WA Murdoch 6150Australia

Tuberous sclerosis complex(TsC)is an autosomal dominant disease caused by inactivating germline mutations in TsC1 or *** genes code for hamartin and tuberin,proteins that normally form a complex that down-regulates the mechanistic(or mammalian)target of rapamycin(mTOR)pathway,which is crucial to cell growth,proliferation and survival.

关键词： needle sclerosis biopsy

sexual signal conspicuity is correlated with tail autotomy in an anoline lizard

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Current Zoology 2022年第1期68卷 129-132页

作者： Kelly LinWUTHRICH derek sTOCK janelle B.TALAVERA Breanna j.PUTMAN Lindsey sWIERK Department of Biological sciences Binghamton UniversityState University of New YorkBinghamtonNY 13902USA Department of Biology California State UniversityNorthridgeCA 91330-8303USA Department of Biology California State UniversitySan BernardinoCA 92407USA Department of Ecology and Evolutionary Biology University of California621 Young Drive SouthLos AngelesCA 90095-1606USA Department of Herpetology and Urban Nature Research Center Natural History Museum of Los Angeles CountyLos AngelesCA 90007USA school of Forestry and Environmental studies Yale UniversityNew HavenCT 06511USA Amazon Conservatory for Tropical studies IquitosLoreto 16001Peru The Morpho Institute Kansas CityMO 64113USA

sexual selection favors conspicuous signals that animals can use to communicate with conspecifics and/or to attract ***,natural and sexual selection are often in opposition,as conspicuous sexual signals can also be detected by eavesdropping predators,forcing these signals to also evolve in light of natural selection(Andersson 1994).

关键词： signal evolve selection

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAs detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht s.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.s. Acharya C. Adam Bourdarios L. Adamczyk s.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.s. Ahmed s. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy s. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali s. Ali s.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei s.P. Amor Dos santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders s.Y. Andrean A. Andreazza s. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal s.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin s. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai s. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos s. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten s. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay s. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-s. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAs Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAs Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAs *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAs jET QUARK GLUON TAGGING

Habitual sedentary time and stationary time are inversely related to aerobic fitness

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sports Medicine and Health science 2022年第4期4卷 260-266页

作者： Myles W.O'Brien Madeline E.shivgulam jennifer L.Petterson Yanlin Wua Ryan j.Frayne said Mekari derek s.Kimmerly Division of Kinesiology School of Health and Human PerformanceFaculty of HealthDalhousie UniversityHalifaxNova ScotiaCanada Department of Family Medicine Universitéde SherbrookeSherbrookeQuebecCanada

A one metabolic-equivalent-of-task increase in peak aerobic fitness(peak MET)is associated with a clinically relevant improvement in survival risk and all-cause *** co-dependent impact of free-living physical behaviours on aerobic fitness are poorly *** purpose of this study was to investigate the impact of theoretically re-allocating time spent in physical behaviours on aerobic *** hypothesized that substituting sedentary time with any physical activity(at any intensity)would be associated with a predicted improvement in aerobic *** volume rate of oxygen uptake(VO_(2)peak)was assessed via indirect calorimetry during a progressive,maximal cycle ergometer protocol in 103 adults(52 females;[38±21]years;[25.0±3.8]kg/m^(2);VO_(2)peak:[35.4±11.5]ml⋅kg^(-1)⋅min^(-1)).Habitual sedentary time,standing time,light-(LPA),moderate-(MPA),and vigorous-physical activity(VPA)were assessed 24-h/day via thigh-worn inclinometry for up to one week(average:[6.3±0.9]days).Isotemporal substitution modelling examined the impact of replacing one physical behaviour with *** time(β=0.8,95%CI:[-1.3,-0.2])and standing time(β=0.9,95%CI:[-1.6,-0.2])were negatively associated with VO_(2)peak,whereas VPA was positively associated with relative VO_(2)peak(β=9.2,95%CI:[0.9,17.6]).substituting 30-min/day of VPA with any other behaviour was associated with a 2.4–3.4 higher peak *** standing time was associated with a lower aerobic *** little as 10-min/day of VPA predicted a clinically relevant 0.8–1.1 peak MET ***,replacing any time with relatively small amounts of VPA is associated with improvements in aerobic fitness.

关键词： Physical activity intensity Cardiorespiratory fitness Objective activity monitoring sedentary activity Isotemporal substitution modelling