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Archite.tural and pe.sonal influe.ce. on ne.shborin8 be.aviors;

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Frontie.s of Archite.tural Re.e.rch 2016年第2期5卷 194-201页

作者： Bruce.K. Fe.suson derek e. Fe.guson 1027 Parkvie. Bird Pittsburgh PA 15217 USA Virginia Commonwe.lth Unive.sity Richmond VA 23284 USA

Archite.tural and pe.sonal influe.ce. on ne.ghboring be.aviors we.e.studie. in a re.ide.tial ne.ghborhood using both qualitative.informal conve.sations, and syste.atic re.ording of activity in the.ne.ghborhood＇s social space. This dual approach produce. ne. insights into ne.ghboring be.aviors and social ne.works. It was discove.e. that the.re.ide.ts who participate. in the.social space.we.e.only a portion of the.re.ide.t population. The.e.was an additional ne.ghborhood-base. ne.work whose.ne.ghboring was not conducte. in the.social space. inste.d it was maintaine. by dire.t house.to-house.contact. It was also found that some.individuals chose.not to participate.in any ne.ghborhood social ne.work. The.social space.was an e.fe.tive.ne.ghboring ve.ue.for those.re.ide.ts who chose.to use.it, but did not attract commingling of groups. Contrary to an assumption in pre.ious ne.ghboring re.e.rch, the.e.are.social groups which de.e.op and maintain the.se.ve. without participation in a social space.

关键词： Ne.ghborhood Social ne.work Community Re.ide.tial de.ign Share. space

Ide.tification of Candidate.Transcription Factor Binding Site. in the.Cattle.Ge.ome

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Ge.omics, Prote.mics & Bioinformatics 2013年第3期11卷 195-198页

作者： derek M. Bickhart Ge.rge.e. Liu Bovine.Functional Ge.omics Laboratory United States Department of Agriculture Agricultural Research Service (USDA-ARS) Be.tsville.Agricultural Re.e.rch Se.vice

A re.ource.that provide. candidate.transcription factor binding site. （TFBSs） doe. not curre.tly e.ist for cattle. Such data is ne.e.sary, as pre.icte. site. may se.ve.as e.ce.le.t starting locations for future.omics studie. to de.e.op transcriptional re.ulation hypothe.e.. In orde. to ge.e.ate.this re.ource. we.e.ploye. a phyloge.e.ic footprinting approach--using se.ue.ce.conse.vation across cattle. human and dog and position-spe.ific scoring matrice. to ide.tify 379,333 putative.TFBSs upstre.m of ne.rly 8000 Mammalian Ge.e.Colle.tion （MGC） annotate. ge.e. within the.cattle.ge.ome. Comparisons of our pre.ictions to known binding site.loci within the.PCKI, ACTA1 and G6PC promote. re.ions re.e.le. 75% se.sitivity for our me.hod of discove.y. Additionally, we.inte.se.te. our pre.ictions with known cattle.SNP variants in dbSNP and on the.lllumina Bovine.D 770k and Bos 1 SNP chips, finding 7534, 444 and 346 ove.laps, re.pe.tive.y. Due.to our stringe.t filte.ing crite.ia, the.e.re.ults re.re.e.t high quality pre.ictions of putative.TFBSs within the.cattle.ge.ome. All binding site.pre.ictions are.fre.ly available.at http：//bfgl. ***/Bovine.FBS/or http：//199.***.54.77/Bovine.FBS.

关键词： Cattle Transcription factor bindingsite. In silico pre.iction

Ge.e.ics of inflammatory bowe. dise.se. The.role.of the.HLA comple.

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World Journal of Gastroe.te.ology 2006年第23期12卷 3628-3635页

作者： Tariq Ahmad Sara e.Marshall derek Je.e.l Gastroe.te.ology Unit University of OxfordGibson LaboratoriesRadcliffe Infirmary Woodstock RoadOxford United Kingdom De.artme.t of Immunology Wright-Fleming InstituteImperial CollegeLondonUnited Kingdom Gastroe.te.ology Unit University of OxfordGibson LaboratoriesRadcliffe InfirmaryWoodstock RoadOxfordUnited Kingdom

The.human le.cocyte.antige. （HLA） comple. on chromosome.6p21.3 is the.most e.te.sive.y studie. ge.e.ic re.ion in Inflammatory bowe. dise.se.（IBD）. Consiste.t e.ide.ce.of linkage.to IBD3 （6p21.1-23）, an are. which e.compasse. the.HLA comple., has be.n de.onstrate. for both Crohn＇s dise.se.and ulce.ative.colitis, and a numbe. of re.licate. associations with dise.se.susce.tibility and phe.otype.have.re.e.tly e.e.ge.. Howe.e., de.pite.the.e.e.forts the.HLA susce.tibility ge.e.（s） for IBD re.ain e.usive. a conse.ue.ce.of strong linkage.dise.uilibrium, e.te.sive.polymorphism and high ge.e.de.sity across this re.ion. This article.re.ie.s curre.t knowle.ge.of the.role.of HLA comple. ge.e. in IBD susce.tibility and phe.otype. and discusse. the.factors curre.tly limiting the.translation of this knowle.ge.to clinical practice.

关键词： Inflammatory bowe. dise.se Human le.cocyte.antige. comple. Crohn's dise.se Ulce.ative.colitis Ge.e.ics

e.pre.sion of an e.doglucanase.from Tribolium castane.m （Tce. 1 ） in Saccharomyce. ce.e.isiae

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Inse.t Scie.ce 2014年第5期21卷 609-618页

作者： derek Shirle. Cris Oppe.t Todd B. Re.nolds Be.hany Miracle.Bre.da Oppe.t William e. Klinge.an Juan Luis Jurat-Fue.te. De.artme.t of e.tomology and Plant Pathology University of Tennessee De.artme.t of Microbiology University of TennesseeKnoxville TN 37996 USDA-Agricultural Re.e.rch Se.vice.Ce.te. for Grain and Animal He.lth Re.e.rch Manhattan KS 66502 De.artme.t of Plant Scie.ce. University of Tennessee Knoxville TN 37996 USA

Inse.ts are.a large.y une.ploite. re.ource.in prospe.ting for nove. ce.lulolytic e.zyme. to improve.the.production of e.hanol fue. from lignoce.lulosic biomass. The.cost of lignoce.lulosic e.hanol production is e.pe.te. to de.re.se.by the.combination of ce.lulose.de.radation （saccharification） and fe.me.tation of the.re.ulting glucose.to e.hanol in a single.proce.s, catalyze. by the.ye.st Saccharomyce. ce.e.isiae.transforme. to e.pre.s e.ficie.t ce.lulase.. While.S. ce.e.isiae.is an e.tablishe. he.e.ologous e.pre.sion syste., the.e.are.no available.data on the.functional e.pre.sion of inse.t ce.lulolytic e.zyme. for this spe.ie.. To addre.s this knowle.ge.gap, S. ce.e.isiae.was transforme. to e.pre.s the.full-le.gth cDNA e.coding an e.doglucanase.from the.re. flour be.tle. Tribolium castane.m （Tce. 1）, and e.aluate. the.activity of the.transge.ic product （rTce. 1）. e.pre.sion of the.Tce.1 cDNA in S. ce.e.isiae.was unde. control of the.strong glyce.alde.yde.3 phosphate.de.ydroge.ase.promote.. Culture. transforme. ye.st se.re.e. rTce.1 prote.n as a functional β-1,4-e.doglucanase. which allowe. transformants to survive.on se.e.tive.me.ia containing ce.lulose.as the.only available.carbon source. e.aluation of substrate.spe.ificity for se.re.e. rTce.1 de.onstrate. e.doglucanase.activity, although some.activity was also de.e.te. against comple. ce.lulose.substrate.. Pote.tially re.e.ant to use. in biofue. production rTce.1 activity incre.se. with pH conditions, with the.highe.t activity de.e.te. at pH 12. Our re.ults de.onstrate.the.pote.tial for functional production of an inse.t ce.lulase.in S. ce.e.isiae.and confirm the.stability of rTce.1 activity in strong alkaline.e.vironme.ts.

关键词： biofue.s inse.t ce.lulase Saccharomyce. ce.e.isiae Tribolium castane.m ye.st

Ce.amic wate. filte. for point-of-use.wate. tre.tme.t in de.e.oping countrie.: Principle., challe.ge. and opportunitie.

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Frontie.s of e.vironme.tal Scie.ce.& e.gine.ring 2020年第5期14卷 37-46页

作者： Haiyan Yang Shangping Xu derek e.hitwood Yin Wang SCNU e.vironme.tal Re.e.rch Institute Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety&MOE Key Laboratory of Theoretical Chemistry of EnvironmentSouth China Normal UniversityGuangzhou 510006China School of e.vironme.t South China Normal UniversityUniversity TownGuangzhou 510006China De.artme.t of Ge.scie.ce. University of Wisconsin-MilwaukeeMilwaukeeWI 53211USA De.artme.t of e.gine.ring Dordt UniversitySioux CenterIA 51250USA De.artme.t of Civil and e.vironme.tal e.gine.ring University of Wisconsin MilwaukeeMilwaukeeWI 53211USA

Drinking wate. source.contamination pose. a gre.t thre.t to human he.lth in de.e.oping ***-of-use.POU)wate. tre.tme.t te.hnique.,which improve.drinking wate. quality at the.house.old le.e.,offe. an affordable.and conve.ie.t way to obtain safe.drinking wate. and thus can re.uce.the.outbre.ks of wate.bome.*** wate. filte.s(CWFs),fabricate. from locally source. mate.ials and manufacture. by local labor,are.one.of the.most socially acce.table.POU wate. tre.tme.t te.hnologie. be.ause.of the.r e.fe.tive.e.s,low-cost and e.se.of *** re.ie. concise.y summarize. the.critical factors that influe.ce.the.pe.formance.of CWFs,including(1)CWF manufacturing proce.s(raw mate.ial se.e.tion,firing proce.s,silve. impre.nation),and(2)source.wate. ***,an in-de.th discussion is pre.e.te. with e.phasis on ke. re.e.rch e.forts to addre.s two major challe.ge. of conve.tional CWFs,including(1)simultane.us incre.se.of filte. flow rate.and bacte.ial re.oval e.ficie.cy,and(2)re.oval of various conce.ning pollutants,such as viruse. and me.al(loid)*** promote.the.application of CWFs,future.re.e.rch dire.tions can focus on:(1)inve.tigation of pore.size.distribution and pore.structure.to achie.e.highe. flow rate. and e.fe.tive.pathoge. re.oval by e.ucidating pathoge. transport in porous ce.amic and adjusting manufacture.parame.e.s;and(2)e.ploration of ne. surface.modification approache. with e.hance. inte.action be.we.n a varie.y of contaminants and ce.amic surface..

关键词： Point-of-use.wate. tre.tme.t Ce.amic wate. filte. Bacte.ial re.oval Surface.modification Wate. quality

Do cratons pre.e.ve.e.ide.ce.of stagnant lid te.tonics?

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Ge.scie.ce.Frontie.s 2018年第1期9卷 3-17页

作者： derek Wyman School of Ge.scie.ce. The University of Sydney

e.ide.ce.for e.isodic crustal growth e.te.ding back to the.Hade.n has re.e.tly prompte. a numbe. of nume.ically base. ge.dynamic mode.s that incorporate.cyclic change. from stagnant lid to mobile.lid te.tonics. A large.part of the.ge.logic re.ord is missing for the.time. at which se.e.al of the.e.cycle. are.infe.re. to have.take. place. The.cratons, howe.e., are.like.y to re.ain important clue. re.ating to similar cycle. de.e.ope. in the.Me.oarche.n and Ne.arche.n. Wide.pre.d acce.tance.of a form of plate.te.tonics by ～3.2 Ga is not at odds with the.sporadic occurre.ce.of stagnant lid te.tonics afte. this time. The.conce.t of scale.as applie. to cratons, mantle.plume. and Ne.arche.n volcanic arcs are.like.y to provide.important constraints on future.mode.s of e.rth's ge.dynamic e.olution. The.Supe.ior Province.will provide.some.of the.most concre.e.e.ide.ce.in this re.ard give. that its constitue.t blocks may have.be.n locke. into a stagnant lid re.ative.y soon afte. the.r formation and the. asse.ble. in the.ne.t global plate.te.tonic inte.val. Pe.ce.ve. comple.itie. associate. with infe.re. mantle.plume.— volcanic arc associations in the.Supe.ior Province.and othe. cratons may be.re.ate. to an ove. e.timation of plume.size. A possible.stagnant lid e.isode.be.we.n ～2.9 Ga and ～2.8 Ga is ide.tifie. by pre.iously une.plaine. lapse. in volcanism on cratons, including the.Kaapvaal, Yilgarn and Supe.ior Province.cratons. If re.l, the. mantle.dynamics associate. with this e.isode.like.y e.iminate. any conte.porane.us mantle.plume.incubation site., which has important implications for wide.pre.d plume. de.e.ope. at ～2.7 Ga and favours a shallow mantle.source.in the.transition zone. The.Supe.ior Province.provide. a unique.y pre.e.ve. local proxy for this global e.e.t and could se.ve.as the.basis for de.aile. nume.ical mode.s in the.future.

关键词： Arche.n Mantle ove.turn Supe.ior Province Mantle plume. Stagnant lid te.tonics

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Se.e.tive.toxicity of hydroxyl-rich carbon nanodots for cance. re.e.rch

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Nano Re.e.rch 2018年第4期11卷 2204-2216页

作者： Tak H. Kim Jose.h P. Sirdaarta Qian Zhang e.san e.te.hari Jame. St. John derek Ke.ne.y Ian e. Cock Qin Li Que.nsland Micro and Nano Te.hnology Ce.te. & School of e.gine.ring Griffith University 170 Kessels Rd Nathan OLD 4111 Australia Australian Rive.s Institute.& School of Natural Scie.ce. Griffith University 170 Kessels Rd Nathan QLD 4111 Australia Griffith Institute.for Drug Discove.y Gfiffith University 46 Don Young Rd Nathan QLD 4111 Australia Me.zie. He.lth Institute.Que.nsland Griffith University Parkland Drive Southport QLD 4222 Australia

The.toxicity of nanoparticle. in a biological syste. is an inte.ration of e.fe.ts arising from surface.functionali~ particle.size. ionic dissolution, e.c. This comple.ity sugge.ts that ge.e.alization of a mate.ial＇s toxicity may be.inappropriate. More.ve., from a me.icinal point of vie., toxicity can be.use. for tre.tme.t of malignant ce.ls, such as cance.. In this stud~ highly biocompatible.carbon nanodots （gCDs） we.e.synthe.ize. by re.cting citric acid and ure. in glyce.ol, which re.ulte. in abundant hydroxyl functional groups on the.particle.surface. gCDs show e.citation-de.e.de.t photolumine.ce.ce.but with bright gre.n to ye.low e.ission. Importantly, a se.ie. of toxicity asse.sme.ts showe. that as-synthe.ize. gCDs posse.se. e.ce.tional biocompatibilitie. to various biological e.titie. including 18 bacte.ia spe.ie., Pe.unia axillaris se.dlings, and Arte.ia franciscana nauplii. Furthe.more. the.particle. we.e.shown to have.low to no toxic e.fe.ts on human e.bryonic kidne. （He.-293）, bre.st （MCF-7）, and oral squamous （CAL-27） carcinoma ce.l line.. Of particular inte.e.t, the.gCDs displaye. antiprolife.ative.activitie. against ovarian choriocarcinoma ce.ls （JAr/Je.-3 ce.l line.）, which may be.furthe. e.plore. for cance. drug discove.y.

关键词： carbon nanodots nanotoxicity fluore.ce.ce choriocarcinoma ce.ls thiore.oxin re.uctase

Digital Se.vo Control of a Robotic e.cavator

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Chine.e.Journal of Me.hanical e.gine.ring 2009年第2期22卷 190-197页

作者： GU Jun Se.ARD derek School of Me.hanical ＆ e.e.tronic e.gine.ring Soochow University Suzhou 215021 China e.gine.ring De.artme.t Lancaster University Lancaster LA1 4YR UK

An e.e.tro-hydraulic control syste. is de.igne. and imple.e.te. for a robotic e.cavator known as the.Lancaste. Unive.sity Compute.ise. and Inte.lige.t e.cavator （LUCIe.. The.e.cavator is be.ng de.e.ope. to autonomously dig tre.che. without human inte.ve.tion. Since.the.be.avior of the.e.cavator arm is dominate. by the.nonline.r dynamics of the.hydraulic actuators and by the.large.and unpre.ictable.e.te.nal disturbance. whe. digging, it is difficult to provide.ade.uate.accurate. quick and smooth move.e.t unde. traditional control me.hodology, e.g., PI/PID, which is comparable.with that of an ave.age.human ope.ator. The.data-base. dynamic mode.s are.de.e.ope. utilizing the.simplifie. re.ine. instrume.tal variable.（SRIV） ide.tification algorithm to pre.ise.y de.cribe.the.nonline.r dynamical be.aviour of the.e.e.tro-hydraulic actuation syste.. Base. on data-base. mode. and proportional-inte.ral-plus （PIP） me.hodology, which is a non-minimal state.space.me.hod of control syste. de.ign base. on the.true.digital control （TDC） syste. de.ign philosophy, a nove. control syste. is introduce. to drive.the.e.cavator arm accurate.y, quickly and smoothly along the.de.ire. path. The.pe.formance.of simulation and fie.d te.ts which drive.the.bucke. along straight line. both de.onstrate.the.fe.sibility and validity of the.propose. control sche.e.

关键词： robotic e.cavator nonline.r dynamics data-base. mode. true.digital control (TDC) proportional-inte.ral-plus (PIP)

Factors shaping community structure.of e.dophytic fungi–e.ide.ce.from the.Pinus-Viscum-syste.

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Fungal Dive.sity 2013年第3期60卷 55-69页

作者： derek Pe.šoh Syste.atische.Botanik und Mykologie Ludwigs-Maximilians Universität MünchenMenzinger Straße 6780638 MünchenGermany Abte.lung Mykologie Universität BayreuthUniversitätsstraße 30–NW I95440 BayreuthGermany

e.dophytic fungal communitie. have.be.n shown to be.highly dive.se.in almost e.e.y host plant spe.ie. analyze. so ***,the.factors shaping the.r compositions are.large.y *** e.ucidate.the.impact of various factors,10 inde.e.de.t re.licate. of DNA e.tracts from e.ch of 17 surface.ste.ilize. le.f and ste. sample. we.e.analyze. by pyrose.ue.cing of fungal ITS1 rRNA ge.e.***,154 fungal OTUs(ope.ational taxonomic units),re.re.e.te. by 953,385 se.ue.ce.,we.e.found in at le.st 2 sample. from Viscum album *** and/or its host Pinus *** from e.rlie.,cultivation-base. asse.sme.ts,the.communitie. we.e.dominate. by OTUs re.ate. to the.ge.us Mortie.e.la and OTUs not assignable.to a ce.tain fungal ***,Ascomycota we.e.still the.most dive.se.group in te.ms of OTU richne.s and alre.dy hypothe.ize. organ and host pre.e.e.ce. of ce.tain e.dophytic Xylariace.e.isolate. from the.Pinus-Viscum-syste. could be.*** spe.ie. and organ type.we.e.also the.major factors shaping the.de.e.te. fungal *** two plant spe.ie. cle.rly diffe.e. according to the.e.dophytic fungal communitie.,but only ste.s and ne.dle. of Pinus we.e.inhabite. by significantly diffe.e.t fungal ***,only the.1 and 3 ye.r old ste. se.tions diffe.e. according to the.e.dophytic fungal community,while.diffe.e.tly age. le.ve. of both plants we.e.indistinguishable.in this *** of the.organs had no impact on fungal communitie. in Pinus,but shorte. inte.node. and smalle. le.ve. showe. at le.st a te.de.cy to diffe. from the.corre.ponding large. organs in *** communitie. also diffe.e. slightly be.we.n the.two sampling site.,lying 200 km apart,and be.we.n the.thre. sampling *** the.sample. we.e.drawn within 15 days,this finding indicate. that se.sonal shifts cle.rly outwe.gh aging e.fe.ts in host plant with pe.e.nial *** re.ults the.e.ore.provide.strong e.ide.ce.against a line.r de.e.opm

关键词： e.dophytic fungi Pyrose.ue.cing Host pre.e.e.ce Ste.s Le.ve. Organ age Pinus sylve.tris Viscum album Ge.e.ic abundance Name.assignme.t