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Characteristics of PM2.5 mass and water-soluble ions during Background and biomass burning periods observed at *** in Taiwan from 2003 to 2009

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Characteristics of PM2.5 mass and water-soluble ions during ...

Nucleotide binding domain 1 pharmacophore modeling for visualization and analysis of P-glycoprotein-flavonoid molecular interactions

第七届海峡两岸气胶技术研讨会暨第二届空气污染技术研讨会

作者： Chung-Te lee Ming-Tung Chuang Neng-Huei Lin Guey-Rong Sheu Shuenn-Chin Chang Sheng-Hsiang Wang Hill Huang horng-Wen Chen Guo-Hau Weng Hsin-YoLai Shao-Peng Hsu Graduate Institute of Environmental Engineering National Central University Department of Atmospheric Sciences National Central University

＜正＞This paper analyzes six years’ PM2.5 mass and water-soluble ions collected at Mt. Lulin （2,862 m a.s.l.） from April 2003 to April 2009. Among global high-elevation sites,Mt. Lulin site is the only observatory that receives aerosol from Southeast Asia in the West Pacific region. Based on a six-year observation,the most active biomass

关键词： Biomass burning PM2.5 Water-soluble ions Long-range transport High-elevation site

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Frontiers in Biology 2016年第5期11卷 391-395页

作者： Pathomwat Wongrattanakamon Vannajan Sanghiran lee Piyarat Nimmanpipug Supat Jiranusomkul Laboratory for Molecular Design and Simulation (LMDS) Department of Pharmaceutical Sciences Faculty of Pharmacy Chiang Mai University Chiang Mai 50200 Thailand Department of Chemistry Faculty of Science University of Malaya Kuala Lumpur 50603 Malaysia Computational Simulation and Modelling Laboratory (CSML) Department of Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand

BACKGROUND： P-glycoprotein （P-gp） is a 170-kDa membrane protein. It provides a barrier function and help to excrete toxins from the body as a transporter. Some bioflavonoids have been shown to block P-gp activity. OBJECTIVE： To evaluate the important amino acid residues within nucleotide binding domain 1 （NBD l） of P-gp that play a key role in molecular interactions with flavonoids using structure-based pharmacophore model. METHODS： In the molecular docking with NBD 1 models, a putative binding site of flavonoids was proposed and compared with the site for ATP. The binding modes for ligands were achieved using LigandScout to generate the P-gp-flavonoid pharmacophore models. RESULTS： The binding pocket for flavonoids was investigated and found these inhibitors compete with the ATP for binding site in NBD1 including the NBD1 amino acid residues identified by the in silico techniques to be involved in the hydrogen bonding and van der Waals （hydrophobic） interactions with flavonoids. CONCLUSION： These flavonoids occupy with the same binding site of ATP in NBD1 proffering that they may act as an ATP competitive inhibitor.

关键词： P-glycoprotein Nucleotide-binding domain 1 pharmacophore model flavonoid competitive inhibition herb-drug interaction

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西南冲绳海槽的微震活动性与断层作用

世界地震译丛 2008年第4期39卷 29-41页

作者： Jean-Claude Sibuet Chao-Shing lee Shu-Kun Hsu Frauke Klingelhoefer Yves Auffret Pascal Pelleau Jacques Crozon Cheng-horng Lin 李细兵国家海洋局第二海洋研究所

2003年12月,在冲绳海槽西南部布设了15台海底地震仪。在10天的被动地震实验中,记录定位到了超过3000次的微震。地震活动的特点表现为在所有仪器的附近始终不断地有小地震发生。除了一群地震位于西南冲绳海槽的南部外(群2),所有的地震活... 详细信息

2003年12月,在冲绳海槽西南部布设了15台海底地震仪。在10天的被动地震实验中,记录定位到了超过3000次的微震。地震活动的特点表现为在所有仪器的附近始终不断地有小地震发生。除了一群地震位于西南冲绳海槽的南部外(群2),所有的地震活动基本上限制在西南冲绳海槽的中部。地震活动带在梨山断层北东-南西向的延伸带上突然中断。大多数地震沿东-西向正断层排列,显示了冲绳海槽当今活动正断层发生的位置以及它是如何解释冲绳海槽南北向扩张的。根据位于弧后火山痕迹区下方的深地震估计出的纵波速度谱,3～10Hz带宽内低频地震的出现证实了下地壳/上地幔岩浆房的存在。

关键词：西南冲绳海槽微震活动性正断层扩张弧后盆地横向火山痕迹

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Nanostructured hafnium-doped strontium oxide film for homeotropic/homogeneous convertible liquid crystal alignment depending on the curing temperature

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International Journal of Smart and Nano Materials 2022年第4期13卷 597-611页

作者： Dong Hyun Kim Dong Wook lee Jin Young Oh Jonghoon Won Hae-Chang Jeong Dae-Shik Seo IT Nano Electronic Device Laboratory Department of Electrical and Electronic EngineeringYonsei UniversitySeoulRepublic of Korea Department of Smart Manufacturing Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea Department of Electrical Electronic and Control Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea

A hafnium strontium oxide(HfSrO)liquid crystal(LC)alignment film was efficiently created through brush coating,and its ability to change the LC alignment direction was confirmed.A brush was applied to HfSrO sol coated on an indium-tin oxide substrate,after which the coating was solidified at var-ious curing *** was confirmed that a directional micro/nanostructure was formed above 280°C due to the shear stresses caused by the movement of the brush *** chemical changes were analyzed by using X-ray photoelectron spectroscopy and contact angle *** the curing temperature increased,the prevalence of oxygen bonds increased and the contact angle decreased,thereby increasing the surface *** anisotropic boundary of the micro-grooves and the van der Waals forces due to an increase in surface energy changed the alignment direction of LC mole-cules from vertical to horizontal,as verified through polarized optical microscopy and pretilt angle ***,the efficiency of the brush-coating method,which dramatically simplifies the LC alignment film process,was *** homeotropic/homogeneous LC alignment property of the HfSrO film produced through brush coating depending on the curing temperature provides an innovative approach for LC alignment.

关键词： Brush coating nanostructure solution process liquid crystal alignment

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郁金香基腐病抗性QTL分析

农业科技与信息(现代园林) 2015年第4期 337-338页

作者：唐楠 Theo van der lee J.M.van Tuyl P.Arens 青海大学高原花卉研究中心 Plant Research International Wageningen University and Research Centre Plant Breeding Wageningen University and Research Centre

郁金香基腐病由尖孢镰刀菌（Fusarium oxysporum ***）引起,严重影响郁金香种球和切花生产。农艺防治措施如避免机械损伤、发现病株及时去除并销毁、实行轮作等,防治效果较差、效率较低,因而生产上主要依靠大量使用化学药剂进行控制。... 详细信息

郁金香基腐病由尖孢镰刀菌（Fusarium oxysporum ***）引起,严重影响郁金香种球和切花生产。农艺防治措施如避免机械损伤、发现病株及时去除并销毁、实行轮作等,防治效果较差、效率较低,因而生产上主要依靠大量使用化学药剂进行控制。长期连续的使用化学药剂对生态环境造成严重威胁,并极有可能使病原菌对杀菌剂产生抗性。因此,选育具有抗基腐病的郁金香品种成为近年来的主要育种目标。郁金香的生长周期长达4;年,采用常规杂交育种选育新品种的过程非常缓慢。通过分子标记辅助选择,可显著加速郁金香的育种过程。但是由于郁金香的基因组太大（1C≈30GB）,已发表的分子标记数目非常有限,尚无可参照的遗传图谱,阻碍了分子标记辅助选择育种的发展。本研究试料为郁金香品种‘Kees Nelis’与‘Cantata’杂交得到的F1代植株。采用土壤感病法及接种法对作图群体及亲本的基腐病抗性进行评价。土壤感病是传统的抗病性鉴定方法,将郁金香种球栽种在受病原菌感染的土壤中,培养6周后开始观察参照品种的感病程度,当感病参照完全发病时,采用1;级标准对其它测试种球进行分级,以每个基因型所有重复的平均值代表其抗病性。接种法是使用携带绿色荧光蛋白（Green Fluorescence Protein,GFP）基因的病原菌菌株,对待测种球进行穿刺接种,利用GFP产生的荧光信号对感病程度进行定量。利用多种分子系统标记对作图群体进行基因型检测,通过软件Join Map4.1,采用双拟假测交策略,分别对两亲本进行连锁分析,构建双亲的遗传连锁图谱。利用软件Map QTL6,分年度、分表型鉴定方法对郁金香抗基腐病进行QTL定位。结果表明:研究发现基腐病抗性在两个郁金香亲本间差异显著,在杂交F1代中呈连续分布,为数量性状遗传。杂交F1代的表型分布符合正态分布,且存在明显的超亲分离。两年土壤感病鉴定结果的相关性较差,2011年土壤感病鉴定和GFP-tagged ***接种鉴定相关性较差,2012年土壤感病鉴定和GFP-tagged ***接种鉴定相关性较高。结合3组表型鉴定数据,依次通过Kruskal-Wallis检验、IM和MQM作图,共检测到6个与郁金香基腐病抗性相关的QTL位点,不同表型鉴定试验中各QTL的显著性不同,单个QTL对表型变异的最大贡献率为12.5%;0.7%。

关键词：美郁金香基腐病 QTL

One Pot Synthesis of Bio-Ethylene Glycol from Cellulose

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Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Modern Research in Catalysis（催化剂现代研究） 2021年第4期

作者： Yu-Wen Chen der-Shing lee

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四川生理科学杂志 2022年第12期44卷 2223-2223页

作者： Danyel lee Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Paris France Paris City University Imagine Institute Paris France Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA St. Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Department of Cancer Biology Lerner Research Institute Cleveland Clinic Cleveland OH USA Human Evolutionary Genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France Doctoral College Sorbonne University Paris France Laboratory of Immunology Lyon Sud Hospital Lyon France Pediatric Intensive Care Department Hospital Sant Joan de Déu Barcelona Spain Kids Corona Platform Barcelona Spain Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain Department of Surgery and Surgical Specializations Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain Respiratory and Immunological Dysfunction in Pediatric Critically Ill Patients Institute of Recerca Sant Joan de Déu Barcelona Spain Bursa City Hospital Bursa Turkey Ankara City Hospital Yildirim Beyazit University Ankara Turkey Immunology and Rheumatology Division Department of Pediatrics University of Montreal CHU Sainte-Justine Montreal QC Canada Human Evolutionary Genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France Center for Translational Research Institut Pasteur Paris City University Paris France Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA Department of Biochemistry and Center for RNA Science and Therapeutics Case Western Reserve University Cleveland OH USA Department of Surgery Weill Cornell Medical College New York NY USA Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA Department of Pediatrics School of Me

Multisystem inflammatory syndrome in children(MIS-C)is a rare and severe condition that follows benign *** report autosomal recessive deficiencies of OAS1,OAS2,or RNASEL in five unrelated children with *** cytosolic d... 详细信息

关键词： inflammatory children multisystem

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西欧的土壤测试和植物分析

土壤学进展 1993年第5期21卷 43-48页

作者： V.J.G Houba I.Novozamsky J.J.Van der lee 王贤忠

本文介绍了西欧的一些土壤测试和植物分析的方法，以及基于这些方法的肥料施用量的推荐。文中也简要地讨论了环境质量检测的一些方法。

关键词：土壤测试植物分析

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郁金香基腐病抗性QTL分析

郁金香基腐病抗性QTL分析