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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 50-51页

作者： Ueland F.R. depriest p.d. de Simone C.p. 张丽娟 division of Gynecologic Oncology Department of Obstetrics and Gynecology University of Kentucky Medical Center-Markey Cancer Center 800 Rose Street Lexington KY 40536-0293 United States

Objective. To compare pelvic examination under anesthesia to transvaginal sonography (TVS) as a method for ovarian detection and measurement. Methods. Two hundred and eighty-nine ovaries from 151 women were evaluated. After induction of anesthesia, a complete pelvic examination and TVS were performed, and the ovaries were removed surgically. Ovarian dimensions generated sonographically and estimated on clinical examination were compared to those obtained from the measured surgical specimen. Results. Forty-four percent of ovaries were palpable clinically whereas 85%were visualized sonographically (p palpable more frequently than left ovaries (p detected clinically in 30%of women >55 years of age versus 51%of women p 200 lb versus 55%of women weighing p d in 12%of women with a uterine weight >200 g versus 51%of women with a uterine weight p detecting ovaries in women with these high risk characteristics. Conclusions. TVS is significantly more accurate than clinical examination in detecting ovaries and in defining their dimensions. Ovaries frequently are not palpable in women ≥55 years of age, women who weigh >200 lb, or women with an enlarged uterus ( > 200 g). The addition of TVS to annual pelvic examination may be beneficial in women >55 years of age who are overweight and therefore at high risk to develop ovarian cancer.

关键词：盆腔检查卵巢大小阴道超声子宫重量右侧卵巢术后标本切除卵巢超声探测麻醉诱导子宫增大

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维普期刊数据库

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以铂类为基础的辅助化疗治疗Ⅰ期子宫浆液乳头状癌(UpSC)的效果

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世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 50-51页

作者： dietrich III C.S. Modesitt S.C. depriest p.d. J.R.Van Nagell Jr. 李奎 division of Gynecologic Oncology Department of Obstetrics and GynecologyUniversity of Kentucky Medical Center 800 Rose Street Lexington KY 40536 United States

Objective. To determine the efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UpSC). Methods. A retrospective multi-institu-tional investigation was performed to identify surgically staged patients with Stage I UpSC who were (1) treated after surgery with 3-6 courses of platinum-based chemotherapy without radiation from 1990-2003, and (2) followed for a minimum of 12 months, or until recurrence. Results. Six patients (IA-2, IB-3, IC-1) were treated with carboplatin (AUC 6) or cisplatin (50 mg/m2) alone. One patient recurred to the vagina, was treated with chemo-radiation, and is alive and well at 122 months. One patient recurred to the lung, liver, and brain, and died of disease at 24 months. The remaining 4 patients are alive with no evidence of disease 15-124 months (mean 62 months) after treatment. Two patients (IB-1, IC-1) were treated with cisplatin (50 mg/m2) and cyclophosphamide (1000 mg/m2), and both are alive and well with no evidence of disease 75 and 168 months after treatment. Twenty-one patients (IA-5, IB-13, IC-3) were treated with a combination of carboplatin (AUC 6)-and paclitaxel (135 mg/m2-175 mg/m2). One patient recurred to the vagina after 3 cycles of carboplatin/paclitaxel, and was treated with chemo-radiation. She is now without evidence of disease 10 months after treatment. At present, all 21 patients with Stage I UpSC treated following surgical staging with carboplatin/ paclitaxel chemotherapy are alive and well with no evidence of disease 10-138 months (mean 41 months) after treatment. Conclusion. Combination carboplatin/paclitaxel chemotherapy following surgery is effective in the treatment of Stage I UpSC.

关键词：浆液乳头状癌 UpSC 辅助化疗手术分期

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维普期刊数据库

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