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Role of Complements and Immunoglobulins in Duchenne Muscular Dystrophy

Open Journal of Applied Sciences 2014年第6期4卷 323-346页

作者： Sanjeev Kumar Reena Mittal Sweety depp chand jain Department of Mathematics Shri.K.K.JAIN. College Khatauli India Department of Neurology Safdarganj Hospital New Delhi India Department of Physics Central Medical Physics Research Laboratory D.A.V. (P.G.) College Muzaffarnagar India

Muscular dystrophies are myopathies and tend to progressive, with ongoing degeneration and regeneration of muscle fibers. Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and polio myelitis are essentially diseases of the anterior horn cells of the spine. It has been reported in literature that humoral immunity is manifested by the antibodies production. These are special chemical substances that react against foreign body. Antibodies are serum proteins, which are immunoglobulins and possess antibody activity and are classified according to antigens and stimulate their production such as IgA, JgG, IgM, IgD and IgE. All the immunological parameters such as of C3, C4, IgG, IgM and IgA, which are measured in Duchenne muscular dystrophy go down in comparison to healthy subjects. Complement C3 and Complement C4 go down about 44.3% and 78.57% respectively from the normal values. The serum IgG, IgM and IgA levels were also go down about 65%, 84% and 99.56% respectively in comparison to healthy subjects. A trend between all the immunoglobulins has been set up and it is rAG.M > rMA.G. > rGM.A, while we have a trend in DMD cases is rMA.G. > rAG.M > rGM.A We are in a position to say that our data have a relevance of high authenticity and reliability to accept that there is a deficit in immunity in DMD cases. The deficit in immunity may be a cause to damage muscle for abnormal functioning.

关键词： Complements Immunoglobulins Duchenne Muscular Dystrophy Regression Coefficients Multiple Correlation Coefficients

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Role of Complements and Immunoglobulins in Alzheimer’s Disease

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Open Journal of Applied Sciences 2014年第6期4卷 285-298页

作者： Sanjeev Kumar Reena Mittal Shweta Chaudhary depp chand jain Department of Mathematics Shri.K.K.JAIN. College Muzaffarnagar India Department of Neurology Safdarganj Hospital New Delhi India Department of Physics Central Medical Physics Research Laboratory D.A.V. (P.G.) College Muzaffarnagar India

Our findings show that the value of IgG in serum of Alzheimer’s Disease patients is (17.2059 ± 2.6317) g/l and in controls i.e. (17.6720 ± 3.1457) g/l. Values of IgM in AD patients go down up to 62.5% in comparison to healthy subjects. A sudden change was observed in the levels of IgA of AD patients. It has been put on the value 137.9% high in comparison to healthy subjects. The levels of complement C3 have also value of lower side and go down up to 52.66% in AD patients. The value of levels of complement C4 shows no deflection from the control values. On the basis of regression and multiple correlation analysis, we found that the partial correlation coefficients rGA.M, which has value 0.44815 in AD patients and 0.45555 in controls, do not show any resemblance. The multiple partial correlation rAM.G has value 0.3082 in AD patients and 0.3912 in controls slightly better correlated in comparison to healthy controls. Multiple *** has strongly correlation in comparison to controls. *** is also strongly correlated. Regression coefficients and regression equations are basic foundations of correlation measurements and show a specific character of variation. A relation between all the three multiple correlations has been established in the present work and it is given by the following relation *** > *** > ***.

关键词： Complements Immunoglobulins Alzheimer’s Disease Regression Coefficients Multiple Correlation Coefficients

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