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Magnetic resonance imaging of hepatocellu.ar carcinoma indu.ed by diethylnitrosamine in Spragu.-dawley rats

Hepatobiliary & Pancreatic diseases International 2005年第3期4卷 427-432页

作者： department of radiology, West china.Hospital, Sichu.n university, Chengdu.610041, china.(Li X, Zhou.XP and Gu.n YS) department of radiology, ruijin hospieal. shanghai second medical university, shanghai 200025 , china. current address:astra zeneca r & d alderley, macclesfield sk 10 4 tg u. k. (Wang YX) department of radiology West China Hospital Sichuan University Chengdu 610041 China.

diethylnitrosamine (dENA) is able to indu.e variou. benign and malignant liver lesions in rats with a high su.cess rate and a low mortality rate. It provides a more appropriate model that better simu.ates the variou. lesions occu.ring in hu.ans than the u.u.l model of tu.or implantations. The aim of the present stu.y was to evalu.te MrI liver examination in Spragu.-dawley(Sd) rats as a rou.ine method to detect hepatocellu.ar carcinoma (HCC) nodu.es indu.ed by dENA and to follow u. their growth. METHOdS:Hepatic carcinogenesis was indu.ed in 80 male Sd rats u.ing oral dENA solu.ion. All animals were imaged for liver tu.or detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) u.ing correspondence scan parameters and a radio-frequ.ncy k.ee coil. Macroscopic examinations were performed along the axial MrI sections to evalu.te magnetic resonance imaging (MrI) findings, and histopathological assessment was also performed. rESu.TS:No false negative resu.ts were obtained on Mr images. Hepatic tu.ors in 72 rats were confirmed macro-scopically and 68 rats were detected by MrI till the 20th week. The smallest and the largest nodu.es detected by MrI were 2 mm and 37 mm in diameter respectively. The agreement rate of MrI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodu.es. CONCLu.IONS:The hepatic tu.or indu.ed by dENA provides a more representative range of tu.ors for imaging diagnosis and interventional treatment. MrI is the best approach for scru.inizing pathological changes of rat livers in the period of observation.

关键词： animal-model hepatocellu.ar carcinoma Spragu.-dawley rat magnetic resonance imaging

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