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Formation of Superoxide Radical and Hydrogen Peroxide Enhanced by Trinitrotoluene in Rat Liver, Brain, Kidney, and Testicle in Vitro and Monkey Liver in Vivo

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Biomedical and Environmental Sciences 1989年第1期2卷 72-77页

作者： KONG LINGYUAN, JIANG QUANGUAN,~2 AND QU QINGSHAN department of occupational health, school of public health, beijing medical university, beijing, China department of occupational health School of Public Health Beijing Medical University China.

Trinitrotoluene (TNT) increased the formation of adrenochrome from adrenaline and the formation of formaldehyde from methanol in rat liver mitochondria and microsomes in vitro as well as in monkey liver mitrochondria and microsomes in vivo. The effects were more prominent at higher TNT concentrations. These findings indicate that TNT enhances the production of superoxide radicals (O_2^-) and hydrogen peroxide (H_2O_2). The production of O_2^- was more prominent in systems containing added TNT than in those containing added benzyl viologen. H_2O_2 production by mitochondria was more pronounced in the liver than in other organs, but its production by microsomes was more pronounced in the brain than in other organs. The results suggest that TNT undergoes cycling reduction which produces oxidative stress. 1989 Academic Press, Inc.

关键词： Brain Formation of Superoxide Radical and Hydrogen Peroxide Enhanced by Trinitrotoluene in Rat Liver Kidney and Testicle in Vitro and Monkey Liver in Vivo

Effects of Exposure to Trinitrotoluene on Male Reproduction

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Biomedical and Environmental Sciences 1993年第2期6卷 154-160页

作者： LI YI, JIANG QUAN-GUAN, YAO SHOU-QI, LIU WEI, TIAN GAO-JUN,AND GUI JING-WEIdepartment of occupational health, school of public health, beijing medical university, beijing ^Hebi Institute of occupational health, Henan Province Anyang Institute of occupational health, Henan Province Xinxiang Institute of occupational health, Henan Province, China Prof. Jiang Quan-guan, department of occupational health, school of public health, beijing medical university, beijing 100083 China. department of occupational health School of Public Health Beijing Medical University China.

A cross-sectional study was performed in 2 plants located in Henan Province in 1990 for observing the reproductive and sexual functions of male workers exposed to trinitrotoluene (TNT). The TNT concentrations in the workplace air, except the packing site, were found to have exceeded MAC (1 mg/m3). TNT exposed male workers complained of more sexual disorders such as impotence, the loss of libido and sexual hypoesthesia than the control group. Compared with the control group, the volume of semen and percentage of motile spermatozoawere found to have significantly decreased, and the sperm malformation incidence increased significantly in TNT exposed workers. The serum testosterone content in TNT exposed male workers was significantly decreased too.

关键词： TNT

传染病多点触发智慧化监测预警系统关键技术专家共识

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中华医学杂志 2024年第32期104卷 2995-3009页

作者：中国医学科学院北京协和医学院群医学及公共卫生学院北京大学公共卫生学院中国疾病预防控制中心传染病管理处四川大学华西公共卫生学院中国科学院地理科学与资源研究所首都医科大学附属北京地坛医院中华医学会公共卫生分会中国医学科学院北京协和医学院群医学及公共卫生学院北京大学公共卫生学院中国疾病预防控制中心传染病管理处四川大学华西公共卫生学院中国科学院地理科学与资源研究所首都医科大学附属北京地坛医院中华医学会公共卫生分会

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算... 详细信息

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算机科学等多学科专家的研究成果与实践经验, 经过反复多轮专家研讨, 形成了传染病多点触发智慧化监测预警系统关键技术专家共识。本共识内容主要包括传染病多点触发智慧化监测预警系统的相关概念和定义, 关键技术框架, 多渠道监测预警数据来源、获取与治理, 预警方法分类, 多点触发智慧化监测预警关键流程及路径, 多点触发预警及综合研判, 预警信号响应以及预警效果评价等方面, 以期为传染病多点触发智慧化监测预警系统建设及应用提供技术参考。

关键词：传染病监测预警多点触发智慧化

An Investigation of Crocidolite Contamination and Mesothelioma in a Rural Area of China^1

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Biomedical and Environmental Sciences 1990年第2期3卷 156-165页

作者： LIU XUEZE, LUO SUQIONG, WANG ZHIMING, WANG MIANZHEN, AND ZHAN CHENGLIE department of occupational health, school of public health, West China university of medical Sciences, Chengdu. Sichuan. China department of occupational health School of Public Health West China University of Medical Sciences Chengdu Sichuan.

Crocidolite was found to be ubiquitous in a county in southwestern China. It had been widely used in the making of road pavement, stoves, wall paint, etc. The environmental levels of the asbestos fibers were determined. Of the 2175 local residents examined. 16 had asbestosis and 232 had pleural plaques. These clinical manifestations were noted mainly in patients over 50 years of age. (c)1990 Academic Press. Inc.

关键词： An Investigation of Crocidolite Contamination and Mesothelioma in a Rural Area of China~1

Climate change and potential distribution of zoonotic cutaneous leishmaniasis in Central Iran: Horizon 2030 and 2050

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Asian Pacific Journal of Tropical Medicine 2019年第5期12卷 204-215页

作者： Babak Shiravand Ahmad Ali Hanafi-Bojd Abbas Ali Dehghani Tafti Mohammad Reza Abai Ali Almodarresi Masoud Mirzaei department of health in Disasters and Emergencies,school of public health,Shahid Sadoughi university of medical Sciences department of medical Entomology&Vector Control,school of public health,Tehran university of medical Sciences Engineering College,GIS&RS department Yazd Branch,Islamic Azad university department of Epidemiology&Biostatistics,school of public health,Shahid Sadoughi university of medical Sciences department of health in Disasters and Emergencies School of Public Health Shahid Sadoughi University of Medical Sciences department of medical Entomology&Vector Control School of Public Health Tehran University of Medical Sciences Engineering College GIS&RS Department Yazd Branch Islamic Azad University department of Epidemiology&Biostatistics School of Public Health Shahid Sadoughi University of Medical Sciences

Objective: To investigate and predict the effects of climate change on the potential distribution of the main vector and reservoir hosts of the disease in Yazd province in the ***: Distribution data for vector and reservoir hosts of zoonotic cutaneous leishmaniasis in Yazd province were obtained from earlier studies conducted in the *** ecological niche modeling was used to predict environmental ***-CSM1-1(m) model and two climate change scenarios, RCP 4.5 and RCP 8.5 were used for horizons 2030 and 2050 climate *** projections were based on data of a regional climate change ***: With both scenarios in 2030 and 2050, the results of jackknife test indicated that the mean temperature of wettest quarter and temperature annual range had the greatest effect on the model for the vector and the reservoir hosts, ***: The climate conditions are the major determinants of zoonotic cutaneous leishmaniasis incidence rate in Yazd *** climate conditions provide favorable habitats for ease transmission of zoonotic cutaneous leishmaniasis in this endemic *** suitability for the vector and reservoir will be expanding in the coming years compared with the current conditions, such that, in horizon 2030 & 2050, the probability of the presence of the vector and reservoir within 38 580 and 37 949 km^2, respectively, from Yazd province is above 60%.Moreover, an increase is predicted in the presence of the vector in the western parts and the reservoir in the northern and central parts of the province in the *** the role of environmental and bioclimatic factors in zoonotic cutaneous leishmaniasis occurrence can provide a guide for policy-makers in the creation and implementation of more effective policies for prevention and control.

关键词： Cutaneous leishmaniasis Climate change RCP scenario Phlebotomus papatasi Rhombomys opimus

Preliminary Validation of Tumor Cell Attachment Inhibition Assay for Developmental Toxicants With Mouse S180 Cells

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Biomedical and Environmental Sciences 1999年第4期12卷 253-259页

作者： LU RONG-ZHU CHEN CHUAN-FEN LIN HUI-FEN HUANG LEI-MING AND JIN XI-PENG.(department of Preventive Medicine, Zhenjiang medical College, 3 YizhengRoad, Zhedeng, 212001 China)(department of occupational health,school of public health, Shanghai medical Univer department of Preventive Medicine Zhenjiang Medical College 3 Yizheng Road Zhenjiang 212001 China department of occupational health School of Public Health Shanghai Medical University 138 Yixueyuan Road Shanghai 200032 China

This study was designed to explore the possibility of using ascitic mouse sarcoma cell line (S180) to validate the mouse tumor cell attachment assay for developmental toxicants, and to test the inhibitory effects of various developmental toxicants. The results showed that 2 of 3 developmental toxicants under consideration, sodium pentobarbital and ethanol, significantly inhibited S180cells attachment to Concanavalin A-coaed surfaces. Inhibition was dependent on concentration, and the IC50 (the concentration tha reduced attachment by 50% ), of these 2 chemicals was 1.2×10-3mol/L and 1 .0 mol/L, respectively. Anoher developmental toxiant, hydmiortisone, did not show inhibitory activity. Two non-developmental toxicants, sodium chloride and glycine were also tested and these did not decrease attachment rates. The main results reported here were generally sindlar to those obtained with ascitic mouse ovdrian tumor cells as a model. Therefore, this study added further evidence to the conclusion that cell specificity does not lindt attachment inhibition to Con A-coated surfaces, so S180 cell may serve as an altemative cell model, especially when other cell lines are unavailable. Furthermore, after optimal validation, it can be suggested that an S180 cell attachment assay may be a candidate for a series of assays to detect developmental toxicants.

关键词： cell Cell In Preliminary Validation of Tumor Cell Attachment Inhibition Assay for Developmental Toxicants With Mouse S180 Cells line

Inhibitory Effect of Green Tea Extract on the Carcinogenesis Induced by Asbestos Plus Benzo(a)pyrene in Rat

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Biomedical and Environmental Sciences 1995年第1期8卷 54-58页

作者： LUO SU-QIONG LIU XUE-ZE AND WANG CHAO-JUN(department of occupational health, school of public health, West China university of medical Sciences, Chengdu 610041, China Institute of Cancer Research, West China university of medical Sciences, Chengdu 6100 department of occupational health School of Public Health West China University of Medical Sciences Chengdu.

In this experiment lung carcinoma was induced by crocidolite plus benzo(a)pyrene in rat. From the cancer models, we observcd that the incidcnce (16.0%) of lung carcinomas was lowel, and the survival time (376 days) of the first case of carcinoma and the mean survival time (758 days) of the rats with carcinoma were higher in the group of rats drinking 2% green tea extract for life than in the positive group (without drinking green tea extract). The mortality ratio (0.5047) was smaller in the cxperimental group than in the positive control group, and the survival curve of the experimental group significantly raised up, in comparison with the positive group.

关键词： a)pyrene in Rat Inhibitory Effect of Green Tea Extract on the Carcinogenesis Induced by Asbestos Plus Benzo Plus

Smelting,Underground Mining,Smoking,and Lung Cancer:A Case-Control Study in a Tin Mine Area

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Biomedical and Environmental Sciences 1989年第2期2卷 98-105页

作者： WU KAI-GUO MO CHUNG-ZHENG department of Preventive Medicine,Guangxi medical College,Nanning,Guangxi,China FU HUA department of occupational Medicine,school of public health,Shanghai medical university,Shanghai,China YU LI-ZHENG health and Anti-epidemic Station,Dachang Mine,Guangxi,China department of Preventive Medicine Guangxi Medical College China.

An increased risk of lung cancer in the Dachang tin mine of Guangxi has been *** investigate the factors contributing to the excessive risk of lung cancer,we conducted a matched case-control study in the mine area and analyzed the effects of multiple factors,such as living and housing conditions,occupational exposure,and smoking,with the methods of conditional logistic *** case series consisted of 69 patients with primary bronchial cancer,55 of whom had *** control series consisted of 138 individuals,55 of whom were *** results showed that the factors contributing to the excessive risk of lung cancer in the mine area related mainly to occupational *** significant risk factors were time of exposure to smelting,time of exposure to underground mining,and age at which underground mining was *** study model II where living controls were used,daily consumption of cigarettes was an additional risk ***,there was a synergistic action among these *** relation of the risk factors to lung cancer is discussed.1989 Academic ***.

关键词： work lung Smelting,Underground Mining,Smoking,and Lung Cancer

Study of Lead Absorption and Its Effect on Children's Development

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Biomedical and Environmental Sciences 1989年第4期2卷 325-330页

作者： WANG LING XU SU-EN ZHANG Guo-DONG WANG WEN-YING department of Child and Adolescent health,school of public health,Shanghai medical university,Shanghai 200032,China department of Child and Adolescent health School of Public Health Shanghai Medical University China.

Blood lead levels of 180 pupils from two elementary schools were determined and the intellec- tual development of the children was *** children in these two groups were similar in most nonlead *** showed that pupils at the school near a battery plant had higher blood lead levels than those at a school in a residential *** evident dose- effect relationship between blood lead level and children's performance on psychological testing existed:the higher the blood level,the lower the intelligence *** relationship re- mained after confounding factors were controlled by stepwise regression *** regres- sion coefficients for PbB and verbal IQ,performance IQ,and full-scale IQ were -0.85,-0.71, and -0.91,respectively.1989 Academic Press,Inc.

关键词： IQ In Study of Lead Absorption and Its Effect on Children’s Development