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Chinese consensus on the diagnosis and treatment of immunoglobulin light-chain cardiac amyloidosis

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Chinese medical Journal 2024年第2期137卷 127-129页

作者： Kaini Shen Zhuang Tian Yajuan Gao Yining Wang Li Huo Jian Li Yun Zhang Shuyang Zhang On behalf of Chinese Society of Rare Diseases and Rare Diseases Branch of china Research hospital Association department of Hematology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Clinical Medicine Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Radiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Nuclear Medicine Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicineState Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Cardiology The Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250012China Cardiovascular Disease Research Center of Shandong First medical university Central Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250013China 不详

Epidemiology of Amyloid Light-Chain Cardiac Amyloidosis(AL-CA)The annual incidence of amyloid light-chain(AL)amyloidosis is 3-5/million,and the incidence in men is slightly higher than that in ***,70%of patients with ... 详细信息

关键词： amyloid cardiac diagnosis

The role of different cues in the brain mechanism on visual spatial attention

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Progress in Natural science:Materials International 2006年第10期16卷 1045-1050页

作者： SONG Weiqun, LUO Yuejia, CHI Song, JI Xunming, LING Feng, ZHAO Lun, WANG Maobin and SHI Jiannong ( department of Rehabilitation, xuanwu hospital,{2., Beijing 100053, china State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal university, Beijing 100875, china School of Psychology, Southwest university, Chongqing 400715, china Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of sciences, Beijing 100101, china {12., Affiliated hospital of Qingdao university, medical College, Qingdao 2.6003, china {12., xuanwu hospital,{2., Beijing 100053, china Institute of Linguistics, Xuzhou Normal university, Xuzhou 2.1116, china) department of Rehabilitation Xuanwu Hospital Capital University of Medical Science Beijing 100053 China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing 100875 China School of Psychology Southwest University Chongqing 400715 China Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China department of neurology Affiliated Hospital of Qingdao University Medical College Qingdao 266003 China department of neurology Xuanwu Hospital Capital University of Medical Science Beijing 100053 China Institute of Linguistics Xuzhou Normal University Xuzhou 221116 China

The visual spatial attention mechanism in the brain was studied in 16 young subjects through the visual search paradigm of precue-target by the event-related potential (ERP) technique, with the attentive ranges cued by different scales of Chinese character and region cues. The results showed that the response time for Chinese character cues was much longer than that for region cues especially for small region cues. With the exterior interferences, the target stimuli recognition under region cues was much quicker than that under Chinese character cues. Compared with that under region cues, targets under Chinese character cues could lead to increase of the posterior P1, decrease of the N1 and increase of the P2. It should also be noted that the differences between region cues and Chinese character cues were affected by the interference types. Under exterior interferences, no significant difference was found between region cues and Chinese character cues; however, it was not the case under the interior interferences. Considering the difference between the exterior interferences and the interior interferences, we could conclude that with the increase of difficulty in target recognition there was obvious difference in the consumption of anterior frontal resources by target stimuli under the two kinds of cues.

关键词： visual spatial attention cue scale event-related potential (ERP) Chinese character cues region cues.

Chinese national clinical practice guidelines on the prevention,diagnosis,and treatment of early gastric cancer

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Chinese medical Journal 2024年第8期137卷 887-908页

作者： Peng Li Ziyu Li Enqiang Linghu Jiafu Ji Society of Digestive Endoscopy of the Chinese medical Association Colorectal Surgery Group of the Chinese medical Association Chinese Association of Gastroenterologists&Hepatologists National Clinical Research Center for Digestive Diseases Chinese medical Journal Clinical Practice Guideline Collaborative department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing 100050China department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142China department of Gastroenterology and Hepatology the First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China 不详

Background:Gastric cancer is one of the most common malignant tumors in the digestive system in *** comprehensive practice guidelines for early gastric cancer in china are currently ***,we created the Chinese national clinical practice guideline for the prevention,diagnosis,and treatment of early gastric ***:This clinical practice guideline(CPG)was developed in accordance with the World Health Organization’s recommended process and with the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)in assessing evidence *** used the Evidence to Decision framework to formulate clinical recommendations to minimize bias and increase transparency in the CPG development *** used the Reporting Items for practice Guidelines in HealThcare(RIGHT)statement and the Appraisal of Guidelines for Research and Evaluation II(AGREE II)as reporting and conduct guidelines to ensure completeness and transparency of the ***:This CPG contains 40 recommendations regarding the prevention,screening,diagnosis,treatment,and follow-up of early gastric cancer based on available clinical studies and *** provide recommendations for the timing of Helicobacter pylori eradication,screening populations for early gastric cancer,indications for endoscopic resection and surgical gastrectomy,follow-up interval after treatment,and other ***:This CPG can lead to optimum care for patients and populations by providing up-to-date medical *** intend this CPG for widespread adoption to increase the standard of prevention,screening,diagnosis,treatment,and follow-up of early gastric cancer;thereby,contributing to improving national health care and patient quality of life.

关键词： Early gastric cancer Prevention Screening Diagnosis Treatment Follow-up

传染病多点触发智慧化监测预警系统关键技术专家共识

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中华医学杂志 2024年第32期104卷 1-15页

作者：中国医学科学院北京协和医学院群医学及公共卫生学院北京大学公共卫生学院中国疾病预防控制中心传染病管理处四川大学华西公共卫生学院中国科学院地理科学与资源研究所首都医科大学附属北京地坛医院中华医学会公共卫生分会

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算... 详细信息

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算机科学等多学科专家的研究成果与实践经验, 经过反复多轮专家研讨, 形成了传染病多点触发智慧化监测预警系统关键技术专家共识。本共识内容主要包括传染病多点触发智慧化监测预警系统的相关概念和定义, 关键技术框架, 多渠道监测预警数据来源、获取与治理, 预警方法分类, 多点触发智慧化监测预警关键流程及路径, 多点触发预警及综合研判, 预警信号响应以及预警效果评价等方面, 以期为传染病多点触发智慧化监测预警系统建设及应用提供技术参考。

关键词：传染病监测预警多点触发智慧化

2.2. Chinese national clinical practice guideline on diagnosis and management of Crohn’s disease

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中华医学杂志(英文版) 2024年第14期137卷 2024 Jul 2页

作者： Inflammatory Bowel Disease Group, Chinese Society of Gastroenterology, Chinese medical Association Inflammatory Bowel Disease Quality Control Center of china Xijing hospital Air Force Medical University China Peking Union medical College hospital China West china hospital Sichuan University China The First Affiliated hospital Dalian Medical University China university of Nottingham Ningbo China GRADE Centre United Kingdom The First Affiliated hospital Sun Yat-sen University China Sir Run Run Shaw hospital Zhejiang University School of Medicine China Peking university People's hospital China The Second Affiliated hospital Zhejiang University School of Medicine China Renmin hospital Wuhan University China Chinese PLA General hospital China The First Affiliated hospital Naval Medical University China The Sixth Affiliated hospital Sun Yat-sen University China The First Affiliated hospital Anhui Medical University China Zhongshan hospital Xiamen University China Zhongnan hospital Wuhan University China The First hospital of Shanxi medical {2. China The Eighth Affiliated hospital Sun Yat-sen University China Peking university Third hospital China Peking university First hospital China Qilu hospital Shandong University China General hospital of Eastern Theater Command China Xiangya hospital Central South University China The Tenth People's hospital Tongji University China The First Affiliated hospital Kunming Medical University China Shanghai Pudong New District Zhoupu hospital China Ruijin hospital Shanghai Jiao Tong University School of Medicine China Tongji medical College Huazhong University of Science and Technology China General hospital of Nanjing Military Command China The Third Xiangya hospital Central South University China Daping hospital Chongqing China The Second Xiangya hospital Central South University China Jiangsu Provincial People's hospital China The Second hospital of Hebei medical {2. China Nanjing Drum Tower hospital China Nanfan hospital Southern Medical University China GRADE Center University of Nottingham Ningbo China The Fifth Affiliated hospital Zhengzhou University

The role of Chinese expert consensus in standardization and improvement of the clinical diagnosis and treatment of inflammatory bowel disease (IBD) is self-evident. As clinical and basic research in china becomes standardized under a better understanding of IBD, more data on Chinese patients have become available to develop a consensus and guideline. This guideline, collaboratively developed by the IBD Group, Chinese Society of Gastroenterology, incorporates the latest international consensus statements,[1-7] domestic research findings, and practical considerations, as an update based on the 2.18 Chinese consensus on IBD management.[8] The IBD guideline consists of two parts: ulcerative colitis (UC) and Crohn's disease, and this manuscript presented the UC part. The evidence used in this guideline was collected and analyzed by the standard of guideline, and the contents were organized as problem statements, for clarity. The formulation of this guideline aimed to reflect the latest progress in IBD, providing comprehensive and valuable guidance for the clinical management of IBD.

关键词：

Clinical Management Guidelines for Intrahepatic Cholestasis of Pregnancy

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Maternal-Fetal Medicine 2024年第1期6卷 13-22页

作者： Obstetrics Group of the Gynecology and Obstetrics Branch of Chinese medical Association Perinatal Medicine Branch of Chinese medical Association Xinyang Yu Huixia Yang Hongbo Qi 不详 medical university Chongqing 400016China department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China department of Obstetrics and Gynecology Women and Children's Hospital of Chongqing Medical UniversityChongqing 401147China

Intrahepatic cholestasis of pregnancy(ICP)is a significant gestational complication in late pregnancy,potentially leading to severe perinatal complications such as intrauterine fetal demise and preterm *** Obstetrics Group of the Gynecology and Obstetrics Branch and the Perinatal Medicine Branch of the Chinese medical Association organized a panel of domestic experts to deliberate and propose recommendations based on domestic and international guidelines,recent evidence-based medical evidence about key clinical issues including risk factors,clinical manifestations,perinatal outcomes,diagnosis,severity grading,maternal and fetal monitoring,treatment methods,timing,and methods of pregnancy termination,and postpartum follow-up for ICP,with the aim to guide its clinical diagnosis,treatment,and management.

关键词： Cholestasis,Intrahepatic Bile Acids Stillbirth Preterm Birth Diagnostic and Therapeutic Guidelines(Theme)

Population pharmacokinetics of valproate in Chinese children with epilepsy

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Acta Pharmacologica Sinica 2007年第10期28卷 1677-1684页

作者： De-chun JIANG~(2.3),Li WANG~4,Yu-qin WANG~(2.6),Lin LI~3,Wei LU~5,Xiang-rong BAI~2.2.department of Pharmacy,Xuan-wu hospital of {2. medical university,Beijing 100053,china ~4 department of Pediatrics,Peking universityFirst hospital,Beijing 100034,china ~3 department of Pharmacology,Xuan-wu hospital of {2. medical university,Education Ministry KeyLaboratory for Neurodegenerative Diseases,Beijing 100053,china ~5 School of Pharmaceutical science,Peking university,Beijing 100083,china department of Pharmacy Xuan-wu Hospital of Capital Medical University Beijing China department of Pharmacology Xuan-wu Hospital of Capital Medical University Education Ministry Key Laboratory for Neurodegenerative Diseases Beijing China department of Pediatrics Peking University First Hospital Beijing China School of Pharmaceutical science Peking University Beijing China

Aim:The aim of the present study is to establish a population pharmacokinetic（PPK） model of valproate （VPA） in Chinese epileptic children to promote thereasonable use of anti-epileptic ***:Sparse data of VPA serumconcentrations from 417 epileptic children were *** patients weredivided into 2.groups:the PPK model group （n=317） and the PPK valid group（n=100）.The PPK parameter values of VPA were calculated by NONMEM soft-ware using the data of the PPK model group.A basic model and a final modelwere set *** validate the 2.models,the concentrations of PPK valid groupwere predicted by each model,*** mean prediction error （MPE）,mean squared prediction error （MSPE）,root mean squared prediction error（RMSPE）,weight residues （WRES）,and the 95% confidence intervals （95%CI） were also ***,the values between the 2.models were ***:The PPK of VPA was determined by a 1-compartment model with afirst-order absorption *** basic model was:Ka=3.09 (h-1),V/F=2..4（L）,CL/F=0.2.6 （L/h）.The final model was:Ka=0.2.1+2.2.·（1-HS）(h-1),V/F=2.88+0.157·WT （L）,CL/F=0.1060.98·CO+0.0157·AGE （L/h）.For thebasic model,the MPE,MSPE,RMSPE,WRES,and the 95% CI were-2..53（-30.36,-16.70）,372..96 （2.72.72.4585.2.）,39.62.（34.34,44.90）,and-0.06 （-0.14,0.02.,*** the final model,the MPE,MSPE,RMSPE,WRES,and the95% CI were-1.16 （-4.85,2.53）,1002.83 （1050.64,1143.61）,2..04 （2..12.2..96）,and0.08 （-0.04,0.2.）,*** final model was more optimal than the ***:The PPK model of VPA in Chinese epileptic children wassuccessfully *** will be valuable to facilitate individualized dosageregimens.

关键词： population pharmacokinetics valproic acid epilepsy children Bayesian method NONMEM software individualized dosage regimens

Evidence-based expert consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2.2.)

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Chinese Journal of Cancer Research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu Hongmei Jing Rongsheng Zhao the Steering Committee,the Consensus Panel and the Evidence Synthesis Group Evidence-based Pharmacy Professional Committee of Chinese Pharmaceutical Association(CPA) hospital Pharmacy Professional Committee of Chinese Pharmaceutical Association(CPA) Division of Therapeutic Drug Monitoring of Chinese Pharmacological Society(CPS) Expert Committee on Lymphoma of Chinese Society of Clinical Oncology(CSCO) Expert Committee on Leukemia of Chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of china Anti-Cancer Association(CACA) Chinese Society of Hematology of Chinese {2. Association(CMA) hospital Pharmacy Professional Committee of Cross-Straits Medicine Exchange Association(SMEA) department of Pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China department of Pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Hematology and Oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China department of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based expert consensus was formulated using an evidence-based approach and the Delphi *** Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

“有效降低全社会物流成本”研讨会专家观点综述

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中国流通经济 2024年第5期38卷 3-17页

作者：本刊编辑部《中国流通经济》编辑部

2.2.年2.2.日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2.2.年4月2.日,北京物资学院党委宣传部、杂志社、科研处... 详细信息

2.2.年2.2.日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2.2.年4月2.日,北京物资学院党委宣传部、杂志社、科研处联合主办了“有效降低全社会物流成本”研讨会。本次研讨会邀请我国流通物流领域的专家学者,围绕物流服务实体经济和人民群众、物流成本构成、交通运输体系改革、统一高效物流市场构建和现代商贸流通体系完善等问题,发表观点,为探索有效降低全社会物流成本可行路径,构建现代流通体系提供理论支持和实践指导。本刊编辑部对专家阐述的主要观点进行了归纳整理,以飨读者。

关键词：全社会社会物流成本新质生产力流通体系降本增效