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Long-term outcome and late toxicities of simultaneous integrated boost-intensity modulated radiotherapy in pediatric and adolescent nasopharyngeal carcinoma

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Chinese Journal of cancer 2013年第10期32卷 525-532页

作者： Chang-Juan Tao Xu Liu Ling-Long Tang Yan-Ping Mao Lei Chen Wen-Fei Li Xiao-Li Yu Li-Zhi Liu Rong Zhang Ai-Hua Lin Jun Ma Ying sun state key laboratory of oncology in south china department of Radiation oncology imaging Diagnosis and interventional center Sun Yat-sen University Cancer Center department of medical Statistics and Epidemiology School of Public Health Sun Yat-sen University

The application of simultaneous integrated boost-intensity modulated radiotherapy(SIB-IMRT)in pediatric and adolescent nasopharyngeal carcinoma(NPC)is *** study aimed to evaluate long-term outcome and late toxicities in pediatric and adolescent NPC after SIB-IMRT combined with ***-four patients(aged 8–20 years)with histologically proven,non-disseminated NPC treated with SIB-IMRT were enrolled in this retrospective *** disease stage distribution was as follows:stage I,1(2.9%);stage III,14(41.2%);and stage IV,19(55.9%).All patients underwent SIBIMRT and 30 patients also underwent cisplatin-based *** prescribed dose of IMRT was64–68 Gy in 29–31 fractions to the nasopharyngeal gross target *** the median follow-up of 52months(range,9–111 months),1 patient(2.9%)experienced local recurrence and 4(11.8%)developed distant metastasis(to the lung in 3 cases and to multiple organs in 1 case).Four patients(11.8%)died due to recurrence or *** 5-year locoregional relapse–free survival,distant metastasis–free survival,disease-free survival,and overall survival rates were 97.1%,88.2%,85.3%,and 88.2%,*** most common acute toxicities were grades 3–4 hematologic toxicities and *** the 24 patients who survived for more than 2 years,16(66.7%)and 15(62.5%)developed grades 1–2 xerostomia and ototoxicity,*** patients(8.3%)developed grade 3 ototoxicity;no grade 4 toxicities were ***-IMRT combined with chemotherapy achieves excellent long-term locoregional control in pediatric and adolescent NPC,with mild incidence of late *** metastasis is the predominant mode of failure.

关键词：急性毒性放射治疗鼻咽癌青少年晚期儿童升压集成

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prognostic scoring system for locoregional control among the patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy

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Chinese Journal of cancer 2013年第9期32卷 494-501页

作者： Chang-Juan Tao Xu Liu Ling-Long Tang Yan-Ping Mao Lei Chen Wen-Fei Li Xiao-Li Yu Li-Zhi Liu Rong Zhang Ai-Hua Lin Jun Ma Ying sun state key laboratory of oncology in south china department of Radiation oncology sun yat-sen university cancer center imaging Diagnosis and interventional center Sun Yat-sen University Cancer Center department of medical Statistics and Epidemiology School of Public HealthSun Yat-sen University

The prognostic value of T category for locoregional control in patients with nasopharyngeal carcinoma(NPC)has decreased with the extensive use of intensity-modulated radiotherapy(IMRT).We aimed to develop a prognostic scoring system(PSS)that incorporated tumor extension and clinical characteristics for locoregional control in NPC patients treated with *** magnetic resonance imaging scans and medical records of 717 patients with nonmetastatic NPC treated with IMRT at sun yat-sen university cancer center between January 2003 and January 2008 were ***,pathologic classification,primary tumor extension,primary gross tumor volume(GTV-p),T and N categories,and baseline lactate dehydrogenase(LDH)level were *** cluster analysis as well as univariate and multivariate analyses were used to develop the *** prognostic factors for locoregional relapse included N2–3 stage,GTV-p≥26.8 mL,and involvement of one or more structures within *** calculated a risk score derived from the regression coefficient of each factor and classified patients into four groups:low risk(score 0),intermediate risk(score>0 and≤1),high risk(score>1 and≤2),and extremely high risk(score>2).The 5-year locoregional control rates for these groups were 97.4%,93.6%,85.2%,and 78.6%,respectively(P<0.001).We have developed a PSS that can help identify NPC patients who are at high risk for locoregional relapse and can guide individualized treatments for NPC patients.

关键词：评分系统鼻咽癌控制率患者预后治疗放疗中山大学

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Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3767-3782页

作者： Jiang He Liyu Liu Feiyu Tang You Zhou Huan Liu Can Lu Deyun Feng Hong Zhu Yitao Mao Zhi Li Lu Zhang Yuemei Duan Zhi Xiao Musheng Zeng Liang Weng Lun-Quan sun department of oncology Xiangya Cancer CenterXiangya HospitalCentral South UniversityChangsha 410008China key laboratory of Molecular Radiation oncology Hunan province Changsha 410008China department of Pathology Tongji Medical College Union HospitalHuazhong University of Science and TechnologyWuhan 430022China department of Pathology Xiangya HospitalCentral South UniversityChangsha 410078China department of radiology Xiangya HospitalCentral South UniversityChangsha 410078China Institute of Gerontological cancer Research National Clinical Research Center for GerontologyChangsha 410008China department of Breast Surgery Xiangya HospitalCentral South UniversityChangsha 410078China state key laboratory of oncology in south china Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China Hunan International Science and Technology Collaboration Base of precision Medicine for cancer Changsha 410008China center for Molecular imaging of Central south university Xiangya HospitalChangsha 410008China

Epstein-Barr virus(EBV)and human papillomavirus(HPV)infection is the risk factors for nasopharyngeal carcinoma and cervical carcinoma,***,clinical analyses demonstrate that EBV or HPV is associated with improved response of patients,although underlying mechanism remains ***,we reported that the oncoproteins of DNA viruses,such as LMP1 of EBV and E7 of HPV,inhibit PERK activity in cancer cells via the interaction of the viral oncoproteins with PERK through a conserved *** of PERK led to increased level of reactive oxygen species(ROS)that promoted tumor and enhanced the efficacy of chemotherapy in ***,disruption of viral oncoprotein-PERK interactions attenuated tumor growth and chemotherapy in both cancer cells and tumor-bearing mouse *** findings uncovered a paradoxical effect of DNA tumor virus oncoproteins on tumors and highlighted that targeting PERK might be an attractive strategy for the treatment of NPC and cervical carcinoma.

关键词： chemotherapy epithelium cervical

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肝癌免疫检查点抑制剂相关不良反应管理中国专家共识(2021版)

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中华消化外科杂志 2021年第12期20卷 1241-1258页

作者：施国明黄晓勇任正刚陈漪程蕾蕾杜世锁方艺葛宁灵李爱民李苏李晓牧卢倩陆品相孙建方王汉萍魏来徐立杨国欢曾昭冲张岚张力赵海涛赵灵赵明周爱萍刘荣乐刘新会伍家鸣张莹樊嘉周俭中华医学会肿瘤学分会肝癌学组复旦大学附属中山医院肝肿瘤外科&肝移植科复旦大学肝癌研究所上海200032 复旦大学附属中山医院肝肿瘤内科复旦大学肝癌研究所上海200032 复旦大学附属中山医院心内科上海200032 复旦大学附属中山医院放疗科上海200032 复旦大学附属中山医院肾内科上海200032 南方医科大学中西医结合医院肝胆胰肿瘤科广州510315 中山大学肿瘤防治中心临床研究部广州510060 复旦大学附属中山医院内分泌科上海200032 清华大学附属北京清华长庚医院肝胆胰中心 102218 上海市徐汇区中心医院普通外科 200020 中国医学科学院皮肤病医院皮肤病理研究室南京210042 中国医学科学院北京协和医院呼吸与危重症医学科 100730 中山大学肿瘤防治中心肝脏外科广州510060 中国医学科学院北京协和医院肝胆外科 100730 复旦大学附属中山医院妇科肿瘤科上海200032 中山大学肿瘤防治中心微创介入治疗科华南国家重点实验室广州510060 中国医学科学院肿瘤医院肿瘤内科北京100021 不详

免疫检查点抑制剂(ICIS)的临床应用显著改善肝细胞癌(简称肝癌)病人预后随着ICIs在肝癌中的广泛应用,免疫相关不良反应(irAE)越来越受到重视,肝癌复杂的疾病特征和多手段结合的治疗模式对irAE管理提出挑战。因此,《肝癌免疫检查点抑制... 详细信息

免疫检查点抑制剂(ICIS)的临床应用显著改善肝细胞癌(简称肝癌)病人预后随着ICIs在肝癌中的广泛应用,免疫相关不良反应(irAE)越来越受到重视,肝癌复杂的疾病特征和多手段结合的治疗模式对irAE管理提出挑战。因此,《肝癌免疫检查点抑制剂相关不良反应管理中国专家共识(2021版)》编审委员会组织多学科专家共同讨论并制订该共识该共识聚焦肝癌irAE管理相关问题,提出建议,旨在提高临床医师规范、安全用药的能力,从而使病人从免疫治疗中得到最大获益。

关键词：肝肿瘤免疫治疗免疫检查点抑制剂不良反应管理专家共识

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Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy

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Chinese Journal of cancer 2017年第12期36卷 757-766页

作者： Hao Peng Lei Chen Ling-Long Tang Wen-Fei Li Yan-Ping Mao Rui Guo Yuan Zhang Li-Zhi Liu Li Tian Xu Zhang Xiao-Ping Lin Ying Guo Ying sun Jun Ma department of Radiation oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China imaging Diagnosis and interventional center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China department of Nuclear Medicine State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China department of Clinical Trials center State Key Laboratory of Oncology in Southern ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT).The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC ***: Magnetic resonance images(MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined ***: In total, 2082 SCLNs were identified, with 808(38.8%) ≥ 5 and predicting overall survival, 0.661 and 0.711 for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free ***: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined.

关键词： Nasopharyngeal carcinoma 18-fluoro-2-deoxy-glucose positron emission tomography with computed tomography (18F-PET/CT) Magnetic resonance image Intensity-modulated radiotherapy Small cervical lymph nodes

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Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma

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cancer Communications 2019年第1期39卷 634-644页

作者： You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060GuangdongP.R.China state key laboratory of oncology in south china Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China department of medical imaging and interventional radiology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China department of Nuclear Medicine Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China department of Clinical Trials center Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:The National Comprehensive cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the *** nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical *** this study,we examined whether ENPG could be an effective treatment for localized stage I ***:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in sun yat-sen university cancer ***,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference *** survival outcomes,quality of life(QOL),and medical costs between two groups were ***:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with *** 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,Pproved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,Ppromising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused ***,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results.

关键词： Nasopharyngeal carcinoma Localized Early stage Endoscopic nasopharyngectomy Intensity-modulated radiotherapy Survival medical cost Quality of life

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Deep Segmentation Feature-Based Radiomics Improves Recurrence prediction of Hepatocellular Carcinoma

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Biomedical Engineering Frontiers 2022年第1期3卷 126-137页

作者： Jifei Wang Dasheng Wu Meili sun Zhenpeng Peng Yingyu Lin Hongxin Lin Jiazhao Chen Tingyu Long Zi-Ping Li Chuanmiao Xie Bingsheng Huang Shi-Ting Feng department of radiology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina medical AI Lab School of Biomedical EngineeringHealth Science CentreShenzhen UniversityShenzhenChina Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions ShenzhenChina department of medical imaging and interventional radiology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouChina

Objective and Impact *** study developed and validated a deep semantic segmentation feature-based radiomics(DSFR)model based on preoperative contrast-enhanced computed tomography(CECT)combined with clinical information to predict early recurrence(ER)of single hepatocellular carcinoma(HCC)after curative *** prediction is of great significance to the therapeutic decision-making and surveillance strategy of *** prediction is important for ***,it cannot currently be adequately ***,208 patients with single HCC after curative resection were retrospectively recruited into a model-development cohort(n=180)and an independent validation cohort(n=28).DSFR models based on different CT phases were *** optimal DSFR model was incorporated with clinical information to establish a DSFR-C *** integrated nomogram based on the Cox regression was *** DSFR signature was used to stratify high-and low-risk ER ***.A portal phase-based DSFR model was selected as the optimal model(area under receiver operating characteristic curve(AUC):development cohort,0.740;validation cohort,0.717).The DSFR-C model achieved AUCs of 0.782 and 0.744 in the development and validation cohorts,*** the development and validation cohorts,the integrated nomogram achieved C-index of 0.748 and 0.741 and time-dependent AUCs of 0.823 and 0.822,respectively,for recurrence-free survival(RFS)*** RFS difference between the risk groups was statistically significant(Ppredict ER in single HCC after curative resection,and its combination with clinical information further improved the performance for ER prediction.

关键词： Carcinoma signature Deep

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Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 227-252,I0011-I0014页

作者： Hui-Chuan sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina department of medical oncology of PLA cancer center Jinling HospitalNanjingChina department of Infectious Disease Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Liver Surgery The First Affiliated Hospital of USTCHefeiChina Minimally Invasive interventional Division Sun Yat-sen University Cancer CenterGuangzhouChina department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina department of Radiation oncology Beijing Tsinghua Changgung HospitalBeijingChina department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina department of Pathology Fudan University Shanghai Cancer CentreShanghaiChina department of Liver Surgery Sun Yat-sen University Cancer CentreGuangzhouChina department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhouChina department of Hepatobiliopancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Division of Hepatobiliary Surgery Department of General SurgeryRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina department of Hepatobiliary and Splenic Surgery Shengjing Hospital Affiliated to China Medical UniversityShenyangChina The department of Hepatobiliary oncology of sun yat-sen university cancer center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouChina department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina key laboratory of Carcinogenesis and Translational Research(Ministry of Education) Sarcoma CenterPeking University Cancer Hospital and InstituteBeijingChina department of Hepatobili

Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response *** has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’***,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being *** the evidence for conversion therapy in HCC and develop consensus statements to guide clinical *** review:Many research centers in china.have accumulated significant experience implementing HCC conversion *** findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related *** order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical *** consensus statements on the implementation of conversion therapy for HCC were *** statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.

关键词： Hepatocellular carcinoma(HCC) conversion therapy surgical resection systematic treatment locoregional treatment consensus china

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