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Targeting Gene-Virotherapy of Cancer and its prosperity

Cell Research 2006年第11期16卷 879-886页

作者： Xin Yuan Liu~(1,2) ~1Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,320 Yue Yang Road,Shanghai 200031,china.~2Xinyuan Institute of Medicine and Biotechnology,School of Life Science,Zhejiang Sci-Tech university,hangzhou 310018,china InstituteofBiochemistryandCellBiology ShanghaiInstitutesforBiologicalSciencesChineseAcademyofSciences320YueYangRoadShanghai200031China XinyuanInstituteofMedicineandBiotechnology SchoolofLifeScience

Gene and viral therapies for cancer have shown some therapeutic effects,but there has been a lack of real *** achieve the goal of complete elimination of tumor xenograft in animal models,we have developed a newstrategy called Targeting Gene-Virotherapy of Cancer,which aims to combine the advantages of both gene therapy *** new strategy has produced stronger anti-tumor effects than either gene or viral therapy alone.A tumor-specific replicative adenovirus vector,designated as ZD55,was constructed by deletion of the 55kDa E1B region *** resulting viral construct not only retains a similar function to ONYX-015 by specifically targeting p53negative tumors,but also allows for the insertion of various therapeutic genes to form appropriate ZD55 derivatives dueto the newly introduced cloning site,a task not feasible with the original ONYX-015 *** showed that the anti-tu-mor effect of one such derivative,ZD55-IL-24,is at least 100 times more potent than that of either ZD55 virotherapy orAd-IL-24 gene ***,complete elimination of tumor mass by the use of ZD55-IL-24 was only observedin some but not all mice,indicating that one therapeutic gene was not sufficient to"cure"these *** genes withcomplementary or synergetic effects were separately cloned into the ZD55 vector and used in combination(designatedas the Dual Gene Therapy strategy),much better results were obtained;and it was possible to achieve complete elimina-tion of all the xenograft tumor masses in all mice if two suitable genes were *** comprehensive studies basedon this new strategy will likely lead to a protocol for clinical ***,the concept of Double Controlled TargetingVirus-Dual Gene Therapy for cancer treatment,and the implication of the recent progress in cancer stem ceils are alsodiscussed.

关键词： targeting therapy cancer therapy gene-virotherapy

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Finite Element Simulation for Interfacial Evolutions

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Communications in Nonlinear Science and Numerical Simulation 1998年第2期3卷 3-5页

作者： Jianming HUANG and Wei YANG (department of Engineering Mechanics, Tsinghua university, Beijing 100084, china. E mail: yw dem@*** department of Engineering Mechanics Tsinghua University Beijing 100084 China

ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｔｅｒｆａｃｅｍｏｔｉｏｎｐｌａｙｓａｄｅｃｉｓｉｖｅｒｏｌｅｉｎｄｅｓｉｇｎｉｎｇｔｈｅｍｉｃｒｏｓｔｒｕｃｔｕｒｅ，ｆａｂｒｉｃａｔｉｎｇｍａｔｅｒｉａｌｓ，ａｎｄｓｈａｐｉｎｇｔｈ... 详细信息

ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｔｅｒｆａｃｅｍｏｔｉｏｎｐｌａｙｓａｄｅｃｉｓｉｖｅｒｏｌｅｉｎｄｅｓｉｇｎｉｎｇｔｈｅｍｉｃｒｏｓｔｒｕｃｔｕｒｅ，ｆａｂｒｉｃａｔｉｎｇｍａｔｅｒｉａｌｓ，ａｎｄｓｈａｐｉｎｇｔｈｅｓｔｒｕｃｔｕｒｅｇｅｏｍｅｔｒ...

关键词： finite element scheme energetics and kinetics interface motion

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NUMERICAL SIMULATION OF AN OSCILLATING FLOW PAST A CIRCULAR CYLINDER IN THE VICINITY OF A PLANE WALL

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Journal of Hydrodynamics 2008年第5期20卷 547-552页

作者： SHAH Syed Bilal Hussain department of Modern Mechanics University of Science and Technology of China

Oscillating flow around a circular cylinder in the vicinity of a plane wall was investigated by solving the two-dimensional incompressible Navier-Stokes equations with a finite element Galarkin residual method. The effect of the gap G/D between the cylinder surface and the wall on the flow behavior was studied. For the case of G/D 〈 0.25, the periodicity in the flow is attributed to both the outer shear layer instability and the oscillating frequency. As G/D 〉 0.25, vortex shedding occurs and the periodicity in the flow is mainly due to the competition of the oscillating frcqucncy and the vortex shedding frequency from an isolated stationary cylinder.

关键词： finite element method vortex shedding oscillating flow circular cylinder

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Construction of tissue-engineered cartilage using human placenta-derived stem cells

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Science china.Life Sciences) 2010年第2期53卷 207-214页

作者： LIU DaShun1,2,HUI HuangFu3,CHAI XiangBin3,WANG BinQuan3 & QIU JianHua1 1 department of ENT,Xijing Hospital,the Foruth Military Medical university of PLA,Xi’an 710032,china.2 department of ENT,264 Hospital of PLA,Taiyuan 030001,china.3 department of ENT,the First Hospital of Shanxi Medical university,Taiyuan 030001,china 1. department of ENT Xijing Hospital the Foruth Military Medical University of PLA Xi’an 710032 China2. Department of ENT 264 Hospital of PLA Taiyuan 030001 China3. Department of ENT the First Hospital of Shanxi Medical University Taiyuan 030001 China

Human placenta-derived stem cells (hPDSCs) were isolated by trypsinization and further induced into cartilage cells in *** engineered cartilage was constructed by combining hPDSCs with collagen sponge and the cartilage formation was observed by implantation into nude *** showed that hPDSCs featured mesenchymal stem cells and maintained proliferation in vitro for over 30 passages while remaining *** results indicated that hPDSCs have the potential to differentiate into functional cartilage cells in vitro when combined with collagen sponge,which provided experimental evidence for prospective clinical application.

关键词： human placenta-derived stem cells collagen sponge cartilage tissue engineering

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The Viscoelastic Behavior of the Melts for Polyethylene Based Montmorillonite Exfoliated Nanocomposites

The Viscoelastic Behavior of the Melts for Polyethylene Base...

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The 4th Pacific Rim Conference on Rheology

作者： Hongmei Yang Qiang Zheng Miao Du department of Polymer Science and Engineering Zhejiang university hangzhou 310027 P.R. china

＜正＞ The viscoelastic properties of melts for nanocomposites with exfoliated structures, composed of low-density polyethylene （LDPE）, ethylene vinyl acetate copolymer （EVA） and montmorillonite modified by using cetyltrimethylammonium bromide and octadecyltrimethylammonium bromide were studied. The results obtained through an examination of the dynamic storage module G’, dynamic loss module G" and transient stress relaxation module G（t） of the composites revealed that the viscoelastic properties of composites strongly depended on the amount of montmorillonite exfoliated into the composites. With the increasing of montmorillonite content, the composites showed significantly a trend of pseudo-solidlike within the region of lower frequency （ω）. The montmorillonite layers could be aligned along the stress direction, and as a result, the dependence of dynamic modules on ωfor the composites appeared quite different before and after they were exposed to large amplitude oscillatory shear.

关键词： polyethylene montmorillonite nanocomposites exfoliation viscoelasticity.

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Eliminate indeterminacies of independent component analysis for chemometrics

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Progress in Natural Science:Materials International 2008年第8期18卷 1009-1014页

作者： Zhixiang Yao a,b, Kai Zhang c,*, Huanbin Liu b, Hui Su a a department of Biological and Chemical Engineering, Guangxi university of Technology, Liuzhou 545006, china.b State Key Laboratory of Pulp and Paper-making Engineering, South china.university of Technology, Guangzhou 510640, china.c State Key Laboratory of Heavy Oil Processing, china.university of Petroleum, Beijing 102249, china department of Biological and Chemical Engineering Guangxi University of Technology Liuzhou 545006 China State Key Laboratory of Pulp and Paper-making Engineering South China University of Technology Guangzhou 510640 China State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 China

An improved method has been proposed to eliminate the indeterminacies of independent component analysis (ICA) for chemometrics. Following the arrangement of principal components analysis (PCA), the ICA mixing matrix is selected as signal content indexes, and ICA output are sorted and directed. After many times reputations, independent components (ICs) are paired according to the maximum correlation coefficient, and then the mean values of each IC substitutes the original ICs. This indicates that the ICA indeterminacies are eliminated. A simulation example is tested to validate this improvement. Finally, a set of experimental LC-MS data is processed without any prior knowledge or specific limitation and the results show that the improved ICA can directly separate the mixed signals in chemometrics, and it is simpler and more reasonable than the simple to use interactive self-modeling mixture analysis (SIMPLISMA).

关键词： Independent component analysis Indeterminacy in ICA Chemometrics

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CONTROLLABILITY OF EVOLUTION INCLUSIONS WITH NONLOCAL CONDITIONS

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Journal of Systems Science & Complexity 2005年第1期18卷 35-42页

作者： LIGuocheng SONGShiji WUCheng departmentofAutomation TsinghuaUniversityBeijing100084China

In this paper we examine controllability problems of evolution inclusions with nonlocal conditions. Using Kakutani's fixed point theorem and Schauder's fixed point the-orem, we establish sufficient conditions for the ... 详细信息

关键词： nonlocal conditions mild solutions evolution inclusions controllability fixed point

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The influence of laser pulse on the photoabsorption spectra of Li atom in strong external field

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Science china.Physics,Mechanics & Astronomy) 2006年第2期49卷 178-186页

作者： WANG Dehua1 & LIN Shenglu2 1. School of Physics and Electronic Engineering, Yantai Normal university, Yantai 264025, china.2. department of Physics, Shandong Normal university, Jinan 250014, china 1. School of Physics and Electronic Engineering Yantai Normal University Yantai 264025 China 2. department of Physics Shandong Normal University Jinan 250014 China

Using the time-dependent perturbation theory and the calculation formula of the single- and double-pulse absorption spectra of the atom in strong external fields, we calculate the single- and double-pulse absorption spectra of Li atom in strong magnetic field for different pulse widths. The results show that a pulse of some width can reduce the contribution of the short period closed orbits and eliminate the contribution of the long period orbits. Compared with the single-pulse absorption spectra, we found that for some phase differences, the double-pulse laser absorption spectra are strengthened; while for others, they are reduced. Therefore, we can use the pulse laser to control the oscillation of the absorption spectra and obtain the optimization object.

关键词： laser pulse closed orbit absorption spectra.

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A new coupled-map car-following model based on a transportation supernetwork framework

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Chinese Physics B 2013年第6期22卷 141-149页

作者：姚静黄婧祎陈关荣许维胜 department of Control Science and Engineering Tongji University department of Electronic and Computer Engineering The Hong Kong University of Science and Technology department of Electronic Engineering City University of Hong Kong

A new car-following model is proposed by considering information from a number of preceding vehicles with intervehicle communication. A supernetwork architecture is first described, which has two layers： a traffic network and a communication network. The two networks interact with and depend on each other. The error dynamic system around the steady state of the model is theoretically analyzed and some nonjam criteria are derived. A simple control signal is added to the model to analyze the criteria of suppressing traffic jams. The corresponding numerical simulations confirm the correctness of the theoretical analysis. Compared with previous studies concerning coupled map models, the controlled model proposed in this paper is more reasonable and also more effective in the sense that it takes into account the formation of traffic congestion.

关键词： traffic flow coupled map car-following model inter-vehicle communication supernetwork

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Progress in Natural Science:Materials International 2005年第12期15卷 1110-1116页

作者： LIU Gang,LI Xin,JIANG Weimei and LI Min department of Atmospheric Sciences,Nanjing university,Nanjing 210093,china.Beijing Municipal Environmental Protection Bureau,Beijing 100044,china department of Atmospheric Sciences Nanjing University Nanjing 210093 China. Beijing Municipal Environmental Protection Bureau Beijing 100044 China

The S-L (She and Leveque) scaling law,also named the hierarchical similarity theory,has been extensively tested for the turbulence made in the laboratory,but seldom been tested for the turbulence in the atmospheric boundary layer (ABL).In this paper, the S-L scaling law is applied to the turbulence in the ABL observed under unstably stratified conditions and over different types of underlying *** results of analyses show that over this type of homogeneous and flat underlying surface,such as the underlying surface in HUBEX (Huaihe River Basin Energy and Water Cycle Experiment),vertical speed and temperature fields well satisfy the S-L scaling *** the turbulence over the homogeneous but rather rough underlying surface of forest and under unstably stratified conditions in PFRD (Park Falls Ranger District of the Chequamegon National Forest,Wisconsin,USA),the analyses show that the vertical speed and temperature fields sometimes conform sometimes do not conform to the S-L scaling ***,at a time,either both of the vertical speed and temperature fields conform to the S-L scaling law,or both of them do *** speed fields in both of the field experiments do not satisfy the S-L scaling *** new explanation of the above-mentioned phenomena is given.

关键词： atmospheric turbulence Reynolds number S-L scaling law in the atmospheric turbulence boundary layer processes nonlinear dynamics

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