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上海生物医学工程 2004年第3期25卷 53-58页

作者：张安兄吕德龙钟伟程为庄杜强国同济大学材料学院上海200092 复旦大学高分子科学系聚合物分子工程教育部重点实验室上海200433

本文就生物材料的血液相容性进行了综述。着重介绍了血栓形成及凝血发生机制、目前提高生物材料血液相容性的技术、血液相容性的研究及评价方法等几方面的内容 ;另外。

关键词：血液相容性生物材料凝血血栓形成发生机制分子水平综述技术展望问题

Proteomic Analysis of Pyrene Stress-Responsive within Plant Roots

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Proteomic Analysis of Pyrene Stress-Responsive within Plant ...

The 2nd International Conference on Asian-European Environmental Technology and Knowledge Transfer

作者： XU Shengyou2,3,4,CHEN Yingxu1,RUAN Aidong3,ZHANG Wei2,LI Feng1,CHEN Xincai1(1,department of Environmental engineering,Zhejiang university,Hangzhou 310029,china 2,Resources and Environmental engineering Institute,East china university of science and Technology,shanghai 200237,china 3,State key laboratory of Hydrology-Water Resources and Hydraulic engineering,Hohai university,Nanjing 210098 4,School of Life and environmental science,Huangshan university,Huangshan 245000,china)

Phytoremediation is a new method for removing polycyclic aromatic hydrocarbons from the environment.A study was conducted to investigate accumulation of pyrene and protein changes in maize of Zea mays L responding to the stress of 1week exposure to pyrene in the growth media.A group of three 5-week maize plants was allowed to grow in a nutrient solution of different pyrene concentration（0,0.1,1,and 10 mg/L） for 1 week,the roots were then taken for proteomic *** proteins in the roots were extracted and separated by two-dimensional gel electrophoresis;28 protein spots were different from those of the control *** comparisons of isoelectric point,molecular weight and abundance showed 14 up-regulated protein spots,four newly induced protein spots,6 down-regulated protein spots,and lost four *** ten proteins of different molecular weight were subjected to trypsin digestion and then peptide separation by MALDI-TOF mass spectrometry;only six of them matched the database at molecular weights of 12.69,21.89,22.30,43.14,57.22 and 102.61 *** six matched proteins were centromere protein-like protein,putative heat shock protein,putative GTP-binding protein,6-phosphofructo-2-kinase,cytochrome P450,and fructose-2,*** study results have demonstrated the benefits of the proteomic approach in phytoremediation of PAHs and also provided new insights into pyrene degradation related proteins in maize roots.

关键词： proteomic maize pyrene accumulation stress response

Viral vectors as a novel tool for clinical and neuropsychiatric research applications

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General Psychiatry 2018年第5期31卷 100-108页

作者： Yao Wang Zhiwei Hu Peijun Ju Shan Yin Fujie Wang Oudong Pan Jinghong Chen Research and development department OBiO Technology (Shanghai) Corp. Ltd. Marketing department OBiO Technology (Shanghai) Corp. Ltd. shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Psychotic Disorders

Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary research fields for expressing genes, such as neuroscience, metabolism, oncology and so on. Neuroscience and psychiatry are the most closely related disciplines in either basic research or clinical research, but the application of viral vectors in neuropsychiatry has not received much attention or not been widely *** This article will focus on the application of viral vectors in basic and clinical neuropsychiatric *** By using viral vectors, scientists can perform neurological labelling, gene expression regulation and physiological manipulation for investigating phenomenon from molecular mechanisms to behaviours. At the same time, to treat mental or neurological disorders, viral vectors can be designed for gene therapy, which alter gene expression levels or repair mutated genes in the brains of *** Viral vectors play an important role in basic research and clinical applications. To further understand brain function and prevent mental and neurological diseases, we hypothesize that viral vectors could be used along with various advanced technologies, such as sequencing and high-throughput expression analysis in the neuroscience research field.

关键词： Methods By using viral vectors Neuroscience and psychiatry

Proteomic Analysis to Identify Prostate Cancer Biomarkers in Prostate Needle Biopsy Specimens

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Proteomic Analysis to Identify Prostate Cancer Biomarkers in...

华东六省一市生物化学与分子生物学学会2006年学术交流会

作者： Jian-feng Lin, Jun Xu, Hong-yu Tian, Xia Gao, Xi Zhu, Qing-xi Chen, Geng-jun Xu, Qi Gu, Fu-kun Zhao (key laboratory of Proteomics, Institute of Biochemistry and Cell Biology, shanghai Institutes for Biological sciences, Chinese Academy of sciences, shanghai 200031,china key laboratory of Ministry of Education for Cell Biology and Tumor Cell engineering, School of Life sciences, Xiamen university, Xiamen 361005, china College of Life science, Zhejiang Sci-Tech university,Hangzhou, china Institute of Gerontology,Huadong Hospital, shanghai, 200040,china department of Urology, Huadong Hospital, shanghai, 200040,china)

Purpose:Although serum prostate specific antigen (PSA) is introduced as a diagnostic tool for prostate cancer (PCa) detection, the definitive diagnosis of PCa is based on the information contained in prostate needle biopsy. The purpose of this study was to define the proteomic features implicated in prostate needle biopsy and profile the candidate biomarkers of prostate cancer. Experimental Design: Prostate needle biopsy specimens from patients with PCa or benign prostatic hyperplasia (BPH) were probed by Western blot for malignant (AMACR) marker to test the tissue homogeneity, and analyzed using comparative proteomics to describe the proteome. Identified candidate biomarkers were further validated by immunoblot analysis. Results: 9 out of 12 PCa prostate needle biopsies showed AMACR positive stained, while the 14 BPH specimens showed AMACR negative. These 23 specimens were separated by two dimensional gel electrophoresis. 52 statistical significantly changed (Pmolecular targets for PCa diagnostics and t

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Enantioselectivity of an Organophosphate Insecticide:Toxic and Mechanistic Aspects

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Enantioselectivity of an Organophosphate Insecticide:Toxic a...

第五届全国环境化学大会

作者： Cui Wang Quan Zhang Meirong Zhao Weiping Liu (Research Center of Environmental science,College of Biological and Environmental engineering,Zhejiang university of Technology,Hangzhou 310032,People''s Republic of china department of Chemistry,Zhejiang university,Hangzhou 310027,People''s Republic of china School of Urban Development and Environmental engineering,shanghai Second Polytechnic university,shanghai 201209,People''s Republic of china)

＜正＞Enantioselectivity occurs widely in the environmental behaviors and toxicity of chiral contaminations such as ***,the investigation on the enantioselective toxicology mechanisms remains very limited especially in food safety. In this study,we used fenamiphos and malathion as the models of organophosphate insecticide to study the enantioselectivity in aquatic toxicity and the inhibition

关键词： Enantioselectivity Fenamiphos molecular docking Toxicity Food safety

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配煤对煤灰熔融特性影响的实验与量化研究

燃料化学学报 2009年第5期37卷 521-526页

作者：陈玉爽张忠孝乌晓江李洁管嵘清闫博上海理工大学动力学院上海200093

采用量子化学计算方法和实验研究,从微观分子结构和宏观煤灰熔融特性两个层面上,研究了高温下高、低灰熔点煤配煤降低高灰熔点煤煤灰熔融温度的熔融特性和熔融机理。实验和计算结果表明,配煤时,Ca2+作为电子受体进入煤灰中莫来石的晶格... 详细信息

采用量子化学计算方法和实验研究,从微观分子结构和宏观煤灰熔融特性两个层面上,研究了高温下高、低灰熔点煤配煤降低高灰熔点煤煤灰熔融温度的熔融特性和熔融机理。实验和计算结果表明,配煤时,Ca2+作为电子受体进入煤灰中莫来石的晶格,使晶格发生重组,易生成熔点较低的钙长石。莫来石的分子结构较钙长石的要稳定得多,Ca2+进入莫来石晶格后位于由[SiO4]4-和[AlO4]5-两种四面体形成的网络之间,与O配位的Ca原子削弱了莫来石中的Si—O键,使得配煤后的混煤灰熔融温度降低。量子化学计算得到的灰中矿物质分子结构及相应的物理化学特性,如化学状态、表面化学活性及成键特性等,能够很好的从灰中矿物质分子微观结构特性解释高温下煤灰熔融过程中耐熔矿物与助熔矿物间的反应机理。

关键词：配煤灰熔融性温度分子微观结构量化计算

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考虑近壁区域分子粘性的置换通风数值模拟

同济大学学报（自然科学版） 2003年第4期31卷 413-417页

作者：马国彬茅清希同济大学热能工程系上海 200092

采用K ε两方程模型对置换通风气流组织进行数值模拟 ,其中在壁面附近的粘性支层中采用壁面函数法 ,并对气流组织的速度场和温度场进行可视化处理 .分析置换通风方式在空态和室内有障碍物时气流组织的异同点。

关键词：气流组织置换通风 K-ε两方程模型壁面函数法障碍物

主链含萘酰亚胺的聚芳醚型聚合物的合成及其光电性能

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发光学报 2012年第3期33卷 243-246页

作者：陈杰贺英潘照东张瑶斐朱棣顾莹王均安上海大学材料科学与工程学院高分子材料系上海200072 上海大学材料科学与工程学院材料研究所上海200072

萘酰亚胺衍生物是一类发光效率优良的电子传输型电致发光材料。本文采用亲核取代反应将其作为聚合物主链的一部分构成主链含1,8-萘酰亚胺的聚芳醚型发光聚合物(PENI),聚合物的重均分子量为4 300。通过FT-IR和NMR对单体及聚合物的结构进... 详细信息

萘酰亚胺衍生物是一类发光效率优良的电子传输型电致发光材料。本文采用亲核取代反应将其作为聚合物主链的一部分构成主链含1,8-萘酰亚胺的聚芳醚型发光聚合物(PENI),聚合物的重均分子量为4 300。通过FT-IR和NMR对单体及聚合物的结构进行了鉴定,并研究了其光致发光性能和电化学性能。在分子量较小时,PENI薄膜的PL发射峰位于407,456,530 nm;当聚合物分子量提高后,发射峰红移14 nm左右。采用循环伏安法测得聚合物的HOMO和LUMO分别为-5.64 eV和-2.93 eV,Eg为2.71 eV。

关键词： 1,8-萘酰亚胺光电聚合物亲核取代

fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism

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fMRI revealed neural substrate for reversible working memory...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： De-Fa ZHU~(1,*),Zhao-Xin WANG~(2,6,*),Da-Ren ZHANG~2,Zhong-Lin PAN~3,Sheng HE~4,Xiao-Ping HU~5,Xiang-Chuan CHEN~(2,*), Jiang-Ning ZHOU~(2,*) 1 department of Endocrinology,Anhui Geriatric Institute,the First Affiliated Hospital of Anhui Medical university, Hefei 230022,china 2 Hefei National laboratory for Physical science at Microscale,and School of Life science,university of science and Technology of china,Hefei,230027,china 3 department of Radiology,PLA 105 hospital,Hefei,230033,china 4 department of Psychology,university of Minnesota,Minneapolis,MN 55455 5 department of Biomedical engineering,Georgia Tech and Emory university,Atlanta,GA 30322 6 Guangdong key Lab of Medical molecular Imaging,Shantou university Medical College,Shantou,515041,china

＜正＞Cognitive impairment has been found in thyroid hormone-related diseases（e.g.,hyperthyroidism and hypothyroidism） for a long ***,whether and how subclinical hypothyroidism（SCH） causes any deficits in brain functions,and whether a hormone replacement treatment is necessary for SCH patients,still remain controversial subjects. In the present study,functional magnetic resonance imaging（fMRI） was used to measure brain functions by asking euthyroid subjects,hyperthyroid patients,and SCH patients to perform the widely used digit n-back working memory task. After having been treated with L-thyroxine for about six months,the SCH patients were asked to do the same fMRI *** hypothyroid and SCH patients scored significantly lower in the 2-back task than either the hyperthyroid patients or the euthyroid subjects（P ＜ 0.012）.The fMRI showed that a common fronto-parietal network,including bilateral middle / inferior frontal gyri（M/IFG）,bilateral dorsolateral prefrontal cortex（DLPFC）,bilateral premotor areas（PreMA）,the supplementary motor area / anterior cingulate cortex（SMA/ACC）,and bilateral parietal areas（PA）,was activated by the nback task in all the *** quantitative analysis showed that the load effect of BOLD response appeared in all the five regions of interest（ROIs） in the euthyroid and hypothyroid *** the pre-treatment SCH patients,however,the load effect of BOLD response was only found in the PA and PreMA,but not in other frontal cortex ROIs（GLM,F ＜ 2.6,P ＞ 0.1）.After an approximately six-month treatment with LT4,the SCH patients exhibited the same load effects in all five ROIs as the euthyroid subjects（GLM,F ＞ 6,P ＜ 0.05） along with an improvement of performance in N-back *** results suggest that working memory（but not other memory functions） is impaired in SCH patients,mainly as far as disorders of the fronto-parietal network were *** the memory performance and frontal executive functions were improved after a

关键词： working memory functional magnetic resonance imaging(fMRI) frontal cortex subclinical hypothyroidism(SCH) L-thyroxine treatment

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结晶高分子的若干问题

高分子材料科学与工程 1987年第5期 1-7页

作者：王立惠复旦大学材料科学系

本文对结晶高分子的模型,形态与分子量的关系,退火,拉伸等作用对结晶形态的影响等问题的研究现状进行了介绍和讨论。对其中待解决的一些问题也进行了评论。

关键词：结晶高分子密度增厚聚乙烯单晶片晶晶形高分子材料科学与工程链折叠高分子链晶体非晶区稀溶液等温结晶