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Electric-stimulus rate encoding algorithm of Mandarin tonal information in cochlear implant

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Progress in Natural Science:Materials International 2006年第12期16卷 1315-1321页

作者： GUAN Tian~1, GONG Qin~1 and YE Datian~2.*(1. department of Biomedical engineering,{2., beijing 100084, china 2. Research Center of Biomedical engineering, Graduate School at Shenzhen,{2., Shenzhen 518055, china) [a]department of Biomedical engineering Tsinghua University Beijing China [b]Research Center of Biomedical engineering Graduate School at Shenzhen Tsinghua University Shenzhen China

The modern multi-channel cochlear implants usually extract and encode the temporal envelope cues. This kind of algorithms can hardly satisfy the users who speak tonal languages, such as Mandarin. Many studies have tried to enhance the recognition ability of Mandarin through encoding tonal information and made suggestions to frequency-modulate the fixed pulse-rate carrier with the extracted tonal information based on the rate-pitch theory in electric hearing. However, how to encode and deliver the tonal information such as F_0by changing electric-stimulus rate has not got further study in clinical electric-stimulus mode. The present paper focuses on this matter by piecewise calculating the appreciable electric-stimulus rates. Then an electric-stimulus encoding algorithm of Mandarin tone is brought forward and testified through acoustic simulations. Such conclusion can be drawn that this algorithm of electric-stimulus rate could convey tonal information well and help to enhance the Mandarin speech recognition ability.

关键词： cochlear implant tone fundamental frequency electric-stimulus rate.

Parameter estimation for whole-body kinetic model of FDG metabolism

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Progress in Natural Science:Materials International 2006年第11期16卷 1164-1170页

作者： CUI Yunfeng~1, BAI Jing~1**, CHEN Yingmao~2.and TIAN Jiahe~2.1. department of Biomedical engineering,{2., beijing 100084, china 2. department of Nuclear Medicine, General Hospital of PLA, beijing 100853, china) [a]department of Biomedical engineering Tsinghua University Beijing China [b]department of Nuclear Medicine General Hospital of PLA Beijing China

Based on the radioactive tracer [ ~ 18 F]2.fluoro-2.deoxy-D-glucose （FDG）, positron emission tomography （PET）, and compartment model, the tracer kinetic study has become an important method to investigate the glucose metabolic kinetics in human body. In this work, the kinetic parameters of three-compartment and four-parameter model for the FDG metabolism in the tissues of myocardium, lung, liver, stomach, spleen, pancreas, and marrow were estimated through some dynamic FDG-PET experiments. Together with published brain and skeletal muscle parameters, a relatively complete whole-body model was presented. In the liver model, the dual blood supply from the hepatic artery and the portal vein to the liver was considered for parameter estimation, and the more accurate results were obtained using the dual-input rather than the single arterial-input. The established whole-body model provides the functional information of FDG metabolism in human body. It can be used to further investigate the glucose metabolism, and also be used for the simulation and visualization of FDG metabolic process in human body.

关键词： compartment model FDG PET parameter estimation.

Expression of lignin peroxidase H2.from Phanerochaete chrysosporium by multi-copy recombinant Pichia strain

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Journal of Environmental Sciences 2009年第2期21卷 218-222页

作者： WANG Wei,WEN Xianghua department of Environmental Science and engineering,{2. university,beijing 100084,china. department of Environmental Science and engineering Tsinghua University Beijing 100084 China

The lipH2.gene, encoding the expression of lignin peroxidase, was cloned from Phanerochaete chrysosporium BKM-F-1767 and expressed in Pichia pastoris X-33, a yeast. The cDNA of LiPH2.was generated from total RNA extracted from P chrysosporium by PCR with primers that do not contain a P. chrysosporium lignin peroxidase secretion signal. The gene was then successfully inserted into the expression vector pPICZα, and resulted in the recombinant vector pPICZα-lipH2. The transformation was conducted in two ways. One was using the wild Pichia pastoris as the recipients, which results in the recombinant P. pastoris with single or low lipH2.gene copy. The second was using P. pastoris and single or low lipH2.gene copy as the recipients, which results in the recombinant P. pastoris with multi-copies of lipH2.genes. This study firstly expressed the gene lipH2.in P. pastoris and achieved the successful expression of the lipH2.depending upon the generation of a recombinant strain that contained multiple copies. The lignin peroxidase activity reached a maximum of 15 U/L after 12.h induction.

关键词： heterologous expression lignin peroxidase Pichia pastoris

CONSERVATION OF THREE-POINT COMPACT SCHEMES ON SINGLE AND MULTIBLOCK PATCHED GRIDS FOR HYPERBOLIC PROBLEMS

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Journal of Computational Mathematics 2003年第3期21卷 383-400页

作者： Zi-niu Wu (department of engineering Mechanics,{2., beijing 100084, china) department of engineering Mechanics Tsinghua University 北京 100084

For nonlinear hyperbolic problems, conservation of the numerical scheme is important for convergence to the correct weak solutions. In this paper the conservation of the well-known compact scheme up to fourth order of accuracy on a single and uniform grid is studied, and a conservative interface treatment is derived for compact schemes on patched grids. For a pure initial value problem, the compact scheme is shown to be equivalent to a scheme in the usual conservative form. For the case of a mixed initial boundary value problem, the compact scheme is conservative only if the rounding errors are small enough. For a patched grid interface, a conservative interface condition useful for mesh refinement and for parallel computation is derived and its order of local accuracy is analyzed.

关键词： Conservation Compact scheme Uniform grid Multiblock patched grid.

LARGE DEFLECTION THEORY OF NANOBEAMS

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Acta Mechanica Solida Sinica 2010年第5期23卷 394-399页

作者： Dujuan Zeng Quanshui Zheng 1(department of engineering Mechanics,{2. university,beijing 100084,china) [a] department of engineering Mechanics Tsinghua University Beijing 100084 China

One-dimensional nanostructured materials are often used as beams in many applications such as ultrahigh-frequency resonators and ultrasensitive sensors. Compared with usual macroscopic beams, nanobeams have much higher surface/volume ratios so that their surface energies may play a significant role. Besides, they often bear large deflections due to their typically large slenderness ratios and larger elastic ranges. There is, however, lack of a theory that takes into account of both the above two features owned by nanobeams. In this paper, we present such a theory and give applied examples to show that surface energy and large deflection may individually or jointly have notable effects.

关键词： nanobeam surface energy large deflection

An atlas-based fuzzy connectedness method for automatic tissue classification in brain MRI

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Progress in Natural Science:Materials International 2006年第10期16卷 1106-1110页

作者： ZHOU Yongxin and BAI Jing (department of Biomedical engineering,{2., beijing 100084, china) [a]department of Biomedical engineering Tsinghua University Beijing China

A framework incorporating a subject-registered atlas into the fuzzy connectedness (FC) method is proposed for the automatic tissue classification of 3D images of brain MRI. The pre-labeled atlas is first registered onto the subject to provide an initial approximate segmentation. The initial segmentation is used to estimate the intensity histograms of gray matter and white matter. Based on the estimated intensity histograms, multiple seed voxels are assigned to each tissue automatically. The normalized intensity histograms are utilized in the FC method as the intensity probability density function (PDF) directly. Relative fuzzy connectedness technique is adopted in the final classification of gray matter and white matter. Experimental results based on the 2. data sets from IBSR are included, as well as comparisons of the performance of our method with that of other published methods. This method is fully automatic and operator-independent. Therefore, it is expected to find wide applications, such as 3D visualization, radiation therapy planning, and medical database construction.

关键词： fuzzy connectedness atlas-based segmentation brain tissue classification MR1.

Study on Numerical Simulation of Mold Filling and Heat Transfer in Die Casting Process

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Journal of Materials Science & Technology 2000年第3期16卷 269-272页

作者： Liangrong JIA, Shoumei XIONG and Baicheng LIU (department of Mechanical engineering,{2., beijing 100084, china) department of Mechanical engineering Tsinghua University Beijing 100084 China

A 3-D mathematical model considering turbulence phenomena has been established based on a computational fluid dynamics technique, so called 3-D SOLA-VOF (Solution Algorithm-Volume of Fluid), to simulate the fluid flow of mold filling process of die casting. In addition, the mathematical model for simulating the heat transfer in die casting process has also been established. The computation program has been developed by the authors with the finite difference method (FDM) recently. As verification, the mold filling process of a S-shaped die casting has been simulated and the simulation results coincide with that of the benchmark test. Finally, as a practical application, the gating design of a motorcycle component was modified by the mold filling simulation and the dies design of another motorcycle component was optimized by the heat transfer simulation. All the optimized designs were verified by the production practice.

关键词： Study on Numerical Simulation of Mold Filling and Heat Transfer in Die Casting Process Mold Simulation

Semi-solid Processing of Al-7Graghite Composite

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Journal of university of Science and Technology beijing 2001年第3期8卷 203-206页

作者： Peng Zhang, Yunhui Du, Daben Zeng department of Mechanical engineering,{2., beijing 100084, china Tsing Hua Univ Dept Engn Mech Beijing 100084 Peoples R China

Al-7graphite composite was processed using Al-7graphite mushy prepared by electromagnetic-mechanical stirring method, and the influence of solid fraction on the distributing of graphite particles in ingot was studied. The results shows that the relationship between solid fraction and stirring temperature of mushy is: f(s) = 591.5-0.897 t (where f(s) is the solid fraction, t is the stirring temperature). For Al-7graphite composite, with the increasing of solid fraction, the aggregation extent of graphite particles reduced gradually, and when solid fraction was larger than 30%, graphite particles could distribute evenly in ingot.

关键词： Al-7graphite composite electromagnetic-mechanical stirring method distributing of graphite particles solid fraction stirring temperature

Thermodynamic Significance of Human Basal Metabolism

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Journal of Thermal Science 1993年第2期2卷 81-86页

作者： Wang Cuncheng Thermal engineering department{2., beijing 100084, P.R. china 1. Thermal engineering department{2. 100084 Beijing P.R. China

The human basal state,a non-equilibrium steady state,is analysed in this paper in the light of the First and Second Laws of Thermodynamics whereby the thermodynamic significance of the basal metabolic rate and its distinction to the dissipation function and exergy loss are *** analysis demonstrates the correct expression of the effects of the blood flow on the heat balance in a human-body bio-heat model and the relationship between the basal metabolic rate and the blood perfusion.

关键词： thermodynamic laws basal metabolism blood perfusion dissipation function exergy loss