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Heat Shock Protein 90 Indirectly Regulates ERK Activity by Affecting Raf Protein Metabolism

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Acta Biochimica et Biophysica Sinica 2005年第7期37卷 501-505页

作者： Fei DOU Liu-Di YUAN Jing-Jing ZHU department of Genetics and development Biology,Southeast university Medical School,Nanjing 210009,china department of Genetics and development Biology Southeast University Medical SchoolNanjing 210009 China

Extracellular signal-regulated protein kinase (ERK) has been implicated in the pathogenesis ofseveral nerve system *** more and more kinases have been discovered to be the client proteins ofthe molecular chaperone Hsp90,the use of Hsp90 inhibitors to reduce abnormal kinase activity is a newtreatment strategy for nerve system *** study investigated the regulation of the ERK pathway *** showed that Hsp90 inhibitors reduce ERK phosphorylation without affecting the total ERKprotein *** investigation showed that Raf,the UPstream kinase in the Ras-Raf-MEK-ERK pathway,forms a complex with Hsp90 and *** cells with Hsp90 inhibitors facilitates Raf degradation,thereby down-regulating the activity of ERK.

关键词： molecular chaperone phosphorylation Hsp90 extracellular signal-regulated protein kinase (ERK) Raf tau

Theoretical Perspectives on Natural and Artificial Micro-swimmers

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Acta Mechanica Solida Sinica 2021年第6期34卷 783-809页

作者： jinan Liu Yiqiang Fu Xiongjun Liu Haihui Ruan Research Center for Fluid-Structure Interactions Department of Mechanical EngineeringThe Hong Konssg Polytechnic UniversityHung HomKowloonHong KongChina State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing100083China

The observations of microorganisms revealed how they *** inspired by them,studies on artificial micro-robots with various actuation mechanisms have been *** elucidate the essential concepts in understanding the dynamic behaviors of natural and artificial micro-swimmers—so as to control the latter in future applications,in this paper,we summarize the historical achievements and describe our theoretical *** first introduce the studies on microorganisms and their propulsion *** reviewing the basic principles and the development of the understanding of them,we take the flagellated micro-swimmers as an example to elaborate on the theories of their *** review the progress in actuation strategies of artificial flagellated micro-swimmers and then propose two possible strategies to realize the turning of a flagellated micro-swimmer—the key step toward steerability through remote ***,we describe the inadequacies of the investigations on this topic and our perspectives on future developments.

关键词： Natural micro-swimmer Artificial micro-swimmer External field actuation Manipulation strategies Propulsion

Changes of testicular ultrastructure of rat after clenbuterol exposure

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Journal of Reproduction and Contraception 2015年第1期26卷 1-5页

作者： Jing LI Wei-jie ZHU department of Pathophysiology Medical College Jinan University department of developmental and Regenerative Biology College of Life Science and Technology Jinan University

Objective To investigate effects of clenbuterol （CLB） on testicular ultrastructure of rat. Methods Twenty adult male Sprague-Dawley rats were randomly divided into four groups （5 rats per group）. CLB solved in normal saline solution was given at the dose of O mg/kg body weight （bw）（group A, as control）, 0.4 mg/kg bw （group B）, 2.0 mg/kg bw （group C）, and 18.5 mg/kg bw （group D）for 14 d by garage consecutively, respectively. Transmission electron microscopy was used to observe changes on testicular ultrastructure. Results In group B, some small vacuoles were found in Sertoli cells. In groups C and D, vacuoles were common in Sertoli cells and spermatogonia. The phenomenon of vacuolation in group D was more severe than that in group C. In group D, basal membrane showed some irregular and wrinkled changes, Leydig cells had more vacuoles and increased lipid droplets. Conclusion Testicular ultrastructure of rat had pathological changes after CLB exposure, and the alterations became more severe with the increasing doses.

关键词： clenbuterol (CLB) ultrastructure Sertoli cell testis rat

Effects of genistein, daidzein and glycitein on the osteogenic and adipogenic differentiation of bone marrow stromal cells and on the adipogenic trans-differentiation of osteoblasts

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Progress in Natural Science:Materials International 2005年第11期15卷 993-999页

作者： LI Xianghui, ZHANG Jinchao, SUI Senfang and YANG Mengsu (State Key Laboratory of Biomembrane, department of Biological Sciences and Biotechnology, Tsinghua university, Beijing 100084, china department of Chemistry, College of Chemistry & Environmental Science, Hebei university, Baoding 071002, china department of Biology and Chemistry, city university of Hong Kong, Hong Kong, china) State Key Laboratory of Biomembrane Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China department of Chemistry College of Chemistry and Environmental Science Hebei University Baoding 071002 China department of Biology and Chemistry City University of Hong Kong Hong Kong Hong Kong

The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), alkaline phosphatase (ALP) activity and oil red O assays were used to examine the effects of genistein, daidzein and glycitein on the osteogenic and adipogenic differentiation of primary mouse bone marrow stromal cells (MSCs) and the adipogenic trans-differentiation of primary mouse osteoblasts. The results indicated that daidzein, genistein and glycitein at concentrations from 1×10-8 mol/L to 1×10-5mol/L promoted the proliferation of MSCs and osteoblasts; genistein, daidzein and glycitein promoted osteogenic differentiation and inhibited adipogenic differentiation of MSCs, and inhibited adipocytic transdifferentiation of osteoblasts at appropriate concentrations as 17β-estradiol. It suggests that genistein, daidzein and glycitein regulate a dual differentiational process of MSCs into the osteogenic and adipogenic lineages, and trans-differentiational process of primary osteoblasts into the adipocyte lineages, causing a lineage shift toward osteoblast. Protective effects of them on bone may be mediated by a reversal of adipogenesis which may promote the proliferation, differentiation and mineralization of osteoblasts, and make adipocytes secrete less cytokines which may promote osteoclast formation and activation. In addition, the results also indicated that genistein, daidzein and glycitein may be helpful in preventing the development of steroid induced osteonecrosis.

关键词： genistein daidzein glycitein bone marrow stromal cells osteoblasts osteogenic differentiation adipogenic differentiation adipogenic trans-differentiation.

Growth of HT-LiCoO2 thin films on Pt-metalized silicon substrates

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Rare Metals 2008年第3期27卷 266-272页

作者： ZHANG Yao~(a,b) CHUNG Chiyuen~b ZHU Min~a ~a School of Mechanical Engineering,South china university of Technology,Guangzhou 510640,china ~b department of Physics and Materials Science,city university of Hong Kong,Hong Kong,china School of Mechanical Engineering South China University of Technology Guangzhou 510640 China department of Physics and Materials Science City University of Hong Kong Hong Kong China

Layered LiCoO2（HT-LiCoO2）films were grown on Pt-metalized silicon（PMS）substrates and polished bulk nickel（PBN）substrates by pulsed laser *** effects of substrate temperature,oxygen pressure,and substrate surface roughness on the microstructure of LiCoO2 films were *** has been found that a higher substrate temperature and a higher oxygen pressure favor the formation of better crystallized and less lithium-deficient HT-LiCoO2 *** HT-LiCoO2 film deposited on PBN substrates consists of large randomly orientated equiaxial grains,whereas on PMS substrate,it is made up of loosely packed highly[001]preferential orientated triangular shaped grains with the average grain size less than 100 *** measurements show that the highly[001]preferentially orientated nanostructured HT-LiCoO2 thin film grown on PMS substrate has good structural stability upon lithium insertion/extraction and can deliver an initial discharge capacity of approximately 45μA·h·cm-2·μm-1with a cycling efficiency of above 99% at the charge/discharge rate of 0.5 C.

关键词： thin film LiCoO2 pulsed laser deposition electrochemical properties thin film growth

Investigation on growth and laser properties of new laser crystal Nd:Gd_(0.8)La_(0.2)VO_4

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Chinese Science Bulletin 1999年第9期44卷 863-864页

作者： ZHANG Huaijin , MENG Xianlin , ZHU Li ZHANG Hongzhen , WANG Pu , Judith Dawes , WANG Changqing and Y. T. ChowInstitute of Crystal Materials and National Laboratory of Crystal Materials , Shandong university , jinan 250100, china Center for Lasers and Applications , Macquarie university , NSW2109, Australia department of Electronic Engineering , city university of Hong Kong , china Institute of Crystal Materials and National Inboratory of Crystal Materialsr Shandng Unitvrsity Jinan China Center for Lasers and Applicatwns Macquarie Uniuersity Australia department of Electronic Engineering City University of Hong Kong China

LASER-DIODE （LD） pumped solid-state lasers have a variety of applications in military, industry, medical treatment and scientific researches due to their high stability, compactness, high efficiency and long lifetime, and become one of the hot points in the laser field. In this field, Nd: YVO4 laser has been commercialized. Nd:GdVO4 crystal has a big absorption coefficient, high thermal conductivity, and excellent laser properties. Nd: Gd0.5La0.5VO4 crystal formed by La3+ ions replacing some Gd3+ ions in Nd:GdVO4 has larger FWHM （full width at half maximum） than Nd: GdVO4 crystal. To combine the merits of Nd : GdVO4 and Nd : Gd0.5 La0.5 VO4, we grow the crystal doped with 20% La (Nd: Gd0.8La0.2VO4, and study its properties. Now we introduce the laser and spectroscopic properties of the crystal in brief.

关键词： Nd Gd VO4 La

Hyperthermia by a nitinol stent in an alternating magnetic field:Safety and feasibility in rabbit esophageal cancer

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Progress in Natural Science:Materials International 2009年第12期19卷 1713-1719页

作者： Jumei Zhou~(a,b),Ning Li~c,Qisheng Xia~d,Lehui Du~a,Xiaowen Wang~b,Linyun Zhao~b, Xufei Wang~b,Jintian Tang~(b,*) a department of Oncology,Xiangya Hospital of Central South university,Changsha 410008,china b Institute of Medical Physics and Engineering,department of Engineering Physics,TsingHua university,Beijing 100084,china c The People Hospital of Zhangqiu city,jinan 250200,china d Clinical Institute of Science,china-Japan Friendship Hospital,Beijing 100029,china department of Oncology Xiangya Hospital of Central South University Changsha 410008 China Institute of Medical Physics and Engineering Department of Engineering Physics TsingHua University Beijing 100084 China The People Hospital of Zhangqiu city Jinan 250200 China Clinical Institute of Science China-Japan Friendship Hospital Beijing 100029 China

Hyperthermia by heating in-stent is a potentially new method to treat esophageal *** study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field(AMF) and investigated whether this method offers a therapeutic option for esophageal *** stents were placed in the cervical esophagi of healthy rabbits,which were heated in an AMF for different times at 43,46 and 50℃.The esophagi were histologically examined after a week to observe whether there was transmural *** esophageal cancer of rabbit placed nitinol stents were heated in an AMF at 46℃for 10 *** were heated to a target temperature within 5 *** highest tolerated temperature and time for the healthy rabbit esophagus was at 46℃for 10 *** growth was delayed by heating and it was statistically *** the rabbit esophageal wall at 46℃for 10 min proves to be safe and effective in delaying tumor growth.

关键词： Hyperthermia Nitinol stent Alternating magnetic field Rabbit Esophageal tumor

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战国秦汉时期私商类型叙论

山东师范大学学报（人文社会科学版） 2001年第5期46卷 54-57页

作者：张弘济南大学学报编辑部山东济南250002

根据战国秦汉时期商人经营商品的性质、类别及经营业务的规模 ,可以把私商划分为 5类 ,即贩运商人、盐铁商人、囤积商人、农林畜牧商人和中小商人。除囤积商人外 ,其他类型的商人 ,特别是人数众多的中小商人。

关键词：战国秦汉时期私商类型

Effect of daidzin,genistin,and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts

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Acta Pharmacologica Sinica 2005年第9期26卷 1081-1086页

作者： Xiang-hui LI~1 Jin-chao ZHANG~(2,3) Sen-fang SUI~(1,4) Meng-su YANG~(3,4)1 State Key Laboratory of Biomembrane department of Biological Sciences and Biotechnology,Tsinghua university,Beijing 100084,china 2 department of Chemistry College of Chemistry and Environmental Science,Hebei university,Baoding 071002,china 3 department of Biology and Chemistry,city university of Hong Kong,Hong Kong,china department of Biological Sciences and Biotechnology State Key Laboratory of Biomembrane Tsinghua University Beijing China department of Chemistry College of Chemistry and Environmental Science Hebei University Baoding China department of Biology and Chemistry City University of Hong Kong Hong Kong China

Aim:To examine the effect of daidzin,genistin,and glycitin on the osteogenic andadipogenic differentiation of bone marrow stromal cells（MSC）and the adipogenictransdifferentiation of ***:MTT test,alkaline phosphatase（ALP）activity measurement,Oil Red O stain and measurement were ***:Daidzin,genistin,and glycitin 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L all promoted the proliferation of primary mouse bone MSC and *** 5×10-7mol/L and genistin 1×10-6mol/L promoted the osteogenesis *** 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L and glycitin 1×10-8,1×10-6,and 1×10-5mol/L inhibited the adipogenesis of ***,genistin,and glycitin 1×10-8,5×10-7,1×10-6,5×10-6,and 1×10-5mol/L all inhibited the adipocytictransdifferentiation of ***:Daidzin,genistin,and glycitinmay modulate differentiation of MSC to cause a lineage shift toward the osteo-blast and away from the adipocytes,and could inhibit adipocytic transdifferen-tiation of *** could also be helpful in preventing the developmentof osteonecrosis.

关键词： daidzin genistin glycitin bone marrow stro-real cells osteogenic differentiation adipogenic differentiation osteoblasts adipocytic transdifferentiation