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第十五届中国神经精神药理学学术会议

作者： JIANG Li-ying~1,TANG Su-su~1,WANG Xiao-yun~1,LIU Li-ping~2, LONG Yan~1,HU Mei~1,LIAO Ming-xing~3,DING Qi-long~3, HU Wei~2,LI Jia-chang~3,HONG Hao~1 (1.department of Pharmacology,china Pharmaceutical university, Nanjing 210009,china 2.department of Pharmacy,the Second hospital Affiliated to Anhui Medical university,Hefei 230031,china 3.Experimental Instruction Center of Pharmaceutical & Medical Basic,china Pharmaceutical university, Nanjing 210009,china)

OBJECTIVE Pioglitazone,known as a peroxisome proliferator-activated receptorγ(PPARγ) agonist,is used to treat type 2 diabetes(T2DM).T2DM has been associated with reduced performance on numerous domains of cognitive function. Here,we investigated the effects of pioglitazone on memory impairment in a mouse model with defects in insulin sensitivity and secretion,namely high-fat diet(HFD) streptozotocin(STZ)-induced diabetic *** ICR mice were fed an HFD for 4 weeks and then injected with a single low dose of STZ followed by continued HFD feeding for an additional 4 *** diabetic mice were orally administered with pioglitazone(9,18 mg·kg) for 4 - 5 weeks.Y-maze test and Morris water maze test(MWM) were employed for testing learning and memory. Serum glucose,serum insulin,serum triglyceride,brain amyloid peptide-β(Aβ),brainβ-site amyloid precursor protein cleaving enzyme(BACE1),brain nuclear factor kB(NF-κB),brain receptor for advanced glycation end products(RAGE) were also *** The STZ/HFD diabetic mice,characterized by hyperglycemia,hyperlipemia and hypoinsulinemia,performed poorly on Y-maze and MWM hence reflecting impairment of learning and memory behavior with increases of Aβ/Aβ, BACE1,NF-κB,and RAGE in *** of PPARγagonist, pioglitazone,significantly reversed diabetes-induced impairment of learning and memory behavior,which is involved in decreases of Aβ/Aβ via inhibition of NF-kB,BACE1 and RAGE in brain as well as attenuation of hyperglycemia,hyperlipemia and *** It is concluded that PPARγagonist pioglitazone may be considered as potential pharmacological agents for the management of cognitive dysfunction in T2DM.

关键词： pioglitazone cognition β-amyloid BACE1 NF-κB diabetes mellitus

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Inhibitive Effect of Genistein on Hypoxia-Induced basic Fibroblast Growth Factor Expression in Human RetinalPigment Epithelium Cells

Inhibitive Effect of Genistein on Hypoxia-Induced basic Fibr...

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第十五届国际药理学大会

作者： Pan Jin-Shun Zhu Huai-Jun Zhang Bei Li Hua Yan Hong Wang Bin.department of Pharmacology NanjingMedical university Nanjing 210029 china.department of Obstetric and gynecology Affiliated hospital of Nanjing Medicaluniversity Nanjing 210029 china.

＜正＞ The time course changes of basic fibroblast growth factor （bFGF） expression in- duced by hypoxia and the effectsof genistein on hypoxia - induced bFGF expression in the human retinal pigment epithelium （RPE） cells werestudied. Hypoxia significantly increased bFGF mRNA expression. The maximal level detected at 24 h was abouttwo times of that at the start of treatment. With pre - treatment of genistein for 30 min. the elevated expression ofbFGF mRNA was suppressed in a concentration - dependent manner. bFGF mRNA expression was reduced to30. 4% by 200 uM genistein when compared with that untreated with genistein. Hypoxia treatment alsoremarkably increased the expression of bFGF protein. At 24 h after hypoxia. the highest expression of bFGF protein was observed, it was about two times as much as that at the start of treatment. Genistein could alsosuppress bFGF protein expression in a concentration- dependent manner. The highest suppression was observedwhen exposed to 200 uM genistein. which was 43 % of control. These results suggested that suppression of bFGF expression in RPE cells might partly account for the inhibitive effect of genistein on retinal neovascularizationinvivo.

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Assessment of three-dimensional ultrasound imaging technology to the morphology of pelvic hiatus in late pregnancy women

Assessment of three-dimensional ultrasound imaging technolog...

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第二届长三角超声医学论坛暨2009年浙江省超声医学学术...

作者： department of Ultrasound in Medicine,Affiliated Sixth People’s hospital Shanghai Jiaotong university,Shanghai 200233,china Chun-juan SHAO Bing HU

Background Female pelvic floor dysfunction(FPFD) happens with a high *** the development for study in this field and increases of people’s awareness,pelvic hiatus(PH) in female has attracted more and more *** imaging...

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超声内镜和多层螺旋CT在SiewertⅡ和Ⅲ型食管胃结合部腺癌术前TN分期中的临床应用价值

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中华肿瘤杂志 2018年第3期40卷 191-195页

作者：郑国良黎家驹向国卿朱佳朱海涛杨东王跃张峻孟祥宇郑志超中国医科大学肿瘤医院辽宁省肿瘤医院胃外科沈阳110042 中国医科大学肿瘤医院辽宁省肿瘤医院影像科沈阳110042 中国医科大学肿瘤医院辽宁省肿瘤医院内镜科沈阳110042

目的探讨超声内镜（EUS）和多层螺旋计算机断层扫描（MSCT）检查对SiewertⅡ和Ⅲ型食管胃结合部腺癌（AEG）术前T、N分期准确性的影响，并评价其临床应用价值。方法回顾性分析术前未行放化疗的145例经术后病理证实且临床资料完整的Siew... 详细信息

目的探讨超声内镜（EUS）和多层螺旋计算机断层扫描（MSCT）检查对SiewertⅡ和Ⅲ型食管胃结合部腺癌（AEG）术前T、N分期准确性的影响，并评价其临床应用价值。方法回顾性分析术前未行放化疗的145例经术后病理证实且临床资料完整的SiewertⅡ和Ⅲ型AEG患者，均于术前进行EUS和MSCT检查，结合术后病理分期进行对比分析。结果EUS诊断SiewertⅡ和Ⅲ型AEG各T分期的敏感度、特异度、准确率均高于MSCT；其中EUS诊断T分期总的准确率为90.3%，明显高于MSCT（63.5%; χ2＝29.52，P〈0.01）；EUS诊断T1、T2、T3期SiewertⅡ和Ⅲ型AEG的敏感度分别为89.5%、91.1%和85.2%，均明显高于MSCT（分别为42.1%、66.7%和29.6%，均P〈0.01）。EUS和MSCT诊断SiewertⅡ和Ⅲ型AEG N分期总的准确率分别为75.9%和64.8%，差异有统计学意义（P＝0.04）。EUS诊断N1期SiewertⅡ和Ⅲ型AEG的敏感度为82.1%，明显高于MSCT（53.6%，P＝0.02）；EUS诊断N2期SiewertⅡ和Ⅲ型AEG的敏感度为79.3%，明显高于MSCT（60.4%，P＝0.03）。但在N0和N3期敏感度的比较中，EUS和MSCT的诊断差异无统计学意义（P〉0.05）。结论EUS诊断T1、T2、T3期SiewertⅡ和Ⅲ型AEG的优势明显大于MSCT；EUS较MSCT对N1、N2期转移淋巴结的判断效果更好。

关键词：食管胃结合部癌胃切除术超声内镜螺旋CT

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从20世纪的最后10年看我国青年婚恋观的变迁

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陕西师范大学学报（哲学社会科学版） 2001年第4期30卷 165-169页

作者：罗渝川张进辅西南师范大学心理系四川成都400715

20世纪最后10年青年婚恋观变迁的主要特点是：择偶中自主意识明显增强，择偶范围从地缘、亲缘扩展到业缘。择偶中爱情已占重要位置，经济地位的重要性逐渐上升。性开放从幕后走到台前，对婚前性行为持宽容态度。离婚与婚外恋逐渐增多。

关键词：青年婚恋观性行为 20世纪90年代择偶观婚姻恋爱婚外恋行为离婚

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去卵巢山羊成骨细胞的体外培养

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生物医学工程学杂志 1999年第3期16卷 355-358页

作者：邓力陈槐卿郑虎彭雪梅华西医科大学药学院成都610041 华西医科大学基础医学院成都610014 华西医科大学法医系成都610041

选用摘除双侧卵巢的山羊颅盖骨，体外分离培养成骨细胞，并对分离的成骨细胞做多方面生物学特性鉴定。结果表明：体外培养的去卵巢山羊成骨细胞具有典型成骨细胞的形态特征、碱性磷酸酶活性以及在体外发生钙化的功能；证实了体外培养的... 详细信息

选用摘除双侧卵巢的山羊颅盖骨，体外分离培养成骨细胞，并对分离的成骨细胞做多方面生物学特性鉴定。结果表明：体外培养的去卵巢山羊成骨细胞具有典型成骨细胞的形态特征、碱性磷酸酶活性以及在体外发生钙化的功能；证实了体外培养的去卵巢山羊成骨细胞具有体内成骨细胞的功能和特性。为骨代谢的研究提供了新的实验手段。

关键词：成骨细胞细胞培养体外培养去卵巢山羊

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Combined holmium:YAG laser and pneumatic ballistic ureteroscopic lithotripsy for impacted ureter calculi

Combined holmium:YAG laser and pneumatic ballistic ureterosc...

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第十五届全国泌尿外科学术会议

作者： He hui, Long qingzhi Urology department of the First Affiliated hospital, Medical School of Xi’an Jiaotong university, Xi’an Shaanxi, 710061, china 710061

Object To indicate the efficacy of Combining holmium:YAG laser and pneumatic ballistic ureteroscopic lithotripsy for impacted ureter calculi. Methods Fourty-one patients with impacted ureteral calculi were divided group A(holmium:YAG laser ureteroscopic lithotripsy, n=22) and group B(holmium:YAG laser and pneumatic ballistics ureteroscopic lithotripsy, n=19), who were performed under continuous epidural anesthesia,

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Robust quantum secure direct communication and authentication protocol against decoherence noise based on six-qubit DF state

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Chinese Physics B 2015年第5期24卷 239-246页

作者：昌燕张仕斌闫丽丽韩桂华 department of Network Engineering Chengdu University of Information Technology

By using six-qubit decoherence-free （DF） states as quantum carriers and decoy states, a robust quantum secure direct communication and authentication （QSDCA） protocol against decoherence noise is proposed. Four six-qubit DF states are used in the process of secret transmission, however only the ｜0＇〉 state is prepared. The other three six-qubit DF states can be obtained by permuting the outputs of the setup for ｜0＇〉. By using the ｜0＇〉 state as the decoy state, the detection rate and the qubit error rate reach 81.3%, and they will not change with the noise level. The stability and security are much higher than those of the ping-pong protocol both in an ideal scenario and a decoherence noise scenario. Even if the eavesdropper measures several qubits, exploiting the coherent relationship between these qubits, she can gain one bit of secret information with probability 0.042.

关键词： quantum secure direct communication decoherence noise authentication six-qubit decohevencefree state

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On a robust and effcient maximum depth estimator

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Science china Mathematics 2009年第6期52卷 1212-1232页

作者： ZUO YiJun1,2 & LAI ShaoYong1 1 School of Economic Mathematics,Southwestern university of Finance and Economics,chengdu 610074,china 2 department of Statistics and Probability,Michigan State university,East Lansing,MI 48823,USA

The best breakdown point robustness is one of the most outstanding features of the univariate *** this robustness property,the median,however,has to pay the price of a low effciency at normal and other light-tailed *** equivariant multivariate analogues of the univariate median with high breakdown points were constructed in the past two *** the high breakdown robustness,most of them also have to sacrifice their effciency at normal and other models,*** affine equivariant maximum depth estimator proposed and studied in this paper turns out to be an *** the univariate median,it also possesses a highest breakdown point among all its multivariate *** the univariate median,it is also highly efficient relative to the sample mean at normal and various other distributions,overcoming the vital low-effciency shortcoming of the univariate and other multivariate generalized *** paper also studies the asymptotics of the estimator and establishes its limit distribution without symmetry and other strong assumptions that are typically imposed on the underlying distribution.

关键词： data depth maximum depth estimator median location estimator breakdown point asymptotic distribution robustness effciency

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中国克罗恩病诊治指南(2023年·广州)

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中华炎性肠病杂志（中英文） 2024年第1期8卷 2-32页

作者：中华医学会消化病学分会炎症性肠病学组中国炎症性肠病诊疗质量控制评估中心陈旻湖吴开春不详中山大学附属第一医院消化内科广州510080 空军军医大学西京医院消化病医院西安710032

克罗恩病(CD)病情复杂,涉及多个学科,规范化诊疗对提高CD的疗效及改善预后非常重要。近年来我国在CD领域的基础及临床研究取得丰硕成果,加上新的诊疗理念、新的治疗药物不断应用于临床,使更新CD诊疗共识意见、为广大临床工作者提供基于... 详细信息

克罗恩病(CD)病情复杂,涉及多个学科,规范化诊疗对提高CD的疗效及改善预后非常重要。近年来我国在CD领域的基础及临床研究取得丰硕成果,加上新的诊疗理念、新的治疗药物不断应用于临床,使更新CD诊疗共识意见、为广大临床工作者提供基于最新循证依据的诊治指南成为必要。本指南是由中华医学会消化病学分会炎症性肠病学组结合国外最新共识、国内研究成果和实际情况,在2018年版炎症性肠病诊断和治疗共识意见基础上进行修订。本指南的制定旨在反映当前CD临床诊治的最新理念及研究成果,为CD的临床诊治提供规范化指导意见。

关键词：克罗恩病指南 GRADE分级德尔菲法

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