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Electroacupuncture on PC6 Prevents Opioid-Induced Nausea and Vomiting after Laparoscopic Surgery

Chinese Journal of Integrative Medicine 2013年第4期19卷 277-281页

作者： Siwoo Lee Myeong Soo Lee deok hwa choi Su Kyung Lee Korea Institute of Oriental Medicine University of Science and Technology DaejeonSouth Korea Department of Anesthesiology Wonkwang University School of MedicineIksanSouth Korea Department of Oriental Rehabilitation Medicine Wonkwang University School of Oriental MedicineIksanSouth Korea

Objective： To investigate the treatment time dependence of electroacupuncture （EA） on Neiguan （PC6） for preventing postoperative nausea and vomiting （PONV）. Methods： One hundred and seventy-eight patients, who had received intravenous patient-controlled analgesia （PCA） with Fentanyl, were assigned randomly to three groups using random numbers： a pre-operative EA group （PrEA）, a post-operative EA group （PoEA）, and a non-acupuncture control group （NC）. An anesthetist evaluated the incidence and severity of nausea and vomiting for 48 h after surgery blindly. The main outcomes were severity and freguency of PONV, which were measured with a self-reported questionnaire and a confirmation from the anesthetist. The data were analyzed with ANOVA and Z-test. Results： The incidence of nausea and vomiting was significantly lower in the PrEA group than the NC group during 48 h after surgery （P〈0.01, P〈0.05）. The incidence of vomiting was also significantly lower in the PrEA group than the PoEA group （P〈0.05）. The PoEA subjects evidenced no significant differences compared with the NC subjects in terms of the incidence of nausea and vomiting （P〈0.05）. The severity of nausea was significantly lower in the PrEA group than in the NC and PoEA groups （P〈0.05）. Conclusions： EA on PC6 is effective in the prevention of PONV, and pre-operative acupuncture is more effective than post-operative acupuncture.

关键词： electroacupuncture Neiguan (PC6) postoperative nausea and vomiting

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Ventral hernia after high-intensity focused ultrasound ablation for uterine fibroids treatment:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11204-11209页

作者： Jung-Woo Park hwa Yeon choi Department of Obstetrics and Gynecology Dong-A University College of MedicineBusan 49201South Korea

BACKGROUND High-intensity focused ultrasound(HIFU) ablation is a minimally invasive approach in gynecology that is used to manage uterine *** this procedure is safe and effective,adverse outcomes are becoming a major *** SUMMARY We present a case of ventral hernia that occurred as a rare and delayed complication of HIFU ablation for uterine fibroids *** patient came to the hospital with abdominal bloating that occurred 6 mo after ultrasound-guided HIFU ablation for managing uterine *** ventral hernia,which occurred due to atrophied muscle layers following the procedure,was confirmed by imaging studies and intraoperative *** required a hernia repair with mesh and hysterectomy for definitive treatment of uterine *** High-intensity ultrasound ablation should be performed only on appropriate *** should be educated about potential complications of the procedure and the possibility of subsequent ***-procedural long-term follow-up for detecting delayed adverse effects is important.

关键词： Uterine fibroids High-intensity focused ultrasound ablation Conservative treatment Ventral hernia Complication Case report

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Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging

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Bioactive Materials 2022年第8期7卷 182-205页

作者： hwa Seung Han Song Yi Koo Ki Young choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health ***,they are a significant resource for drug discovery in the development of modern *** many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to *** have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of *** review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and *** review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic ***,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.

关键词： Natural products Phytocompound Nanoformulation Drug delivery Phototherapy

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Intermittent, low-dose, antiandrogen monotherapy as an alternative therapeutic option for patients with positive surgical margins after radical prostatectomy

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Asian Journal of Andrology 2018年第3期20卷 270-275页

作者： Kyung hwa choi Seung Ryeol Lee Young Kwon Hong Dong Soo Park Department Urology CHA Bundang Medical Center CHA University Seongnam Korea.

The aim of the present study was to determine whether oncologic outcomes and adverse events associated with active on/off intermittent antiandrogen monotherapy （daily bicalutamide, 50 mg per day） are comparable with those of standard external beam radiation therapy （EBRT） or combined androgen blockade （CAB） therapy in prostate cancers with positive surgical margins after radical prostatectomy. Two hundred twenty-three patients with positive surgical margins post-radical prostatectomy who underwent active surveillance （AS, n = 32）, EBRT without hormone therapy （n = 55）, intermittent antiandrogen monotherapy without EBRT （IAAM, n= 50）, or CAB without EBRT （n = 86）, between 2007 and 2014, were reviewed retrospectively. Pathologic outcomes, biochemical recurrence rates, radiological disease progression, and adverse events were collected from medical records. Biochemical recurrence rates, biochemical recurrence-free survival rates, and radiological recurrence were not different between the groups （P = 0.225, 0.896, and 0.284, respectively）. Adverse event rates and severities were lower for IAAM compared with EBRT or CAB （both P 〈 0.05）, but were comparable to those for AS （P = 0.591 and 0.990, respectively）. Grade ：〉3 adverse events were not reported in the IAAM or AS groups. Erectile dysfunction and loss of libido rates were lower in the IAAM group compared with the EBRT and CAB groups （P = 0.032）. Gastrointestinal complications were more frequently reported in the EBRT group （P = 0.008）. Active on/off IAAM treatment might be an appropriate treatment option for patients with positive surgical margins after radical prostatectomy. Furthermore, regarding oncologic outcomes, IAAM was comparable to standard EBRT but had a milder adverse event profile.

关键词： androgen receptor antagonists disease progression margins of excision prostatectomy prostatic neoplasms

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Miniaturized multicolor fluorescence imaging system integrated with a PDMS light-guide plate for biomedical investigation

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npj Flexible Electronics 2023年第1期7卷 494-503页

作者： Hyogeun Shin Gun-Wook Yoon Woongsun choi Donghwan Lee Hoyun choi deok Su Jo Nakwon choi Jun-Bo Yoon Il-Joo Cho Department of Biomedical Sciences College of MedicineKorea UniversitySeoulRepublic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DeajeonRepublic of Korea Center for Brain Technology Brain Science InstituteKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea Biotechnology Research Institute of CHROMACH Co. LtdSuwonRepublic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulRepublic of Korea Department of Anatomy College of MedicineKorea UniversitySeoulRepublic of Korea Noul Co. LtdYonginRepublic of Korea

Miniaturized fluorescence imaging systems are promising platforms that overcome the limited use of conventional microscopes in the biomedical ***,there are physical limitations for multicolor fluorescence imaging in existing miniaturized imaging systems because multiple filters have to be integrated into a small ***,we present a miniaturized multicolor fluorescence imaging system integrated with single polydimethylsiloxane(PDMS)light-guide plate(LGP)for multicolor fluorescence *** PDMS LGP allows guiding the transmitted light from the light source only to the fluorescent samples regardless of the wavelength of the light ***,our system is capable of multicolor fluorescence imaging without multiple filters that block the excitation *** demonstrated the usability of our system in the biomedical field by observing green-and red-labeled cells in the *** proposed system can be used in a wide range of applications for studies that require multicolor fluorescence imaging in the biomedical field.

关键词： structure field system

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Gene-diet interactions in gastric cancer risk: A systematic review

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World Journal of Gastroenterology 2014年第28期20卷 9600-9610页

作者： Jeongseon Kim Young Ae Cho Wook Jin choi Seung hwa Jeong Molecular Epidemiology Branch Division of Cancer Epidemiology and PreventionResearch InstituteNational Cancer Center

AIM:To conduct a systematic review of the published epidemiological studies investigating the association of the interactions between gene variants and dietary intake with gastric cancer ***:A literature search was conducted in PubMed,EMBASE,and MEDLINE for articles published between January 2000 and July 2013,and 38 studies were *** studies included various dietary factors(e.g.,fruits and vegetables,soybean products,salt,meat,and alcohol)and genetic variants that are involved in various metabolic ***:Studies suggest that individuals who carry high-risk genetic variants and demonstrate particular dietary habits may have an increased risk of gastric cancer compared with those who do not carry high-risk genetic *** dietary patterns and variations in the frequency of genetic variants may explain the higher incidence of gastric cancer in a particular ***,most previous studies have limitations,such as a small sample size and a retrospective casecontrol *** addition,past studies have been unable to elucidate the specific mechanism in gene-diet interaction associated with gastric ***:Additional large prospective epidemiological and experimental studies are required to identify the gene-diet metabolic pathways related to gastric cancer susceptibility.

关键词： Gastric cancer Gene Diet Interaction

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C-terminal domain of hepatitis C virus core protein is essential for secretion

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World Journal of Gastroenterology 2005年第25期11卷 3887-3892页

作者： Soo-Ho choi Kyu-Jin Park So-Yeon Kim Dong-hwa choi Jung-Min Park Soon B. hwang Ilsong Institute of Life Science

AIM: We have previously demonstrated that hepatitis C virus (HCV) core protein is efficiently released into the culture medium in insect cells. The objective of this study is to characterize the HCV core secretion in insect cells. METHODS: We constructed recombinant baculoviruses expressing various-length of mutant core proteins, expressed these proteins in insect cells, and examined core protein secretion in insect cells. RESULTS: Only wild type core was efficiently released into the culture medium, although the protein expression level of wild type core was lower than those of other mutant core proteins. We found that the shorter form of the core construct expressed the higher level of protein. However, if more than 18 amino acids of the core were truncated at the C-terminus, core proteins were no longer secreted into the culture medium. Membrane flotation data show that the secreted core proteins are associated with the cellular membrane protein, indicating that HCV core is secreted as a membrane complex. CONCLUSION: The C-terminal 18 amino acids of HCV core were crucial for core secretion into the culture media. Since HCV replication occurs on lipid raft membrane structure, these results suggest that HCV may utilize a unique core release mechanism to escape immune surveillance, thereby potentially representing the feature of HCV morphogenesis.

关键词： Hepatitis C virus Core secretion Morphogenesis Virus assembly

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Hybrid gold/DNA nanowire circuit with sub-10nm nanostructure arrays

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Microsystems & Nanoengineering 2020年第1期6卷 221-228页

作者： Jong Seob choi Hye Bin Park Jonathan HTsui Byungyou Hong deok-Ho Kim Hyung Jin Kim Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMD 21205USA Digital Healthcare Research Center Gumi Electronics and Information Technology Research Institute(GERI)350-27GumidaeroGumiGyeongbuk 39253South Korea College of Information and Communication Engineering Sungkyunkwan UniversitySuwon 440-746South Korea Department of Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA

We report on a simple and efficient method for the selective positioning of Au/DNA hybrid nanocircuits using a sequential combination of electron-beam lithography(EBL),plasma ashing,and a molecular patterning *** nanostructures produced by the EBL and ashing process could be uniformly formed over a 12.6 in 2 substrate with sub-10 nm patterning with good pattern *** addition,DNA molecules were immobilized on the selectively nanopatterned regions by alternating surface coating procedures of 3-(aminopropyl)triethoxysilane(APS)and diamond like carbon(DLC),followed by deposition of DNA molecules into a well-defined single DNA *** single DNA nanowires were used not only for fabricating Au/DNA hybrid nanowires by the conjugation of Au nanoparticles with DNA,but also for the formation of Au/DNA hybrid *** nanocircuits prepared from Au/DNA hybrid nanowires demonstrate conductivities of up to 4.3×10^(5) S/m in stable electrical *** selective and precise positioning method capable of controlling the size of nanostructures may find application in making sub-10 nm DNA wires and metal/DNA hybrid nanocircuits.

关键词： nanowires precise method

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Plant-derived nanovesicles: Current understanding and applications for cancer therapy

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Bioactive Materials 2023年第4期22卷 365-383页

作者： Ngoc Phung Ly hwa Seung Han Myungsuk Kim Jae Hyung Park Ki Young choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea School of Chemical Engineering College of EngineeringSungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Sciences and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Biomedical Institute for Convergence at SKKU Sungkyunkwan UniversitySuwon16419Republic of Korea

Plant-derived vesicles(PDVs)are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological *** the last decade,PDVs have gained much attention for their involvement in different biological processes,including intercellular communication and defense response,and recent scientific evidence has opened a new avenue for their applications in cancer ***,much remains unknown about these vesicles,and current research remains *** review aims to provide a comprehensive introduction to PDVs,from their biological characteristics to purification methods,and to summarize the status of their potential development for cancer therapy.

关键词： Plant-derived vesicles Extracellular vesicles Cancer therapy Anti-cancer Drug delivery

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Effects of electroacupuncture on the functionality of NG2-expressing cells in perilesional brain tissue of mice following ischemic stroke

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Neural Regeneration Research 2022年第7期17卷 1556-1565页

作者： Hong Ju Lee Da Hee Jung Nam Kwen Kim hwa Kyoung Shin Byung Tae choi Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanRepublic of Korea Graduate Training Program of Korean Medicine for Healthy Aging Pusan National UniversityYangsanRepublic of Korea Department of Korean Ophthalmology Otolaryngology and DermatologySchool of Korean MedicinePusan National UniversityYangsanRepublic of Korea

Neural/glial antigen 2(NG2)-expressing cells has multipotent stem cell activity under cerebral *** study examined the effects of electroacupuncture(EA)therapy(2 Hz,1 or 3 mA,20 minutes)at the Sishencong acupoint on motor function after ischemic insult in the brain by investigating the rehabilitative potential of NG2-derived cells in a mouse model of ischemic *** stimulation alleviated motor deficits caused by ischemic stroke,and 1 mA EA stimulation was more efficacious than 3 mA EA stimulation or positive control treatment with edaravone,a free radical *** properties of NG2-expressing cells were altered with 1 mA EA stimulation,enhancing their survival in perilesional brain tissue via reduction of tumor necrosis factor alpha *** stimulation robustly activated signaling pathways related to proliferation and survival of NG2-expressing cells and increased the expression of neurotrophic factors such as brain-derived neurotrophic factor,tumor growth factor beta,and neurotrophin *** the perilesional striatum,EA stimulation greatly increased the number of NG2-expressing cells double-positive for oligodendrocyte,endothelial cell,and microglia/macrophage markers(CC1,CD31,and CD68).EA therapy also greatly activated brain-derived neurotrophic factor/tropomyosin receptor kinase B and glycogen synthase kinase 3 beta *** results indicate that EA therapy may prevent functional loss at the perilesional site by enhancing survival and differentiation of NG2-expressing cells via the activation of brain-derived neurotrophic factor-induced signaling,subsequently ameliorating motor *** animal experiments were approved by the Animal Ethics Committee of Pusan National University(approval ***2019-2199 and PNU2019-2884)on April 8,2019 and June 19,2019.

关键词： brain-derived neurotrophic factor differentiation electroacupuncture motor function neural/glial antigen 2 perilesional striatum stroke survival

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