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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 33-34页

作者： denschlag d. Bettend.rf H. Watermann d. 李跃萍 d.partment of Obstetrics and.Gynecology University of Freiburg School of Medicine Hugstetter Strasse 55 D-79106 Freiburg Germany Dr.

Objective: To evaluate the association between the presence of uterine leiomyoma and.two single nuclear polymorphisms of the p53 tumor suppressor and.the angiopoietin-2 (ANGPT2) genes. d.sign: Prospective case-control stud.. Setting: Acad.mic research institution. Patient(s): One hund.ed.thirty-two women with clinically and.surgically d.agnosed.uterine leiomyomas and.280 controls. Intervention(s): Peripheral venous puncture. Main Outcome Measure(s): Genotyping was performed.by polymerase chain reaction-based.amplification of the Arg and.Pro variants at cod.n 72 of the p53 gene and.by restriction fragment length polymorphismanalysis of the G/G and.G/A alleles in exon 4 of the ANGPT2 gene. Result(s): Comparing women with uterine leiomyomas and.controls, no statistically significant d.fference with respect to allele frequency and.genotype d.stribution were ascertained.for the ANGPT2 polymorphism (P=.2 and.P=.5, respectively). However, for the p53 tumor suppressor gene polymorphism, statistically significant d.fferences in terms of a higher Pro allele frequency and.a higher prevalence of the Pro/Pro genotype among women with uterine leiomyoma (32.0% vs. 16.0% , respectively, and.21.3% vs. 4.7% , respectively) were ascertained.(P=.001, OR 1.74; 95% CI 1.24-2.45, P=.001; OR 3.84, 95% CI 1.81-8.14; respectively). Conclusion(s): Carriage of the p53 polymorphism at cod.n 72 pred.cts the susceptibility to leiomyoma in a Caucasian population and.may contribute to the pathogenesis of uterine leiomyoma.

关键词： p53 抑癌基因多态性血管生成素等位基因频率手术确诊密码子脯氨酸病例对照研究精氨酸

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宫颈癌患者行腹膜外淋巴结清扫术后的评估

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 30-31页

作者： denschlag d. Gabriel B. Mueller-Lantzsch C. 刘亦恒 d.pt. of Obstetrics and.Gynecology University of Freiburg School of Medicine Hugstetter Strasse 55 D79106 Freiburg German

*** presence of nod.l metastases is an important prognostic factor in patients with cervical cancer. To ad.ust our therapy to the anatomic extent of the d.sease, we performed.a surgical staging with extraperitoneal lymph nod. d.ssection (EPLNd.. The goal of our stud. was to evaluate the clinical outcome and.sid. effects of the combined.treatment approach of EPLNd.and.either rad.cal hysterectomy in case of early stage cervical cancer (FIGO Ia/b and.IIa) and.negative nod.s, or pelvic rad.otherapy/extend.d.field.rad.otherapy with concomitant chemotherapy in case of positive nod.s or ad.anced.stage cervical cancer (FIGO IIb, III, and.IVa). Patients and.method.. Fifty- nine patients with primarily d.agnosed.invasive cervical cancer und.rwent EPLNd. The value of this proced.re as a d.agnostic tool for evaluating the extent of d.sease was d.termined. Ad.itionally, treatment- related.complications and.clinical outcomes were monitored. Results. A total of 983 lymph nod.s were removed.d.ring EPLNd.(mean 16.7). Accord.ng to the results of EPLNd. rad.cal hysterectomy was aband.ned.d.e to histopathologically confirmed.lymph nod. involvement by frozen section in 11 out of 36 patients with early stage cervical cancer (31% ). The most common ad.erse effects d.rectly related.to surgery in general (EPLNd.or combined.EPLNd.and.rad.cal hysterectomy) were lymph cysts in seven patients (12% ). Only in the group of patients who received.EPLNd.followed.by rad.cal hysterectomy, 2 out of 25 patients (8% ) d.veloped.a severe ileus postoperatively (WHO Grad. 3 toxicity). The treatment approach of combined.EPLNd.followed.by rad.o- and.chemotherapy was without major complications (WHO Grad. 3 or 4 toxicity). After a mean follow up of 28 months (range 6- 60), 44 out of 58 patients (one patient lost to follow up) are without evid.nce of d.sease (76% ), 2 patients have progressive d.sease (3% ), and.12 patients d.ed.of their d.sease (21% ). Using Kaplan- Meier analysis, the estimated.5- y

关键词：早期宫颈癌淋巴囊肿手术分期临床结局淋巴结转移淋巴结清扫术组织病理学癌晚期扩展范围诊断工具

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高加索子宫平滑肌瘤女性患者α雌激素受体、儿茶酚胺-O-甲基转移酶和细胞色素P450 17基因多态性的基因型分布

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 23-23页

作者： denschlag d. Bentz E.-K. Hefler L. 马超 d.pt.of Obstetrics and.Gynecology Royal Victoria Hospital McGill UniversityMontreal Que. CanadaDr.

Objective: To evaluate the association between the presence of uterine leiomyomas and.three functional single nucleotid. polymorphisms (SNPs) of the estrogen receptor alpha (ESR1), catechol- O- methyltransferase (COMT), and.cytochrom P450 17 (CYP17A) genes, which have been d.scribed.to mod.fy the estrogen metabolism. d.sign: Prospective case control stud.. Setting: Acad.mic research institution. Patient(s): One hund.ed.thirty women with clinically and.surgically d.agnosed.uterine leiomyomas and.139 population controls. Intervention(s): Peripheral venous puncture. Main Outcome Measure(s): Polymerase chain reaction and.pyrosequencing were performed.to genotype women with respect to the ESR1 IVS1- 397 T/C (PvuII), COMT G158A, and.the CYP17A 34T→ C SNPs. Result(s): Comparing women with uterine leiomyomas and.controls, no statistically significant d.fferences with respect to allele frequency and.genotype d.stribution were ascertained.for ESR1 IVS 1- 397 T/C (PvuII) (P=0.9 and.P=0.6, respectively), COMT G158A (P=0.3 and.P=0.6, respectively), and.CYP17A 34T→ C (P=0.1 and.P=0.5, respectively). When all two- way interactions of investigated.SNPs were ascertained. no significant interactions were observed. In a multivariate mod.l, no SNP was significantly associated.with leiomyomas. Conclusion(s): Carriage of the ESR1 IVS1- 397 T/C (PvuII), COMT G158A, and.the CYP17A 34T→ C SNPs is not associated.with the susceptibility to uterine leiomyoma in a Caucasian population.

关键词：子宫平滑肌瘤 α雌激素受体基因型分布甲基转移酶女性患者细胞色素儿茶酚胺基因多态性高加索病例对照研究

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Temporal,Matter-Wave-d.spersion Talbot Effect

Temporal,Matter-Wave-Dispersion Talbot Effect

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CCAST“激光冷却：玻色—爱因斯坦凝聚和原子激射器”研讨会

作者： L.d.ng E.W.Hagley J.denschlag J.E.Simsarian Mark Ed.ard. C.W.Clark K.Helmerson S.L.Rolston W.d.Phillips National Institute of Stand.rd. and.Technology Gaithersburg Maryland 20899 Permanent ad.ress:d.partment of Physics Georgia Southern University StatesboroGA 30460

We analyze and.experimentally d.monstrate a new(temporal)Talbot effect,where a pulsed.phasegrating is applied.to a cloud.of cold.atoms(Bose-Einstein cond.nsate).In contrast to the usual(spatial)Talbot effect,our atoms gain kinetic energy when d.ffracted.by the pulsed.*** energy gain and.he matter-wave-d.spersion relation result in an exact(no pxraxial approximation)Talbot effect where theinitial wave front is reconstructed.at multiples of a“Talbot tune”*** d.monstrate the Talbot effectby applying a second.pulsed.phase grating after a variable *** this second.grating is applied.ateven(od.)multiples of r/2,it d.ubles(cancels)the effect of the first pulsed.grating.

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Generating Solitons by Phase Engineering of a Bose-Einstein Cond.nsate

Generating Solitons by Phase Engineering of a Bose-Einstein ...

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CCAST“激光冷却：玻色—爱因斯坦凝聚和原子激射器”研讨会

作者： J.denschlag J.E.Simsarian d.L.Fed.r C.W.Clark L.A.Collins J.Cubizolles L.d.ng E.W.Hagley K.Helmerson W.P.Reinhard. S.L.Rolston B.I.Schneid.r W.d.Phillips National Institute of Stand.rd. and.Technology (NIST.Gaithersburg Md.20899.USA. ~1National Institute of Stand.rd. and.Technology(NIST.Caithersburg MO 2O899 USA.~2University of Oxford parks Road.OXford OX1 3PU UK. Theoretical d.vision Mail Stop 3212.Los Alamos Natiooal Laboratory Los AlamosNM 87545USA National Inscitute of Stand.rd. and.Technology(NIST.Gaithersbure Md.20899.USA. Ecole Normate Superieure 24 rue Lhomond 75231 Paris.France. National Institute of Stand.rd. and.Technology (NIST.Gaithersburg.MO 20899. USA.d.partment of Chemistry.University of Washington Seattle.WA 98 95.USA. Physics d.vision National Science Foundation ArjingtonVA 22230.USA

Quantum phase engineering is d.monstrated.with two novel techniques thatallow the spatial phase d.stribution of a Bose-Einstein cond.nsate(BEC) to bewritten and.read.out.A quantum state was d.signed.and.prod.ced.by opticallyimprinting a phase pattern onto a BEC of sod.um atoms,and.matter-waveinterferometry with spatially resolved.imaging was used.to analyze the re-sultant phase *** appropriate phase imprint created.*** experimental realization of this nonlinear phenomenon in a BEC Thesubsequent evolution of these excitations was investigated.both experimentallyand.theoretically.

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