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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi dennis yan-yin tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau ying Lo Law Chi Seng Leung Chun yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo dennis yan-yin tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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Experience of Drug Abusers Participating in Community-Based Drug Rehabilitation Services Provided by the Counselling Centres for Psychotropic Substance Abusers (CCPSAs) in Hong Kong

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Health 2020年第8期12卷 1008-1028页

作者： Mimi Mei Ha Tiu Carmen Ka Man Fung Wing yan Fung yin Yee Lai Chui Man tse Tsz Hung Wong Tsz Kwan Wong Wing Yi Wong Mei Suet Wu Ka Man Yeung Lok Tung Yeung Yuk ying Yu School of Nursing and Health Studies The Open University of Hong Kong HKSAR China

Despite the official statistics showing that the number of drug users has been declining, the problem of drug abuse remains serious in Hong Kong. This problem is evidenced by the trend of hidden and prolonged drug abuse. The recovery of drug abusers is an important process, because the misuse of drugs can cause many bio-psycho-social complications. Therefore, 11 Counselling Centres for Psychotropic Substance Abusers (CCPSAs) in different districts in Hong Kong play an important role on those drug abusers [1]. As a core community-based drug rehabilitation service in Hong Kong, studies about CCPSAs are limited. This study uses a descriptive qualitative approach to explore the experience of drug abusers participating in community-based drug rehabilitation services provided by CCPSAs. Five CCPSA users, who utilized the services for more than two months, participated in the semi-structured face-to-face interviews. Data collected were then analysed by thematic analysis, and five themes were generated: 1) receiving supportive counselling service in CCPSAs, 2) revealing variance towards nonmandatory services in CCPSAs, 3) encountering intrapersonal conflicts when participating in CCPSAs, 4) expanding social network through integration in group activities and 5) wishing to be a companion to other drug abusers. Findings of this study provide valuable insights towards services modification and the enhancement of drug rehabilitation and drug abusers’ wellbeing over the collaboration of healthcare workers, services providers and the media. However, this study has some limitations, and it presents suggestions for future research.

关键词： Drug Rehabilitation Services Counselling Centres Substances Abusers

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论延安时期刘少奇对马克思主义中国化的理论贡献

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延边大学学报（社会科学版） 2009年第3期42卷 66-71页

作者：李振印中共宝钢集团有限公司委员会党校上海200941

延安时期刘少奇对"马克思主义中国化"这个命题作出了许多精辟的论述和科学的分析。他在党内首先同时使用"马克思主义中国化"和"中国化的马克思主义"这两个概念并科学地阐述了两者之间的关系;在丰富和发展毛泽东思想的基础上,他系统地阐... 详细信息

延安时期刘少奇对"马克思主义中国化"这个命题作出了许多精辟的论述和科学的分析。他在党内首先同时使用"马克思主义中国化"和"中国化的马克思主义"这两个概念并科学地阐述了两者之间的关系;在丰富和发展毛泽东思想的基础上,他系统地阐述了"中国化的马克思主义"的理论体系;他还对马克思主义中国化的历史经验作出了总结,强调党的历史就是马克思主义中国化的历史,强调党的自身建设对于马克思主义中国化的高度重要性。

关键词：刘少奇延安时期马克思主义中国化中国化的马克思主义

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高场强MRI与超声内镜对可切除性食管癌术前T分期应用价值的比较

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中华放射学杂志 2018年第3期52卷 199-203页

作者：郭佳王昭琦张风光张宏凯鲁亚南秦建军张忠宪张廷张首宁董亚锋李印赵妍刘慧严序 Dominik Nickel 黎海亮曲金荣郑州大学附属肿瘤医院放射科 450008 郑州大学附属肿瘤医院胸外科 450008 郑州大学附属肿瘤医院病理科 450008 西门子(中国)有限公司医疗业务领域磁共振事业部 MR Pre-development Siemens Healthcare GmbH Erlangen 91052 Germany

目的比较高场强MRI与超声内镜（EUS）对可切除性食管癌患者术前T分期的应用价值。方法前瞻性收集2015年3月至2016年9月经临床及病理活检判定为可切除性食管癌的患者，所有入组患者于病理活检1周后进行MRI，扫描序列包括膈肌导航的应... 详细信息

目的比较高场强MRI与超声内镜（EUS）对可切除性食管癌患者术前T分期的应用价值。方法前瞻性收集2015年3月至2016年9月经临床及病理活检判定为可切除性食管癌的患者，所有入组患者于病理活检1周后进行MRI，扫描序列包括膈肌导航的应用刀锋采集技术的快速自旋回波的T2WI加权成像（BLADE-tse-T2WI）、DWI及自由呼吸放射状K空间填充方式的容积内插体部检查（radial-VIBE）,同时行超声内镜（EUS）检查。MRI检查均在EUS之前进行，手术均在MRI与EUS检查后1周内进行。由2名具有5年以上MRI诊断经验的医师分别采用5分制对MR图像进行评分，参照美国癌症联合委员会（AJCC）第7版食管癌TNM分期标准。2名MRI阅片者采用双盲法分别对MR图像进行独立分期，结果不一致时，由第3名高级职称MRI医师共同讨论，达成一致意见，由1名具有5年以上内镜工作经验的内镜医师进行EUS分期。采用Kappa一致性检验，评价2名MRI阅片者对图像质量评分和可切除性食管癌术前T分期的一致性，以术后病理T分期结果为金标准，分别计算MRI及EUS对食管癌术前T分期的准确率，并采用χ2检验进行对照分析。结果入组患者共70例，MRI图像质量评分不低于3分者分别有66例（阅片者1）和68例（阅片者2），2名MRI阅片者对图像质量评分的一致性非常好（Kappa=0.824，P〈0.05）。术后病理证实T1期16例、T2期18例、T3期30例、T4a期6例。2名MRI阅片者对食管癌术前T分期的一致性非常好（Kappa=0.809，P〈0.05），MRI和EUS对可切除性食管癌术前T分期的准确率分别为92.9%（65/70）和67.1%（47/70），两种技术的准确率差异有统计学意义（χ2=14.5，P〈0.05）。结论MRI对食管癌术前T分期的准确率明显高于EUS，可以成为判断食管癌术前T分期的无创性检查方法。

关键词：食管肿瘤肿瘤分期磁共振成像超声内镜

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