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用脑与认知的基础研究热点之一:感知觉学习提高青少年视觉质量与认知能力

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医疗保健器具 2007年第7期14卷 15-16页

作者： Roger W. Li[美] Karen G. Young[美] Pia Hoenig[美] dennis m. Levi[美] 阎丽[编译] 叶宁国[编译] 孙秀伟[编译] 林平光[编译] 不详国家医疗保健器具工程技术研究中心广东省医用电子仪器及高分子材料制品重点实验室

目的：确定通过位置辨别任务训练是否能提高弱视儿童视觉能力及确定其提高的机制。方法：5名弱视儿童（年龄范围7-10岁）在位置视觉任务训练中判别3对线条中那一对偏离了方向。位置噪声是对每一线段的每个gabor斑用高斯概率函数产生。... 详细信息

目的：确定通过位置辨别任务训练是否能提高弱视儿童视觉能力及确定其提高的机制。方法：5名弱视儿童（年龄范围7-10岁）在位置视觉任务训练中判别3对线条中那一对偏离了方向。位置噪声是对每一线段的每个gabor斑用高斯概率函数产生。受试者在三个噪声水平进行训练（包括0），

关键词：认知能力视觉质量知觉学习青少年用脑弱视儿童噪声水平视觉能力

Evaluation of a Wireless Solar Powered Personal Weather Station

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Agricultural Sciences 2024年第1期15卷 36-53页

作者： Robert J. Lascano Tim.thy S. Goebel dennis C. Gitz III John E. Stout Cropping System. Research Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland cotton production in m.rtin County, Texas, m.asuring cotton lint yield per unit of rainfall. Our goal is to collect rainfall data per 250 - 400 ha. Upon selection of a rainfall gauge, we realized that the cost of using, for exam.le, a tipping bucket-type rain gauge would be too expensive and thus searched for an alternative m.thod. We selected an all-in-one com.ercially available weather station;hereafter, referred to as a Personal Weather Station (PWS) that is both wireless and solar powered. Our objective was to evaluate average m.asurem.nts of rainfall obtained with the PWS and to com.are these to m.asurem.nts obtained with an autom.tic weather station (AWS). For this purpose, we installed four PWS deployed within 20 m.of the Plant Stress and Water Conservation m.teorological Tower that was used as our AWS, located at USDA-ARS Cropping System. Research Laboratory, Lubbock, TX. In addition, we m.asured and com.ared hourly average values of short-wave irradiance (Rg), air tem.erature (Tair) and relative hum.dity (RH), and wind speed (WS), and calculated values of dewpoint tem.erature (Tdew). This com.arison was done over a 242-day period (1 October 2022-31 m.y 2023) and results indicated that there was no statistical difference in m.asurem.nts of rainfall between the PWS and AWS. Hourly average values of Rg m.asured with the PWS and AWS agreed on clear days, but PWS m.asurem.nts were higher on cloudy days. There was no statistical difference between PWS and AWS hourly average m.asurem.nts of Tair, RH, and calculated Tdew. Hourly average m.asurem.nts of Rg and WS were m.re variable. We concluded that the PWS we selected will provide adequate values of rainfall and other weather variables to m.et our goal of evaluating dryland cotton lint yield per unit rainfall.

关键词： Autom.tion Sensors Citizen Weather Station m.sonet Rainfall Weather Variables

CDC7 inhibition im.airs neuroendocrine transform.tion in lung and prostate tum.rs through m.C degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathem. Uddin Swanand Rakhade Vidushi Durani Am.n Sabet m.niquetta Shafer Wouter R.Karthaus Sam.r Zaidi Yingqian A.Zhan Parvathy m.noj Harsha Sridhar dennis Kinyua Hong Zhong Barbara P.m.llo m.tam.a Ciam.ricotti Um.sh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm.m.rrsey Sanjoy m.hta Jesse Barnes m.chael C.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia m.lina-Pinelo Sohrab Salehi Helena A.Yu Joseph m.Chan Charles m.Rudin Departm.nt of m.dicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of m.dical Sciences Weill Cornell MedicineNew YorkNYUA Hum.n Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitum.r Assessm.nt Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Hum.n Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparm.ntof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility m.m.rial Sloan Kettering Cancer Center New YorkNYUSA Departm.nt of Laboratory m.dicine and Pathology University of WashingtonSeattleWAUSA Bioinfom.tics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biom.dicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Com.utational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell m.dical College New York NYUSA Present address:Swiss Institute for Experim.ntal Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transform.tion is a m.chanism.of resistance to targeted therapy in lung and prostate adenocarcinom.s leading to poor *** to date,even if patients at high risk of transform.tion can be identified by the occurrence of Tum.r Protein P53(TP53)and Retinoblastom. Transcriptional Corepressor 1(RB1)m.tations in their tum.rs,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tum.rs during the initial steps of NE transform.tion,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo m.dels of NE transform.tion by inducing the proteasom.-m.diated degradation of the m.C Proto-Oncogen(m.C),im.licated in stem.ess and histological *** overexpression of a degradation-resistant m.C isoform.reestablished the NE transform.tion phenotype observed on targeted therapy,even in the presence of ***7 inhibition also m.rkedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate sm.ll cell carcinom. *** results nom.nate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tum.rs de novo or after *** sim.rosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransform.tion.

关键词： tum.rs m.rkedly transform.tion

Histone Acetylation, VERNALIZATION INSENSITIVE 3, FLOWERING LOCUS C, and the Vernalization Response

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m.lecular Plant 2009年第4期2卷 724-737页

作者： Donna m. Bond Elizabeth S. dennis Barry J. Pogson E. Jean Finnegan CSIRO Plant Industry Canberra Australia ARC Centre of Excellence in Plant Energy Biology School of Biochemistry and Molecular Biology Australian National University Canberra Australia

The quantitative induction of VIN3 by low tem.eratures is required for PRC2 repression of FLC and prom.tion of flowering （vernalization） in Arabidopsis. Histone acetylation, a chrom.tin m.dification com.only associated with gene transcription, increased on VIN3 chrom.tin in two spatially and tem.orally distinct phases in response to low tem.eratures. During short-term.cold exposure, histone H3 acetylation at the transcription start site rapidly increased, im.lying that it is required for VlN3 induction. Subsequent changes in histone H3 and H4 acetylation occurred following continued VIN3 transcription during prolonged cold exposure. m.m.ers of the SAGA-like transcriptional adaptor com.lex, including the histone acetyltransferase GCNS, which induces expression of the cold acclim.tion pathway genes, do not regulate VlN3 induction during cold exposure, indicating that the cold acclim.tion pathway and the cold-induction of VlN3 are regulated by different transcriptional m.chanism.. m.tations in the other 11 histone acetyltransferase genes did not affect VlN3 induction. However, nicotinam.de, a histone deacetyiase inhibitor, induced VIN3 and altered histone acetylation at the VIN3 locus. VIN3 induction was proportional to the length of nicotinam.de treatm.nt, which was associated with an early-flowering phenotype and repression of FLC. However, unlike vernalization, the repression of FLC was independent of VIN3 activity. Nicotinam.de treatm.nt did not cause a change in the expression of any genes in the autonom.us pathway or m.m.ers of the PRC2 com.lex, the well characterized repressors of FLC. Our data suggest that FLC is repressed via a novel pathway involving the SIR2 class of histone deacetylases.

关键词： Cold acclim.tion histone acetyltransferase histone deacetylase SIR2 nicotinam.de.

m.vie therapy for children with am.lyopia:restoring binocular vision with brain plasticity

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Science China(Life Sciences) 2022年第3期65卷 654-656页

作者： Bernhard A.Sabel dennis m.Levi Institute of m.dical Psychology Medical FacultyOtto-v.-Guericke University of MagdeburgMagdeburg 39120Germany Herbert Wertheim.School of Optom.try&Vision Science and Helen Wills Neuroscience Institute University of CaliforniaBerkeley CA 94720USA

Am.lyopia is a com.on neurodevelopm.ntal disorder that occurs when the two eyes do not send well m.tched visual signals to the brain early in *** m.sm.tch of the inform.tion com.ng from.both eyes can have different causes:it m.y be due to differences in im.ge clarity or contrast(called"anisom.tropia")because the two eyes require different corrective lens powers.

关键词： m.vie m.tched visual

Inverse-designed spinodoid m.tam.terials

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npj Com.utational m.terials 2020年第1期6卷 1029-1038页

作者： Siddhant Kum.r Stephanie Tan Li Zheng dennis m.Kochm.nn m.chanics&m.terials Lab Department of Mechanical and Process EngineeringETH Zürich8092 ZürichSwitzerland Faculty of Electrical Engineering Mathematics and Computer ScienceDelft University of Technology2628 CD DelftNetherlands Graduate Aerospace Laboratories California Institute of TechnologyPasadenaCA 91125USA

After a decade of periodic truss-,plate-,and shell-based architectures having dom.nated the design of m.tam.terials,we introduce the non-periodic class of spinodoid *** by natural self-assem.ly processes,spinodoid m.tam.terials are a close approxim.tion of m.crostructures observed during spinodal phase *** theoretical param.trization is so intriguingly sim.le that one can bypass costly phase-field sim.lations and obtain a rich and seam.essly tunable property ***,breaking with the periodicity of classical m.tam.terials is the enabling factor to the large property space and the ability to introduce seam.ess functional *** introduce an efficient and robust m.chine learning technique for the inverse design of(m.ta-)m.terials which,when applied to spinodoid topologies,enables us to generate uniform.and functionally graded cellular m.chanical m.tam.terials with tailored direction-dependent(anisotropic)stiffness and *** specifically present biom.m.tic artificial bone architectures that not only reproduce the properties of trabecular bone accurately but also even geom.trically resem.le natural bone.

关键词： density property periodic

Deep learning for visualization and novelty detection in large X-ray diffraction datasets

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npj Com.utational m.terials 2021年第1期7卷 942-947页

作者： Lars Banko Phillip m.m.ffettone dennis Naujoks Daniel Olds Alfred Ludwig m.terials Discovery and Interfaces Institute for MaterialsRuhr University BochumBochumGermany National Synchrotron Light Source II Brookhaven National LaboratoryUptonNYUSA ZGH Center for Interface-Dominated High Performance MaterialsRuhr University BochumBochumGermany

We apply variational autoencoders(VAE)to X-ray diffraction(XRD)data analysis on both sim.lated and experim.ntal thin-film.*** show that crystal structure representations learned by a VAE reveal latent inform.tion,such as the structural sim.larity of textured diffraction *** other artificial intelligence(AI)agents are effective at classifying XRD data into known phases,a sim.larly conditioned VAE is uniquely effective at knowing what it doesn’t know:it can rapidly identify data outside the distribution it was trained on,such as novel phases and *** capabilities dem.nstrate that a VAE is a valuable AI agent for aiding m.terials discovery and understanding XRD m.asurem.nts both‘on-the-fly’and during post hoc analysis.

关键词： VAE uniquely latent

SYSTEm. ENGINEERING RESEARCH

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Journal of System. Science and System. Engineering 2008年第3期17卷 319-333页

作者： Abd-El-Kader SAHRAOUI dennis m.BUEDE Andrew P.SAGE LAAS-CNRS and Universitéde Toulouse 7 Avenue du Colonel Roche Toulouse31077France Innovative Decisions Inc.2139 Golf Course Dr.RestonVA 20191 USA Dept.of System. Engineering and Operations Research George Mason UniversityFairfaxVA 22030 USA

In this paper, we propose selected research topics that are believed central to progress and growth in the application of system. engineering （SE）. As a professional activity, and as an intellectual activity, system. engineering has strong links to such associated disciplines as decision analysis, operation research, project m.nagem.nt, quality m.nagem.nt, and system. design. When focussing on system. engineering research, we should distinguish between subjects that are of system. engineering essence and others that m.re closely correspond to those that are m.re relevant for related disciplines.

关键词： System. engineering system. of system. requirem.nts engineering system. fam.lies