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Ne.natal Dire.t Rigid Laryngoscopy and Bronchoscopy: A Ne.r Miss

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Ope. Journal of Ane.the.iology 2024年第4期14卷 126-130页

作者： dennis e. Fe.e.man Mark Krone.fe.d Jacob Sutton Gil Zoizne. e.an P. Salant De.artme.t of Ane.the.iology Maimonides Medical Center New York USA Rutge.s Robe.t Wood Johnson Unive.sity Hospital New Brunswick USA Me.r Hospital Clalit Health Services Kefar Sava Israel

Airway manage.e.t is a skill ne.e.sary for he.lthcare.provide.s who manage.patie.ts. Intubation is a skill that both ane.the.iologists and inte.sivists use.daily. We.pre.e.t a case.of a ne.nate.that de.e.ope. significant worse.ing stridor afte. a succe.sful intubation for a he.nia re.air. Afte. 4 intubation atte.pts, with e.sy visualization of the.vocal cords and unsucce.sful place.e.t of the.e.dotrache.l tube. the.patie.t was e.e.ge.tly brought to the.ope.ating room for e.aluation.

关键词： Ne.nate Dire.t Laryngoscopy Intubation

e.aluation of a Wire.e.s Solar Powe.e. Pe.sonal We.the. Station

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Agricultural Scie.ce. 2024年第1期15卷 36-53页

作者： Robe.t J. Lascano Timothy S. Goe.e. dennis C. Gitz III John e. Stout Cropping Syste.s Re.e.rch Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We.are.e.aluating dryland cotton production in Martin County, Te.as, me.suring cotton lint yie.d pe. unit of rainfall. Our goal is to colle.t rainfall data pe. 250 - 400 ha. Upon se.e.tion of a rainfall gauge. we.re.lize. that the.cost of using, for e.ample. a tipping bucke.-type.rain gauge.would be.too e.pe.sive.and thus se.rche. for an alte.native.me.hod. We.se.e.te. an all-in-one.comme.cially available.we.the. station;he.e.fte., re.e.re. to as a Pe.sonal We.the. Station (PWS) that is both wire.e.s and solar powe.e.. Our obje.tive.was to e.aluate.ave.age.me.sure.e.ts of rainfall obtaine. with the.PWS and to compare.the.e.to me.sure.e.ts obtaine. with an automatic we.the. station (AWS). For this purpose. we.installe. four PWS de.loye. within 20 m of the.Plant Stre.s and Wate. Conse.vation Me.e.rological Towe. that was use. as our AWS, locate. at USDA-ARS Cropping Syste.s Re.e.rch Laboratory, Lubbock, TX. In addition, we.me.sure. and compare. hourly ave.age.value. of short-wave.irradiance.(Rg), air te.pe.ature.(Tair) and re.ative.humidity (RH), and wind spe.d (WS), and calculate. value. of de.point te.pe.ature.(Tde.). This comparison was done.ove. a 242-day pe.iod (1 Octobe. 2022-31 May 2023) and re.ults indicate. that the.e.was no statistical diffe.e.ce.in me.sure.e.ts of rainfall be.we.n the.PWS and AWS. Hourly ave.age.value. of Rg me.sure. with the.PWS and AWS agre.d on cle.r days, but PWS me.sure.e.ts we.e.highe. on cloudy days. The.e.was no statistical diffe.e.ce.be.we.n PWS and AWS hourly ave.age.me.sure.e.ts of Tair, RH, and calculate. Tde.. Hourly ave.age.me.sure.e.ts of Rg and WS we.e.more.variable. We.conclude. that the.PWS we.se.e.te. will provide.ade.uate.value. of rainfall and othe. we.the. variable. to me.t our goal of e.aluating dryland cotton lint yie.d pe. unit rainfall.

关键词： Automation Se.sors Citize. We.the. Station Me.one. Rainfall We.the. Variable.

Suppre.sive.e.fe.ts of e.e.cise.conditione. se.um on cance. ce.ls:A narrative.re.ie. of the.influe.ce.of e.e.cise.mode.volume.and inte.sity

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Journal of Sport and He.lth Scie.ce 2024年第4期13卷 484-498,F0003页

作者： France.co Be.tariga dennis R.Taaffe.Danie. A.Galvao Chris Bishop Jin-Soo Kim Robe.t U.Ne.ton e.e.cise.Me.icine.Re.e.rch Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Me.ical and He.lth Scie.ce. Edith Cowan UniversityJoondalupWA 6027Australia London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Move.e.t and Nutrition Scie.ce. University of QueenslandSt.LuciaQLD 4072Australia

Cance. is a major cause.of morbidity and mortality worldwide.and the.incide.ce.is incre.sing,highlighting the.ne.d for e.fe.tive.strate.ie. to tre.t this *** has e.e.ge. as fundame.tal the.ape.tic me.icine.in the.manage.e.t of cance.,associate. with a lowe. risk of re.ur-re.ce.and incre.se. *** ave.ue. of re.e.rch de.onstrate.re.uction in growth,prolife.ation,and incre.se. apoptosis of cance. ce.ls,including bre.st,prostate.colore.tal,and lung cance.,whe. culture. by se.um colle.te. afte. e.e.cise.in vitro(i.e.,the.cultivation of cance. ce.l line. in an e.pe.ime.tal se.ting,which simpliﬁe. the.biological syste. and provide. me.hanistic insight into ce.l re.ponse.).The.unde.lying me.hanisms of e.e.cise.induce. cance. suppre.sive.e.fe.ts may be.attribute. to the.alte.ation in circulating factors,such as ske.e.al muscle.induce. cytokine.(i.e.,myokine.)and ***,e.e.cise.induce. tumor suppre.sive.e.fe.ts and de.aile. information about training inte.ve.tions are.not we.l inve.tigate.,constraining more.pre.ise.application of e.e.cise.me.icine.within clinical *** date.it re.ains uncle.r what role.diffe.e.t training mode.(i.e.,re.istance.and ae.obic training)as we.l as volume.and inte.sity have.on e.e.cise.condi-tione. se.um and its e.fe.ts on cance. ***,the.available.e.ide.ce.is that a single.bout of ae.obic training at mode.ate.to vigorous inte.sity has cance. suppre.sive.e.fe.ts,while.for chronic training inte.ve.tions,e.e.cise.volume.appe.rs to be.an inﬂue.tial candidate.driving cance. inhibitory e.fe.ts re.ardle.s of training *** for future.re.e.rch inve.tigating training mode.,volume.and inte.sity are.provide. to furthe. our unde.standing of the.e.fe.ts of e.e.cise.conditione. se.um on cance. ce.ls.

关键词： Cance. ce.ls High inte.sity inte.val training Mode.ate.inte.sity continuous training Re.istance.training Myokine.

Nucle.r me.hanics during constricte. migration

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Acta Me.hanica Sinica 2019年第2期35卷 299-308页

作者： Yuntao Xia Charlotte.R. Pfe.fe. dennis e. Dische. Physical Scie.ce. Oncology Ce.te. at Pe.nsylvania (PSOC@Pe.n) University of Pennsylvania PhiladelphiaPA 19104USA Mole.ular and Ce.l Biophysics Lab University of PennsylvaniaPhiladelphiaPA 19104 USA De.artme.t of Physics and Astronomy University of Pennsylvania Philadelphia PA 19104USA

Ce.l migration through narrow inte.stitial space.in tissue. is commonly se.n in both physiological and pathological conditions. For e.ample. immune.ce.ls have.to sque.ze.through vasculature.and e.trace.lular matrix to re.ch the.wound or dise.se. site., and similarly cance. ce.ls ne.d to crawl through porous space.in tissue. to invade.surrounding tumor-fre. re.ions. The.e.ore. the.bulky stiff nucle.s in the.ce.l be.ome. a barrie. during constricte. migration making such proce.s pore.size.de.e.de.t with smalle. pore. e.pone.tially alle.iate.the.passage.capability. Howe.e., in some.case., ce.ls can active.y de.orm the.r nucle. to sque.ze.through constrictions although some.price.ne.ds to be.paid. In this re.ie., we.focus on:(1) nucle.r structure. and morphological re.ulations,(2) propose. me.hanisms that drive.constricte. migration,(3) short-te.m conse.ue.ce. such as nucle.r e.ve.ope.(Ne. rupture.and DNA damage.during such proce.s,(4) biophysical factors that facilitate.Ne.rupture. and (5) long te.m conse.ue.ce. such as ge.omic variation cause. by re.e.itive.Ne.rupture. Both e.pe.ime.tal re.ults and mode.ing are.provide. with the.inte.tion to be.te. unde.stand the.constricte. migration.

关键词： Constricte. migration Nucle.r e.ve.ope rupture DNA damage

Particle.e.asticity influe.ce. polyme.ic artificial antige. pre.e.ting ce.l e.fe.tive.e.s in vivo via CD8+T ce.l activation,macrophage.uptake.and the.prote.n corona

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Nano Re.e.rch 2024年第10期17卷 9052-9064页

作者： Savannah e.e.t-Witte.Sydne. R.Shannon dennis H.Gong Kaitlyn G.Calabre.i Jawaun J.Harris Kaitlyn Storm e.win J.Yoo Arie. Isse. Vive. P.Jani Natalie.K.Livingston Mary O.Omotoso Ke.ly Rhode. e.ana Be.-Akiva Randall A.Me.e. Zoe.T.Hsie. Simone.Sidoli Ste.hany Y.Tze.g Jonathan P.Schne.k Jordan J.Gre.n Translational Tissue.e.gine.ring Ce.te. Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute.for Ce.l e.gine.ring Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA De.artme.t of Bioche.istry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive.ce.l the.apy(ACT)is an immunothe.apy strate.y for cance. that has se.n wide.pre.d clinical *** ACT,patie.t-de.ive. lymphocyte. are.stimulate. with the.antige. of inte.e.t e. vivo,prolife.ate.,the. re.urne. to the.patie.t to initiate.an antige.-spe.ific antitumor *** e.fe.tive.this proce.s is re.ource.inte.sive.and logistically impossible.for many *** artificial antige. pre.e.ting ce.ls(aAPCs)offe. a pote.tial“off-the.she.f”alte.native.to e. vivo *** particulate.aAPCs pe.form we.l in vitro,the. have.had limite. succe.s in vivo due.to poor bioavailability afte. *** to bioavailability include.rapid cle.rance.unfavorable.biodistribution,and inade.uate.inte.actions with CD8+T ce.ls at site. of *** prope.tie. such as e.asticity have.be.n shown to vastly impact the.bioavailability and particle.ce.l inte.actions,but this has ye. to be.inve.tigate. in the.conte.t of aAPCs for in vivo T-ce.l *** lite.ature.like.ise.indicate. that biomate.ial prope.tie.,e.pe.ially e.asticity,can modulate.T-ce.l activation in *** the.goal of cre.ting a more.biomime.ic,ne.t-ge.e.ation particulate.aAPC,we.de.e.ope. a poly(e.hyle.e.glycol hydroge. particle.platform with tunable.e.asticity to inve.tigate.the.impact of e.asticity on antige.-spe.ific T ce.l activation for in vivo adoptive.*** this knowle.ge.we.we.e.able.to gain more.pre.ise.control ove. in vivo T ce.l activation and inve.tigate.possible.me.hanisms including the.e.fe.ts of aAPC e.asticity on T ce.l binding,macrophage.uptake.and the.prote.n corona.

关键词： adoptive.ce.l the.apy artificial antige. pre.e.ting ce.ls particle.drug de.ive.y e.asticity prote.n corona poly(e.hyle.e.glycol)

Application of the.Shrinking Particle.Mode. for the.e.aluation of Mole.ular Re.yclability of Pe. ve.sus Se.i-Aromatic Polye.te.s

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Ope. Journal of Physical Che.istry 2024年第2期14卷 21-35页

作者： Jack van Schijnde. Sanne.de.Krom dennis Mole.dijk Koe. van Be.rde. Amarante.Böttge. Re.e.rch Group Biopolyme.s/Gre.n Che.istry Centre of Expertise Safe & Resilient Society Avans University of Applied Science Breda Netherlands Ne. Mate.ials and The.r Applications Centre of Expertise Safe & Resilient Society Avans University of Applied Science Breda Netherlands De.artme.t of Mate.ials Scie.ce.and e.gine.ring Delft University of Technology Delft Netherlands

The.mole.ular re.yclability of poly (e.hyle.e.te.e.hthalate. (Pe.) and thre. se.i-aromatic polye.te.s poly (phlore.ic acid) (poly-H), poly (dihydrofe.ulic acid) (poly-G), and poly (dihydrosinapinic acid) (poly-S) is e.aluate. in this study. Pe. is an e.te.sive.y use. aromatic polye.te., and poly-H, poly-G, and poly-S can be.conside.e. se.i-aromatic poly (lactic acid) modifications. All the.e.polye.te.s have.be.n de.olyme.ize. at ne.tral pH and by acid- and base.catalyze. hydrolysis at two te.pe.ature., i.e., 50˚C and 80˚C. Base.catalyze. de.olyme.ization of virgin Pe. le.ds to an isolate. yie.d of 38% afte. 48 hours of re.ction at 80˚C. Contrary to the.e.re.ults for Pe., almost all the.monome.s of the.se.i-aromatic polye.te.s poly-H, poly-G, and poly-S are.re.ove.e. with isolate. yie.ds large. than 90% at the.same.te.pe.ature.afte. 15 minute. in a facile.manne.. A shrinking particle.mode. use. to de.e.mine.the.global kine.ics of the.base.catalyze. de.olyme.ization showe. that the.rate.rise. with incre.sing te.pe.ature. Using the.shrinking particle.mode., the.intrinsic re.ction rate.constants we.e.de.e.mine.. It has be.n de.onstrate. that the.rate.coe.ficie.ts of the.de.olyme.ization of the.se.i-aromatic polye.te.s poly-H, poly-G, and poly-S are.be.we.n 2 and 3 orde.s of magnitude.highe. than those.for Pe..

关键词： De.olyme.ization Mole.ular Re.ycling Poly-H Poly-G Poly-S Pe. Circular Polyme.s

Advance. in the.phyloge.e.is of Agaricale. and its highe. ranks and strate.ie. for e.tablishing phyloge.e.ic hypothe.e.

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Journal of Zhe.iang Unive.sity-Scie.ce.B(Biome.icine.& Biote.hnology) 2008年第10期9卷 779-786页

作者： Rui-lin ZHAO dennis e. De.JARDIN Kase. SOYTONG Ke.in D. HYDe Faculty of Biology Conse.vation Southwest Forestry University Kunming 650224 China De.artme.t of Biology San Francisco State University San Francisco California 94132 USA Faculty of Agricultural Te.hnology King Mongkut＇s Institute of Technology Ladkrabang （KMITL） Ladkrabang Bangkok 10520 Thailand Inte.national Fungal Re.ource.and De.e.opme.t Ce.tre the Research Institute of Resources Insects Chinese Academy of Forestry Kunming 650224 China Fungal Re.e.rch Group School of Science Mae Fah Luang University Tasud Chiang Rai 57100 Thailand

We.pre.e.t an ove.vie. of pre.ious re.e.rch re.ults on the.mole.ular phyloge.e.ic analyse. in Agaricale. and its highe. ranks (Agaricomyce.e./Agaricomycotina/Basidiomycota) along with the.most re.e.t tre.tme.ts of taxonomic syste.s in the.e.taxa. e.tablishing phyloge.e.ic hypothe.e. using DNA se.ue.ce., from which an unde.standing of the.natural e.olutionary re.ationships amongst clade. may be.de.ive., re.uire. a robust datase.. It has be.n re.ognize. that single.ge.e.phyloge.ie. may not truly re.re.e.t organismal phyloge.ie., but the.concordant phyloge.e.ic ge.e.logie. from multiple.ge.e.datase.s can re.olve.this proble.. The.ge.e. commonly use. in mushroom phyloge.e.ic re.e.rch are.summarize..

关键词： Ge.e Mole.ular Mushrooms Phyloge.y

Histone.Ace.ylation, Ve.NALIZATION INSe.SITIVe.3, FLOWe.ING LOCUS C, and the.Ve.nalization Re.ponse

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Mole.ular Plant 2009年第4期2卷 724-737页

作者： Donna M. Bond e.izabe.h S. dennis Barry J. Pogson e. Je.n Finne.an CSIRO Plant Industry Canberra Australia ARC Ce.tre.of e.ce.le.ce.in Plant e.e.gy Biology School of Biochemistry and Molecular Biology Australian National University Canberra Australia

The.quantitative.induction of VIN3 by low te.pe.ature. is re.uire. for PRC2 re.re.sion of FLC and promotion of flowe.ing （ve.nalization） in Arabidopsis. Histone.ace.ylation, a chromatin modification commonly associate. with ge.e.transcription, incre.se. on VIN3 chromatin in two spatially and te.porally distinct phase. in re.ponse.to low te.pe.ature.. During short-te.m cold e.posure. histone.H3 ace.ylation at the.transcription start site.rapidly incre.se., implying that it is re.uire. for VlN3 induction. Subse.ue.t change. in histone.H3 and H4 ace.ylation occurre. following continue. VIN3 transcription during prolonge. cold e.posure. Me.be.s of the.SAGA-like.transcriptional adaptor comple., including the.histone.ace.yltransfe.ase.GCNS, which induce. e.pre.sion of the.cold acclimation pathway ge.e., do not re.ulate.VlN3 induction during cold e.posure. indicating that the.cold acclimation pathway and the.cold-induction of VlN3 are.re.ulate. by diffe.e.t transcriptional me.hanisms. Mutations in the.othe. 11 histone.ace.yltransfe.ase.ge.e. did not affe.t VlN3 induction. Howe.e., nicotinamide. a histone.de.ce.yiase.inhibitor, induce. VIN3 and alte.e. histone.ace.ylation at the.VIN3 locus. VIN3 induction was proportional to the.le.gth of nicotinamide.tre.tme.t, which was associate. with an e.rly-flowe.ing phe.otype.and re.re.sion of FLC. Howe.e., unlike.ve.nalization, the.re.re.sion of FLC was inde.e.de.t of VIN3 activity. Nicotinamide.tre.tme.t did not cause.a change.in the.e.pre.sion of any ge.e. in the.autonomous pathway or me.be.s of the.PRC2 comple., the.we.l characte.ize. re.re.sors of FLC. Our data sugge.t that FLC is re.re.se. via a nove. pathway involving the.SIR2 class of histone.de.ce.ylase..

关键词： Cold acclimation histone.ace.yltransfe.ase histone.de.ce.ylase SIR2 nicotinamide.

Anothe. Way to Use.the.Larynge.l Mask Airway (LMA)

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Ope. Journal of Ane.the.iology 2016年第4期6卷 67-69页

作者： Jame. Smit dennis e. Fe.e.man De.artme.t of Ane.the.iology Maimonides Medical Center Brooklyn NY USA

The.larynge.l mask airway (LMA) has change. airway manage.e.t. Be.ide. its use.as an airway conduit, it is also use. to he.p obtain a se.ure.airway, i.e., it is use. to facilitate.the.place.e.t of an e.dotrache.l tube...

关键词： LMA Pe.iatric Airway