检索结果-南通市图书馆

Upregulation of PIP3-Dependent Rac Exchanger 1 （P-Rex1）Promotes Prostate Cancer Metastasis

The First International Symposium on Membrane Biology--The Tenth National Symposium on Membrane Biology

作者： dennis w.wolff Joseph K.Kirui Peter w.Abel Department of Pharmacology Creighton University School of Medicine

＜正＞Aberrant signaling through G-protein coupled receptors promotes metastasis,the major cause of breast cancer *** identified Regulator of G-protein Signaling4（RGS4）as a novel suppressor of breast cancer migration and invasion,important steps of metastatic *** blocking signals initiated through Gi-coupled receptors,such as protease-activated receptor1and CXC chemokine receptor4,

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Upregulation of PIP3-Dependent Rac Exchanger 1 （P-Rex1）Pro...

Upregulation of PIP3-Dependent Rac Exchanger 1(P-Rex1) Promotes Prostate Cancer Metastasis

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Mikio Hoshino dennis w.wolff Margaret A.Scofield Frank J.Dowd Department of Biochemistry and Cellular Biology National Institute of NeuroscienceNational Center of Neurology and Psychiatry Departments of Pharmacology Creighton University School of Medicine

＜正＞Excessive activation of G-protein coupled receptor（GPCR）and receptor tyrosine kinase（RTK）pathways has been linked to prostate cancer *** activation by

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

生物物理学报 2009年第S1期25卷 229-229页

作者： Mikio Hoshino dennis w.wolff Margaret A.Scofield Frank J.Dowd Department of Biochemistry and Cellular Biology National Institute of Neuroscience National Center of Neurology and Psychiatry Kyoto Japan Departments of Pharmacology Creighton University School of Medicine Omaha NE 68178 USA

Excessive activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) pathways has been linked to prostate cancer metastasis. Rac activation

关键词： PIP P-Rex1 Promotes Prostate Cancer Metastasis Upregulation of PIP3-Dependent Rac Exchanger 1

B-cell and antibody responses to SARS-CoV-2:infection,vaccination,and hybrid immunity

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： dennis Lapuente Thomas H.winkler Matthias Tenbusch Institut für klinische und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientific,medical,and biotech communities to investigate infection-and vaccine-induced immune responses in the context of this pathogen.B-cell and antibody responses are at the center of these investigations,as neutralizing antibodies(nAbs)are an important correlate of protection(COP)from infection and the primary target of SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics for scientists and health policy *** recent pandemic was and still is a unique setting in which to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of infection-and vaccine-induced *** also provided an opportunity to explore new vaccine platforms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort *** with the technological advances of recent years,this situation has provided detailed mechanistic insights into the development of B-cell and antibody responses but also revealed some unexpected *** this review,we summarize the key findings of the last 2.5 years regarding infection-and vaccine-induced B-cell immunity,which we believe are of significant value not only in the context of SARS-CoV-2 but also for future vaccination approaches in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines IgG4

Advancing emergency preparedness in a postpandemic world:global collaboration and innovative approaches for hospitals

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emergency and Critical Care Medicine 2024年第3期4卷 103-104页

作者： Krzysztof Goniewicz dennis G.Barten Department of Security Studies Polish Air Force UniversityDęblinPoland Department of Emergency Medicine VieCuri Medical CenterVenlothe Netherlands

As the world transitions into a postpandemic era,hospitals and healthcare systems must adapt their emergency management plans to address the unique challenges that *** upon the previous Hospital Emergency Management Plan^([1])during the coronavirus disease 2019 pandemic,this commentary offers updated and novel suggestions for emergency preparedness,emphasizing the need for international coordination and the implementation of innovative strategies.

关键词： innovative prepare global

FE65:a hub for neurodevelopment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 1883-1884页

作者： Yuqi Zhai Laura Lok-Haang Ng dennis Dik-Long Chau Kwok-Fai Lau School of Life Sciences Faculty of ScienceThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during ***65 belongs to the FE65 protein *** family is comprised of three memb... 详细信息

关键词： family development partner

Sequential good lattice point sets for computer experiments

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第9期67卷 2153-2170页

作者： Xue-Ru Zhang Yong-Dao Zhou Min-Qian Liu dennis K.J.Lin NITFID LPMC&KLMDASRSchool of Statistics and Data ScienceNankai UniversityTianjin 300071China Department of Statistics Purdue UniversityWest LafayetteIN 47907USA

Sequential Latin hypercube designs(SLHDs) have recently received great attention for computer experiments, with much of the research restricted to invariant spaces. The related systematic construction methods are inflexible, and algorithmic methods are ineffective for large designs. For designs in contracting spaces, systematic construction methods have not been investigated yet. This paper proposes a new method for constructing SLHDs via good lattice point sets in various experimental spaces. These designs are called sequential good lattice point(SGLP) sets. Moreover, we provide efficient approaches for identifying the(nearly)optimal SGLP sets under a given criterion. Combining the linear level permutation technique, we obtain a class of asymptotically optimal SLHDs in invariant spaces, where the L1-distance in each stage is either optimal or asymptotically optimal. Numerical results demonstrate that the SGLP set has a better space-filling property than the existing SLHDs in invariant spaces. It is also shown that SGLP sets have less computational complexity and more adaptability.

关键词： contracting space maximin distance nested Latin hypercube design sequential design space-fillingdesign

Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2024年

作者： weidong Liu dennis Leung Qiman Shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICM Southern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model, the number of pairwise comparisons can become large even with a moderate number of groups. Motivated by this, we consider a regime with a growing number of groups and prove that, when testing pairwise comparisons, the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries, despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) control. Following Tukey's perspective that the difference between the means of any two groups cannot be exactly zero, our main result provides control over the directional false discovery rate and directional false discovery proportion. A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR control. Our analysis does not rely on conventional assumptions such as normality, variance homogeneity, or a balanced design, thereby offering a theoretical foundation for applications in more general settings.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB